当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > Complete biochemical (prostate-specific antigen) response to sipuleucel-T with enzalutamide in castration-resistant prostate cancer: a case report with implications for future research.

Complete biochemical (prostate-specific antigen) response to sipuleucel-T with enzalutamide in castration-resistant prostate cancer: a case report with implications for future research.

Abstract：

OBJECTIVE:To describe the case of a patient with castration-resistant, metastatic prostate cancer who achieved a complete and durable biochemical response after treatment with sipuleucel-T while continuing with enzalutamide and to explore the immunologic basis for such a response. MATERIALS AND METHODS:We obtained serial prostate-specific antigen (PSA) measurements and bone scans to assess the patient's response to enzalutamide followed by the addition of sipuleucel-T. Using preclinical and clinical data, we describe his response through known immunobiologic mechanisms. RESULTS:This patient's PSA level became undetectable during treatment with enzalutamide and began to increase again after 14 months. He opted for treatment with sipuleucel-T, while continuing with the enzalutamide. This resulted in another complete PSA response 6 months after exposure to sipuleucel-T. CONCLUSION:Sipuleucel-T typically does not produce significant PSA reductions, and, to the best of our knowledge, only 1 previous report of a durable complete PSA response in a patient with metastatic disease has been published. The timing of this response supports an immune mechanism. The biologic rationale for the combination, coupled with the clinical result observed in our patient, provides a basis for studies of the combination of sipuleucel-T and enzalutamide.

journal_name

Urology

journal_title

Urology

authors

Graff JN,Drake CG,Beer TM

doi

10.1016/j.urology.2012.10.044

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

381-3

issue

2

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(12)01344-1

journal_volume

81

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.

    abstract：:The role of human papillomavirus (HPV) infection and other reported cofactors in the genesis, evolution, and clinical manifestations of precancerous and cancerous squamous cell lesions of the penis were studied in 34 men. Clinically, all lesions demonstrated aceto-whitening. Histologic changes of HPV infection formed ...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/0090-4295(93)90640-v

    authors： Malek RS,Goellner JR,Smith TF,Espy MJ,Cupp MR

    更新日期：1993-08-01 00:00:00

  • Treatment-related Outcomes for Patients With Atypical Peyronie's Disease Using Xiaflex Injections.

    abstract：OBJECTIVE:To evaluate the efficacy and safety of collagenase Clostridium histolyticum (CCH) for the management of penile deformities in patients presenting with different categories of atypical Peyronie's disease (PD). METHODS:We conducted a retrospective review of charts of patients who presented to a men's health cl...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2020.05.076

    authors： El-Khatib FM,Osman MM,Kopelevich A,Towe M,Yafi FA

    更新日期：2020-09-01 00:00:00

  • Fluoroscopy-guided renal access in supine percutaneous nephrolithotomy.

    abstract：OBJECTIVE:To describe a standardized and easily reproducible method for fluoroscopy-guided renal access during supine percutaneous nephrolithotomy (sPCNL). PATIENTS AND METHODS:From January 2009 to January 2010, 35 patients underwent sPCNL. In 10 patients, ultrasound-guided puncture was unsuccessful. In these patients...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.02.058

    authors： Hoznek A,Ouzaid I,Gettman M,Rode J,De La Taille A,Salomon L,Abbou CC

    更新日期：2011-07-01 00:00:00

  • Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

    abstract：OBJECTIVE:To investigate the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) protein in the interstitial cells of Cajal (ICCs) of the human bladder and to determine the relative expression of the HCN subtypes. METHODS:A total of 30 bladder specimens were obtained, and each bladder sample was di...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.04.005

    authors： Xue L,Li Y,Han X,Yao L,Yuan J,Qin W,Liu F,Wang H

    更新日期：2012-07-01 00:00:00

  • Torulopsis glabrata fungal cystitis.

    abstract：:The finding of Torulopsis glabrata fungal cystitis has become increasingly evident. The presence of indwelling urinary catheters, diabetes mellitus, and prior antibiotic therapy are significant risk factors in its development. Three cases are presented exemplifying the presentation of this disease. A discussion of its...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(84)90206-1

    authors： Siminovitch JM,Herman GP

    更新日期：1984-10-01 00:00:00

  • Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer.

    abstract：OBJECTIVES:To update our previously published nomogram predicting for biochemical outcome with 10-year data from a larger cohort of patients treated with three-dimensional conformal radiotherapy (RT) or intensity-modulated RT for localized prostate cancer. METHODS:From 1988 to 2004, 2253 patients were treated with thr...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.03.060

    authors： Zelefsky MJ,Kattan MW,Fearn P,Fearon BL,Stasi JP,Shippy AM,Scardino PT

    更新日期：2007-08-01 00:00:00

  • Extracorporeal shock-wave lithotripsy in horseshoe kidneys.

    abstract：:Using the Dornier HM-3 lithotriptor, 10 patients (11 renal units) with calculi in horseshoe kidneys were treated with extracorporeal shock-wave lithotripsy (ESWL) and ancillary procedures. Six renal units (55%) underwent pre-ESWL manipulation consisting of a Double J stent, ureteral catheter, or percutaneous nephrosto...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(90)80082-x

    authors： Locke DR,Newman RC,Steinbock GS,Finlayson B

    更新日期：1990-05-01 00:00:00

  • Whole body calcium deficit in cadmium-exposed workers with hypercalciuria.

    abstract：:Whole body elemental composition of 15 men occupationally exposed to cadmium was determined by total body in vivo neutron activation analysis and whole body counting. A significant deficit (P less than 0.01) in calcium was observed, compared with two groups of control subjects. The deficit increased with length of tim...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(80)90469-0

    authors： Scott R,Haywood JK,Boddy K,Williams ED,Harvey I,Paterson PJ

    更新日期：1980-04-01 00:00:00

  • Cystography after radical retropubic prostatectomy: clinical implications of abnormal findings.

    abstract：OBJECTIVES:In many institutions, cystography is obtained routinely after radical retropubic prostatectomy to assess the integrity of the vesicourethral anastomosis before the removal of the catheter. This study presents the Indiana experience with cystograms performed following radical retropubic prostatectomy. METHOD...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/S0090-4295(99)80163-0

    authors： Leibovitch I,Rowland RG,Little JS Jr,Foster RS,Bihrle R,Donohue JP

    更新日期：1995-07-01 00:00:00

  • Adjunctive tamsulosin improves stone free rate after ureteroscopic lithotripsy of large renal and ureteric calculi: a prospective randomized study.

    abstract：OBJECTIVES:To prospectively evaluate the role of tamsulosin on the stone free rate and the rate of colic episodes after ureteroscopic laser lithotripsy. The presence of alpha-1A adrenoceptor in the distal ureteral smooth muscle prompted the use of tamsulosin, a selective alpha-1 blocker, to promote spontaneous passage ...

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2009.07.1257

    authors： John TT,Razdan S

    更新日期：2010-05-01 00:00:00

  • Solitary metastasis of renal cell carcinoma to urethra.

    abstract：:A case report of a solitary metastasis to the urethra from previously resected renal cell carcinoma is reported. The patient presented with total gross painless hematuria. We believe this is the first such case to be reported. ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(90)80164-i

    authors： Goldberg MG,Plaine L

    更新日期：1990-04-01 00:00:00

  • Tricuspid valve metastasis from testicular carcinoma: a case report and review of the literature.

    abstract：:A 20-year-old man with Stage II nonseminomatous germ cell tumor underwent chemotherapy and multiple surgical resections of recurrent abdominal and supradiaphragmatic mature teratomas. Evaluation of a new heart murmur led to the diagnosis of tricuspid valve teratoma, which required complete valve excision and replaceme...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(00)00578-1

    authors： Deck AJ,True LD,Higano CS

    更新日期：2000-08-01 00:00:00

  • Dietary management of idiopathic hyperoxaluria and the influence of patient characteristics and compliance.

    abstract：OBJECTIVE:To assess the efficacy of dietary management for the treatment of idiopathic hyperoxaluria in a large tertiary care center and examine the influence of patient factors, compliance, and follow-up on oxalate reduction, which has not been previously investigated. METHODS:Retrospectively, 149 patients with kidne...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.08.002

    authors： Schwen ZR,Riley JM,Shilo Y,Averch TD

    更新日期：2013-12-01 00:00:00

  • Endourologic treatment of nephrocalcinosis.

    abstract：:Calcifications of the kidney may be located free within the collecting system, attached to a papilla, trapped beneath the urothelium, or sequestered in the renal parenchyma. Extracorporeal shock wave lithotripsy has failed to render patients who presented with nephrocalcinosis stone free because of the submucosal loca...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(00)00675-0

    authors： Kerbl K,Clayman RV

    更新日期：2000-09-01 00:00:00

  • Biological considerations in the assessment of urothelial cancer: a retrospective.

    abstract：:In bladder cancer, variations in clinical course and treatment outcomes support the concept that the condition may comprise a compendium of different types of tumor diathesis with unique, albeit interrelated, pathways of development. This concept and the schema of developmental pathways of bladder cancer derived from ...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.urology.2005.06.128

    authors： Droller MJ

    更新日期：2005-11-01 00:00:00

  • Laparoscopic radical cystectomy with intracorporeal orthotopic ileal neobladder: technique and clinical outcomes.

    abstract：OBJECTIVE:To study the feasibility and safety of laparoscopic radical cystectomy with intracorporeal orthotopic ileal neobladder and to evaluate the role of endoscopic stapling in neobladder construction. MATERIALS AND METHODS:Fifty-five patients with bladder cancer who underwent laparoscopic radical cystectomy were r...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2014.09.059

    authors： Shao P,Li P,Ju X,Qin C,Li J,Lv Q,Meng X,Yin C

    更新日期：2015-02-01 00:00:00

  • Correlation of heterogeneity index score (HIS) of DNA content in bladder cancer recurrence.

    abstract：:Automated flow cytometry (FCM) has been used to monitor the effects of therapy and progression of human bladder carcinoma. We have previously reported a computer-based model which has shown a correlation to relative mean DNA content in cell populations analyzed by FCM. Two patients with superficial transitional cell c...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(87)90394-3

    authors： Nakamura K,Kasabian NG,Addonizio JC,Chiao JW,Choudhury MS,Owens GF,Tachibana M,Nagamatsu GR

    更新日期：1987-11-01 00:00:00

  • Effect of diagnostic hydrodistension and four intravesical hyaluronic acid instillations on bladder ICAM-1 intensity and association of ICAM-1 intensity with clinical response in patients with interstitial cystitis.

    abstract：OBJECTIVES:To study the clinical effect of diagnostic overdistension plus hyaluronic acid (HA) instillations in interstitial cystitis and the association of the clinical response with the intensity of intercellular adhesion molecule (ICAM)-1 expression. HA is an important component in the urothelium. It inhibits adhere...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(02)01613-8

    authors： Leppilahti M,Hellström P,Tammela TL

    更新日期：2002-07-01 00:00:00

  • A Prospective Study to Evaluate Sexual Dysfunction and Enlargement of Seminal Vesicles in Sexually Active Men Treated for Benign Prostatic Hyperplasia by Alpha-blockers.

    abstract：OBJECTIVE:To evaluate sexual dysfunction and enlargement of seminal vesicles in sexually active men who were treated by α1-blockers for benign prostatic hyperplasia and its possible clinical application. MATERIALS AND METHODS:This is a prospective cohort study from January 2015 to December 2016. We enrolled sexually a...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2017.08.025

    authors： Sokhal AK,Sankhwar S,Goel A,Singh K,Kumar M,Purkait B,Saini DK

    更新日期：2018-08-01 00:00:00

  • Addition of antimuscarinics to alpha-blockers for treatment of lower urinary tract symptoms in men: a meta-analysis.

    abstract：:Alpha-blockers and antimuscarinics combination therapy has been commonly used for treatment of male lower urinary tract symptoms (LUTS). We conducted a meta-analysis aimed to access the relative efficacy and safety of combination therapy. We systematically searched Medline, Cochrane, and Embase for eligible studies. F...

    journal_title：Urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.urology.2013.04.045

    authors： Xin Z,Huang Y,Lu J,Zhang Q,Chen C

    更新日期：2013-08-01 00:00:00

  • Financial comparative analysis of minimally invasive surgery to open surgery for localized prostate cancer: a single-institution experience.

    abstract：OBJECTIVES:To evaluate the financial implications of how the costs of new minimally invasive surgery such as laparoscopic robotic prostatectomy (LRP) and cryosurgical ablation of the prostate (CAP) technologies compare with those of conventional surgery. METHODS:From January 2002 to July 2005, 452 consecutive patients...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2006.10.025

    authors： Mouraviev V,Nosnik I,Sun L,Robertson CN,Walther P,Albala D,Moul JW,Polascik TJ

    更新日期：2007-02-01 00:00:00

  • Validation of the Advanced Scope Trainer for Flexible Ureterorenoscopy Training.

    abstract：OBJECTIVE:To validate the Advanced Scope Trainer (AST; Mediskills, Northampton, UK). The AST is a currently unvalidated simulator, developed for flexible ureterorenoscopy (fURS) training. This study aims to assess the face, content, construct, and concurrent validity to assess the level of transferability of skills to ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2017.07.047

    authors： Al-Jabir A,Aydin A,Abe T,Raison N,Khan MS,Dasgupta P,Ahmed K

    更新日期：2017-12-01 00:00:00

  • Endoscopic treatment of complete urethral obstruction using thin trocar.

    abstract：:We used an endoscopic thin trocar to reestablish the continuity of the completely obliterated urethra in 2 patients. In 1 man the obstruction resulted from a pelvic fracture and in 1 woman from early removal of the urethral catheter after a bladder neck reconstruction. We found this technique safe and effective, and w...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(85)90454-6

    authors： Chiou RK,Gonzalez R

    更新日期：1985-05-01 00:00:00

  • Testicular seminoma originating in an undescended testis in a renal allograft recipient.

    abstract：:Immunosuppressed transplant recipients are at significantly increased risk for developing neoplasms than are nonimmunosuppressed individuals. However, only six cases of pure testicular seminoma following renal transplantation have been reported in the English literature. This case report represents the first descripti...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(96)00104-5

    authors： Modlin CS,Flechner SM,Penn I

    更新日期：1996-07-01 00:00:00

  • Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.

    abstract：:Using cultured HeLa S3 cells an ID50 of 2.5 micrograms/ml was found after a twenty-four-hour incubation with estradiol-17 beta- 3N -bis-(2-chloroethyl) carbamate (estramustine). Similar ID90 values were found in two Walker 256 rat carcinoma cell lines which were either sensitive or resistant to nitrogen mustards. Alka...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(84)80094-1

    authors： Tew KD,Hartley-Asp B

    更新日期：1984-06-01 00:00:00

  • Margin, ischemia, and complications system to report perioperative outcomes of robotic partial nephrectomy: a European Multicenter Observational Study (EMOS project).

    abstract：OBJECTIVE:To explore the margin, ischemia, and complications (MIC) system achievement rate within a population of patients who were treated with robotic partial nephrectomy (RAPN), at 3 different tertiary care centers, and to determine the factors predicting MIC achievement. METHODS:The study population consisted of 3...

    journal_title：Urology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.urology.2014.09.068

    authors： Lista G,Buffi NM,Lughezzani G,Lazzeri M,Abrate A,Mistretta A,Larcher A,Dell'Oglio P,Fossati N,Porter J,Ficarra V,Mottrie A,Guazzoni G

    更新日期：2015-03-01 00:00:00

  • Effects of ultrasound on ultrastructure of human testes.

    abstract：:Studies to detect ultrastructural changes in testicular tissues after a fifteen-minute exposure to ultrasonic waves were done in 10 men undergoing bilateral orchiectomies for prostatic carcinoma. Examination of Sertoli cells and germ cells in different stages of differentiation failed to reveal significant differences...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(87)90232-9

    authors： Grunberger I,Suhrland MJ,Greco MA,Glasser J,Al-Askari S

    更新日期：1987-09-01 00:00:00

  • Three-dimensional ultrasound bladder characteristics and their association with prostate size and lower urinary tract dysfunction among men in the community.

    abstract：OBJECTIVES:To characterize ultrasound bladder measures, and to determine whether these measures were associated with measures of lower urinary tract dysfunction. METHODS:Three-dimensional ultrasounds were used to assess bladder surface area (SA), bladder wall thickness (BWT), and estimated bladder weight (EBW) in a ra...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2009.04.081

    authors： Rule AD,St Sauver JL,Jacobson DJ,McGree ME,Girman CJ,Lieber MM,Jacobsen SJ

    更新日期：2009-10-01 00:00:00

  • Growth factors in urologic tissues: detection, characterization, and clinical applications.

    abstract：:During the last two decades, enormous strides have been made in understanding cellular and molecular biology. The direction of treatment of many neoplasms and other diseases are starting at the microscopic level. Growth factors are polypeptides that play a part in the development and maintenance of living tissues. We,...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/0090-4295(92)90400-q

    authors： Mydlo JH,Macchia RJ

    更新日期：1992-12-01 00:00:00

  • Prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract.

    abstract：OBJECTIVES:To elucidate the prognostic significance of lymphovascular invasion (LVI) in patients with upper tract transitional cell carcinoma. METHODS:Of 86 patients with upper tract transitional cell carcinoma who underwent nephroureterectomy with bladder cuff (95%) or parenchymal-sparing (5%) surgery from 1991 to 20...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2004.11.001

    authors： Hong B,Park S,Hong JH,Kim CS,Ro JY,Ahn H

    更新日期：2005-04-01 00:00:00