Enhancement of dissolution and absorption of mefenamic acid by egg albumin.


:The dissolution behavior and absorption of mefenamic acid following oral and rectal administration from drug:egg albumin solid dispersions have been studied in comparison with those of the drug alone. The interaction of drug with egg albumin in aqueous solution and solid state were examined by solubility analysis, dialysis experiments, and X-ray diffractometry. The results showed that the dissolution rate of mefenamic acid, and also the release of drug from witepsol H-15 suppositories, were significantly increased by using egg albumin:drug solid dispersions. Although egg albumin:drug solid dispersion enhanced the mean serum levels and the area under serum concentration-time curves after oral and rectal administration compared with those of the drug alone, no significant differences were found between the mean residence time values of drug and its solid dispersion. It was also noted that the extent of bioavailability of mefenamic acid and its solid dispersion following oral administration was significantly greater than that following rectal administration.


J Pharm Sci


Imai T,Nohdomi K,Acartürk F,Otagiri M




Has Abstract


1991-05-01 00:00:00














  • Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride.

    abstract::The purpose of this study was to investigate the feasibility of delivering sinomenine hydrochloride (SH) transdermally using composite dissolving microneedles (DM) which integrated with liquid crystals (H2). The fabricated SH-loaded composite DM was evaluated for their appearance, mechanical strength, irritation, and ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gui Z,Wu X,Wang S,Cao Y,Wan J,Shan Q,Yang Z,Zhang J,Gui S

    更新日期:2017-12-01 00:00:00

  • Enhanced potency of human calcitonin when fibrillation is avoided.

    abstract::The peptide hormone calcitonin (CT) is a potent drug for the therapy of different bone diseases. Salmon CT (sCT) is reported to be more active than human CT (hCT). Human CT, but not sCT, has a strong tendency to aggregate and fibrillate in aqueous solutions. Recent investigations of the fibrillation mechanisms contrib...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cudd A,Arvinte T,Das RE,Chinni C,MacIntyre I

    更新日期:1995-06-01 00:00:00

  • Compressibility of anhydrous tricalcium phosphate.

    abstract::It is shown that tricalcium phosphate follows a simple Heckel relationship in pressures of usual tablet compression, only if a density of 1.92 g/mL is used. This coincides with the density obtained by wet pycnometry, whereas the crystallographical density is 3.1 g/mL. The interpretation is that some of the pore space ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hou XP,Carstensen JT

    更新日期:1985-04-01 00:00:00

  • Colorimetric assay of benzocaine and some dosage forms.

    abstract::A colorimetric procedure for benzocaine and a number of its dosage forms was developed; it offers improvement in ease, speed, and sensitivity over the official method. The method is based on the formation of a red Schiff base between benzocaine and p-dimethylaminocinnamaldehyde in a nonaqueous acidic medium. At the ma...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tan HS,Bruemmer GA,Shelton D

    更新日期:1977-07-01 00:00:00

  • Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier.

    abstract::The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knockout mice and "chemi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cutler L,Howes C,Deeks NJ,Buck TL,Jeffrey P

    更新日期:2006-09-01 00:00:00

  • Inulin hydrogels as carriers for colonic drug targeting. Rheological characterization of the hydrogel formation and the hydrogel network.

    abstract::Free radical polymerization converts aqueous solutions of methacrylated inulin into cross-linked hydrogels. The purpose of this work was to study the hydrogel formation and to characterize the fully cured hydrogels. The gelation process of aqueous solutions of methacrylated inulin was monitored as a function of time b...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vervoort L,Vinckier I,Moldenaers P,Van den Mooter G,Augustijns P,Kinget R

    更新日期:1999-02-01 00:00:00

  • Effect of characteristics of compounds on maintenance of an amorphous state in solid dispersion with crospovidone.

    abstract::Solid dispersion (SD) of indomethacin with crospovidone (CrosPVP) shows useful characteristics for preparation of dosage forms. This study aimed to determine the types of drugs that could adopt a stable amorphous form in SD. Twenty compounds with various melting points (70-218 degrees C), molecular weights (135-504) a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shibata Y,Fujii M,Kokudai M,Noda S,Okada H,Kondoh M,Watanabe Y

    更新日期:2007-06-01 00:00:00

  • Quantitative Estimation of Plasma Free Drug Fraction in Patients With Varying Degrees of Hepatic Impairment: A Methodological Evaluation.

    abstract::Quantitative prediction of unbound drug fraction (fu) is essential for scaling pharmacokinetics through physiologically based approaches. However, few attempts have been made to evaluate the projection of fu values under pathological conditions. The primary objective of this study was to predict fu values (n = 105) of...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li GF,Yu G,Li Y,Zheng Y,Zheng QS,Derendorf H

    更新日期:2018-07-01 00:00:00

  • Amorphous stabilization and dissolution enhancement of amorphous ternary solid dispersions: combination of polymers showing drug-polymer interaction for synergistic effects.

    abstract::The purpose of this study was to understand the combined effect of two polymers showing drug-polymer interactions on amorphous stabilization and dissolution enhancement of indomethacin (IND) in amorphous ternary solid dispersions. The mechanism responsible for the enhanced stability and dissolution of IND in amorphous...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Prasad D,Chauhan H,Atef E

    更新日期:2014-11-01 00:00:00

  • Viscosity and surface tension of dilute salicylic acid-cetrimide systems.

    abstract::The viscosity and surface tension of systems containing small amounts of salicylic acid in aqueous solutions of cetrimide were determined. An abrupt increase in viscosity was observed, and the molar ratio of salicylic acid to certrimide at which this viscosity increase occurred was 1:2. The surface tension of these sy...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wan LS

    更新日期:1977-12-01 00:00:00

  • Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.

    abstract::Hexamidine isethionate in various pharmaceutical formulations was analyzed quantitatively by high-performance liquid chromatography. The method is rapid, accurate, and precise. Excellent results were obtained from four commercial bases. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Taylor P,Braddock PD,Ross S

    更新日期:1983-12-01 00:00:00

  • Effect of basic cholane derivatives on intestinal cholic acid metabolism: in vitro and in vivo activity.

    abstract::A representative series of hydroxy-5 beta-cholanyl-24-amines were tested both in vitro and in vivo with respect to their activity against the intestinal bacteria responsible for bile acid metabolism. For the in vitro studies, radiolabeled [14C]cholic acid was incubated with human stools both in aerobic and anaerobic c...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Roda A,Bellini AM,Mencini E,Minutello A,Fini A,Guarneri M

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  • Delivery of MUC1 mucin peptide by Poly(d,l-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses.

    abstract::Synthetic peptides corresponding to the variable tandem repeat domain of the cancer-associated antigen MUC1 mucin are candidates for cancer vaccines. In our investigation mice were immunized via subcutaneous injection with poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres containing a MUC1 mucin peptide. It was hy...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Newman KD,Sosnowski DL,Kwon GS,Samuel J

    更新日期:1998-11-01 00:00:00

  • Oil-frozen W₁/O/W₂ double emulsions for dermal biomacromolecular delivery containing ethanol as chemical penetration enhancer.

    abstract::Oil-frozen water-in-oil-in-water (W₁/O/W₂) double emulsions (DE) containing ethanol up to 40% (w/v) in the external aqueous W₂ phase exhibited external coalescence upon thawing of the oil phase, releasing up to 85% of the encapsulated protein of the internal aqueous phase. These emulsions were studied in vitro as pote...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jaimes-Lizcano YA,Lawson LB,Papadopoulos KD

    更新日期:2011-04-01 00:00:00

  • α-Lipoic Acid in Soluplus(®) Polymeric Nanomicelles for Ocular Treatment of Diabetes-Associated Corneal Diseases.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Alvarez-Rivera F,Fernández-Villanueva D,Concheiro A,Alvarez-Lorenzo C

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  • Synthesis of 10alpha-methoxy-delta8,9-lysergaldehyde from elymoclavine.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Choong TC,Thompson BL,Shough HR

    更新日期:1977-09-01 00:00:00

  • Analysis of transcutaneous antigenic protein delivery by a hydrogel patch formulation.

    abstract::We have developed a hydrogel patch, which could promote antigen penetration through stratum corneum (SC), and have demonstrated its safety and efficacy in animals and humans. For the availability improvement of our system, it is important to develop a device, which enhances antigen penetration through SC more efficien...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matsuo K,Ishii Y,Kawai Y,Saiba Y,Quan YS,Kamiyama F,Hirobe S,Okada N,Nakagawa S

    更新日期:2013-06-01 00:00:00

  • Cross-linked low molecular weight glycopeptide-mediated gene delivery: relationship between DNA metabolic stability and the level of transient gene expression in vivo.

    abstract::DNA co-condensates were formed by reacting [125I]DNA with an admixture of a high-mannose glycopeptide (Man9-CWK(18)) and either of two poly(ethylene glycol) peptides (PEG-VS-CWK(18) or PEG-SS-CWK(18)) followed by cross-linking with 6-50 mol equiv of glutaraldehyde. [125I]DNA co-condensates were administered intravenou...

    journal_title:Journal of pharmaceutical sciences

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    authors: Yang Y,Park Y,Man S,Liu Y,Rice KG

    更新日期:2001-12-01 00:00:00

  • Characterization of native and drug-loaded human low density lipoproteins.

    abstract::Low-density lipoproteins (LDLs), the physiological vehicles for lipids, are potentially useful drug delivery devices for (hydrophobic) drugs. The physicochemical characteristics of LDL loaded with the adriamycin derivative AD 32 or the N-mustard derivative WB 4291 were compared to that of native and reconstituted LDL ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Westesen K,Gerke A,Koch MH

    更新日期:1995-02-01 00:00:00

  • Comparative pharmacokinetics of butylated hydroxyanisole and butylated hydroxytoluene in rabbits.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: El-Rashidy R,Niazi S

    更新日期:1980-12-01 00:00:00

  • Does electrostatic charge affect powder aerosolisation?

    abstract::To study if electrostatic charge initially present in mannitol powder plays a role in the generation of aerosols, mannitol was unipolarly charged to varying magnitudes by tumbling the powder inside containers of different materials. The resulting charge in the powder was consistent with predictions from the triboelect...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Adi H,Kwok PC,Crapper J,Young PM,Traini D,Chan HK

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  • Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Becker C,Dressman JB,Amidon GL,Junginger HE,Kopp S,Midha KK,Shah VP,Stavchansky S,Barends DM

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  • New synthetic amphiphilic polymers for steric protection of liposomes in vivo.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Torchilin VP,Trubetskoy VS,Whiteman KR,Caliceti P,Ferruti P,Veronese FM

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  • Effect of milling and compression on the solid-state Maillard reaction.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Qiu Z,Stowell JG,Cao W,Morris KR,Byrn SR,Carvajal MT

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Johari GP,Shanker RM

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  • Effect of food on the bioavailability of lisinopril, a nonsulfhydryl angiotensin-converting enzyme inhibitor.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章,随机对照试验


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  • Determination of the chemical constituents and spectral properties of commercial and NF reference standard potassium guaiacolsulfonate: implications of the findings on compendial analytical methodology.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tangtatsawasdi P,Krikorian SE

    更新日期:1984-09-01 00:00:00

  • Quantitative microradiographic study of simultaneous demineralization/remineralization of dental enamel in weak acid buffers.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bergstrom DH,Fox JL,Higuchi WI

    更新日期:1984-05-01 00:00:00

  • Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kumru OS,Liu J,Ji JA,Cheng W,Wang YJ,Wang T,Joshi SB,Middaugh CR,Volkin DB

    更新日期:2012-10-01 00:00:00

  • Chlorthalidone analysis using carbonic anhydrase inhibition.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Johnston MM,Li H,Mufson D

    更新日期:1977-12-01 00:00:00