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Experience of the Reina Sofia Hospital in lung transplantation from donors older than forty years.

Abstract：

INTRODUCTION:The shortage of suitable donors for lung transplantation (LT) has led to liberalization of criteria for donor selection. This study evaluated the outcomes of LT among a subset of patients receiving organs from standard donors older than 40 years of age. METHODS:We distributed patients who underwent LTs performed between 1993 and 2007 into 2 groups: Group A, donors younger than 40 years; and Group B, donors 40 years of age or older. We compared donor and recipient preoperative, operative, and recipient postoperative factors by univariate analyses. RESULTS:We reviewed 255 consecutive LT patients: Group A, 198 patients (78%); and Group B, 57 patients (22%). Donors from Group A showed longer intubation times (43 hours vs 34 hours; P = .026) and a better PaO2/FiO2 ratio (477 vs 454 mm Hg; P = .020), with no differences in other donor variables. Among patients dying of primary graft failure, 20% were from Group B versus 5.6% from Group A (P = .04). There were no differences in mortality or other postoperative variables. Survival rates did not differ between groups (70%, 62%, 52%, and 45% in Group A vs 60%, 45%, 45%, and 20% in Group B at 1, 3, 5, and 10 years, respectively; P = .13). CONCLUSION:The use of ideal donors older than 40 years of age might be related to a higher incidence of primary graft failure. However, long-term survival is similar to that of recipients from younger donors.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Moreno P,Alvarez A,Algar FJ,Cano JR,Espinosa D,Cerezo F,Baamonde C,Salvatierra A

doi

10.1016/j.transproceed.2008.09.001

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

3079-81

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)01257-8

journal_volume

40

pub_type

杂志文章

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