Abstract：
:Understanding the contribution of different molecular processes to evolution and development is crucial for identifying the mechanisms of adaptation. Here, we used RNA-seq data to test the importance of alternative splicing and differential gene expression in a case of parallel adaptive evolution, the replicated postglacial divergence of the salmonid fish Arctic charr (Salvelinus alpinus) into sympatric benthic and pelagic ecotypes across multiple independent lakes. We found that genes differentially spliced between ecotypes were mostly not differentially expressed (<6% overlap) and were involved in different biological processes. Differentially spliced genes were primarily enriched for muscle development and functioning, while differentially expressed genes were involved in metabolism, immunity and growth. Furthermore, alternative splicing and gene expression were mostly controlled by independent cis-regulatory quantitative trait loci (<3.4% overlap). Cis-regulatory regions were associated with the parallel divergence in splicing (16.5% of intron clusters) and expression (6.7 - 10.1% of differentially expressed genes), indicating shared regulatory variation across ecotype pairs. Contrary to theoretical expectation, we found that differentially spliced genes tended to be highly central in regulatory networks ('hub genes') and were annotated to significantly more gene ontology terms compared to non-differentially spliced genes, consistent with a higher level of pleiotropy. Together, our results suggest that the concerted regulation of alternative splicing and differential gene expression through different regulatory regions leads to the divergence of complementary processes important for local adaptation. This provides novel insights into the importance of contrasting but putatively complementary molecular processes in rapid parallel adaptive evolution.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Jacobs A,Elmer KRdoi
10.1111/mec.15817subject
Has Abstractpub_date
2021-01-27 00:00:00eissn
0962-1083issn
1365-294Xpub_type
杂志文章abstract：:As a result of an intense host-parasite evolutionary arms race, parasitic wasps frequently display high levels of specialization on very few host species. For instance, in braconid wasps very few generalist species have been described. However, within this family, Cotesia sesamiae is a generalist species that is wides...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2010.04977.x
更新日期：2011-03-01 00:00:00
abstract：:Naturally occurring heat shock (HS) during pupation induces abnormal wing development in Drosophila; we examined factors affecting the severity of this induction. The proportion of HS-surviving adults with abnormal wings varied with HS duration and intensity, and with the pupal age or stage at HS administration. Pretr...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2003.01771.x
更新日期：2003-05-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2002.01518.x
更新日期：2002-07-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294x.1992.tb00152.x
更新日期：1992-05-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2000.01106.x
更新日期：2000-12-01 00:00:00
abstract：:Adaptation to new environments often occurs in the face of gene flow. Under these conditions, gene flow and recombination can impede adaptation by breaking down linkage disequilibrium between locally adapted alleles. Theory predicts that this decay can be halted or slowed if adaptive alleles are tightly linked in regi...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.14226
更新日期：2017-09-01 00:00:00
abstract：:Animals generally benefit from their gastrointestinal microbiome, but the factors that influence the composition and dynamics of their microbiota remain poorly understood. Studies of nonmodel host species can illuminate how microbiota and their hosts interact in natural environments. We investigated the role of migrat...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15660
更新日期：2020-12-01 00:00:00
abstract：:In plants, pollination syndromes (the correlated presence of many features of relevance to pollination mode, for instance pollination by a particular animal clade) are a striking feature of plant biodiversity, providing great floral phenotypic diversity (Fenster et al. ). Adaptation to a particular animal pollinator p...
journal_title：Molecular ecology
pub_type： 评论,新闻
doi：10.1111/mec.13903
更新日期：2016-12-01 00:00:00
abstract：:Recently evolved species typically share genetic variation across their genomes due to incomplete lineage sorting and/or ongoing gene flow. Given only subtle allele frequency differences at most loci and the expectation that divergent selection may affect only a tiny fraction of the genome, distinguishing closely rela...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15091
更新日期：2019-05-01 00:00:00
abstract：:Over the past 100 years, Arctic temperatures have increased at almost twice the global average rate. One consequence is the acceleration of glacier retreat, exposing new habitats that are colonized by microorganisms whose diversity and function are unknown. Here, we characterized bacterial diversity along two approxim...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2009.04479.x
更新日期：2010-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.13404
更新日期：2015-11-01 00:00:00
abstract：:Hybridization among conspecifics in native and introduced habitats has important implications for biological invasions in new ecosystems. Bighead (Hypophthalmichthys nobilis) and silver carp (H. molitrix) are genetically isolated and occur in sympatry within their native range. Following their introduction to North Am...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.13285
更新日期：2015-08-01 00:00:00
abstract：:Infections with maternally inherited Wolbachia bacteria may have dramatic influences on reproductive traits and speciation patterns of their hosts. We here show that in the beetle genus Altica, infection has influenced phylogenetic patterns of the host's mtDNA and different strains led to repeated selective sweeps. By...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12389
更新日期：2013-08-01 00:00:00
abstract：:Carrion beetles (Coleoptera, Silphidae) are well known for their behaviour of exploiting vertebrate carcasses for nutrition. While species in the subfamily Silphinae feed on large carcasses and on larvae of competing scavengers, the Nicrophorinae are unique in monopolizing, burying and defending small carrion, and pro...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12469
更新日期：2014-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15422
更新日期：2020-04-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.14165
更新日期：2017-08-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15571
更新日期：2020-09-01 00:00:00
abstract：:Molecular techniques have enabled behavioural ecologists to reassess mating systems from a genetic perspective. Studies of paternity frequently reveal that mating behaviour does not always reflect parentage, and may bring to light alternative mating tactics. Here we present a comparison of behavioural and genetic meas...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.1999.00683.x
更新日期：1999-07-01 00:00:00
abstract：:While microsatellites have been used to examine genetic structure in local populations of Neotropical trees, genetic studies based on such high-resolution markers have not been carried out for Mesoamerica as a whole. Here we assess the genetic structure of the Mesoamerican mahogany Swietenia macrophylla King (big-leaf...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2003.01951.x
更新日期：2003-11-01 00:00:00
abstract：:It is challenging to unravel the history of organisms with highly scattered populations. Such species may have fragmented distributions because extant populations are remnants of a previously more continuous range, or because the species has narrow habitat requirements in combination with good dispersal capacity (natu...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.12313
更新日期：2013-06-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2004.02225.x
更新日期：2004-08-01 00:00:00
abstract：:Noninvasive samples are useful for molecular genetic analyses of wild animal populations. However, the low DNA content of such samples makes DNA amplification difficult, and there is the potential for erroneous results when one of two alleles at heterozygous microsatellite loci fails to be amplified. In this study we ...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.0962-1083.2001.01308.x
更新日期：2001-07-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2008.03879.x
更新日期：2008-09-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1046/j.1365-294x.2003.01841.x
更新日期：2003-05-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/j.1365-294X.2010.04662.x
更新日期：2010-07-01 00:00:00
abstract：:Much of the world's terrestrial landscapes are being altered by humans in the form of agriculture, urbanization and pastoral systems, with major implications for biodiversity. Bumble bees are one of the most effective pollinators in both natural and cultivated landscapes, but are often the first to be extirpated in hu...
journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.13090
更新日期：2015-03-01 00:00:00
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journal_title：Molecular ecology
pub_type： 杂志文章
doi：10.1111/mec.15585
更新日期：2020-11-01 00:00:00
