Comparative Effectiveness of Patient-Controlled Analgesia for Treating Acute Pain in the Emergency Department.

Abstract:

STUDY OBJECTIVE:We assess the effectiveness of patient-controlled analgesia in the emergency department (ED). We hypothesized that decline in pain intensity from 30 to 120 minutes after initial intravenous opioid administration is greater in patients receiving morphine by patient-controlled analgesia compared with usual care and would differ by a clinically significant amount. METHOD:This was a pragmatic randomized controlled trial of patient-controlled analgesia and usual care (opioid and dose at physician's discretion) in 4 EDs. Entry criteria included age 18 to 65 years and acute pain requiring intravenous opioids. The primary outcome was decline in numeric rating scale pain score 30 to 120 minutes postbaseline. Secondary outcomes included satisfaction, time to analgesia, adverse events, and patient-controlled analgesia pump-related problems. We used a mixed-effects linear model to compare rate of decline in pain (slope) between groups. A clinically significant difference between groups was defined as a difference in slopes equivalent to 1.3 numeric rating scale units. RESULTS:Six hundred thirty-six patients were enrolled. The rate of decline in pain from 30 to 120 minutes was greater for patients receiving patient-controlled analgesia than usual care (difference=1.0 numeric rating scale unit; 95% confidence interval [CI] 0.6 to 1.5; P<.001) but did not reach the threshold for clinical significance. More patients receiving patient-controlled analgesia were satisfied with pain management (difference=9.3%; 95% CI 3.3% to 15.1%). Median time to initial analgesia was 15 minutes longer for patient-controlled analgesia than usual care (95% CI 11.4 to 18.6 minutes). There were 7 adverse events in the patient-controlled analgesia group and 1 in the usual care group (difference=2.0%; 95% CI 0.04% to 3.9%), and 11 pump-programming errors. CONCLUSION:The findings of this study do not favor patient-controlled analgesia over usual ED care for acute pain management.

journal_name

Ann Emerg Med

authors

Bijur PE,Mills AM,Chang AK,White D,Restivo A,Persaud S,Schechter CB,Gallagher EJ,Birnbaum AJ

doi

10.1016/j.annemergmed.2017.03.064

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

809-818.e2

issue

6

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(17)30360-8

journal_volume

70

pub_type

杂志文章,随机对照试验
  • The emergency management of a medicinal leech bite.

    abstract::Leeches have been used as a medicinal remedy for years untold. Recently, there appears to have been a resurgence in the use of the medicinal leech, Hirudo medicinalis. Presented is the case of a patient who called the emergency department for advice concerning the management of a bleeding leech bite. We discuss briefl...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(89)80422-6

    authors: Adams SL

    更新日期:1989-03-01 00:00:00

  • Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure.

    abstract:STUDY OBJECTIVE:We determine the cost-effectiveness of out-of-hospital continuous positive airway pressure (CPAP) compared with standard care for adults presenting to emergency medical services with acute respiratory failure. METHODS:We developed an economic model using a United Kingdom health care system perspective ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2014.12.028

    authors: Thokala P,Goodacre S,Ward M,Penn-Ashman J,Perkins GD

    更新日期:2015-05-01 00:00:00

  • Electronic Mass Casualty Assessment and Planning Scenarios (EMCAPS): development and application of computer modeling to selected National Planning Scenarios for high-consequence events.

    abstract::Few tools exist that are sufficiently robust to allow manipulation of key input variables to produce casualty estimates resulting from high-consequence events reflecting local or specific regions of concern. This article describes the design and utility of a computerized modeling simulation tool, Electronic Mass Casua...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2008.09.014

    authors: Scheulen JJ,Thanner MH,Hsu EB,Latimer CK,Brown J,Kelen GD

    更新日期:2009-02-01 00:00:00

  • In-hospital cardiac arrest.

    abstract::Patients who suffer an in-hospital cardiac arrest represent a neglected and underutilized resource for resuscitation research. There exists an unwritten, but widely held, belief among resuscitation researchers that the in-hospital arrest population is unsuitable for resuscitation research because it is composed mostly...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-0644(05)80263-x

    authors: Jastremski MS

    更新日期:1993-01-01 00:00:00

  • Treatment of acute ischemic stroke.

    abstract::Acute ischemic stroke is the third leading cause of death in the United States and the leading cause of adult disability. The direct and indirect costs of stroke care exceed $51 billion annually. In 1996, the US Food and Drug Administration approved the first treatment for acute ischemic stroke, intravenous tissue pla...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1067/mem.2001.111573

    authors: Lewandowski C,Barsan W

    更新日期:2001-02-01 00:00:00

  • Olfactory and gustatory hallucinations presenting as partial status epilepticus because of glioblastoma multiforme.

    abstract::Olfactory and gustatory hallucinations are not often encountered in the acute care setting but may represent the subtle presenting features of a significant underlying disease process. We describe a patient whose most striking presenting symptoms were of olfactory and gustatory hallucinations and in whom the diagnosis...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2010.02.020

    authors: Capampangan DJ,Hoerth MT,Drazkowski JF,Lipinski CA

    更新日期:2010-10-01 00:00:00

  • Should payment policy be changed to allow a wider range of EMS transport options?

    abstract::The Institute of Medicine and other national organizations have asserted that current payment policies strongly discourage emergency medical services (EMS) providers from transporting selected patients who call 911 to non-ED settings (eg, primary care clinics, mental health centers, dialysis centers) or from treating ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2013.09.025

    authors: Morganti KG,Alpert A,Margolis G,Wasserman J,Kellermann AL

    更新日期:2014-05-01 00:00:00

  • Breath alcohol analyzer mistakes methanol poisoning for alcohol intoxication.

    abstract::Breath alcohol analyzers are used to detect ethanol in motorists and others suspected of public intoxication. One concern is their ability to detect interfering substances that may falsely increase the ethanol reading. A 47-year-old-man was found in a public park, acting intoxicated. A breath analyzer test (Intoxilyze...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2009.07.021

    authors: Caravati EM,Anderson KT

    更新日期:2010-02-01 00:00:00

  • Acoustic otoscopy in the diagnosis of otitis media.

    abstract::Acoustic otoscopy detects middle ear pathology by measuring the ability of the tympanic membrane to reflect sound. Fluid or thickening of the tympanic membrane increases sound reflection. We conducted a study to compare acoustic otoscopy with pneumatic otoscopy in identifying middle ear pathology in 80 children (160 e...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0196-0644(89)80578-5

    authors: Jehle D,Cottington E

    更新日期:1989-04-01 00:00:00

  • Emergency department and inpatient hospital use by Medicare beneficiaries in patient-centered medical homes.

    abstract:STUDY OBJECTIVE:Patient-centered medical homes are primary care practices that focus on coordinating acute and preventive care. Such practices can obtain patient-centered medical home recognition from the National Committee for Quality Assurance. We compare growth rates for emergency department (ED) use and costs of ED...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2015.01.002

    authors: Pines JM,Keyes V,van Hasselt M,McCall N

    更新日期:2015-06-01 00:00:00

  • American Board of Emergency Medicine Report on Residency Training Information (2015-2016).

    abstract::The American Board of Emergency Medicine (ABEM) gathers extensive background information on emergency medicine residency programs and the residents training in those programs. We present the 2016 annual report on the status of US emergency medicine training programs. ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2016.03.031

    authors: Marco CA,Baren JM,Beeson MS,Carius ML,Counselman FL,Gausche-Hill M,Goyal DG,Kowalenko T,Muelleman RL,Nelson LS,Wahl RP,Joldersma KB,Research Committee, American Board of Emergency Medicine.

    更新日期:2016-05-01 00:00:00

  • Ventricular arrhythmias during treatment for acute asthma.

    abstract::A double-blind, randomized study was performed to determine the occurrence of ventricular arrhythmias in acute asthma patients treated with epinephrine, aminophylline, or both in combination. Sixty patients were studied with Holter monitoring during the 90-minute study period. There was no statistical difference among...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0196-0644(86)80428-0

    authors: Emerman CL,Crafford WA,Vrobel TR

    更新日期:1986-06-01 00:00:00

  • Managed care ethics: an emergency?

    abstract::The rapid expansion of cost-consciousness and managed care into the medical marketplace has challenged the autonomy of physicians and patients. These challenges have taken a variety of forms, including limitations on reimbursement and restrictions on the amount and type of emergency care patients may receive. Challeng...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(96)70094-x

    authors: Larkin GL,Adams JG,Derse AR,Iserson KV,Gotthold WE

    更新日期:1996-12-01 00:00:00

  • Clotting competence of intracavitary blood in trauma victims.

    abstract::In order to assess more rationally the requirement for anticoagulation during intraoperative autotransfusion, the clotting competence of blood collected from the body cavities of 31 trauma victims entering our emergency department with indications for intraoperative transfusion was assessed. Blood was collected at tho...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(81)80375-7

    authors: Broadie TA,Glover JL,Bang N,Bendick PJ,Lowe DK,Yaw PB,Kafoure D

    更新日期:1981-03-01 00:00:00

  • Optimizing emergency department front-end operations.

    abstract::As administrators evaluate potential approaches to improve cost, quality, and throughput efficiencies in the emergency department (ED), "front-end" operations become an important area of focus. Interventions such as immediate bedding, bedside registration, advanced triage (triage-based care) protocols, physician/pract...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.annemergmed.2009.05.021

    authors: Wiler JL,Gentle C,Halfpenny JM,Heins A,Mehrotra A,Mikhail MG,Fite D

    更新日期:2010-02-01 00:00:00

  • Antibiotic use for emergency department patients with upper respiratory infections: prescribing practices, patient expectations, and patient satisfaction.

    abstract:STUDY OBJECTIVE:Physicians often prescribe antibiotics to patients even when there is no clear indication for their use. Previous studies examining antibiotic use in acute bronchitis and upper respiratory infections have been conducted in primary care settings. We evaluate the factors that physicians in the emergency d...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.annemergmed.2007.03.026

    authors: Ong S,Nakase J,Moran GJ,Karras DJ,Kuehnert MJ,Talan DA,EMERGEncy ID NET Study Group.

    更新日期:2007-09-01 00:00:00

  • Shortness of breath, syncope, and cardiac arrest caused by systemic mastocytosis.

    abstract::During a 3-month period, a 33-year-old man presented to the emergency department on 4 occasions with dyspnea, palpitations, and syncope. His initial presentation was accompanied by acute myocardial injury and ventricular fibrillation. An extensive evaluation spanned the 3 months and included echocardiography, cardiac ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2005.02.002

    authors: Rohr SM,Rich MW,Silver KH

    更新日期:2005-06-01 00:00:00

  • Implementation of Evidence-Based Practice for Benign Paroxysmal Positional Vertigo in the Emergency Department: A Stepped-Wedge Randomized Trial.

    abstract:STUDY OBJECTIVE:We evaluated a strategy to increase use of the test (Dix-Hallpike's test [DHT]) and treatment (canalith repositioning maneuver [CRM]) for benign paroxysmal positional vertigo in emergency department (ED) dizziness visits. METHODS:We conducted a stepped-wedge randomized trial in 6 EDs. The population wa...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.annemergmed.2019.09.017

    authors: Kerber KA,Damschroder L,McLaughlin T,Brown DL,Burke JF,Telian SA,Tsodikov A,Fagerlin A,An LC,Morgenstern LB,Forman J,Vijan S,Rowell B,Meurer WJ

    更新日期:2020-04-01 00:00:00

  • Mixed fluoxetine/loxapine overdose and atrial flutter.

    abstract::A 19-year-old man who attempted suicide by ingesting approximately 600 mg fluoxetine (Prozac) and 140 mg loxapine (Loxitane) had two episodes of atrial flutter shortly thereafter. Admission serum fluoxetine, norfluoxetine, and loxapine levels were 1,053 ng/mL, 702 ng/mL, and 40 ng/mL, respectively. This case of atrial...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(94)70083-4

    authors: Roberge RJ,Martin TG

    更新日期:1994-03-01 00:00:00

  • Association of Antibiotic Choice With Hospital Length of Stay and Risk Factors for Readmission in Patients With Sickle Cell Disease and Acute Chest Syndrome: An Observational Cohort Study.

    abstract:STUDY OBJECTIVE:We determine the association between use of specific cephalosporins and macrolides and hospital length of stay in patients with sickle cell disease (SCD) who are admitted with acute chest syndrome, and determine treatment risk factors for acute chest syndrome-related 30-day readmission. METHODS:Patient...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2020.08.011

    authors: Badaki-Makun O,Casella JF,Tackett S,Tao X,Chamberlain JM

    更新日期:2020-09-01 00:00:00

  • Coronary computed tomographic angiography for rapid discharge of low-risk patients with potential acute coronary syndromes.

    abstract:STUDY OBJECTIVE:Coronary computed tomographic (CT) angiography has excellent performance characteristics relative to coronary angiography and exercise or pharmacologic stress testing. We hypothesize that coronary CT angiography can identify a cohort of emergency department (ED) patients with a potential acute coronary ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2008.09.025

    authors: Hollander JE,Chang AM,Shofer FS,McCusker CM,Baxt WG,Litt HI

    更新日期:2009-03-01 00:00:00

  • Fatal systemic fluorosis due to hydrofluoric acid burns.

    abstract::A patient with a 70% hydrofluoric acid burn developed systemic dissemination of fluoride ion from a 9% to 10% body surface area exposure on the lower extremities. Severe hypocalcemia and intractable ventricular arrhythmias resulted. This case is the second documented occurrence of hypocalcemia from hydrofluoric acid b...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(85)81078-7

    authors: Mayer TG,Gross PL

    更新日期:1985-02-01 00:00:00

  • Life-threatening airway obstruction from rattlesnake bite to the tongue.

    abstract::We describe the case of a 41-year-old man who suffered a bite to the tongue from the Western Diamondback rattlesnake (C atrox). Life-threatening obstruction of his upper airway secondary to massive edema of the tongue and other soft tissue structures quickly followed envenomation. Nasotracheal intubation, IV antivenin...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(87)80584-x

    authors: Gerkin R,Sergent KC,Curry SC,Vance M,Nielsen DR,Kazan A

    更新日期:1987-07-01 00:00:00

  • Analysis of pediatric hospitalizations after emergency department release as a quality improvement tool.

    abstract:STUDY OBJECTIVE:We characterize repeat pediatric emergency department visits and determine the cause for such visits as an indicator of potential need for quality improvement. We hypothesized that most repeat ED visits resulting in hospitalization do not represent medical errors. METHODS:The study was performed at a l...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/mem.2002.116595

    authors: Depiero AD,Ochsenschlager DW,Chamberlain JM

    更新日期:2002-02-01 00:00:00

  • Routine pelvic radiography in severe blunt trauma: is it necessary?

    abstract::To evaluate the hypothesis that all victims of severe blunt trauma require a pelvic radiograph, we prospectively studied all such patients admitted to the Southern New Jersey Regional Trauma Center during a seven-month period. All patients were classified as unconscious; impaired; awake, alert, and symptomatic; or ale...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(88)80244-0

    authors: Civil ID,Ross SE,Botehlo G,Schwab CW

    更新日期:1988-05-01 00:00:00

  • The use of mixed venous blood gas determinations in traumatic shock.

    abstract::A series of 10 seriously injured patients requiring resuscitation and definitive operative control of hemorrhage was studied. Simultaneous arterial and mixed venous blood gases were measured sequentially throughout the resuscitative and operative periods. Improvement of the mixed venous oxygen saturation was associate...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(80)80002-3

    authors: Kazarian KK,Del Guercio LR

    更新日期:1980-04-01 00:00:00

  • Worst headache and subarachnoid hemorrhage: prospective, modern computed tomography and spinal fluid analysis.

    abstract:STUDY OBJECTIVE:This study investigated the hypothesis that modern computed tomographic (CT) imaging is sufficient to exclude subarachnoid hemorrhage (SAH) in patients with severe headache. METHODS:All 38,730 adult patients who presented to Hermann Hospital in Houston, Texas, during a 16-month period were prospectivel...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:

    authors: Morgenstern LB,Luna-Gonzales H,Huber JC Jr,Wong SS,Uthman MO,Gurian JH,Castillo PR,Shaw SG,Frankowski RF,Grotta JC

    更新日期:1998-09-01 00:00:00

  • Near-fatal intoxication by 1, 1, 1-trichloroethane.

    abstract::This report describes a case of near-fatal intoxication following accidental exposure to 1, 1, 1-trichloroethane in a child. This solvent, generally safe, is widely used to 1, 1, 1-trichloroethane in a child. This solvent, generally safe, is widely used in industrial and domestic preparations. Exposure to high levels ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(81)80011-x

    authors: Gerace RV

    更新日期:1981-10-01 00:00:00

  • Out-of-hospital endotracheal intubation experience and patient outcomes.

    abstract:STUDY OBJECTIVE:Previous studies suggest improved patient outcomes for providers who perform high volumes of complex medical procedures. Out-of-hospital tracheal intubation is a difficult procedure. We seek to determine the association between rescuer procedural experience and patient survival after out-of-hospital tra...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2009.12.020

    authors: Wang HE,Balasubramani GK,Cook LJ,Lave JR,Yealy DM

    更新日期:2010-06-01 00:00:00

  • Physical Restraint Use in Adult Patients Presenting to a General Emergency Department.

    abstract:STUDY OBJECTIVE:The prevalence of agitation among emergency department (ED) patients is increasing. Physical restraints are routinely used to prevent self-harm and to protect staff, but are associated with serious safety risks. To date, characterization of physical restraint use in the emergency setting has been limite...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2018.06.020

    authors: Wong AH,Taylor RA,Ray JM,Bernstein SL

    更新日期:2019-02-01 00:00:00