Flammability of endotracheal tubes during Nd-YAG laser application in the airway.

abstract：BACKGROUND:: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice...

journal_title：Anesthesiology

authors： Shen X,Dong Y,Xu Z,Wang H,Miao C,Soriano SG,Sun D,Baxter MG,Zhang Y,Xie Z

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The direct action of sevoflurane on systemic resistance arteries is not fully understood. METHODS:Isometric force was recorded in isolated rat small mesenteric arteries. RESULTS:Sevoflurane (2-5%) enhanced contractile response to norepinephrine only in the presence of endothelium, but inhibited it in its a...

journal_title：Anesthesiology

authors： Izumi K,Akata T,Takahashi S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...

journal_title：Anesthesiology

authors： Morey TE,Martynyuk AE,Napolitano CA,Raatikainen MJ,Guyton TS,Dennis DM

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Morbidly obese patients, during anesthesia and paralysis, experience more severe impairment of respiratory mechanics and gas exchange than normal subjects. The authors hypothesized that positive end-expiratory pressure (PEEP) induces different responses in normal subjects (n = 9; body mass index < 25 kg/m2) ...

journal_title：Anesthesiology

authors： Pelosi P,Ravagnan I,Giurati G,Panigada M,Bottino N,Tredici S,Eccher G,Gattinoni L

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulo...

journal_title：Anesthesiology

authors： Fu MJ,Tsen LY,Lee TY,Lui PW,Chan SH

更新日期：1997-12-01 00:00:00

abstract：:To determine the percentage of anesthetic metabolized and to assess the role of metabolism in the total elimination of inhaled anesthetics, the authors administered isoflurane, enflurane, halothane, and methoxyflurane simultaneously, for 2 h, to nine healthy patients. Total anesthetic uptake during the 2 h of washin a...

journal_title：Anesthesiology

authors： Carpenter RL,Eger EI 2nd,Johnson BH,Unadkat JD,Sheiner LB

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:The extent to which isoflurane anesthesia alters systemic vascular regulation has received considerable attention. In contrast, the pulmonary vascular effects of isoflurane have not been elucidated. Our initial objective was to investigate the net effect of isoflurane on the baseline left pulmonary vascular ...

journal_title：Anesthesiology

authors： Lennon PF,Murray PA

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The mechanisms of amino-amide local anesthetic agent-induced vasoconstriction remain unclear. The current study was designed to examine the roles of the protein kinase C (PKC), Rho kinase, and p44/42 mitogen-activated protein kinase (p44/42 MAPK) signaling pathways in calcium (Ca2+)-sensitization mechanisms ...

journal_title：Anesthesiology

authors： Yu J,Tokinaga Y,Kuriyama T,Uematsu N,Mizumoto K,Hatano Y

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Valdecoxib and its intravenous prodrug parecoxib are reported to increase thromboembolic risk after coronary artery bypass grafting. The authors conducted a randomized trial to examine their safety and analgesic efficacy in patients recovering from major noncardiac surgical procedures. METHODS:The trial was...

journal_title：Anesthesiology

authors： Nussmeier NA,Whelton AA,Brown MT,Joshi GP,Langford RM,Singla NK,Boye ME,Verburg KM

更新日期：2006-03-01 00:00:00

abstract：:The dose-response and plasma concentration-response relationships for pancuronium in man were studied during its intravenous administration to eight patients at a rate of 1.62 microgram/kg/min. The (log) dose-response relationships resulted in a sigmoid curve that was linear in its central range. At 20, 50 and 80 per ...

journal_title：Anesthesiology

authors： Shanks CA,Somogyi AA,Triggs EJ

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article pres...

journal_title：Anesthesiology

authors： Gätke MR,Ostergaard D,Bundgaard JR,Varin F,Viby-Mogensen J

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations. METHODS:Ketamine or saline was administered in a single-blinded crossover prot...

journal_title：Anesthesiology

authors： Bowdle TA,Radant AD,Cowley DS,Kharasch ED,Strassman RJ,Roy-Byrne PP

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Neurocognitive dysfunction is a common complication of cardiac surgery using cardiopulmonary bypass (CPB). Elucidating injury mechanisms and developing neuroprotective strategies have been hampered by the lack of a suitable long-term recovery model of CPB. The purpose of this study was to investigate neurolo...

journal_title：Anesthesiology

authors： Mackensen GB,Sato Y,Nellgård B,Pineda J,Newman MF,Warner DS,Grocott HP

更新日期：2001-12-01 00:00:00

abstract：:Administration of the oxidant lipid peroxide tertiary butyl hydroperoxide (t-bu-OOH) in the isolated rabbit lung leads to acute pulmonary vasoconstriction, which is caused by the synthesis of thromboxane. The inhalational anesthetics, halothane, nitrous oxide, and cyclopropane, markedly enhance t-bu-OOH-induced pulmon...

journal_title：Anesthesiology

authors： McShane AJ,Crowley K,Shayevitz JR,Michael JR,Adkinson NF Jr,Traystman RJ,Gurtner GH

更新日期：1989-05-01 00:00:00

abstract：:Minute ventilation (VE), tidal volume (VT), carbon dioxide elimination (VCO2), and end-tidal (PETCO2) and arterial CO2 tensions (PaCO2) were measured in 39 anesthetized infants and children with body weights ranging from 3.1 to 31 kg. Eighteen children had normal cardiopulmonary function, seven had acyanotic congenita...

journal_title：Anesthesiology

authors： Lindahl SG,Yates AP,Hatch DJ

更新日期：1987-02-01 00:00:00

abstract：:Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...

journal_title：Anesthesiology

authors： Kambam JR,Holaday DA

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on...

journal_title：Anesthesiology

authors： Kagawa K,Mammoto T,Hayashi Y,Kamibayashi T,Mashimo T,Yoshiya I

更新日期：1997-10-01 00:00:00

abstract：:The authors hypothesized that relaxation of airway smooth muscle by halothane lessens the dependence of airway resistance on lung volume, and that halothane alters the relationship between pulmonary resistance and lung volume by changing both the airway and tissue components of pulmonary resistance. The relationship a...

journal_title：Anesthesiology

authors： Joyner MJ,Warner DO,Rehder K

更新日期：1992-02-01 00:00:00

abstract：:It is now well established that the pathophysiology of the malignant hyperthermia (MH) syndrome is related to a malfunction of intracellular calcium homeostasis. Magnesium plays important roles in the basic contractile properties of muscle, and many of its actions are antagonistic to those of calcium. The aim of this ...

journal_title：Anesthesiology

authors： Lopez JR,Sanchez V,Lopez I,Ryan JF,Mendoza M,Sreter FA,Allen PD

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neuron...

journal_title：Anesthesiology

authors： Putrenko I,Schwarz SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Although considerable evidence indicates neuronal Ca channels play significant roles in pain perception, their possible importance in hypersensitization after acute inflammation has not been investigated. METHODS:Using carrageenan for inducing hypersensitization, the authors investigated the analgesic effec...

journal_title：Anesthesiology

authors： Yokoyama K,Kurihara T,Makita K,Tanabe T

更新日期：2003-12-01 00:00:00

abstract：:This study examined the efficacy of patient-controlled epidural analgesia (PCEA) during labor and compared the suitability of three different PCEA solutions. After establishing effective epidural analgesia with 12 ml of 0.25% bupivacaine, 72 parturients in active labor were randomly assigned to one of four groups: phy...

journal_title：Anesthesiology

authors： Lysak SZ,Eisenach JC,Dobson CE 2nd

更新日期：1990-01-01 00:00:00

abstract：:The effect of neuromuscular blockade with vecuronium on the hemodynamic responses to a noxious stimulus was investigated in male Sprague-Dawley rats. The rats were anesthetized with either halothane (group 1, n = 10), or isoflurane (group 2, n = 10). The maximum values for heart rate and mean arterial pressure during ...

journal_title：Anesthesiology

authors： Gibbs NM,Larach DR,Schuler HG

更新日期：1989-08-01 00:00:00

abstract：:Previous investigators have identified an aortic-to-radial artery pressure gradient thought to develop during rewarming and discontinuation of cardiopulmonary bypass. The authors measured mean aortic and radial artery pressures before, during, and after cardiopulmonary bypass in 30 patients, to determine when the pres...

journal_title：Anesthesiology

authors： Rich GF,Lubanski RE Jr,McLoughlin TM

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide. The authors wanted to determine whether circulating catecholamine concentrations depend on the anesthetic agent and whether sympathetic ganglionic blockade affects anesthetic...

journal_title：Anesthesiology

authors： Mackensen GB,Nellgård B,Miura Y,Chu CT,Dexter F,Pearlstein RD,Warner DS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:During laparoscopic surgery utilizing carbon dioxide as the insufflating agent, nitrous oxide will diffuse into the peritoneal cavity if it is used as part of the anesthetic. Bowel perforation and the subsequent release of volatile bowel gas could create a explosion hazard. METHODS:Two related studies were ...

journal_title：Anesthesiology

authors： Neuman GG,Sidebotham G,Negoianu E,Bernstein J,Kopman AF,Hicks RG,West ST,Haring L

更新日期：1993-05-01 00:00:00

abstract：:The formation of acute edema in the tracheobronchial mucosa following local instillation of hydrochloric acid or gastric juice was studied in rats. Protein extravasation using the Evans blue technique was measured and used to indicate edema formation. A pH dependent Evans blue extravasation was observed whereby pH 2 p...

journal_title：Anesthesiology

authors： Martling CR,Lundberg JM

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors...

journal_title：Anesthesiology

authors： Todd MM,Weeks JB,Warner DS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperativ...

journal_title：Anesthesiology

authors： Farag E,Liang C,Mascha EJ,Argalious MY,Ezell J,Maheshwari K,Esa WAS,Troianos CA,Sessler DI

更新日期：2020-07-01 00:00:00

abstract：:Hepatic drug-metabolizing enzymes and hepatic ultrastructure were studied in rats after two hours of anesthesia with 1 MAC halothane or diethyl ether. Twelve hours after cessation of either anesthetic smooth endoplasmic reticulum was increased in centrilobular but not in periportal hepatocytes. This change persisted a...

journal_title：Anesthesiology

authors： Ross WT Jr,Cardell RR Jr

更新日期：1978-05-01 00:00:00