Electrochemistry of flavonoids. Relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids.

abstract：:Rhodamine 123 is a mitochondrial dye that is retained for prolonged periods by carcinoma cells. While investigating causes of retention of this dye, we found that 10 microM progesterone caused a rapid stimulation of efflux of rhodamine 123 within 15 min from KB V20C cells, which overexpress the multidrug resistance pu...

journal_title：Biochemical pharmacology

authors： Jancis EM,Chen HX,Carbone R,Hochberg RB,Dannies PS

更新日期：1993-11-02 00:00:00

abstract：:Bcr-abl kinase inhibitors have provided proof of principal that targeted therapy holds great promise for the treatment of cancer. However, despite the success of these agents in treating chronic myelogenous leukemia (CML), the majority of patients continue to present with minimal residual disease contained within the ...

journal_title：Biochemical pharmacology

authors： Nair RR,Tolentino J,Hazlehurst LA

更新日期：2010-09-01 00:00:00

abstract：:Milrinone [2-methyl-5-cyano-(3,4'-bipyridin)-6(1H)-one] is a positive cardiac inotropic agent recently shown to have thyromimetic activity in vitro in a rabbit myocardial membrane Ca2+-ATPase system [K. M. Mylotte et al., Proc. natn. Acad. Sci. U.S.A. 82, 7974 (1985)]. In the present studies, milrinone was examined fo...

journal_title：Biochemical pharmacology

authors： Davis PJ,Cody V,Davis FB,Warnick PR,Schoenl M,Edwards L

更新日期：1987-11-01 00:00:00

abstract：:The formation of morphine glucuronides is enantio- and regioselective in rats and humans. In rat liver microsomes, natural (-)-morphine formed only the 3-O-glucuronide, whereas the unnatural (+)-morphine formed glucuronides at both the 3-OH and 6-OH positions, with the 6-O-glucuronide being the principal product. In h...

journal_title：Biochemical pharmacology

authors： Coughtrie MW,Ask B,Rane A,Burchell B,Hume R

更新日期：1989-10-01 00:00:00

abstract：:The primary objective of this research was to test the hypothesis that low level lead (Pb) exposure during early life leads to disruption in blood-brain barrier (BBB) function in the young rat. Newborn rats received lead via milk from lactating dams that were drinking water containing 0.1% lead acetate Pb(Ac)2. Pups w...

journal_title：Biochemical pharmacology

authors： Michaelson IA,Bradbury M

更新日期：1982-05-15 00:00:00

abstract：:The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain reaction involving the superoxide anion radical and produces the corresponding chromogen 6-hydroxydopamine quinone and hydrogen peroxide. The rate of this reaction is increased in the presence of ceruloplasmin and peroxid...

journal_title：Biochemical pharmacology

authors： Padiglia A,Medda R,Lorrai A,Biggio G,Sanna E,Floris G

更新日期：1997-04-25 00:00:00

abstract：:The effect of cyclosporin A (CyA) on 2-deoxyglucose (2DG) uptake by soleus muscles of ICR mice was studied in vivo and in vitro. The basal and insulin-stimulated uptakes of 2DG by the muscles as well as the plasma insulin level were significantly decreased by the in vivo treatment of mice with 20 mg/kg/day of CyA for ...

journal_title：Biochemical pharmacology

authors： Ikeuchi M,Kida K,Goto Y,Kaino Y,Matsuda H

更新日期：1992-04-01 00:00:00

abstract：:The amino acid conjugation of the phenoxyherbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T) by animals was examined at the level of the enzymes catalyzing the reactions. The phenoxyherbicides were not substrates for the bile acid conjugating system but were substrates for the mit...

journal_title：Biochemical pharmacology

authors： Kelley M,Vessey DA

更新日期：1986-01-15 00:00:00

abstract：:The transcription factor NF-kappaB plays a key role in a wide variety of cellular processes such as innate and adaptive immunity, cellular proliferation, apoptosis and development. In unstimulated cells, NF-kappaB is sequestered in the cytoplasm through its tight association with inhibitory proteins called IkappaBs, c...

journal_title：Biochemical pharmacology

authors： Gloire G,Dejardin E,Piette J

更新日期：2006-10-30 00:00:00

abstract：:We recently found that simvastatin can modulate the nuclear factor-kappaB (NF-kappaB) activation pathway, but whether other statins have similar effects to those of simvastatin is unknown. Therefore, we evaluated the effect six different statins on TNF-induced NF-kappaB activation in human myeloid leukemia cells. We t...

journal_title：Biochemical pharmacology

authors： Ahn KS,Sethi G,Aggarwal BB

更新日期：2008-02-15 00:00:00

abstract：:Induction of the breast cancer resistance protein (BCRP/ABCG2) expression has been found in various tissues and cell-types after exposure to chemicals including 17β-estradiol, rosiglitazone, imatinib, as well as aryl hydrocarbon receptor (AhR) activators such as 2,3,7,8-tetrachlorodibenzodioxin, 3-methylcholanthrene (...

journal_title：Biochemical pharmacology

authors： Tompkins LM,Li H,Li L,Lynch C,Xie Y,Nakanishi T,Ross DD,Wang H

更新日期：2010-12-01 00:00:00

abstract：:Male mice were exposed via their diet to perfluoro fatty acids of various chain-lengths (2-10 carbon atoms) at different doses (0.02 and 0.1% weight) and for different periods of time (2-10 days). Thereafter, we monitored effects on liver and body weights and a number of hepatic parameters, including mitochondrial pro...

journal_title：Biochemical pharmacology

authors： Permadi H,Lundgren B,Andersson K,DePierre JW

更新日期：1992-09-25 00:00:00

abstract：:The oxazaphosphorine agent cyclophosphamide (CP) is an alkylating agent with a relative low stem cell toxicity. The aim of this study was to further evaluate the stem cell toxicity of the active metabolites of CP and its structural analogue ifosfamide (IFO) in comparison to their antileukemic efficacy. Cells of differ...

journal_title：Biochemical pharmacology

authors： Brueggemann SK,Schlenke P,Klich S,Deeken M,Peters SO,Wagner T

更新日期：2002-04-01 00:00:00

abstract：:MCF-7 human breast cancer cell homogenates and subcellular organelles were submitted to isopycnic centrifugation on Percoll gradients to investigate the subcellular localization of triphenylethylene antiestrogen specific binding sites (AEBS). Electron microscopy revealed that gradient fractions coincident with the mig...

journal_title：Biochemical pharmacology

authors： Gulino A,Vacca A,Modesti A,Screpanti I,Farina A,Frati L

更新日期：1986-11-01 00:00:00

abstract：:Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I cli...

journal_title：Biochemical pharmacology

authors： Lind S,Sundqvist M,Holmdahl R,Dahlgren C,Forsman H,Olofsson P

更新日期：2019-08-01 00:00:00

abstract：:Free radical-induced damage to lipid and protein constituents of neuronal membranes contributes to the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD). The development of an effective inhibitor of oxidative stress represents an important goal for the treatment of AD. In this study, th...

journal_title：Biochemical pharmacology

authors： Mason RP,Olmstead EG,Jacob RF

更新日期：2000-09-01 00:00:00

abstract：:The tyrosine kinase inhibitors (TKIs) and multikinase inhibitors (MKIs) are oncology drugs of increasing importance that have improved the treatment of multiple tumors types. In some patients these agents produce adverse effects, including pharmacokinetic drug-drug interactions, due to cytochrome P450 (CYP) inhibition...

journal_title：Biochemical pharmacology

authors： Gu R,Hibbs DE,Ong JA,Edwards RJ,Murray M

更新日期：2014-03-15 00:00:00

abstract：UNLABELLED:ZD1839 ("Iressa"), a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is currently undergoing preclinical and clinical evaluation in several solid tumors. The present study aimed to assess the effect of ZD1839 in combination with oxaliplatin in the colon cancer cell lines HT-2...

journal_title：Biochemical pharmacology

authors： Xu JM,Azzariti A,Severino M,Lu B,Colucci G,Paradiso A

更新日期：2003-08-15 00:00:00

abstract：:The increasing incidence of severe liver diseases worldwide has resulted in a high demand for curative liver transplantation. Unfortunately, the need for transplants by far eclipses the availability of suitable grafts leaving many waitlisted patients to face liver failure and often death. Routine use of smaller grafts...

journal_title：Biochemical pharmacology

authors： Greenbaum LE,Ukomadu C,Tchorz JS

更新日期：2020-05-01 00:00:00

abstract：:The tissue distributions of debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities in microsomes from bovine and rabbit tissues were analysed. Debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities were found in liver, and at low levels in cerebral cortex, kidney cortex, lung, small int...

journal_title：Biochemical pharmacology

authors： Matsuo Y,Iwahashi K,Ichikawa Y

更新日期：1992-05-08 00:00:00

abstract：:The adverse effects of smoking during pregnancy on fetal development are, in part, due to nicotine. These effects may be due to the actions of nicotine in fetal circulation or on placental functions. In pregnant rats, vaccination with a nicotine immunogen reduces the transfer of nicotine from the maternal to fetal cir...

journal_title：Biochemical pharmacology

authors： Nekhayeva IA,Nanovskaya TN,Pentel PR,Keyler DE,Hankins GD,Ahmed MS

更新日期：2005-11-25 00:00:00

abstract：:Resveratrol decreases basal and induced CYP1A1 mRNA/protein levels in both in vitro and in vivo models, and some studies suggest that resveratrol acts as an aryl hydrocarbon receptor (AhR) antagonist. Treatment of T47D or MCF-7 cells with 10 microM resveratrol inhibited induction of CYP1A1 mRNA and CYP1A1-dependent ac...

journal_title：Biochemical pharmacology

authors： Lee JE,Safe S

更新日期：2001-10-15 00:00:00

abstract：:Studies were carried out using a tetraphenylphosphonium (TPP+)-selective electrode to monitor the effect of selected calcium (Ca2+) antagonists and the dihydropyridine Ca2+ agonist Bay K8644 on membrane potential (psi) associated with isolated rat heart mitochondria. Verapamil and diltiazem (10-500 microM), standard C...

journal_title：Biochemical pharmacology

authors： Fox RM,Morgan RM,Markham A

更新日期：1993-05-25 00:00:00

abstract：:The role of nitric oxide (NO)/guanosine 3',5'-cyclic monophosphate (cGMP) signaling pathway in the regulation of fatty acid metabolism was investigated in rat hepatocytes. Treatment with NO donors, which are known to activate soluble guanylyl cyclase, inhibited in parallel fatty acid synthesis de novo and acetyl-CoA c...

journal_title：Biochemical pharmacology

authors： García-Villafranca J,Guillén A,Castro J

更新日期：2003-03-01 00:00:00

abstract：:A nuclear envelope-associated epoxide hydrolase in mouse liver that hydrates trans-stilbene oxide has been identified and characterized. This epoxide hydrolase is distinct from the enzyme in nuclear envelopes that hydrates benzo[a]pyrene 4,5-oxide and other arene oxides. This distinction was demonstrated by the criter...

journal_title：Biochemical pharmacology

authors： Guenthner TM

更新日期：1986-10-01 00:00:00

abstract：:The effect of natural polyphenols on three isoforms of NO-synthase was investigated. Among the compounds tested, tannin was the most potent, inhibiting endothelial constitutive NO synthase (eNOS) with an IC50 of 2.2 microM. Other NOS isoforms (i.e. neuronal constitutive NOS and smooth muscle inducible NOS) were also i...

journal_title：Biochemical pharmacology

authors： Chiesi M,Schwaller R

更新日期：1995-02-14 00:00:00

abstract：:The purpose of this study was to investigate in rats the effects of three anthracyclines, pirarubicin, doxorubicin and epirubicin on gastric prostaglandin E2 (PGE2) metabolism and phospholipase A2 (PLA2, EC 3.1.1.4) activity. The level of the membrane precursor, arachidonic acid, and the stability of the membrane were...

journal_title：Biochemical pharmacology

authors： Grataroli R,Leonardi J,Chautan M,Lafont H,Nalbone G

更新日期：1993-08-03 00:00:00

abstract：:The effect of metformin (N,N-dimethylbiguanide) on the rate-limiting enzymes of cholesterol metabolism was observed. 3-Hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) and acyl-CoA-cholesterol acyltransferase (ACAT) activities were estimated in hepatic microsomal and intestinal cell preparations from normal ...

journal_title：Biochemical pharmacology

authors： Scott LM,Tomkin GH

更新日期：1983-03-01 00:00:00

abstract：:Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate (DEHA) has been achieved using primary hepatocyte cultures derived from different species and cyanide-insensitive fatty acyl CoA oxidase (PCO) as a marker enzyme for peroxisome proliferation. In rat and mouse hepatocytes,...

journal_title：Biochemical pharmacology

authors： Cornu MC,Lhuguenot JC,Brady AM,Moore R,Elcombe CR

更新日期：1992-05-28 00:00:00

abstract：:The oxidation of thiourea, phenylthiourea, 1,3-diphenylthiourea, 1,3-bis-(3,4-dichlorophenyl)-2-thiourea and 1,1-dibenzyl-3-phenyl-2-thiourea was measured in reactions catalyzed by purified pig liver flavin-containing monooxygenase (FMO-1) and by microsomal fractions isolated from pig, guinea pig, chicken, rat and rab...

journal_title：Biochemical pharmacology

authors： Guo WX,Poulsen LL,Ziegler DM

更新日期：1992-11-17 00:00:00