Abstract:
OBJECTIVES:To retrospectively assess the periablational 3D safety margin in patients with colorectal liver metastases (CRLM) referred for stereotactic radiofrequency ablation (RFA) and to evaluate its influence on local treatment success. METHODS:Forty-five patients (31 males; mean age 64.5 [range 31-87 years]) with 76 CRLM were treated with stereotactic RFA and retrospectively analyzed. Image fusion of pre- and post-interventional contrast-enhanced CT scans using a non-rigid registration software enabled a retrospective assessment of the percentage of predetermined periablational 3D safety margin and CRLM successfully ablated. Periablational safety zones (1-10 mm) and percentage of periablational zone ablated were calculated, analyzed, and compared with subsequent tumor growth to determine an optimal safety margin predictive of local treatment success. RESULTS:Mean overall follow-up was 36.1 ± 18.5 months. Nine of 76 CRLMs (11.8%) developed local tumor progression (LTP) with mean time to LTP of 18.3 ± 11.9 months. Overall 1-, 2-, and 3-year cumulative LTP-free survival rates were 98.7%, 90.6%, and 88.6%, respectively. The periablational safety margin assessment proved to be the only independent predictor (p < 0.001) of LTP for all calculated safety margins. The smallest safety margin 100% ablated displaying no LTP was 3 mm, and at least 90% of a 6-mm circumscribed 3D safety margin was required to achieve complete ablation. CONCLUSIONS:Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success in patients with CRLM referred to stereotactic RFA. Ablations achieving 100% 3D safety margin of 3 mm and at least 90% 3D safety margin of 6 mm can predict treatment success. KEY POINTS:• Volumetric assessment of the periablational safety margin can be used as an intraprocedural tool to evaluate local treatment success following thermal ablation of colorectal liver metastases. • Ablations with 100% 3D periablational safety margin of 3 mm and ablations with at least 90% 3D safety margin of 6 mm can be considered indications of treatment success. • Image fusion of pre- and post-interventional CT scans with the software used in this study is feasible and could represent a useful tool in daily clinical practice.
journal_name
Eur Radioljournal_title
European radiologyauthors
Laimer G,Jaschke N,Schullian P,Putzer D,Eberle G,Solbiati M,Solbiati L,Goldberg SN,Bale Rdoi
10.1007/s00330-020-07579-xsubject
Has Abstractpub_date
2021-01-14 00:00:00eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07579-xpub_type
杂志文章abstract:OBJECTIVES:To determine whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from hepatic magnetic resonance (MR) relaxometry with gadoxetic acid (Gd-EOB-DTPA). METHODS:One hundred and seven patients underwent an ICG clearance test and Gd-EOB-DTPA-enhanced MRI, incl...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3919-5
更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European radiology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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journal_title:European radiology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:European radiology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-009-1310-0
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pub_type: 杂志文章
doi:10.1007/s00330-014-3157-2
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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更新日期:2012-06-01 00:00:00
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pub_type: 已发布勘误
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更新日期:2019-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
abstract::This report describes a malpractice case involving a delayed diagnosis of a malignant bone tumour in the proximal tibia in a 10-year-old child. This was caused by a combination of factors. The final report on the first examination failed to reach the patient files, and two subsequent X-ray exams failed to diagnose the...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300051021
更新日期:2000-01-01 00:00:00
abstract::The original version of this article, published on 02 September 2020, unfortunately contained a mistake. ...
journal_title:European radiology
pub_type: 已发布勘误
doi:10.1007/s00330-020-07285-8
更新日期:2020-09-18 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06805-w
更新日期:2020-09-01 00:00:00