Abstract：
OBJECTIVES:Prostate cryosurgery has been increasingly used for the management of localized prostate cancer since its introduction in a minimally invasive form in the early 1990s. We performed a retrospective study of the largest and most mature patient group treated with cryosurgery reported thus far. METHODS:We retrospectively analyzed the data from 370 patients treated consecutively from 1991 to 1996 with a focus on the determination of biochemical disease-free survival for a group of patients with T1 to T3 prostate cancer who had undergone prostate cryosurgery as primary monotherapy. Only patients with no previous radiotherapy, hormonal therapy, or surgery were included. RESULTS:The median follow-up was 12.55 years. Using a nadir plus 2 ng/dL definition, Kaplan-Meier analysis demonstrated a biochemical disease-free survival rate at 10 years of 80.56%, 74.16%, and 45.54% for low, moderate, and high-risk groups, respectively. The 10-year negative biopsy rate was 76.96%. CONCLUSIONS:The results for this pilot group of patients who underwent percutaneous prostate cryosurgery monotherapy demonstrated biochemical disease-free survival rates that overlap with those of similar groups of patients treated under similar circumstances using other types of nonextirpative monotherapy.
journal_name
Urologyjournal_title
Urologyauthors
Cohen JK,Miller RJ Jr,Ahmed S,Lotz MJ,Baust Jdoi
10.1016/j.urology.2007.09.059subject
Has Abstractpub_date
2008-03-01 00:00:00pages
515-8issue
3eissn
0090-4295issn
1527-9995pii
S0090-4295(07)02193-0journal_volume
71pub_type
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