Artificial sweetener consumption and urinary tract tumors in Cordoba, Argentina.

Abstract:

OBJECTIVE:To determine the role of the habitual use of the most common artificial sweeteners (AS) in the development of urinary tract tumors (UTT) in Argentina. METHODS:Case-control study of 197 patients with histologically confirmed UTT of transitional varieties, and 397 controls with acute, non-neoplastic, and non-urinary tract diseases, admitted to the same hospitals in Córdoba (Argentina) between 1999 and 2006. All subjects were interviewed about their use of AS and their exposure to other known or suspected risk factors for UTT. RESULTS:Fifty-one UTT patients (26%) and 87 controls (22%) used AS. The risk of UTT was significantly increased in long-term (> or =10 years) AS users compared with none-AS users. The OR (95% CI) for long-term consumers was 2.18 (1.22-3.89) and for short-term users was 1.10 (0.61-2.00) after adjustment for age, gender, BMI, social status. and years of tobacco use. CONCLUSION:Regular use of AS for 10 years or more was positively associated with UTT.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Andreatta MM,Muñoz SE,Lantieri MJ,Eynard AR,Navarro A

doi

10.1016/j.ypmed.2008.03.015

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

136-9

issue

1

eissn

0091-7435

issn

1096-0260

pii

S0091-7435(08)00157-6

journal_volume

47

pub_type

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