Cimetidine protection against alpha-amanitin hepatotoxicity in mice: a potential model for the treatment of Amanita phalloides poisoning.

Abstract:

:The ingestion of the mushroom Amanita phalloides is associated with hepatic necrosis appearing clinically two to three days after ingestion. The mechanism of this toxicity is unknown, and no reliable antidote is available. Because of the similarity of Amanita poisoning to other toxins affecting cytochrome P450, we investigated the use of cimetidine (as a P450 cytochrome inhibitor) as an antidote against a primary toxin of the mushroom alpha-amanitin. Mice injected with alpha-amanitin and given cimetidine either prophylactically or within six hours showed histologic protection from the hepatic damage seen in control mice. Control animals displayed significant mitochondrial changes when examined by electron-microscopy, while the mitochondria of the cimetidine-treated animals were preserved, suggesting a possible site for toxin action. Further trials will be necessary before treatment of human cases with cimetidine is indicated.

journal_name

Ann Emerg Med

authors

Schneider SM,Borochovitz D,Krenzelok EP

doi

10.1016/s0196-0644(87)80472-9

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

1136-40

issue

10

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(87)80472-9

journal_volume

16

pub_type

杂志文章
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    abstract:STUDY OBJECTIVE:Efficient management and allocation of scarce medical resources can improve outcomes for victims of mass casualty events. However, the effectiveness of specific strategies has never been systematically reviewed. We analyze published evidence on strategies to optimize the management and allocation of sca...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.annemergmed.2013.02.005

    authors: Timbie JW,Ringel JS,Fox DS,Pillemer F,Waxman DA,Moore M,Hansen CK,Knebel AR,Ricciardi R,Kellermann AL

    更新日期:2013-06-01 00:00:00

  • Effect of alcohol on cellular membranes.

    abstract::Ethanol disrupts the physical structure of cell membranes. The most fluid membranes, including those that are low in cholesterol, are the most easily disordered by ethanol. Although the membrane-disordering effect is small, there is pharmacological, temporal, and genetic evidence that it is important. Animals that are...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-0644(86)80120-2

    authors: Goldstein DB

    更新日期:1986-09-01 00:00:00

  • The emergency management of a medicinal leech bite.

    abstract::Leeches have been used as a medicinal remedy for years untold. Recently, there appears to have been a resurgence in the use of the medicinal leech, Hirudo medicinalis. Presented is the case of a patient who called the emergency department for advice concerning the management of a bleeding leech bite. We discuss briefl...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(89)80422-6

    authors: Adams SL

    更新日期:1989-03-01 00:00:00

  • Evaluation of a rapid theophylline test strip assay in the emergency department setting.

    abstract::Test strips recently have become available to measure theophylline levels. One such test strip (AccuLevel) had not been tested in an actual clinical situation with nontechnician personnel. We prospectively evaluated the test strip on consecutive emergency department patients, comparing it with the agglutination inhibi...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(88)80440-2

    authors: Hurley WT,Saglio SD,Henley CE,Gatrell CB

    更新日期:1988-10-01 00:00:00

  • The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology.

    abstract::The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology. One patient ingested 20.5 mg alprazolam before crashing his truck into parked automobiles. The patient was awakened by flumazenil administration, and the severity of his injuries was evaluated reliably. A sec...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0196-0644(05)82054-2

    authors: Burkhart KK,Kulig KW

    更新日期:1990-03-01 00:00:00

  • Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice.

    abstract:STUDY OBJECTIVE:A 2-hour accelerated diagnostic pathway based on the Thrombolysis in Myocardial Infarction score, ECG, and troponin measures (ADAPT-ADP) increased early discharge of patients with suspected acute myocardial infarction presenting to the emergency department compared with standard care (from 11% to 19.3%)...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.annemergmed.2016.01.001

    authors: Than MP,Pickering JW,Aldous SJ,Cullen L,Frampton CM,Peacock WF,Jaffe AS,Goodacre SW,Richards AM,Ardagh MW,Deely JM,Florkowski CM,George P,Hamilton GJ,Jardine DL,Troughton RW,van Wyk P,Young JM,Bannister L,Lord SJ

    更新日期:2016-07-01 00:00:00

  • Acute respiratory failure during therapy for salicylate intoxication.

    abstract::The case of a patient who developed severe acute respiratory failure during therapy for salicylate intoxication is described. The individual with aspirin overdose is at risk for this complication because of the potential for treatment modalities to cause or worsen lung edema initiated by the effects of salicylates on ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(81)80349-6

    authors: Zimmerman GA,Clemmer TP

    更新日期:1981-02-01 00:00:00

  • A decision rule for identifying children at low risk for brain injuries after blunt head trauma.

    abstract:STUDY OBJECTIVE:Computed tomography (CT) is frequently used in evaluating children with blunt head trauma. Routine use of CT, however, has disadvantages. Therefore, we sought to derive a decision rule for identifying children at low risk for traumatic brain injuries. METHODS:We enrolled children with blunt head trauma...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/s0196-0644(03)00425-6

    authors: Palchak MJ,Holmes JF,Vance CW,Gelber RE,Schauer BA,Harrison MJ,Willis-Shore J,Wootton-Gorges SL,Derlet RW,Kuppermann N

    更新日期:2003-10-01 00:00:00

  • Successful conversion of unstable supraventricular tachycardia to sinus rhythm with adenosine.

    abstract:STUDY PURPOSE:To evaluate the efficacy of adenosine in the treatment of emergency department patients with unstable paroxysmal supraventricular tachycardia (PSVT). DESIGN:A retrospective chart review conducted over two years. SETTING:A university-affiliated hospital ED. PARTICIPANTS:Patients with unstable PSVT (syst...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)81853-0

    authors: Melio FR,Mallon WK,Newton E

    更新日期:1993-04-01 00:00:00

  • Investigation of bone developmental and histopathologic changes from intraosseous infusion.

    abstract:STUDY OBJECTIVE:To evaluate clinical and cellular changes of bone through the rapid growth phase of development after intraosseous infusion of hypertonic or isotonic solutions at slow or fast infusion rates in a pig model. METHODS:This was a prospective, randomized, partially blinded, comparative study using a porcine...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(96)70010-0

    authors: Brickman KR,Rega P,Schoolfield L,Harkins K,Weisbrode SE,Reynolds G

    更新日期:1996-10-01 00:00:00

  • Do children require hospitalization after immediate posttraumatic seizures?

    abstract:STUDY OBJECTIVE:We determine whether children with immediate posttraumatic seizures require hospitalization for observation of possible neurologic complications. METHODS:This was a prospective observational cohort study of children younger than 18 years with blunt head trauma resulting in immediate posttraumatic seizu...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/S0196064403012071

    authors: Holmes JF,Palchak MJ,Conklin MJ,Kuppermann N

    更新日期:2004-06-01 00:00:00

  • Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk.

    abstract:STUDY OBJECTIVE:To develop clinical rules for the safe and effective use of flumazenil in suspected benzodiazepine overdose. METHODS:We assembled a retrospective series of 35 consecutive comatose patients admitted between October 1992 and July 1993 to a toxicologic ICU with the presumptive diagnosis of drug overdose. ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(96)70191-9

    authors: Gueye PN,Hoffman JR,Taboulet P,Vicaut E,Baud FJ

    更新日期:1996-06-01 00:00:00

  • Guidelines for evaluation of international emergency medicine assistance and development projects.

    abstract::Interest in the development of the specialty of emergency medicine and of emergency health care systems has greatly increased worldwide in the last few years. The guidelines in this article were developed in an effort to assist others in design and evaluation of all types of emergency medicine projects. ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(97)70054-4

    authors: Holliman CJ,Kirsch TD,Green GB,Wolfson AB,Tom PA

    更新日期:1997-12-01 00:00:00

  • Older emergency department patients with acute myocardial infarction receive lower quality of care than younger patients.

    abstract:STUDY OBJECTIVE:We assessed the independent relationship between age and the quality of medical care provided to patients presenting to the emergency department (ED) with acute myocardial infarction. METHODS:We conducted a 2-year retrospective cohort study of 2,216 acute myocardial infarction patients presenting urgen...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2004.12.012

    authors: Magid DJ,Masoudi FA,Vinson DR,van der Vlugt TM,Padgett TG,Tricomi AJ,Lyons EE,Crounse L,Brand DW,Go AS,Ho PM,Rumsfeld JS

    更新日期:2005-07-01 00:00:00

  • Soluble intercellular adhesion molecule-1 as a predictor of early adverse events in patients with chest pain compatible with myocardial ischemia.

    abstract:STUDY OBJECTIVE:Inflammation plays an important role in acute coronary syndromes, and some evidence indicates that patients with a more pronounced vascular inflammatory response have a poorer outcome. Soluble intercellular adhesion molecule-1 (sICAM-1) is a specific marker for vascular endothelial cell activation. The ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/mem.2001.117199

    authors: Hillis GS,Terregino C,Taggart P,Killian A,Zhao N,Kaplan J,Dalsey WC,Mangione A

    更新日期:2001-09-01 00:00:00

  • Derivation of a decision rule for the use of radiography in acute knee injuries.

    abstract:STUDY OBJECTIVE:To derive a highly sensitive decision rule for the selective use of radiography in acute knee injuries. DESIGN:Prospectively administered survey. SETTING:Emergency departments of two university hospitals. PARTICIPANTS:Convenience sample of 1,047 adults with acute knee injuries. RESULTS:Attending eme...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(95)70106-0

    authors: Stiell IG,Greenberg GH,Wells GA,McKnight RD,Cwinn AA,Cacciotti T,McDowell I,Smith NA

    更新日期:1995-10-01 00:00:00

  • Accidental firearm fatalities among New Mexico children.

    abstract:STUDY HYPOTHESIS:Risk factors associated with unintentional gunshot fatalities among children include gender and race of the decedent, type of firearm used, and whether loaded guns are stored within the home. STUDY POPULATION:All New Mexico children 0 to 14 years old unintentionally killed by a firearm between 1984 an...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)81120-5

    authors: Martin JR,Sklar DP,McFeeley P

    更新日期:1991-01-01 00:00:00

  • Development and implementation of emergency CPR instruction via telephone.

    abstract::We developed a cardiopulmonary resuscitation (CPR) message that can be given via telephone by emergency dispatchers directly to an individual reporting a cardiac arrest. The message was developed and evaluated on the basis of empirical observation of CPR performance of 203 community volunteers during simulated cardiac...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(84)80730-1

    authors: Carter WB,Eisenberg MS,Hallstrom AP,Schaeffer S

    更新日期:1984-09-01 00:00:00

  • Outpatient management of acute urticaria: the role of prednisone.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients. DESIGN:Prospective, randomized, double-blinded, clinical trial. SETTING:Emergency department of an urban tertiary care teaching hosp...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0196-0644(95)70002-1

    authors: Pollack CV Jr,Romano TJ

    更新日期:1995-11-01 00:00:00

  • Beer potomania: an unusual cause of symptomatic hyponatremia.

    abstract::A 43-year-old woman presented to the emergency department with acute agitation, confusion, and tonic seizures. She had a history of drug abuse, most notably beer, which constituted her major dietary intake. The patient's seizures were at first thought to be factitious in association with an acute psychosis; however, h...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(86)80442-5

    authors: Joyce SM,Potter R

    更新日期:1986-06-01 00:00:00

  • Acoustic otoscopy in the diagnosis of otitis media.

    abstract::Acoustic otoscopy detects middle ear pathology by measuring the ability of the tympanic membrane to reflect sound. Fluid or thickening of the tympanic membrane increases sound reflection. We conducted a study to compare acoustic otoscopy with pneumatic otoscopy in identifying middle ear pathology in 80 children (160 e...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0196-0644(89)80578-5

    authors: Jehle D,Cottington E

    更新日期:1989-04-01 00:00:00

  • Needlestick injuries and hepatitis B immunization in Florida paramedics: a statewide survey.

    abstract:STUDY OBJECTIVES:To determine the incidence of needlestick injury among paramedics working in Florida during 1987, to describe the circumstances surrounding such injuries, and to assess the hepatitis B vaccination status of this group. DESIGN:Survey of a systematic random sample of paramedics using a self-administered...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)81072-8

    authors: Klontz KC,Gunn RA,Caldwell JS

    更新日期:1991-12-01 00:00:00

  • Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.

    abstract:STUDY OBJECTIVE:Salicylate poisoning is a challenging clinical entity associated with substantial morbidity and mortality. The indications for extracorporeal treatments such as hemodialysis are poorly defined. We present a systematic review of the literature along with evidence- and consensus-based recommendations on t...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.annemergmed.2015.03.031

    authors: Juurlink DN,Gosselin S,Kielstein JT,Ghannoum M,Lavergne V,Nolin TD,Hoffman RS,EXTRIP Workgroup.

    更新日期:2015-08-01 00:00:00

  • Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures.

    abstract::This clinical policy focuses on critical issues in the evaluation and management of adult patients with seizures. The medical literature was reviewed for articles that pertained to the critical questions posed. Subcommittee members and expert peer reviewers also supplied articles with direct bearing on this policy. Th...

    journal_title:Annals of emergency medicine

    pub_type: 指南,杂志文章,实务指引

    doi:10.1016/S019606440400068X

    authors: ACEP Clinical Policies Committee.,Clinical Policies Subcommittee on Seizures.

    更新日期:2004-05-01 00:00:00

  • Ventilatory strategies affect gas exchange in a pig model of closed-chest cardiac compression.

    abstract:STUDY OBJECTIVE:To identify the arterial and mixed venous blood gas changes caused by different ventilatory strategies during resuscitation from ventricular fibrillation in a pig model of closed-chest cardiac compression. METHODS:A prospective randomized animal study was performed using 27 domestic pigs (body weight, ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(98)70203-3

    authors: Whitehurst ME,Blount AD,Austin PE,Carroll RG

    更新日期:1998-05-01 00:00:00

  • Closed thoracic cavity lavage in the treatment of severe hypothermia in human beings.

    abstract::Life-threatening hypothermia can be treated by active and passive rewarming techniques, the treatment of choice being partial cardiopulmonary bypass. The use of closed thoracic cavity lavage has been evaluated in animals, but no formal presentations in human beings have been reported. We report two cases in which rapi...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)81810-4

    authors: Hall KN,Syverud SA

    更新日期:1990-02-01 00:00:00

  • Selective aortic arch perfusion during cardiac arrest: enhanced resuscitation using oxygenated perflubron emulsion, with and without aortic arch epinephrine.

    abstract:STUDY OBJECTIVE:To evaluate selective aortic arch perfusion (SAAP) with an oxygenated fluorocarbon emulsion, with and without aortic arch epinephrine during cardiac arrest. METHODS:This randomized, controlled study, undertaken at a university research laboratory, involved 15 mixed-breed dogs. After 10 minutes of ventr...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(97)70244-0

    authors: Manning JE,Batson DN,Payne FB,Adam N,Murphy CA,Perretta SG,Norfleet EA

    更新日期:1997-05-01 00:00:00

  • Comparative Effectiveness of Patient-Controlled Analgesia for Treating Acute Pain in the Emergency Department.

    abstract:STUDY OBJECTIVE:We assess the effectiveness of patient-controlled analgesia in the emergency department (ED). We hypothesized that decline in pain intensity from 30 to 120 minutes after initial intravenous opioid administration is greater in patients receiving morphine by patient-controlled analgesia compared with usua...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.annemergmed.2017.03.064

    authors: Bijur PE,Mills AM,Chang AK,White D,Restivo A,Persaud S,Schechter CB,Gallagher EJ,Birnbaum AJ

    更新日期:2017-12-01 00:00:00

  • The bacteriology of dog bite wounds on initial presentation.

    abstract::Four hundred twenty patients with open dog bite wounds on initial presentation to the emergency department had Gram stains, aerobic and anaerobic cultures, and antibiotic sensitivities of the bacterial isolates of each wound. Forty-eight percent of the wounds evidenced no bacterial growth. Staphylococcus epidermidis w...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(86)80620-5

    authors: Ordog GJ

    更新日期:1986-11-01 00:00:00

  • A randomized, controlled trial of the use of music during laceration repair.

    abstract:STUDY OBJECTIVES:To determine whether music significantly reduces the pain and anxiety associated with laceration repair in the emergency department. PARTICIPANTS AND SETTING:Adult patients presenting to the ED at an urban teaching hospital for laceration repair. Exclusion criteria included patients less than 18 years...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0196-0644(05)81652-x

    authors: Menegazzi JJ,Paris PM,Kersteen CH,Flynn B,Trautman DE

    更新日期:1991-04-01 00:00:00