Enhancement of dissolution and absorption of mefenamic acid by egg albumin.

abstract：:It is shown that tricalcium phosphate follows a simple Heckel relationship in pressures of usual tablet compression, only if a density of 1.92 g/mL is used. This coincides with the density obtained by wet pycnometry, whereas the crystallographical density is 3.1 g/mL. The interpretation is that some of the pore space ...

journal_title：Journal of pharmaceutical sciences

authors： Hou XP,Carstensen JT

更新日期：1985-04-01 00:00:00

abstract：:This work investigated the impact of primary drying conditions on the microstructure and protein stability of bovine serum albumin (BSA) containing lyophilized cakes. Two primary drying conditions were employed (termed 'conservative', slower drying rate and 'aggressive', higher drying rate) at two protein loadings (5 ...

journal_title：Journal of pharmaceutical sciences

authors： Parker A,Rigby-Singleton S,Perkins M,Bates D,Le Roux D,Roberts CJ,Madden-Smith C,Lewis L,Teagarden DL,Johnson RE,Ahmed SS

更新日期：2010-11-01 00:00:00

abstract：:Tissue-specific ultrasonic enhancement can be used for the detection and characterization of atherosclerosis. We have previously demonstrated the generation of inherently echogenic (acoustically reflective) liposomes solely by varying lipid composition and controlling the method of production. In this study, echogenic...

journal_title：Journal of pharmaceutical sciences

authors： Demos SM,Onyüksel H,Gilbert J,Roth SI,Kane B,Jungblut P,Pinto JV,McPherson DD,Klegerman ME

更新日期：1997-02-01 00:00:00

abstract：:Inclusion complexes between beta-cyclodextrin derivatives and 1, 2-dithione-3-thiones were studied in aqueous solution and in the solid state. Phase solubility study was used to evaluate the complexation in solution, at 37 degrees C, of three cyclodextrins, i. e., beta-cyclodextrin (betaCD), hydroxypropyl-beta-cyclode...

journal_title：Journal of pharmaceutical sciences

authors： Dollo G,Le Corre P,Chollet M,Chevanne F,Bertault M,Burgot JL,Le Verge R

更新日期：1999-09-01 00:00:00

abstract：:We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR ...

journal_title：Journal of pharmaceutical sciences

authors： Farin D,Avnir D

更新日期：1992-01-01 00:00:00

abstract：:Chitosan microspheres were evaluated for sustained-release of recombinant human interleukin-2 (rIL-2) in this study. In addition, the effects of different formulation factors, such as chitosan and protein concentrations, the volume of sodium sulfate solution, addition technique of rIL-2, and presence of glutaraldehyde...

journal_title：Journal of pharmaceutical sciences

authors： Ozbaş-Turan S,Akbuğa J,Aral C

更新日期：2002-05-01 00:00:00

abstract：:Angiogenesis, the sprouting of capillaries from preexisting ones, is essential for the sustained growth of solid tumors. In this study, we used SU5416, a hydrophobic molecule with potent tyrosine kinase inhibitor of type 2 receptor for vascular endothelial growth factor (VEGF), as PEGylated emulsion (SU5416-PE), and e...

journal_title：Journal of pharmaceutical sciences

authors： Ogawara K,Abe S,Un K,Yoshizawa Y,Kimura T,Higaki K

更新日期：2014-08-01 00:00:00

abstract：:We have used rheological and thermal methods to study the colloidal characteristics of a widely used technical latex. The dispersions of poly(methacrylic acid-ethyl acrylate) (Eudragit L100-55) were found to be stabilized by a combination of electrostatic and steric mechanisms termed as electrosteric stabilization. Th...

journal_title：Journal of pharmaceutical sciences

authors： Paulsson M,Singh SK

更新日期：1999-04-01 00:00:00

abstract：:A stability-specific high-pressure liquid chromatographic (HPLC) method was developed to assay intact chlorambucil (I) in the presence of its hydrolytic decomposition products. The HPLC method was used to follow the degradation kinetics of I over pH 1.0-10.0 in the presence of various buffers with and without added ch...

journal_title：Journal of pharmaceutical sciences

authors： Chatterji DC,Yeager RL,Gallelli JF

更新日期：1982-01-01 00:00:00

abstract：:Crystallization of polymorphs still has a touch of art, as even prior observations of polymorphs do not guarantee their crystallization. However, once crystals of various polymorphs have been obtained, their relative stabilities can be established with a straightforward thermodynamic approach even if the conclusion wi...

journal_title：Journal of pharmaceutical sciences

authors： Rietveld IB,Céolin R

更新日期：2015-12-01 00:00:00

abstract：:A method for the simultaneous determination of etoricoxib and its carbon-13 analog ((13)C(6)-etoricoxib) from human plasma has been developed and used to support bioavailability studies. Plasma samples (0.5 mL) were extracted by using a 3M Empore 96-well plate (C(8)) and the resulting extracts were analyzed by using a...

journal_title：Journal of pharmaceutical sciences

authors： Rose MJ,Agrawal N,Woolf EJ,Matuszewski BK

更新日期：2002-02-01 00:00:00

abstract：:Intravenously administered (i.v.) drug-cyclodextrin (CD) inclusion complexes are generally expected to dissociate rapidly and completely, such that the i.v. pharmacokinetic profile of a drug is unchanged in the presence of CD. The altered pharmacokinetics of a synthetic ozonide in rats has been attributed to an unusua...

journal_title：Journal of pharmaceutical sciences

authors： Leong NJ,Prankerd RJ,Shackleford DM,Mcintosh MP

更新日期：2015-04-01 00:00:00

abstract：:The effect of caffeine on the absorption of ergotamine from the rat small intestine was studied. The results of a series of experiments showed that caffeine significantly enhanced absorption of ergotamine from solutions of pH 5.0 when both substances were in solution and when an intact blood supply was either absent (...

journal_title：Journal of pharmaceutical sciences

authors： Anderson JR,Drehsen G,Pitman IH

更新日期：1981-06-01 00:00:00

abstract：:Hydrastine, canadine, and berberine were determined by the acid-dye technique. At pH 5.6, both the tertiary and the quaternary hydrastis alkaloids formed ion-pairs with bromcresol purple. The liberated hydrastine and canadine from the alkaloid-dye complexes were determined spectrophotometrically in the presence of ber...

journal_title：Journal of pharmaceutical sciences

authors： El-Masry S,Korany MA,Abou-Donia AH

更新日期：1980-05-01 00:00:00

abstract：:Sucrose is a common cryoprotectant and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage. Sucrose-based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb) containing products need to be stored refrigerated. The objective of this stud...

journal_title：Journal of pharmaceutical sciences

authors： Haeuser C,Goldbach P,Huwyler J,Friess W,Allmendinger A

更新日期：2020-01-01 00:00:00

abstract：:For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge because as particles are reduced in size by conventional milling techniq...

journal_title：Journal of pharmaceutical sciences

authors： Lechuga-Ballesteros D,Charan C,Stults CL,Stevenson CL,Miller DP,Vehring R,Tep V,Kuo MC

更新日期：2008-01-01 00:00:00

abstract：:Quantification analysis with near-infrared (NIR) spectroscopy typically requires utilizing chemometric techniques, such as partial least squares (PLS) method, to achieve the desired selectivity. This article points out a major limitation of these statistical-based calibration methods. The limitation is that the techni...

journal_title：Journal of pharmaceutical sciences

authors： Xiang D,Berry J,Buntz S,Gargiulo P,Cheney J,Joshi Y,Wabuyele B,Wu H,Hamed M,Hussain AS,Khan MA

更新日期：2009-03-01 00:00:00

abstract：:The intrinsic absorption of salbutamol in different intestinal segments of the rat was measured and related with the corresponding intestinal P-glycoprotein (P-gp) expression levels. The apparent absorption rate constants (k(a), h(-1)) observed in each fraction by means of the "in situ" rat gut absorption method after...

journal_title：Journal of pharmaceutical sciences

authors： Valenzuela B,Nácher A,Ruiz-Carretero P,Martín-Villodre A,López-Carballo G,Barettino D

更新日期：2004-06-01 00:00:00

abstract：:Jet-milling as the common way for micronization of drugs shows several disadvantages. Drug powder properties are decisive for pulmonary use because, besides a small particle size, a good deagglomeration behavior is required. In this study, several anti-inflammatory drugs [beclomethasone-17,21-dipropionate (BDP), betam...

journal_title：Journal of pharmaceutical sciences

authors： Rasenack N,Steckel H,Müller BW

更新日期：2003-01-01 00:00:00

abstract：:New dihydropyridine in equilibrium pyridinium salt-type redox carrier systems were developed in which the drug is linked via the ring nitrogen atom of nicotinamide. The rate of oxidation of the dihydropyridine forms, and thus the overall and brain-specific distribution of the corresponding 3-carbamoyl-1-carbamoylalkyl...

journal_title：Journal of pharmaceutical sciences

authors： Bodor N,AbdelAlim AM

更新日期：1985-03-01 00:00:00

abstract：:A rotating-basket apparatus for dissolution testing of veterinary bolus tablets was designed and constructed. Sulfamethazine boluses containing different disintegrating agents were evaluated in vitro and by blood level data following administration to cattle. The dissolution t50 and various pharmacokinetic parameters ...

journal_title：Journal of pharmaceutical sciences

authors： Frazier WF,Nuessle NO

更新日期：1976-12-01 00:00:00

abstract：:Carbamazepine is the first-line anti-epileptic drug for focal seizures and generalized tonic-clonic seizures. Although sustained-release formulations exist, an initial burst of drug release is still present and this results in side effects. Zero-order release formulations reduce fluctuations in serum drug concentratio...

journal_title：Journal of pharmaceutical sciences

authors： Lim SH,Chia SM,Kang L,Yap KY

更新日期：2016-07-01 00:00:00

abstract：:In this study, curcumin and/or docosahexaenoic acid (DHA) were encapsulated in Thai silk fibroin/gelatin (SF/G) sponges, prepared at different blending ratios, aimed to be applied as a controlled release system for localized cancer therapy. The SF/G sponges were fabricated by freeze-drying and glutaraldehyde cross-lin...

journal_title：Journal of pharmaceutical sciences

authors： Lerdchai K,Kitsongsermthon J,Ratanavaraporn J,Kanokpanont S,Damrongsakkul S

更新日期：2016-01-01 00:00:00

abstract：:The dissolution kinetics of theophylline monohydrate and anhydrous theophylline were investigated with a rotating-disk apparatus in buffer solutions at 298 K under sink conditions. The observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simu...

journal_title：Journal of pharmaceutical sciences

authors： de Smidt JH,Fokkens JG,Grijseels H,Crommelin DJ

更新日期：1986-05-01 00:00:00

abstract：:The release through silicone rubber membranes of benzocaine suspended in carbomer hydrogels containing different concentrations of low molecular weight polysols (ethylene glycol, propylene glycol, glycerol, and sorbitol) was studied to establish general principles and procedures for control of the effects on percutane...

journal_title：Journal of pharmaceutical sciences

authors： Di Colo G,Carelli V,Giannaccini B,Serafini MF,Bottari F

更新日期：1980-04-01 00:00:00

abstract：:The axial and radial tensile strengths were compared to the hardness of compressed tablets containing various concentrations of lubricants. Since radial tensile strength measurement considers the thickness of a tablet, and only tensile stress and axial tensile strength express the strength in the direction in which ca...

journal_title：Journal of pharmaceutical sciences

authors： Jarosz PJ,Parrott EL

更新日期：1982-06-01 00:00:00

abstract：:Quality-by-design (QbD) is a systematic approach to drug development, which begins with predefined objectives, and uses science and risk management approaches to gain product and process understanding and ultimately process control. The concept of QbD can be extended to analytical methods. QbD mandates the definition ...

journal_title：Journal of pharmaceutical sciences

authors： Vogt FG,Kord AS

更新日期：2011-03-01 00:00:00

abstract：:A wide variety of computational models covering statistical, mechanistic, and machine learning (locked and adaptive) methods are explored for use in biopharmaceutical manufacturing. Limited discussion exists on how to establish the credibility of a computational model for application in biopharmaceutical manufacturing...

journal_title：Journal of pharmaceutical sciences

authors： Bideault G,Scaccia A,Zahel T,Forero RL,Daluwatte C

更新日期：2021-01-22 00:00:00

abstract：:The reaction kinetics of blue tetrazolium with selected arylhydrazines were investigated under pseudo-first-order conditions. The reaction rate constants were obtained at various temperatures, and the enthalpy (8.4-11.2 kcal/mole) and entropy (-38--45 eu) of activations were calculated. A Hammett plot yielded a straig...

journal_title：Journal of pharmaceutical sciences

authors： Biehl ER,Wooten R,Kenner CT,Graham RE

更新日期：1978-07-01 00:00:00

abstract：:Surface activity and critical micelle concentrations are reported for two diuretic drugs, furosemide and triamterene. The drugs generate a liquid membrane on a supporting membrane. Transport of chloride, sodium, and potassium ions through the liquid membranes generated by the drugs was studied. The data suggest that t...

journal_title：Journal of pharmaceutical sciences

authors： Bhise SB,Bhattacharjee D,Srivastava RC

更新日期：1984-11-01 00:00:00