The diagnostic utility of flumazenil (a benzodiazepine antagonist) in coma of unknown etiology.

Abstract:

:The use of flumazenil, a benzodiazepine antagonist, was studied in two patients with coma of unknown etiology. One patient ingested 20.5 mg alprazolam before crashing his truck into parked automobiles. The patient was awakened by flumazenil administration, and the severity of his injuries was evaluated reliably. A second patient ingested 7.5 mg triazolam and attempted suicide with carbon monoxide from car exhaust. His coma resolved completely after the administration of the double-blind study drug, obviating treatment with hyperbaric oxygen. Flumazenil had a clear diagnostic and therapeutic role in the treatment of these patients and should be a useful tool for emergency physicians and toxicologists.

journal_name

Ann Emerg Med

authors

Burkhart KK,Kulig KW

doi

10.1016/s0196-0644(05)82054-2

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

319-21

issue

3

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(05)82054-2

journal_volume

19

pub_type

临床试验,杂志文章,多中心研究
  • Adolescents and young adults presenting to the emergency department intoxicated from a caffeinated alcoholic beverage: a case series.

    abstract::We describe a case series of emergency department (ED) visits for intoxication related to the use of the caffeinated alcoholic beverage Four Loko. Medical records from the 4-month period July to November 2010 were hand searched for key words such as "intoxicated," "caffeinated," "Four Loko," "alcohol," and "EtOH." Pat...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2011.06.015

    authors: Cleary K,Levine DA,Hoffman RS

    更新日期:2012-01-01 00:00:00

  • Heat-related illness and the automobile.

    abstract::To evaluate the heat burden in parked cars, a study was done to measure inside car temperatures in different situations. A large car and a small car were parked in direct sunlight and in shade. In direct sun, the highest temperatures recorded in the small and large cars were 78 C and 65 C, respectively. The highest te...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(82)80097-8

    authors: Surpure JS

    更新日期:1982-05-01 00:00:00

  • Continuous monitoring of tissue pH with a fiberoptic conjunctival sensor.

    abstract::To assess the relationship between conjunctival pH (pHcj), arterial pH (pHa), and cardiorespiratory variables during normal and low-flow conditions, hemorrhagic hypotension was induced in eight dogs. Conjunctival pH became significantly less than control values after a hemorrhage volume of 15 mL/kg (P less than .05); ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(85)80630-2

    authors: Abraham E,Fink SE,Markle DR,Pinholster G,Tsang M

    更新日期:1985-09-01 00:00:00

  • Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.

    abstract:STUDY OBJECTIVE:Debate exists about the mortality benefit of administering antibiotics within either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of immediate (0 to 1 hour after onset) versus early (1 to 3 hours after onset) antibiotics on mortality in patients with severe sepsis ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.annemergmed.2020.04.042

    authors: Rothrock SG,Cassidy DD,Barneck M,Schinkel M,Guetschow B,Myburgh C,Nguyen L,Earwood R,Nanayakkara PWB,Nannan Panday RS,Briscoe JG

    更新日期:2020-10-01 00:00:00

  • Electrolytes, BUN, creatinine: who's at risk?

    abstract::Electrolytes, BUN, and creatinine are some of the most frequently ordered laboratory tests. The use of these tests in emergency practice has not been studied critically, and few investigations of their use in other disciplines have been performed. A review of the available literature and an analysis of medical problem...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-0644(86)80586-8

    authors: Checchio LM,Como AJ

    更新日期:1986-03-01 00:00:00

  • Detecting acute thoracic aortic dissection in the emergency department: time constraints and choice of the optimal diagnostic test.

    abstract:STUDY OBJECTIVES:To compare diagnostic strategies for the emergency assessment of patients with suspected acute thoracic aortic dissection and to measure the effect of delays related to the availability of these tests on the selection of the most appropriate one. METHODS:We carried out a decision analysis representing...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(96)70026-4

    authors: Sarasin FP,Louis-Simonet M,Gaspoz JM,Junod AF

    更新日期:1996-09-01 00:00:00

  • Ultrasound detection of ventricular fibrillation disguised as asystole.

    abstract::Ultrasonography in the emergency department is being used for many purposes, including the evaluation of patients with cardiac arrest. Ultrasound testing has been shown to be useful in such patients in determining the presence of true electromechanical dissociation and pericardial effusions. We report a case of ventri...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(99)70372-0

    authors: Amaya SC,Langsam A

    更新日期:1999-03-01 00:00:00

  • Management of anaphylactoid reactions to intravenous N-acetylcysteine.

    abstract:STUDY OBJECTIVE:To develop management guidelines for the treatment of anaphylactoid reactions to intravenous N-acetylcysteine (NAC) and to assess the safety of restarting the infusion after a reaction. METHODS:In phased 1, we used a 6-year retrospective case series of hospitalized patients and a review of the literatu...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-0644(98)70229-x

    authors: Bailey B,McGuigan MA

    更新日期:1998-06-01 00:00:00

  • The use of antiarrhythmics in advanced cardiac life support.

    abstract::Antiarrhythmic agents have been used to treat malignant ventricular arrhythmias in the setting of acute myocardial ischemia with proven efficacy for many years. Thus, it has been presumed that these agents would be efficacious for the treatment of cardiac arrest. Unfortunately, hard data supporting this contention are...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1016/s0196-0644(05)80461-5

    authors: Jaffe AS

    更新日期:1993-02-01 00:00:00

  • Fracture of the carpal navicular--efficacy of clinical findings and improved diagnosis with six-view radiography.

    abstract::A prospective study was conducted to determine the usefulness of clinical findings and 25-degree pronation and supination radiologic views to diagnose carpal navicular fractures. All patients presenting to the emergency department during a two-year period who fell on their outstretched hand and had pain and/or swellin...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)82039-6

    authors: Mehta M,Brautigan MW

    更新日期:1990-03-01 00:00:00

  • Lower gastrointestinal hemorrhage from an arterioenteric fistula in a pancreatorenal transplant patient.

    abstract::We report a case of a severe lower gastrointestinal hemorrhage caused by arterioenteric fistula formation in a pancreas transplant patient. A rare but potentially deadly complication of pancreas transplant surgery, arterioenteric fistulas should be considered in every transplant patient presenting with voluminous gast...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/s0196-0644(03)00388-3

    authors: McBeth BD,Stern SA

    更新日期:2003-10-01 00:00:00

  • Lisfranc fracture-dislocation: a frequently missed diagnosis in the emergency department.

    abstract::Lisfranc fracture-dislocations are rare, and their correct diagnosis is important. Misdiagnosis is common and can lead to grave, chronic disability. We present two cases of Lisfranc fracture-dislocation to highlight the mechanisms of injury, clinical presentation, diagnosis, and treatment. Accurate diagnosis by emerge...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(95)70156-7

    authors: Englanoff G,Anglin D,Hutson HR

    更新日期:1995-08-01 00:00:00

  • Two separate unintentional fatalities with the same revolver.

    abstract::We report 2 deaths and 1 injury that resulted from 2 separate unintentional discharges of the same Ruger Blackhawk revolver. One discharge was a consequence of careless firearm handling combined with a slip during a decocking procedure unique to certain hammer-action firearms. The second discharge occurred when the fi...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/mem.2001.112251

    authors: Lee C,Nolte KB

    更新日期:2001-03-01 00:00:00

  • Rapid HIV testing in a southeastern emergency department serving a semiurban-semirural adolescent and adult population.

    abstract:OBJECTIVE:We determine the feasibility and yield of universal opt-out HIV screening among adolescents and adults in a southeastern emergency department (ED) serving a semiurban-semirural population. METHODS:Individuals aged 13 to 64 years who visited the ED during specified hours received the OraQuick rapid HIV test (...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2011.03.026

    authors: Sattin RW,Wilde JA,Freeman AE,Miller KM,Dias JK

    更新日期:2011-07-01 00:00:00

  • Soluble intercellular adhesion molecule-1 as a predictor of early adverse events in patients with chest pain compatible with myocardial ischemia.

    abstract:STUDY OBJECTIVE:Inflammation plays an important role in acute coronary syndromes, and some evidence indicates that patients with a more pronounced vascular inflammatory response have a poorer outcome. Soluble intercellular adhesion molecule-1 (sICAM-1) is a specific marker for vascular endothelial cell activation. The ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/mem.2001.117199

    authors: Hillis GS,Terregino C,Taggart P,Killian A,Zhao N,Kaplan J,Dalsey WC,Mangione A

    更新日期:2001-09-01 00:00:00

  • Shoulder pain and pneumoperitoneum following a diving accident.

    abstract::We present the case of a diver who experienced the acute onset of shoulder pain after a rapid ascent. It was determined that the patient had decompression sickness ("the bends") of the right shoulder and pulmonary barotrauma resulting in secondary pneumoperitoneum. He underwent decompression, with prompt resolution of...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(87)80240-8

    authors: Schriger DL,Rosenberg G,Wilder RJ

    更新日期:1987-11-01 00:00:00

  • Probabilistic linkage of computerized ambulance and inpatient hospital discharge records: a potential tool for evaluation of emergency medical services.

    abstract:STUDY OBJECTIVES:Emergency medical services (EMS) is an important part of the health care system. The effect of EMS on morbidity, mortality, and costs of illness is difficult to evaluate because hospital information is not available in out-of-hospital databases. We used probabilistic linkage to create such a database f...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1067/mem.2001.115214

    authors: Dean JM,Vernon DD,Cook L,Nechodom P,Reading J,Suruda A

    更新日期:2001-06-01 00:00:00

  • Accuracy of Emergency Department Clinical Findings for Diagnosis of Coronavirus Disease 2019.

    abstract:STUDY OBJECTIVE:We seek to describe the medical history and clinical findings of patients attending the emergency department (ED) with suspected coronavirus disease 2019 (COVID-19) and estimate the diagnostic accuracy of patients' characteristics for predicting COVID-19. METHODS:We prospectively enrolled all patients ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2020.05.022

    authors: Peyrony O,Marbeuf-Gueye C,Truong V,Giroud M,Rivière C,Khenissi K,Legay L,Simonetta M,Elezi A,Principe A,Taboulet P,Ogereau C,Tourdjman M,Ellouze S,Fontaine JP

    更新日期:2020-10-01 00:00:00

  • Nonprice barriers to ambulatory care after an emergency department visit.

    abstract:STUDY OBJECTIVE:Availability of timely follow-up care is essential in emergency medicine. We describe nonprice barriers to care experienced by callers reporting to be emergency department (ED) patients in need of follow-up care. METHODS:This was a secondary analysis of data collected during a survey of ambulatory clin...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.annemergmed.2007.10.027

    authors: Vieth TL,Rhodes KV

    更新日期:2008-05-01 00:00:00

  • Ventilatory strategies affect gas exchange in a pig model of closed-chest cardiac compression.

    abstract:STUDY OBJECTIVE:To identify the arterial and mixed venous blood gas changes caused by different ventilatory strategies during resuscitation from ventricular fibrillation in a pig model of closed-chest cardiac compression. METHODS:A prospective randomized animal study was performed using 27 domestic pigs (body weight, ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(98)70203-3

    authors: Whitehurst ME,Blount AD,Austin PE,Carroll RG

    更新日期:1998-05-01 00:00:00

  • To be blunt: are we wasting our time? Emergency department thoracotomy following blunt trauma: a systematic review and meta-analysis.

    abstract:STUDY OBJECTIVE:The role of emergency department (ED) thoracotomy after blunt trauma is controversial. The objective of this review is to determine whether patients treated with an ED thoracotomy after blunt trauma survive and whether survivors have a good neurologic outcome. METHODS:A structured search was performed ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.annemergmed.2014.08.020

    authors: Slessor D,Hunter S

    更新日期:2015-03-01 00:00:00

  • Premedication With Midazolam or Haloperidol to Prevent Recovery Agitation in Adults Undergoing Procedural Sedation With Ketamine: A Randomized Double-Blind Clinical Trial.

    abstract:STUDY OBJECTIVE:We evaluate the effect of midazolam and haloperidol premedication for reducing ketamine-induced recovery agitation in adult patients undergoing procedural sedation. We also compare physician satisfaction and recovery time. METHODS:We randomized emergency department patients older than 18 years who need...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.annemergmed.2018.11.016

    authors: Akhlaghi N,Payandemehr P,Yaseri M,Akhlaghi AA,Abdolrazaghnejad A

    更新日期:2019-05-01 00:00:00

  • Frequent users of emergency departments: the myths, the data, and the policy implications.

    abstract:STUDY OBJECTIVE:Frequent emergency department (ED) users have been the targets of health care reform proposals and hospital crowding interventions, but it is not clear that common assumptions about this group are supported by data. We review the literature pertaining to frequent ED users, their demographics, acuity of ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.annemergmed.2010.01.032

    authors: LaCalle E,Rabin E

    更新日期:2010-07-01 00:00:00

  • Faculty attrition among three specialties.

    abstract:STUDY OBJECTIVES:To survey faculty attrition in emergency medicine and compare it with faculty attrition in the specialties of orthopedic surgery and cardiology. DESIGN:Chairmen of the three departments were surveyed regarding faculty attrition, work hours, and motivation for leaving. Those emergency physicians having...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(05)81110-2

    authors: Thomas H Jr,Moorhead J,Magnusson AR,Schwartz E

    更新日期:1991-01-01 00:00:00

  • Outpatient management of acute urticaria: the role of prednisone.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy of a 4-day "burst" course of prednisone added to standard treatment with H1 antihistamines for the management of acute urticaria in outpatients. DESIGN:Prospective, randomized, double-blinded, clinical trial. SETTING:Emergency department of an urban tertiary care teaching hosp...

    journal_title:Annals of emergency medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0196-0644(95)70002-1

    authors: Pollack CV Jr,Romano TJ

    更新日期:1995-11-01 00:00:00

  • Failure of adjunctive bicarbonate to improve outcome in severe pediatric diabetic ketoacidosis.

    abstract:STUDY OBJECTIVE:Although adjunctive intravenous bicarbonate therapy is commonly recommended for children with severe diabetic ketoacidosis (DKA), no studies assessing clinical outcome with this therapy have ever been performed. Our objective was to determine whether bicarbonate therapy influenced outcome for pediatric ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-0644(98)70279-3

    authors: Green SM,Rothrock SG,Ho JD,Gallant RD,Borger R,Thomas TL,Zimmerman GJ

    更新日期:1998-01-01 00:00:00

  • Preliminary program evaluation of emergency department HIV prevention counseling.

    abstract:OBJECTIVE:Controversy surrounds the linkage of prevention counseling with emergency department (ED)-based HIV testing. Further, the effectiveness and feasibility of prevention counseling in the ED setting is unknown. We investigate these issues by conducting a preliminarily exploration of several related aspects of our...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2011.03.036

    authors: Sitlinger AP,Lindsell CJ,Ruffner AH,Wayne DB,Hart KW,Trott AT,Fichtenbaum CJ,Lyons MS

    更新日期:2011-07-01 00:00:00

  • The time dependence of antithrombin initiation in patients with non-ST-segment elevation acute coronary syndromes: subgroup analysis from the ACUITY trial.

    abstract:STUDY OBJECTIVE:Antithrombins are among standard treatment agents for patients with non-ST-segment elevation acute coronary syndromes. We aimed to determine the association between time from emergency department (ED) presentation to treatment with an antithrombin and adverse cardiac events. METHODS:The study cohort wa...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.annemergmed.2010.06.567

    authors: Diercks DB,Pollack CV Jr,Hollander JE,Blomkalns AL,Emerman CL,Rokos IC,Larson DM,Hoekstra JW,Mehran R,Stone GW

    更新日期:2011-03-01 00:00:00

  • Performance characteristics of clinical diagnosis, a clinical decision rule, and a rapid influenza test in the detection of influenza infection in a community sample of adults.

    abstract:STUDY OBJECTIVE:The accurate diagnosis of influenza remains a diagnostic dilemma. We examine the performance of various strategies for diagnosing influenza infection in an unselected sample of adults during influenza season. METHODS:Consecutive adults presenting to a university emergency department or urgent care clin...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/j.annemergmed.2005.05.020

    authors: Stein J,Louie J,Flanders S,Maselli J,Hacker JK,Drew WL,Gonzales R

    更新日期:2005-11-01 00:00:00

  • Management of a vaginal foreign body.

    abstract::A case is presented of a vaginal foreign body. A drinking glass was inserted in the vagina of an intoxicated patient by her irate lover. Infection followed. The emergency care is described, including the method of extraction of the object, along with discussion of the principles involved and associated complications. ...

    journal_title:Annals of emergency medicine

    pub_type: 杂志文章

    doi:10.1016/s0196-0644(81)80287-9

    authors: Kurzel RB,Chaudhuri G,Hall D

    更新日期:1981-09-01 00:00:00