Effect of anthracyclines on phospholipase A2 activity and prostaglandin E2 production in rat gastric mucosa.

abstract：:An intestinal active transport system specific to small peptides and peptide-like drugs such as beta-lactam antibiotics was functionally expressed in Xenopus laevis oocytes after microinjection of messenger RNA (mRNA) derived from rat intestinal mucosal cells. The transport activity was evaluated by measuring the upta...

journal_title：Biochemical pharmacology

authors： Tamai I,Tomizawa N,Kadowaki A,Terasaki T,Nakayama K,Higashida H,Tsuji A

更新日期：1994-08-30 00:00:00

abstract：:Antioxidant and anti-inflammatory therapy approaches have been in the focus of attention in the treatment of neurodegenerative Parkinson's and Alzheimer's diseases where oxidative stress has been implicated. Tea extracts have been previously reported to possess radical scavenger, iron chelating and anti-inflammatory p...

journal_title：Biochemical pharmacology

authors： Levites Y,Youdim MB,Maor G,Mandel S

更新日期：2002-01-01 00:00:00

abstract：:Administration of non-cholestatic doses of manganese (Mn2+) followed by injection of bilirubin (BR) results in a severe reduction in rat bile flow. Male Sprague-Dawley rats were given various doses of Mn2+ (2, 4.5, 8, and 18 mg/kg, i.v.) and killed 0.25, 1, 3, or 5 hr later. 54Mn2+ was used to evaluate Mn2+ content (m...

journal_title：Biochemical pharmacology

authors： Ayotte P,Plaa GL

更新日期：1985-11-01 00:00:00

abstract：:Vindesine biotransformation was investigated using a bank of human liver microsomes. The drug was converted into one major metabolite (M) upon incubation with the microsomes. Large interindividual variations were observed: vindesine biotransformation rates ranged from 1.2 to 12.9 pmol/min/mg protein. Vindesine metabol...

journal_title：Biochemical pharmacology

authors： Zhou XJ,Zhou-Pan XR,Gauthier T,Placidi M,Maurel P,Rahmani R

更新日期：1993-02-24 00:00:00

abstract：:As theophylline, caffeine and acetaminophen (APAP) are commonly found in combination in prescription and non-prescription drugs, the present study was designed to evaluate changes of hepatic glutathione (GSH) and lipid peroxidation in rats treated concurrently with these widely used drugs. In rats treated with differe...

journal_title：Biochemical pharmacology

authors： Farag MM,Abdel-Meguid EM

更新日期：1994-02-09 00:00:00

abstract：:Carbon tetrachloride (CCl4)-induced inhibition of very low density lipoprotein (VLDL) secretion was studied in isolated hepatocytes. The hypothesis that inhibition of secretion is due to altered calcium homeostasis following CCl4-dependent inhibition of endoplasmic reticulum calcium sequestration was investigated. Inh...

journal_title：Biochemical pharmacology

authors： Pencil SD,Brattin WJ Jr,Glende EA Jr,Recknagel RO

更新日期：1984-08-01 00:00:00

abstract：:Human erythroleukemic K 562 cells were induced to were induced to differentiate along the erythroid lineage by anthracycline antitumor drugs, such as aclacinomycin (ACLA) and doxorubicin (DOX). Subsequent stimulation of heme and globin synthesis led to a differential quantitative expression of hemoglobins. Gower 1 (ep...

journal_title：Biochemical pharmacology

authors： Morceau F,Aries A,Lahlil R,Devy L,Jardillier JC,Jeannesson P,Trentesaux C

更新日期：1996-03-22 00:00:00

abstract：:The effects of sulfobromophthalein (SBP) and ethacrynic acid (ECA), both inhibitors of glutathione S-transferase (GST), or glyceryl trinitrate (GTN)-induced vasorelaxation were investigated in rabbit aortic strips. The aortic strips were pre-contracted with phenylephrine, followed by relaxation with 0.5 microM GTN, wi...

journal_title：Biochemical pharmacology

authors： Lau DT,Benet LZ

更新日期：1992-05-28 00:00:00

abstract：:Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and the loss of PRKN function is linked to sporadic Parkinson's disease (...

journal_title：Biochemical pharmacology

authors： González-Barbosa E,García-Aguilar R,Vega L,Cabañas-Cortés MA,Gonzalez FJ,Segovia J,Morales-Lázaro SL,Cisneros B,Elizondo G

更新日期：2019-10-01 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:A marked inhibition of the growth of solid tumor adenocarcinoma 755 was achieved by the combination of 5-fluorouracil (5-FU) with bromovinyldeoxyuridine (BVDU). The therapeutic index (LD50/ED50) for the combination of BVDU plus 5-FU was 8.1 and 3.9 upon intraperitoneal (i.p.) or oral (p.o.) administration, respectivel...

journal_title：Biochemical pharmacology

authors： Iigo M,Araki E,Nakajima Y,Hoshi A,De Clercq E

更新日期：1988-04-15 00:00:00

abstract：:There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC 2.3.1.5), although first identified as a homologue of a drug-metabolising enzyme, appears to be a marker in human oestrogen receptor positive breast cancer. Mouse Nat2 is the mouse equivalent of human NAT1. The development of mouse ...

journal_title：Biochemical pharmacology

authors： Kawamura A,Westwood I,Wakefield L,Long H,Zhang N,Walters K,Redfield C,Sim E

更新日期：2008-04-01 00:00:00

abstract：:In the present study, a novel synthetic compound 4-(2-(cyclohex-2-enylidene)hydrazinyl)quinolin-2(1H)-one (CYL-4d) was found to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting cell viability or enzyme activity of expressed inducible NO synthase (iNOS) in RAW 264.7 macrophages. C...

journal_title：Biochemical pharmacology

authors： Lin MW,Tsao LT,Chang LC,Chen YL,Huang LJ,Kuo SC,Tzeng CC,Lee MR,Wang JP

更新日期：2007-06-01 00:00:00

abstract：:Certain human hepatocarcinoma cells undergo differentiation when grown at confluence. In order to understand the basis for this differentiation, we investigated the phenotypic changes occurring during confluent growth of the human hepatoma B16A2 cell line. The global gene expression profile of B16A2 cells grown during...

journal_title：Biochemical pharmacology

authors： Butura A,Johansson I,Nilsson K,Wärngård L,Ingelman-Sundberg M,Schuppe-Koistinen I

更新日期：2004-04-01 00:00:00

abstract：:Epidemiological and experimental animal data indicate that exposure to both metals and metalloid species exacerbates the risk of human diseases, particularly cancers. Vascular endothelial growth factor (VEGF), which performs a primary function in both tumor progression and angiogenesis, is up-regulated due to exposure...

journal_title：Biochemical pharmacology

authors： Lee M,Hwang JT,Yun H,Kim EJ,Kim MJ,Kim SS,Ha J

更新日期：2006-06-28 00:00:00

abstract：:The 5-HT1A receptor is a critical mediator of serotonergic (5-HT) function. We have identified 13 potential single nucleotide polymorphisms resulting in amino acid changes throughout the human 5-HT1A receptor. The pharmacological profiles of these 13 polymorphic variants were then characterized using a high-throughput...

journal_title：Biochemical pharmacology

authors： Del Tredici AL,Schiffer HH,Burstein ES,Lameh J,Mohell N,Hacksell U,Brann MR,Weiner DM

更新日期：2004-02-01 00:00:00

abstract：:Cilostamide derivatives are potent inhibitors of human platelet aggregation and selectively inhibit human platelet cyclic adenosine monophosphate (cyclic AMP) phosphodiesterase. N-Cyclohexyl-N-(2-hydroxybutyl)-5-[6-1,2,3,4-tetrahydro-2-oxoquinolyl oxy)] -butyramide (OPC-13135) is one of these derivatives, and the conc...

journal_title：Biochemical pharmacology

authors： Umekawa H,Tanaka T,Kimura Y,Hidaka H

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Salvinorin A (SA) is a potent anti-inflammatory diterpene isolated from the Mexican plant S. divinorum. Recently we showed that the novel SA analog, PR-38 has an inhibitory effect on mouse gastrointestinal (GI) motility mediated by opioid and cannabinoid (CB) receptors. The aim of the study was to characteri...

journal_title：Biochemical pharmacology

authors： Sałaga M,Polepally PR,Zakrzewski PK,Cygankiewicz A,Sobczak M,Kordek R,Zjawiony JK,Krajewska WM,Fichna J

更新日期：2014-12-15 00:00:00

abstract：:We have studied the effects of TPA on the metabolism of porcine thyroid cells cultured for 1-4 days in the absence (control cells) and in the presence of 0.1 mU/ml TSH (TSH cells). The phospholipid turnover, evaluated after a 2 hr incorporation of 32P-phosphate into phospholipids, is markedly modified by the presence ...

journal_title：Biochemical pharmacology

authors： Haye B,Aublin JL,Champion S,Lambert B,Jacquemin C

更新日期：1985-11-01 00:00:00

abstract：:Hep G2 cells, an established cell line derived from a human hepatoma, have retained a number of hepatocytic phase I and II reactions. The influence of picolines (2-, 3- and 4-methylpyridine), related compounds and some classical enzyme inducers on specific glutathione transferase (GST) activity and its subunit composi...

journal_title：Biochemical pharmacology

authors： Dierickx PJ

更新日期：1994-11-16 00:00:00

abstract：:Previously, we reported that the multidrug resistance proteins MRP1, MRP2 and MRP3 confer resistance to therapeutic antifolates by mediating their cellular extrusion. We now determined whether MRPs also play a role in controlling cellular homeostasis of natural folates. In MRP1, MRP2 and MRP3-transfected 2008 human ov...

journal_title：Biochemical pharmacology

authors： Hooijberg JH,Peters GJ,Assaraf YG,Kathmann I,Priest DG,Bunni MA,Veerman AJ,Scheffer GL,Kaspers GJ,Jansen G

更新日期：2003-03-01 00:00:00

abstract：:Chlorpromazine, imipramine and amitriptyline, drugs structurally related to riboflavin, each inhibited the formation in vivo of flavin adenine dinucleotide (FAD) from riboflavin in rat heart at 2-5 mg/kg body weight, doses comparable on a weight basis to those used clinically. All three drugs inhibited FAD formation i...

journal_title：Biochemical pharmacology

authors： Pinto J,Huang YP,Pelliccione N,Rivlin RS

更新日期：1982-11-01 00:00:00

abstract：:Casein-elicited rat peritoneal polymorphonuclear leukocytes (PMNL) and rabbit platelets were prelabelled with [1-14C]arachidonic acid, and the effect of timegadine, a new anti-inflammatory agent, on the release and metabolism of arachidonic acid induced by A23187 (PMNL) and thrombin (platelets) was studied and compare...

journal_title：Biochemical pharmacology

authors： Ahnfelt-Rønne I,Arrigoni-Martelli E

更新日期：1982-08-15 00:00:00

abstract：:Chiral inversion at a sulphoxide position of flosequinan enantiomers [(+/-)-7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone] occurred in conventional rats but not in either germ-free rats or rats treated with antibiotics after an oral administration of each enantiomer. Thus, it was postulated that the chiral inversion...

journal_title：Biochemical pharmacology

authors： Kashiyama E,Yokoi T,Todaka T,Odomi M,Kamataki T

更新日期：1994-07-19 00:00:00

abstract：:Endosulfan (E) is an organochloric insecticide, which is quickly metabolized and eliminated from the body system. Toxic effects of E and its metabolites have been reported. The influence of E and its metabolites, viz. endosulfan sulfate (ES), endosulfan diol (ED) and endosulfan lactone (EL), has been examined on rat l...

journal_title：Biochemical pharmacology

authors： Dubey RK,Beg MU,Singh J

更新日期：1984-11-01 00:00:00

abstract：:Chlorpyrifos (CPF) is a pesticide that causes tens of thousands of deaths per year worldwide. Chlorpyrifos oxon (CPO) is the active metabolite of CPF that inhibits acetylcholinesterase. However, this presumed metabolite has escaped detection in human samples by conventional methods (HPLC, GC-MS, LC-MS) until now. A re...

journal_title：Biochemical pharmacology

authors： Eyer F,Roberts DM,Buckley NA,Eddleston M,Thiermann H,Worek F,Eyer P

更新日期：2009-09-01 00:00:00

abstract：:It has been reported that chelerythrine chloride, a benzophenanthridine alkaloid, with a wide variety of biologic effects stimulates the phosphorylation of an approximately 20 kDa protein present in the mitochondrial fraction of the rat retina. It has also been shown previously that both the serine and threonine resid...

journal_title：Biochemical pharmacology

authors： Lombardini JB

更新日期：1996-07-26 00:00:00

abstract：:The identification of proliferation/survival pathways constitutively activated by genetic alterations in multiple myeloma (MM), or sustained by the bone marrow (BM) microenvironment, provides novel opportunities for the development of targeted therapies. The deregulated function of protein tyrosine kinases plays a cri...

journal_title：Biochemical pharmacology

authors： Cassinelli G,Ronchetti D,Laccabue D,Mattioli M,Cuccuru G,Favini E,Nicolini V,Greco A,Neri A,Zunino F,Lanzi C

更新日期：2009-11-01 00:00:00

abstract：:Glutamatergic hypofunction and elevated levels of kynurenic acid (KYNA) in the brain are common features of patients with schizophrenia. In vivo studies indicate that in the hippocampus KYNA decreases glutamate levels, presumably via inhibition of α7 nicotinic receptors (nAChRs). Here we tested the hypothesis that bas...

journal_title：Biochemical pharmacology

authors： Banerjee J,Alkondon M,Albuquerque EX

更新日期：2012-10-15 00:00:00

abstract：:A series of N-hydroxy-N'-aminoguanidine derivatives was studied for their effects on L1210 cell growth and ribonucleotide reductase activity. With the twelve compounds studied, there was a good correlation between the inhibition of L1210 cell growth and the inhibition of ribonucleotide reductase activity. The most pot...

journal_title：Biochemical pharmacology

authors： Cory JG,Carter GL,Bacon PE,T'ang A,Lien EJ

更新日期：1985-08-01 00:00:00