Abstract:
:On the occasion of this Fourth World Conference on Lung Cancer, I am privileged to present the opening keynote address. This presentation has been sponsored by the Ontario Cancer Treatment and Research Foundation. In 1952, the Foundation established an annual lectureship in memory of one of their prominent physicians. Dr. Gordon Earle Richards was one of Canada's pioneer radiologists and radiotherapists who was appointed Director of the Institute of Radiotherapy at Toronto General Hospital at a time when radium and high-voltage x-rays were just coming into common use for the treatment of malignant disease. He established an international reputation for his contributions to clinical radiotherapy, and was subsequently appointed Professor of Radiology at the University of Toronto. He was Managing Director of the Ontario Cancer Treatment and Research Foundation between 1945 and 1949. I wish to thank the Foundation for the privilege of presenting the 33rd Gordon Richards Memorial Lecture.
journal_name
Chestjournal_title
Chestauthors
Pearson FGdoi
10.1378/chest.89.4.200ssubject
Has Abstractpub_date
1986-04-01 00:00:00pages
200S-205Sissue
4 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(16)61950-5journal_volume
89pub_type
临床试验,历史文章,杂志文章,评审相关文献
CHEST文献大全abstract:STUDY OBJECTIVE:To assess the accuracy of the respiratory inductive plethysmography in the measurement of PEEP-induced changes in end-expiratory lung volume during mechanical ventilation and its accuracy and stability in the measurement of ventilation during controlled mechanical ventilation and spontaneous breathing. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.1.234
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:The purpose of the study was to evaluate a novel, combined sensor for transcutaneous monitoring of arterial oxygen saturation and carbon dioxide tension. DESIGN:The new monitoring technique was compared to established reference methods. SETTING:ICU and sleep laboratory of a university hospital. PATIENTS:E...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1291
更新日期:2005-09-01 00:00:00
abstract::Pulmonary infections, which frequently occur during the early and late period following bone marrow transplantation for hematologic malignancies, are associated with significant morbidity and mortality. In this study the incidence, the infectious causes of pneumonia and the mortality related to pneumonia in 130 alloge...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.2.371
更新日期:1993-08-01 00:00:00
abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0266
更新日期:2015-02-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effectiveness of treatment with corticosteroids in patients with COPD. METHODS:In this study, we investigated the effect of a 2-year treatment with corticosteroids on clinical symptoms and the decline of lung function in 58 nonallergic patients with COPD. Subjects were treated in a dou...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.109.5.1156
更新日期:1996-05-01 00:00:00
abstract:STUDY OBJECTIVES:COPD patients run a risk of developing nocturnal oxygen desaturation. When evaluating patients with nocturnal hypoxemia, an unfamiliar hospital environment and the monitoring equipment may cause sleep disturbances. It was hypothesized that increased sleep disruption will lead to fewer instances of desa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.6.1820
更新日期:2001-06-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the oxygen pulse curve (O(2)P-C) as measured during cardiopulmonary exercise testing (CPET) with left ventricular (LV) ejection fraction (LVEF) rest-exercise response as measured by multigated equilibrium (99m)Tc radionuclide cineangiography (MUGA) in patients with different degrees of ische...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.3.841
更新日期:2002-03-01 00:00:00
abstract::In the case reported, a patient with severe right ventricular failure following coronary revascularization was successfully weaned from cardiopulmonary bypass following creation of an atrial septal defect. This technique facilitated rapid decompression of the failing right ventricle by shunting blood to the more compl...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.5.950
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate patients with stage I non-small cell lung cancer (NSCLC) and tumors up to 3 cm in maximum dimension who underwent surgical resection on the revised TNM classification and to investigate the risk factors for recurrence. METHODS:Between 1994 and 2003, 713 consecutive ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-3046
更新日期:2010-08-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is an autosomal recessive disease affecting predominantly populations surrounding the Mediterranean basin. It is the most prevalent hereditary periodic fever syndrome characterized mainly by recurrent and short attacks of fever and serositis (pleuritis, arthritis, peritonitis). Unila...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-1736
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Physician productivity, practice expense, resource allocation, facilities, staff, and malpractice are variables in medical practice profitability. The ongoing challenge of collecting reliable and consistent data created an opportunity in 2001 for the American College of Chest Physicians (ACCP) Practice Admin...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.3.885
更新日期:2006-09-01 00:00:00
abstract::In assessing the effectiveness of lower-limb and upper-limb nonspecific physical training, we have considered 3 objectives in this study: (1) determination of clinical and functional actual state in patients with chronic airway obstruction (CAO), before and after training; (2) determination of the tests, level of work...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.101.5_supplement.279s
更新日期:1992-05-01 00:00:00
abstract::We describe 12 patients with simultaneous bilateral spontaneous pneumothorax (SBSP). They represent 4 percent of patients with spontaneous pneumothorax seen at our hospital from 1971 to 1990. Five of the 12 had no underlying lung disease. In the seven remaining patients, SBSP was secondary to histiocytosis X, lymphang...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.4.1142
更新日期:1994-04-01 00:00:00
abstract::The object of this study was to compare the diagnostic yield of Abrams and Cope needles. Pleural biopsies were performed in 24 patients with both needles. In two patients, the procedure was repeated within a few days. All patients had pleural effusion. The biopsies were performed at the same time; the biopsy sites wer...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.6.1050
更新日期:1987-12-01 00:00:00
abstract::We describe the Ca2+ movements in smooth muscle cells at rest and during activation and relaxation as deduced from transplasmalemmal Ca2+ fluxes and contractile respnses. The general picture which emerges is: the resting cell has a [Ca2+]cyt below 10(-7) M and large gradients are poised across both the cell membrane a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1_supplement.157
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:While the complexity of flexible bronchoscopy has increased, standard options for moderate sedation medications have not changed in three decades. There is a need to improve moderate sedation while maintaining safety. Remimazolam was developed to address shortcomings of current sedation strategies. METHODS:...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.chest.2018.09.015
更新日期:2019-01-01 00:00:00
abstract::Although the principal actions of clonidine are linked to its centrally mediated suppression of sympathetic activity, its inhibition of the renin axis also may contribute to its antihypertensive effects. In patients with essential hypertension studied in a clinical research center, clonidine-induced decreases in diast...
journal_title:Chest
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced OSA severity, likely by increasing upper airway dilator muscle activity during sleep. In patients with OSA who performed the ato-oxy tria...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.01.012
更新日期:2020-06-01 00:00:00
abstract::Echocardiography has proven a useful and sensitive means to determine noninvasively the cardiac dimensions. This report describes the echocardiographic detection of progressive dilatation of the aortic root over an 18-month period, which led to death in a 33-year-old man with Marfan's syndrome; however, at no time was...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.6.789
更新日期:1977-12-01 00:00:00
abstract:STUDY OBJECTIVES:The etiologic role of bacterial pathogens isolated from sputum culture in 40 to 50% of acute exacerbations of chronic bronchitis (AECB) is controversial. If bacterial pathogens cause these AECB, they should be associated with greater neutrophilic airway inflammation than pathogen-negative exacerbations...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.6.1557
更新日期:2000-12-01 00:00:00
abstract::Two recent epidemiologic case-control studies suggested that fenoterol, a selective beta-adrenergic agonist, was associated with an increase in the risk of asthma death. The results of these studies were criticized because of methodologic problems in the choice and selection of control subjects; the different methods ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.6.1586
更新日期:1991-12-01 00:00:00
abstract::Our understanding of asthma epidemiology is growing increasingly complex. Asthma outcomes are clearly socially patterned, with asthma ranking as a leading cause of health disparities among minority and low socioeconomic groups. Yet, the increasing prevalence and marked disparities in asthma remain largely unexplained ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.07-1904
更新日期:2007-11-01 00:00:00
abstract::Hemodynamic and metabolic effects of methylprednisolone were investigated in a double-blind study of 28 patients with acute myocardial infarction (AMI), confirmed by unequivocal electrocardiographic and enzyme changes. Measurements were performed prior to and at 1.5, 3, 4, 4.5, 12 and 24 hours following infusion of me...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.79.2.186
更新日期:1981-02-01 00:00:00
abstract::To determine whether sectional development in pulmonary and critical care medicine influences medical house officers' (HO) interests and knowledge about respiratory medicine, we reviewed HO performance on the American Board of Internal Medicine (ABIM) certifying examination during 4 years before and 5 years after reor...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.2.533
更新日期:1996-08-01 00:00:00
abstract:STUDY OBJECTIVES:Previous studies have reported that magnesium (Mg) deficiency is associated with coronary spasm. However, little is known about the preventive effect of Mg on coronary spasm. The present study investigated whether Mg prevents coronary spasm in patients with vasospastic angina (VSA). DESIGN:Effectivene...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.118.6.1690
更新日期:2000-12-01 00:00:00
abstract::A 41-year-old man was found to have a miliary infiltrate on chest roentgenogram two months after recovery from varicella pneumonia. The patient remained in good health and there was no objective sign of pulmonary disease. The infiltrate showed no change in subsequent serial chest films, and after one year, open lung b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.3.457
更新日期:1986-03-01 00:00:00
abstract::To study the effects of upper mantle radiation therapy on pulmonary function, forced expiratory volume in one second (FEV1), vital capacity (VC), inspiratory capacity (IC), diffusing capacity for CO (DLCO) and diffusion per unit of alveolar volume (DL/VA were determined in 28 patients with Hodgkin's disease, stages 1-...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.6.688
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and health-care-associated pneumonia (HCAP). These infections are associated with significant morbidity, mortality, and cost. The impact of vancomycin minimum inh...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.09-2453
更新日期:2010-12-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the extent to which a mixture of human gastric juice and enteral formula stained with two concentrations of FD&C Blue No. 1 food dye (0.8 and 1.5 mL/L) is visible in suctioned tracheobronchial secretions following three forced small-volume pulmonary aspirations over a 6-h period in an anima...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.1.276
更新日期:2002-07-01 00:00:00
abstract::Eighteen postmenopausal women were examined by Doppler echocardiography before initiation of HRT (T1), then after ten weeks (T2) and one year (T3). This study group was compared with another in which HRT was not used. Flow velocity integral, which correlates with SV, and MA, an indicator of cardiac contractility, were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.5.1496
更新日期:1992-11-01 00:00:00