Toxoplasmic Encephalitis Followed by Primary EBV-Associated Post-Transplant Lymphoproliferative Disorder of the Central Nervous System in a Patient Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.


:Toxoplasmic encephalitis (TE) and post-transplant lymphoproliferative disorder of the central nervous system (CNS-PTLD) are major complications after allogeneic hematopoietic stem cell transplant (allo-SCT); both are fatal without timely diagnosis and disease-specific treatment. Differential diagnosis of TE and CNS-PTLD can be challenging because brain biopsy, a gold standard for diagnosis, is sometimes not possible, owing to poor patient condition after allo-SCT. Here, we describe a case of isolated CNS-PTLD arising during the therapeutic course of TE. A 51-year-old man was admitted with mental abnormalities and fever on Day 106 after allo-SCT to treat myelodysplastic syndrome. Magnetic resonance imaging (MRI) revealed multiple nodular and ring-enhanced lesions in the brain, and the result of polymerase chain reaction (PCR) for Toxoplasma gondii in cerebrospinal fluid was positive; therefore, he was diagnosed with TE. Anti-Toxoplasma therapy led to clinical improvement, and the result of subsequent PCR was negative. However, he developed left-sided hemiplegia on Day 306. Head MRI revealed a new lesion and a growing lesion, presenting as ring-enhanced nodules. Brain biopsy was performed, and a pathologic diagnosis of Epstein-Barr virus-associated CNS-PTLD was made. There was no evidence of TE. He was treated successfully by reducing immunosuppressants, followed by rituximab administration and a donor lymphocyte infusion, resulting in complete remission. While T.gondii-specific PCR has great value for diagnosis of TE, CNS-PTLD can be diagnosed only by brain biopsy; hence, brain biopsy may be warranted in cases of suspected PTLD.


Transplant Proc


Mayumi A,Yamashita T,Matsuda I,Hikosaka K,Fujino S,Norose K,Kato Y,Hirota S,Nakajima T,Ogawa H,Ikegame K




Has Abstract


2020-11-01 00:00:00














  • Porcine islet cells microencapsulated in sodium cellulose sulfate.

    abstract::One hundred fifty million people suffer from diabetes mellitus worldwide. Modern exogenous insulin therapy cannot prevent late complications. Islet cell transplantation could be a sufficient therapeutic option but the shortage of human organs limits this option. The use of xenogeneic porcine islet cells may also be a ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Schaffellner S,Stadlbauer V,Stiegler P,Hauser O,Halwachs G,Lackner C,Iberer F,Tscheliessnigg KH

    更新日期:2005-01-01 00:00:00

  • Conversion to everolimus in liver transplant patients with renal dysfunction.

    abstract::Calcineurin inhibitor (CNI) immunosuppressive therapy post-liver transplantation (OLT) is important to reduce graft rejection episodes. However, these drugs show important side effects, particularly renal dysfunction (RDF). Changing from CNI to a nonnephrotoxic drug, as mammalian target of rapamycin (mTOR) inhibitor m...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pérez T,Segovia R,Castro L,Roblero JP,Estela R

    更新日期:2011-07-01 00:00:00

  • Treatment of complex airway lesions after lung transplantation with self-expandable nitinol stents: early experience.

    abstract::Airway complications (AC) are considered a serious cause of morbidity after lung transplantation (LT). Mechanical dilatation, laser vaporization, and silicone stent placement usually solve it. However, the use of self-expandable metallic stents (SENS) may be indicated in selected cases. Ten lung transplant recipients ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Anile M,Venuta F,Diso D,Liparulo V,Ricella C,De Giacomo T,Pugliese F,Rolla M,Quattrucci S,Pecoraro Y,Rendina EA,Coloni GF

    更新日期:2010-05-01 00:00:00

  • Hemodynamic, biochemical, and morphological characteristics during preservation of normal porcine livers by hypothermic machine perfusion.

    abstract::In renal transplantation, hypothermic machine perfusion optimizes preservation of marginal grafts, assesses their quality prior to transplantation, improves outcome, and may contribute to an increased number of transplantations. Recently, hypothermic machine perfusion has become increasingly popular given the organ sh...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Monbaliu D,Vekemans K,De Vos R,Brassil J,Heedfeld V,Qiang L,D'hollander M,Roskams T,Pirenne J

    更新日期:2007-10-01 00:00:00

  • Contrast-enhanced sonography in early kidney graft dysfunction.

    abstract:OBJECTIVES:The aim of this study was a comparison of contrast-enhanced sonography (CEUS) and power Doppler ultrasound (US) findings in renal grafts within 30 days posttransplantation. METHODS:A total of 39 kidney recipients underwent CEUS (SonoVue bolus injection) and US examinations at 5 (T0), 15 (T1), and 30 (T2) da...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Benozzi L,Cappelli G,Granito M,Davoli D,Favali D,Montecchi MG,Grossi A,Torricelli P,Albertazzi A

    更新日期:2009-05-01 00:00:00

  • Laparoscopic donor nephrectomy: single-center experience.

    abstract:OBJECTIVE:Laparoscopic living donor nephrectomy (LLDN) has become the standard procedure for renal transplantation. This technique is considered less invasive for the donor, allowing lower postoperative analgesic requirements and a faster return to daily activities. In Japan, 1123 renal transplantation were performed i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hayashi T,Nose K,Nozawa M,Nishioka T,Yoshimura K,Ishii T,Uemura H

    更新日期:2012-01-01 00:00:00

  • Persistent thrombocytopenia in liver transplant patients.

    abstract:INTRODUCTION:The occurrence of thrombocytopenia in the perioperative period after a liver transplant is not uncommon. However, there are few studies on persistent thrombocytopenia during the longer follow up period of patients after liver transplantation. We examined the prevalence of and contributing factors to persis...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sutedja DS,Wai CT,Teoh KF,Lee HL,DaCosta M,Kaur M,Lee YM,Lee KH,Mak K,Quak SH,Isaac J,Lim SG,Prabhakaran K

    更新日期:2004-10-01 00:00:00

  • Massive ascites due to right heart failure after cardiac transplantation and its treatment: a case report.

    abstract::Ascites is a common clinical condition during right heart failure. In this short report we have presented a patient with massive ascites due to right heart failure after cardiac transplantation who was previously operated for Ebstein's anomaly and pulmonary stenosis as well as mitral and tricuspid valve repairs. Right...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sezgin A,Uguz E,Akay T,Aşlamaci S

    更新日期:2008-01-01 00:00:00

  • São Paulo lung transplantation waiting list: patient characteristics and predictors of death.

    abstract:INTRODUCTION:Nowadays, lung transplantation (LTx) allocation in Brazil is based mainly on waiting time. There is a need to evaluate the equity of the current lung allocation system. OBJECTIVES:We sought to (1) determine the characteristics of registered patients on the waiting list and (2) identify predictors of death...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Costa da Silva F Jr,Afonso JE Jr,Pêgo-Fernandes PM,Caramori ML,Jatene FB

    更新日期:2009-04-01 00:00:00

  • Liver Allocation in Urgent MELD Score ≥30: The Italian Experience.

    abstract:INTRODUCTION:Patients with an urgent MELD score ≥30 are managed by the Italian Operative National Transplant Center on the basis of a division of Italy into 2 main areas, the northern macro area (NMA) and the southern macro area (SMA). The object of this study was to evaluate the possibility and the need to transform t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Trapani S,Morabito V,Oliveti A,Peritore D,Rizzo A,Cacciotti AR,Gaeta A,Montemurro A,Rizzato L,Nanni Costa A

    更新日期:2016-03-01 00:00:00

  • "Real-time" assessment of human islet preparations with confocal live cell imaging.

    abstract::Pancreatic islet cell transplantation is a promising approach to restoring normoglycemia in diabetic patients. The outcome of islet transplantation is uncertain for two reasons: The quality of isolated islets is still poorly defined and the functional potential of transplanted islets is difficult to predict. Therefore...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hermann M,Pirkebner D,Draxl A,Margreiter R,Hengster P

    更新日期:2005-10-01 00:00:00

  • Impact of HLA-DPB1 Matching on Outcome of Unrelated Transplant for Hematologic Malignant Diseases: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:Human leukocyte antigen match is the most important donor factor affecting transplant outcome. The HLA-DPB1 mismatch on the clinical outcome of hematopoietic stem cell transplant (HSCT) is less clear. This study is the first meta-analysis to investigate the impact of HLA-DPB1 loci mismatch on clinical outcome...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,meta分析


    authors: Wang Y,Xu S,Fang P

    更新日期:2019-01-01 00:00:00

  • Paired Analysis of Outcomes After Kidney Transplantation in Peritoneal and Hemodialysis Patients.

    abstract:BACKGROUND:The impact of dialysis modality before kidney transplantation (hemodialysis or peritoneal dialysis) on outcomes is not clear. In this study we retrospectively analyzed the impact of dialysis modality on posttransplant follow-up. METHODS:To minimize donor bias, a paired kidney analysis was applied. One hundr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dębska-Ślizień A,Bobkowska-Macuk A,Bzoma B,Moszkowska G,Milecka A,Zadrożny D,Wołyniec W,Chamienia A,Lichodziejewska-Niemierko M,Król E,Śledziński Z,Rutkowski B

    更新日期:2018-01-01 00:00:00

  • Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus.

    abstract:BACKGROUND:The effectiveness of everolimus (EVR) for ABO-incompatible (ABOi) kidney transplantation is unknown. We evaluated outcomes of conversion from steroid to EVR in ABOi kidney transplant recipients. METHODS:We performed a retrospective observational cohort study of 33 de novo consecutive adult ABOi living donor...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nanmoku K,Shinzato T,Kubo T,Shimizu T,Kimura T,Yagisawa T

    更新日期:2018-05-01 00:00:00

  • Do mechanical fluid laws dictate the branching pattern of the renal artery?

    abstract:INTRODUCTION:Anatomy of the renal artery is an important issue in the renal transplantation era. Multi-detector computed tomography angiography (MDCTA) is an accurate modality for the preoperative assessment of live renal donors, and it provides excellent details of donor arterial anatomy. We studied the relationship b...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ardalan MR,Tarzamni MK,Ghafari A,Tubbs RS,Loukas M,Shoja MM

    更新日期:2008-01-01 00:00:00

  • Strategies to control massive abdominal bleeding.

    abstract::Abdominal trauma is divided into blunt and penetrating causes. Massive intraabdominal hemorrhage after injury represents the most dangerous precipitating factor that can affect survival if not promptly managed. The first target to achieve management of bleeding patients is control of the source, and then adequate resu...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Busani S,Cavazzuti I,Marietta M,Pasetto A,Girardis M

    更新日期:2008-05-01 00:00:00

  • Small interfering RNA targeting nuclear factor kappa B to prevent vein graft stenosis in rat models.

    abstract:BACKGROUND:Intimal hyperplasia plays an important role in vein graft stenosis. Inflammatory injury, especially nuclear factor kappaB (NF-κB) gene activation, is highly involved in stenosis progression. We examined whether neointimal hyperplasia and vein graft stenosis could be inhibited by silencing the NF-κB gene with...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Meng XB,Bi XL,Zhao HL,Feng JB,Zhang JP,Song GM,Sun WY,Bi YW

    更新日期:2013-07-01 00:00:00

  • Risk factors for delayed renal graft function and their impact on renal transplantation outcome.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors for delayed graft function (DGF) and their influence on renal graft outcome. PATIENTS AND METHODS:We reviewed 1462 consecutive renal transplantation and identified 245 patients (17.1%) with delayed graft function and 1120 patients with immediate gr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Figueiredo A,Moreira P,Parada B,Nunes P,Macário F,Bastos C,Mota A

    更新日期:2007-10-01 00:00:00

  • Nicardipine reverses vasoactivity associated with University of Wisconsin solution in the rat peripheral circulation.

    abstract:BACKGROUND:The rapid uniform delivery of University of Wisconsin solution (UW) to the microcirculation may be compromised by its vasoactivity. METHODS:In 2 different rodent models, we tested whether UW-mediated vasoconstriction could be reversed with nicardipine. RESULTS:In the perfused, splanchnic circulation, intra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Raveh Y,Lubarsky DA,Pretto EA Jr,Proctor KG

    更新日期:2011-09-01 00:00:00

  • Streptozotocin-induced diabetic rat-derived bone marrow mesenchymal stem cells have impaired abilities in proliferation, paracrine, antiapoptosis, and myogenic differentiation.

    abstract:BACKGROUND:Diabetes has been widely recognized as a major risk factor for cardiovascular disease. With the development of the regenerative medicine, autologous bone marrow-derived mesenchymal stem cells (BMSCs), transplantation can effectively improve cardiac function after myocardial infarction. However, the BMSCs use...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jin P,Zhang X,Wu Y,Li L,Yin Q,Zheng L,Zhang H,Sun C

    更新日期:2010-09-01 00:00:00

  • Simultaneous Deceased Donor Liver and Kidney Transplantation in a Human Immunodeficiency Virus/Hepatitis C Virus -Coinfected Patient With Hemophilia in Japan: A Case Report.

    abstract::The authors describe the first case of simultaneous liver and kidney transplantation (SLK) in a human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patient with severe hemophilia in Japan, and it could be second case in the world. The patient was a 61-year-old Japanese man with HCV cirrhosis complica...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Eguchi S,Hidaka M,Natsuda K,Hara T,Kugiyama T,Hamada T,Tanaka T,Ono S,Adachi T,Kanetaka K,Soyama A,Mochizuki Y,Sakai H

    更新日期:2020-11-01 00:00:00

  • Desensitized renal transplant recipients show reduced cellular responses to in vitro challenge.

    abstract::Intravenous immunoglobulin (IVIG) desensitization protocols permit transplantation of sensitized renal recipients against alloantibody incompatibility barriers. It appears that IVIG induces a sustained down-regulation of alloantibody that facilitates crossmatch compatibility. However, the consequence of desensitizatio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kimball P,King A

    更新日期:2006-12-01 00:00:00

  • Current concepts of autoimmune disease.

    abstract::Our concepts of autoimmune disease have evolved with our changing understanding of the immune response. In recent years, clonal deletion theories have gradually given way to more dynamic views of the regulation of anti-self immune reactions. It is now clear that self-reactive B cells and some self-reactive T cells per...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Rose NR

    更新日期:1988-06-01 00:00:00

  • Hematologic recovery in patients who are treated with autologous stem cells transplantation taken from bone marrow after granulocyte-colony-stimulating factor stimulation.

    abstract:BACKGROUND:We sought to compare hematologic recovery between patients who did or did not receive granulocyte-colony-stimulating factor (G-CSF)-stimulated bone marrow (rich bone marrow [RBM]). MATERIALS AND METHODS:The study subjects were 20 patients whose bone marrow was taken without prior stimulation with G-CSF and ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gawronski K,Rzepecki P,Oborska S,Wasko-Grabowska A

    更新日期:2011-10-01 00:00:00

  • Blood pressure control according to the prevalence of diabetes in renal transplant recipients.

    abstract::Hypertension is one of the most frequent complications of renal transplantation. About 70% to 90% of this population display either high blood pressure (BP) or require antihypertensive therapy. Diabetes mellitus is also a common finding among kidney transplant recipients. The aim of the study was to assess the BP cont...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zbroch E,Malyszko J,Glowinska I,Maciorkowska D,Kobus G,Mysliwiec M

    更新日期:2013-01-01 00:00:00

  • SNPs Within the MTOR Gene Are Associated With an Increased Risk of Developing De Novo Diabetes Mellitus Following the Administration of Everolimus in Liver Transplant Recipients.

    abstract:BACKGROUND:The impact of immunosuppressive drugs in patients following liver transplantation (LT) is very individual. Despite the multiple beneficial effects of the mammalian target of rapamycin (mTOR) inhibitor everolimus (EVR) in LT recipients, some patients do not benefit from EVR administration. We investigated whe...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Husen P,Straub K,Willuweit K,Hagemann A,Wedemeyer H,Bachmann HS,Herzer K

    更新日期:2019-01-01 00:00:00

  • Further evidence that NK cells may contribute to the development of cardiac allograft vasculopathy.

    abstract::In prior experiments, we found that recipients, even though specifically tolerant of donor antigens, will develop striking cardiac allograft vasculopathy (CAV) in allogeneic mouse heart transplants. This suggested that innate immune responses, in addition to conventional adaptive immunity, may be involved in the devel...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Uehara S,Chase CM,Colvin RB,Russell PS,Madsen JC

    更新日期:2005-01-01 00:00:00

  • Hepatic arterial buffer response fails to restore hepatic oxygenation after temporary liver dearterialization in canines.

    abstract:BACKGROUND:Hepatic artery thrombosis is a rare but extremely troublesome condition after liver transplantation. Recently, urgent arterial revascularization has been used as rescue therapy, leading to improved graft and patient survivals. Hepatic artery ligation produces a progressive reduction in portal vein blood flow...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cruz RJ Jr,Ribeiro EA,Poli de Figueiredo LF,Cantos OR,Rocha e Silva M

    更新日期:2005-12-01 00:00:00

  • Stented Lich-Gregoir ureteroneocystostomy: case series report and cost-effectiveness analysis.

    abstract:UNLABELLED:Extravesical ureteroneocystostomy to reestablish urinary tract continuity in renal transplantation has been examined through a meta-analysis of more than 14,000 kidney transplants leading to the finding that stented anastomosis was associated with a lower urologic complication rate compared with nonstented a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mangus RS,Haag BW,Carter CB

    更新日期:2004-12-01 00:00:00

  • Single-Center Experience of Living Donor Liver Transplantation for Patients With Secondary Biliary Cirrhosis.

    abstract:BACKGROUND:Secondary biliary cirrhosis (SBC) represents a unique form of cirrhosis that develops in the liver secondary to persistent biliary obstruction. This study aimed to review the living donor liver transplants (LDLTs) performed at our center for patients with SBC and end-stage liver disease and to share the peri...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chang JG,Yoon YI,Lee SG,Hwang S,Kim KH,Ahn CS,Moon DB,Ha TY,Song GW,Jung DH,Park GC,Park JI

    更新日期:2021-01-01 00:00:00