当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Statins, low-density lipoprotein cholesterol, and risk of cancer.

Statins, low-density lipoprotein cholesterol, and risk of cancer.

Abstract：

OBJECTIVES:We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer. BACKGROUND:We recently reported an inverse association between on-treatment LDL-C levels and incident cancer in statin-treated patients enrolled in large randomized controlled trials, raising concern that LDL-C lowering by statins may increase cancer risk. However, meta-analyses suggest a neutral overall effect of statins on incident cancer. METHODS:A systematic literature search identified 15 eligible randomized controlled trials of statins with >or=1,000 person-years of follow-up that provided on-treatment LDL-C levels and rates of incident cancers (19 statin and 14 control arms, 437,017 person-years cumulative follow-up, and 5,752 incident cancers). RESULTS:In the statin arms, meta-regression analysis demonstrated an inverse association between on-treatment LDL-C and incident cancer, with an excess of 2.2 (95% confidence interval: 0.7 to 3.6) cancers per 1,000 person-years for every 10 mg/dl decrement in on-treatment LDL-C (p=0.006). The corresponding difference among control arms was 1.2 (95% confidence interval: -0.2 to 2.7, p=0.09). Compared with the control arms, the statin regression line was significantly shifted leftward, such that similar rates of incident cancer were associated with lower on-treatment LDL-C (p<0.05). Meta-regression demonstrated that statins lack an effect on cancer risk across all levels of on-treatment LDL-C. CONCLUSIONS:There is an inverse association between on-treatment LDL-C and incident cancer. However, statins, despite producing marked reductions in LDL-C, are not associated with an increased risk of cancer.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Alsheikh-Ali AA,Trikalinos TA,Kent DM,Karas RH

doi

10.1016/j.jacc.2008.06.037

subject

Has Abstract

pub_date

2008-09-30 00:00:00

pages

1141-7

issue

14

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(08)02396-6

journal_volume

52

pub_type

杂志文章,meta分析

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Reversal of calcium cycling defects in advanced heart failure toward molecular therapy.

    abstract：:Heart failure is a growing major cause of human morbidity and mortality worldwide. A wave of new insights from diverse laboratories has begun to uncover new therapeutic strategies that affect the molecular pathways within cardiomyocytes that drive heart failure progression. Using an integrative approach that employs i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2006.06.070

    authors： Hoshijima M,Knöll R,Pashmforoush M,Chien KR

    更新日期：2006-11-07 00:00:00

  • Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) Trial.

    abstract：OBJECTIVES:The purpose of this study was to assess the effects of ramipril on left ventricular mass (LVM) and function in vascular disease patients with controlled blood pressure (BP) and with preserved left ventricular ejection fraction (LVEF). BACKGROUND:Increased LVM and left ventricular (LV) volume and decreased L...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2003.10.073

    authors： Lonn E,Shaikholeslami R,Yi Q,Bosch J,Sullivan B,Tanser P,Magi A,Yusuf S

    更新日期：2004-06-16 00:00:00

  • Short- and long-term recovery of left ventricular function predicted at the time of primary percutaneous coronary intervention in anterior myocardial infarction.

    abstract：OBJECTIVES:The aim of this study was to determine predictors of left ventricular (LV) function recovery at the time of primary percutaneous coronary intervention (PCI). BACKGROUND:Angiographic, intracoronary Doppler flow, and electrocardiographic variables have been reported to be predictors of recovery of LV function...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jacc.2003.08.055

    authors： Bax M,de Winter RJ,Schotborgh CE,Koch KT,Meuwissen M,Voskuil M,Adams R,Mulder KJ,Tijssen JG,Piek JJ

    更新日期：2004-02-18 00:00:00

  • Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.

    abstract：OBJECTIVES:The purpose of this study was to evaluate the role of the myocardial redox state in the development of in-hospital complications after cardiac surgery and the effect of statins on the myocardial redox state. BACKGROUND:Statins improve clinical outcome after cardiac surgery, but it is unclear whether they ex...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2011.08.062

    authors： Antoniades C,Demosthenous M,Reilly S,Margaritis M,Zhang MH,Antonopoulos A,Marinou K,Nahar K,Jayaram R,Tousoulis D,Bakogiannis C,Sayeed R,Triantafyllou C,Koumallos N,Psarros C,Miliou A,Stefanadis C,Channon KM,Casadei B

    更新日期：2012-01-03 00:00:00

  • Echocardiographic-morphologic correlations in tricuspid atresia.

    abstract：OBJECTIVES:Our aim was to clarify the anatomic substrate in hearts diagnosed as having tricuspid atresia by studying autopsy specimens and comparing the findings with those in two-dimensional echocardiograms. BACKGROUND:Traditionally, tricuspid atresia was thought, and is still believed by some, to be due to an imperf...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00250-8

    authors： Orie JD,Anderson C,Ettedgui JA,Zuberbuhler JR,Anderson RH

    更新日期：1995-09-01 00:00:00

  • Transcatheter aortic valve replacement with the St. Jude Medical Portico valve: first-in-human experience.

    abstract：OBJECTIVES:The purpose of this study was to demonstrate the feasibility and procedural outcomes with a new self-expanding and repositionable transcatheter heart valve. BACKGROUND:Transcatheter aortic valve replacement is a viable option for selected patients with severe symptomatic aortic stenosis. However, suboptimal...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2012.02.045

    authors： Willson AB,Rodès-Cabau J,Wood DA,Leipsic J,Cheung A,Toggweiler S,Binder RK,Freeman M,DeLarochellière R,Moss R,Nombela-Franco L,Dumont E,Szummer K,Fontana GP,Makkar R,Webb JG

    更新日期：2012-08-14 00:00:00

  • Association of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation.

    abstract：OBJECTIVES:This study tried to determine the association between left atrial (LA) fibrosis, detected using delayed-enhanced magnetic resonance imaging (DE-MRI), and the CHADS(2) score (point system based on individual clinical risk factors including congestive heart failure, hypertension, age, diabetes, and prior strok...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2010.09.049

    authors： Daccarett M,Badger TJ,Akoum N,Burgon NS,Mahnkopf C,Vergara G,Kholmovski E,McGann CJ,Parker D,Brachmann J,Macleod RS,Marrouche NF

    更新日期：2011-02-15 00:00:00

  • Relationship between renal function and plasma brain natriuretic peptide in patients with heart failure.

    abstract：OBJECTIVES:This study sought to evaluate the relationship between brain natriuretic peptide (BNP), renal function, and the severity of congestive heart failure (CHF). BACKGROUND:Both BNP and renal function are prognostic predictors in CHF patients. METHODS:We measured the plasma BNP level in the aortic root and coron...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.10.038

    authors： Tsutamoto T,Wada A,Sakai H,Ishikawa C,Tanaka T,Hayashi M,Fujii M,Yamamoto T,Dohke T,Ohnishi M,Takashima H,Kinoshita M,Horie M

    更新日期：2006-02-07 00:00:00

  • Current complications of diagnostic and therapeutic cardiac catheterization.

    abstract：:Data from 2,883 cardiac catheterizations performed during an 18 month period (from July 1986 through December 1987) were analyzed to assess the current complication profile of diagnostic and therapeutic procedures. Procedures performed during the study period included 1,609 diagnostic catheterizations, 933 percutaneou...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(88)80002-0

    authors： Wyman RM,Safian RD,Portway V,Skillman JJ,McKay RG,Baim DS

    更新日期：1988-12-01 00:00:00

  • Sustained ventricular tachyarrhythmias during the early postinfarction period: electrophysiologic findings and prognosis for survival.

    abstract：:Forty patients with sustained tachycardia occurring 3 to 65 days after myocardial infarction underwent programmed ventricular stimulation within 3 months of the infarction. Patients were characterized clinically by a complicated initial 48 hours of hospitalization for their acute infarction (85% of study group). The d...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80159-4

    authors： Marchlinski FE,Waxman HL,Buxton AE,Josephson ME

    更新日期：1983-08-01 00:00:00

  • Reduced Cardiac Index Is Not the Dominant Driver of Renal Dysfunction in Heart Failure.

    abstract：BACKGROUND:It is widely believed that a reduced cardiac index (CI) is a significant contributor to renal dysfunction in patients with heart failure (HF). However, recent data have challenged this paradigm. OBJECTIVES:This study sought to determine the relationship between CI and renal function in a multicenter populat...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2016.02.058

    authors： Hanberg JS,Sury K,Wilson FP,Brisco MA,Ahmad T,Ter Maaten JM,Broughton JS,Assefa M,Tang WHW,Parikh CR,Testani JM

    更新日期：2016-05-17 00:00:00

  • Localization of aortic dissection intimal flap by intraoperative two-dimensional echocardiography.

    abstract：:Ascending (type I) aortic dissection carries a high morbidity and mortality. Proper identification of the proximal origin of the dissection and determination of concomitant aortic valve involvement significantly facilitate surgical repair, which may improve survival. In this case, intraoperative two-dimensional echoca...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80324-7

    authors： Goldman ME,Guarino T,Mindich BP

    更新日期：1985-11-01 00:00:00

  • Results of the arterial switch operation in patients with transposition of the great arteries and abnormalities of the mitral valve or left ventricular outflow tract.

    abstract：:Between January 1983 and October 1989, 290 patients underwent an arterial switch operation for transposition of the great arteries; 30 (10.3%) of the patients had abnormalities of the left ventricular outflow tract or mitral valve, or both. These abnormalities included isolated pulmonary valve stenosis (n = 9), septal...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(90)90391-2

    authors： Wernovsky G,Jonas RA,Colan SD,Sanders SP,Wessel DL,Castanñeda AR,Mayer JE Jr

    更新日期：1990-11-01 00:00:00

  • Myocardial strain and torsion quantified by cardiovascular magnetic resonance tissue tagging: studies in normal and impaired left ventricular function.

    abstract：:Accurate quantification and timing of regional myocardial function allows early identification of dysfunction, and therefore becomes increasingly important for clinical risk assessment, patient management, and evaluation of therapeutic efficacy. For this purpose, the application of tissue Doppler echocardiography has ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2006.07.048

    authors： Götte MJ,Germans T,Rüssel IK,Zwanenburg JJ,Marcus JT,van Rossum AC,van Veldhuisen DJ

    更新日期：2006-11-21 00:00:00

  • Susceptibility-sensitive magnetic resonance imaging detects human myocardium supplied by a stenotic coronary artery without a contrast agent.

    abstract：OBJECTIVES:Evaluation of the severity of a coronary artery stenosis is of paramount importance for therapy. A relevant stenosis provokes post-stenotic microvascular dilation with capillary recruitment. This autoregulatory response was investigated in the present study by use of susceptibility-sensitive magnetic resonan...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02931-5

    authors： Wacker CM,Hartlep AW,Pfleger S,Schad LR,Ertl G,Bauer WR

    更新日期：2003-03-05 00:00:00

  • Payment source, quality of care, and outcomes in patients hospitalized with heart failure.

    abstract：OBJECTIVES:The aim of this study was to analyze the relationship between payment source and quality of care and outcomes in heart failure (HF). BACKGROUND:HF is a major cause of morbidity and mortality. There is a lack of studies assessing the association of payment source with HF quality of care and outcomes. METHOD...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.06.034

    authors： Kapoor JR,Kapoor R,Hellkamp AS,Hernandez AF,Heidenreich PA,Fonarow GC

    更新日期：2011-09-27 00:00:00

  • Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis.

    abstract：OBJECTIVES:The aim of this study was to compare the effectiveness of the implantable cardioverter defibrillator (ICD) and medical strategies for prevention of arrhythmic events and death. BACKGROUND:The ICD is a potential strategy to reduce mortality in patients at risk of sudden death. METHODS:The MEDLINE, EMBASE, a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/s0735-1097(03)00253-5

    authors： Lee DS,Green LD,Liu PP,Dorian P,Newman DM,Grant FC,Tu JV,Alter DA

    更新日期：2003-05-07 00:00:00

  • Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial.

    abstract：OBJECTIVES:This trial examined the relative clinical efficacy, angiographic outcomes, and safety of zotarolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stents (SES). BACKGROUND:Whether a cobalt-based alloy stent coated with the novel antiproliferative agent, zotarolimus,...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2006.08.035

    authors： Kandzari DE,Leon MB,Popma JJ,Fitzgerald PJ,O'Shaughnessy C,Ball MW,Turco M,Applegate RJ,Gurbel PA,Midei MG,Badre SS,Mauri L,Thompson KP,LeNarz LA,Kuntz RE,ENDEAVOR III Investigators.

    更新日期：2006-12-19 00:00:00

  • The prevalence of treatable left ventricular systolic dysfunction in patients who present with noncardiac vascular episodes: a case-control study.

    abstract：OBJECTIVES:We sought to determine the prevalence of treatable left ventricular (LV) systolic dysfunction (LVSD) in patients who present with their first noncardiac vascular episode. BACKGROUND:Screening for LV dysfunction in patients who present with their first stroke (cerebrovascular accident), their first transient...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01725-9

    authors： Kelly R,Staines A,MacWalter R,Stonebridge P,Tunstall-Pedoe H,Struthers AD

    更新日期：2002-01-16 00:00:00

  • Chronic performance of a leadless cardiac pacemaker: 1-year follow-up of the LEADLESS trial.

    abstract：BACKGROUND:A leadless cardiac pacemaker (LCP) system was recently introduced to overcome lead-related complications of conventional pacing systems. To date, long-term results of an LCP system are unknown. OBJECTIVES:The aim of this study was to assess the complication incidence, electrical performance, and rate respon...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jacc.2015.02.022

    authors： Knops RE,Tjong FV,Neuzil P,Sperzel J,Miller MA,Petru J,Simon J,Sediva L,de Groot JR,Dukkipati SR,Koruth JS,Wilde AA,Kautzner J,Reddy VY

    更新日期：2015-04-21 00:00:00

  • Renal response to candoxatrilat in patients with heart failure.

    abstract：OBJECTIVES:Our primary objective was to compare the effects of three different doses of candoxatrilat with the effects of placebo on urinary volume in patients with moderately severe heart failure. The effects of candoxatrilat on urinary composition, neuroendocrine indexes and renal hemodynamic function were also studi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0735-1097(94)00561-4

    authors： Good JM,Peters M,Wilkins M,Jackson N,Oakley CM,Cleland JG

    更新日期：1995-05-01 00:00:00

  • Atheroma morphology and distribution in proximal left anterior descending coronary artery: in vivo observations.

    abstract：OBJECTIVES:This study sought to examine, in vivo, the shape and position of atheroma in the proximal left anterior descending coronary artery. BACKGROUND:The prevalence, shape and location of atheromas involving the proximal left anterior descending artery have implications regarding the role of disturbed shear forces...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00551-x

    authors： Kimura BJ,Russo RJ,Bhargava V,McDaniel MB,Peterson KL,DeMaria AN

    更新日期：1996-03-15 00:00:00

  • Complexity of atherosclerotic coronary artery disease and long-term outcomes in patients with unprotected left main disease treated with drug-eluting stents or coronary artery bypass grafting.

    abstract：OBJECTIVES:The aim of this study was to compare treatment effects of drug-eluting stents (DES) or coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease according to the complexity of atherosclerotic disease burden. BACKGROUND:Limited information is available on the relationships between t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.01.033

    authors： Park DW,Kim YH,Yun SC,Song HG,Ahn JM,Oh JH,Kim WJ,Lee JY,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

    更新日期：2011-05-24 00:00:00

  • Outcome of patients with nonischemic dilated cardiomyopathy and unexplained syncope treated with an implantable defibrillator.

    abstract：OBJECTIVES:The purpose of this study was to determine the outcome of patients with nonischemic dilated cardiomyopathy, unexplained syncope and a negative electrophysiology test who are treated with an implantable defibrillator. BACKGROUND:Patients with nonischemic cardiomyopathy and unexplained syncope may be at high ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00148-5

    authors： Knight BP,Goyal R,Pelosi F,Flemming M,Horwood L,Morady F,Strickberger SA

    更新日期：1999-06-01 00:00:00

  • Noninvasive characterization of myocardial molecular interventions by integrated positron emission tomography and computed tomography.

    abstract：OBJECTIVES:We sought to investigate the usefulness of integrated positron emission tomography (PET) and computed tomography (CT) for in vivo characterization of an angiogenesis-directed molecular intervention. BACKGROUND:Controversies about the effectiveness of molecular therapies for cardiovascular disease have promp...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.08.029

    authors： Wagner B,Anton M,Nekolla SG,Reder S,Henke J,Seidl S,Hegenloh R,Miyagawa M,Haubner R,Schwaiger M,Bengel FM

    更新日期：2006-11-21 00:00:00

  • Echocardiographic findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia: new insights from the multidisciplinary study of right ventricular dysplasia.

    abstract：OBJECTIVES:The purpose of this study was to quantify the echocardiographic abnormalities in probands who were newly diagnosed with arrhythmogenic right ventricular dysplasia (ARVD). BACKGROUND:The diagnosis of ARVD remains challenging. The Multidisciplinary Study of Right Ventricular Dysplasia was initiated to charact...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2004.10.070

    authors： Yoerger DM,Marcus F,Sherrill D,Calkins H,Towbin JA,Zareba W,Picard MH,Multidisciplinary Study of Right Ventricular Dysplasia Investigators.

    更新日期：2005-03-15 00:00:00

  • Myocardial contrast echocardiography in humans. II. Assessment of coronary blood flow reserve.

    abstract：:The hypothesis that myocardial contrast echocardiography could be used to simultaneously assess coronary blood flow reserve and the size of the perfusion bed supplied by a coronary artery was examined in nine patients and six dogs. All patients were undergoing cardiac catheterization and had single vessel coronary art...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(88)90456-1

    authors： Keller MW,Glasheen W,Smucker ML,Burwell LR,Watson DD,Kaul S

    更新日期：1988-10-01 00:00:00

  • Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study.

    abstract：OBJECTIVES:Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens. BACKGROUND:Most acute coronary events and sudden death are believed to arise from rupture of a TCFA followe...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.04.086

    authors： Cheruvu PK,Finn AV,Gardner C,Caplan J,Goldstein J,Stone GW,Virmani R,Muller JE

    更新日期：2007-09-04 00:00:00

  • A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging.

    abstract：OBJECTIVES:This study was designed to investigate if tissue synchronization imaging (TSI) is useful to identify regional wall delay and predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). BACKGROUND:Echocardiographic assessment of systolic asynchrony is helpful to predict a ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2004.12.003

    authors： Yu CM,Zhang Q,Fung JW,Chan HC,Chan YS,Yip GW,Kong SL,Lin H,Zhang Y,Sanderson JE

    更新日期：2005-03-01 00:00:00

  • Race and the decision to refer for coronary revascularization: the effect of physician awareness of patient ethnicity.

    abstract：OBJECTIVES:We sought to assess whether there were differences, relative to racial ethnicity, in coronary revascularization recommendations made by a panel that had no knowledge of the patients' ethnicity. BACKGROUND:Coronary revascularization is employed less frequently in African American than in white patients. It i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01418-8

    authors： Okelo S,Taylor AL,Wright JT Jr,Gordon N,Mohan G,Lesnefsky E

    更新日期：2001-09-01 00:00:00