Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise.

Abstract:

:The purpose of this review is to provide information about the role of exercise in the prevention of skeletal muscle insulin resistance, that is, the inability of insulin to properly cause glucose uptake into skeletal muscle. Insulin resistance is associated with high levels of stored lipids in skeletal muscle cells. Aerobic exercise training decreases the amounts of these lipid products and increases the lipid oxidative capacity of muscle cells. Thus, aerobic exercise training may prevent insulin resistance by correcting a mismatch between fatty acid uptake and fatty acid oxidation in skeletal muscle. Additionally, a single session of aerobic exercise increases glucose uptake by muscle during exercise, increases the ability of insulin to promote glucose uptake, and increases glycogen accumulation after exercise, all of which are important to blood glucose control. There also is some indication that resistance exercise may be effective in preventing insulin resistance. The information provided is intended to help clinicians understand and explain the roles of exercise in reducing insulin resistance.

journal_name

Phys Ther

journal_title

Physical therapy

authors

Turcotte LP,Fisher JS

doi

10.2522/ptj.20080018

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1279-96

issue

11

eissn

0031-9023

issn

1538-6724

pii

ptj.20080018

journal_volume

88

pub_type

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