Abstract:
INTRODUCTION:Van der Woude syndrome (VWS), an autosomal dominant condition associated with clefts of the lip and/or palate and lower lip pits, is caused by mutations in interferon regulatory factor 6 gene. It is reported to be the most common syndromic cleft worldwide. This case series presents the phenotypic characteristics and treatment outcomes in a group of 9 patients diagnosed with VWS. METHODS:A retrospective review was performed on records of patients given a diagnosis of VWS presenting to the Department of Plastic Surgery of Sohag University between July 2009 and November 2019. Data analyses included age and sex of affected patients, type of the cleft, associated anomalies, presence of lower lip pits, and history of lower lip pits/cleft in the family and treatment outcomes. RESULTS:The study identified 9 patients (male = 2, female = 7). Age at first presentation ranged between 1 week and 7 years (mean = 1.3 years). Four patients had bilateral cleft lip and palate and 1 patient had unilateral cleft lip and palate (UCLP), whereas 4 patients had isolated cleft palate. Bilateral lower lip pits were presented in 8 patients, whereas the ninth patient has unilateral pit. Family history was positive in 3 patients. Most patients in this study developed after palatal repair speech problems with an increased rate of secondary surgical procedures needed for correction of velopharyngeal insufficiency. CONCLUSIONS:All reviewed cases of VWS presented with lower lip pits and cleft palate with or without cleft lip. A positive family history of similar conditions was demonstrated in 33.3% of our patients. This study suggests an increased incidence of secondary palatal surgeries for velopharyngeal insufficiency in patients with VWS; this warrant further studies including control group of nonsyndromic cleft patients.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Allam KA,Haredy MMdoi
10.1097/SAP.0000000000002605subject
Has Abstractpub_date
2020-12-16 00:00:00eissn
0148-7043issn
1536-3708pii
00000637-900000000-96380journal_volume
Publish Ahead of Printpub_type
杂志文章abstract::Surgical errors in the length and orientation of a flap pedicle can result in kinks, twists, or tension on the pedicle vessels. When these errors occur together with the microvascular repairs associated with free flap transfer, thrombosis and flap failure may be the outcome. A model was designed to simulate these even...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199405000-00006
更新日期:1994-05-01 00:00:00
abstract::In this case, after augmentation mammaplasty without infection or gross inflammatory reaction, Etheron implants decreased to a small volume of densely hyalinized tissue, leaving essentially no breast augmentation. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198803000-00016
更新日期:1988-03-01 00:00:00
abstract::Breast augmentation is one of the leading esthetic surgeries, enjoying high satisfaction rates. Pain, nausea, and vomiting are frequent shortcomings of the immediate postoperative period. The aim of this study was to compare breast augmentation from the anesthetic point of view: general anesthesia (GA) versus monitore...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31815bfe98
更新日期:2008-09-01 00:00:00
abstract::The majority of patients with breast carcinoma are being treated with breast conservation therapy (BCT): lumpectomy and postoperative radiation. Local recurrence reported at 8% to 11% is often treated with salvage mastectomy. This has led to a growing group of patients requiring breast reconstruction after failed BCT....
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000215252.05233.b0
更新日期:2006-08-01 00:00:00
abstract::Reestablishing anterior rectus fascial integrity remains a clinical challenge after transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. The main concerns include herniation and bulging due to abdominal weakness. Mesh-assisted closure of the fascial defect has improved bulging and herniation rat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822af89d
更新日期:2012-03-01 00:00:00
abstract::Locoregional recurrent and distant metastases from squamous cell carcinomas, despite multimodality therapy, remain troublesome clinical realities. Discrepancies in success rates of various surgery and radiation treatment regimens dealing with these problems are confusing to the clinician attempting to recommend the mo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199508000-00010
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Breast capsular contracture (BCC) is a commonly adverse event postmammoplastly characterized by an immune response mediated by cytokines and transforming growth factor (TGF)-β1 resulting in excessive synthesis and deposit of extracellular matrix around the breast implant. Presence of TGF-β1 polymorphisms has...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822284f4
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Despite a plethora of monitoring techniques reported in the literature, only a small number of studies directly address clinical relevant end points, such as the flap salvage rate and false-positive rate. METHOD:We conducted a systematic review of current evidence regarding the postoperative monitoring of m...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e3181f8cb32
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Artificial Intelligent Virtual Assistants (AIVA) is a segment of artificial intelligence that is rapidly developing. However, its utilization to address patients' frequently asked questions remains unexplored. METHODS:We developed an AIVA to answer questions related to 10 frequent topics asked by plastic su...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002252
更新日期:2020-04-01 00:00:00
abstract::Seven male patients and 8 total ears underwent composite excision for neoplasm of the auricular helix. Defect size ranged from 2.5 to 4.5 cm exceeding the conventional limit of l.5 cm for wedge excision with primary closure. An incision at the root of the helix released the superior auricular muscle and a portion of t...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181a395fb
更新日期:2009-05-01 00:00:00
abstract::Many techniques have been developed for the correction of eyelid ptosis. A new tarsal plate resection technique is described for use in cases of minimal ptosis with fair to good levator function. The procedure involves a horizontal lenticular excision of the tarsal plate, placed so that equal amounts of tarsus remain ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199007000-00002
更新日期:1990-07-01 00:00:00
abstract:INTRODUCTION:Use of the omentum for poststernotomy mediastinitis is typically viewed as a last resort. Formal debridement and muscle flap coverage is sufficient most of the time; however, there are situations when the omental flap is more appropriate. The purpose of this series is to critically evaluate the outcome in ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318054718e
更新日期:2008-02-01 00:00:00
abstract::Fatty tumors of the peripheral nerves, although rare, occur with sufficient frequency to pose problems in diagnosis and treatment. Moreover, the nomenclature of these tumors has suffered from controversy over their morpological description. These factors have contributed to a misunderstanding about the treatment of th...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-197803000-00011
更新日期:1978-03-01 00:00:00
abstract::Thirty-eight patients with significant weight loss after vertical banded gastroplasty were studied prospectively while undergoing abdominal dermolipectomy to determine if the current intensity used during electrosurgical dissection influenced wound complication rates after this surgery. Patients were assigned randomly...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000637-199609000-00002
更新日期:1996-09-01 00:00:00
abstract::A 66-year-old woman with an abdominal wound caused by infected synthetic mesh had failed to heal in spite of many surgical attempts to close the wound. A sealed transparent vinyl chamber was glued to the periphery of the wound and antibiotics in high concentrations (up to 2,500 times the minimum inhibitory concentrati...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199601000-00016
更新日期:1996-01-01 00:00:00
abstract::Treatment of neuroma-in-continuity involves neurolysis or resection with interposition nerve grafting of the involved segment. These techniques may be complicated by loss of remaining conduction through axons that were intact prior to surgical neurolysis or grafting. The authors have shown previously that axonal regen...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199904000-00018
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:Rhabdomyolysis often occurs after traumatic compartment syndrome, and high morbidity and mortality have been reported with the acute kidney injury that develops subsequently. We focused on the risk factors for rhabdomyolysis and acute kidney injury in patients with traumatic compartment syndrome. We also analyz...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000460
更新日期:2015-05-01 00:00:00
abstract::Over the past four years we have performed total phallic reconstructions in 12 patients. Six patients underwent reconstruction following trauma, 3 were female-to-male transsexuals, and 3 had micropenis deformities. These reconstructions were one-stage microsurgical tissue transfers that included urethral reconstructio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198702000-00006
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Several techniques for vaginal reconstruction after pelvic exenteration such as myocutaneous and myoperitoneal flaps are available. However, the use of a myofascial flap has not been previously described. Thus, the objective of this article is to present our experience of vaginal reconstruction with rectus a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001578
更新日期:2018-11-01 00:00:00
abstract::Whether operating on soft tissue, bony tissue, or both, as in major craniofacial procedures, patient safety is enhanced by better understanding of the anatomical details of the orbit. The myth and mystery of the optic nerve is made clear here, especially by our magnification techniques. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198004000-00001
更新日期:1980-04-01 00:00:00
abstract::In cases of severe macromastia, the free nipple graft technique has been the traditional alternative to pedicle transposition. Distress over nipple survival in large reduction mammaplasty and long pedicle transposition is largely responsible for this.A retrospective investigation of the records of 142 reduction mammap...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000174363.04135.b9
更新日期:2005-09-01 00:00:00
abstract::Glomus tumors are uncommon, benign soft tissue tumors that can occur in a familial or sporadic pattern. Only 15 pedigrees have been reported to date. We report a family with three generations developing multiple glomus tumors of the skin. Although controversy exists over pattern of inheritance, review of the published...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199401000-00013
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Suboptimal pain management is a common, yet largely unrecognized, problem in the postsurgical patient population. Current treatment protocols heavily rely on opioid use and, though generally effective in providing pain relief, are associated with multiple side effects. The present systematic review aims to o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001916
更新日期:2019-12-01 00:00:00
abstract::Whereas any contemplation suggesting routinization in a plastic surgery endeavor may engender abhorrence or bespeak heresy, some generalizations are essential at least as a foundation from which a logical divergence may proceed. Such an approach for the selection of preferable local flaps in wound coverage within the ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199012000-00009
更新日期:1990-12-01 00:00:00
abstract::Extra-articular crystalline deposition secondary to gout, and less commonly, pseudogout is a well known phenomenon. Despite this well-documented entity of extra-articular deposition, there have been few reports of infiltration of the flexor tendon sheath of the hand. Here, we present a case series of this unique occur...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181788e98
更新日期:2009-02-01 00:00:00
abstract::Circumcision is a commonly performed minor surgical procedure; however, it may lead to serious complications if performed by poorly trained health care providers. In this case report, a subglanular stricture causing a mushroom-like deformity resulting from circumcision is presented. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000024754.83430.05
更新日期:2003-02-01 00:00:00
abstract::Nitric oxide (NO), identified as the mediator of endothelium-dependent relaxation of vascular smooth muscle, is known to cause a number of inflammatory conditions, especially in ischemia/reperfusion injury. This experimental study, using a rabbit epigastric island flap, was designed to investigate whether skin flap is...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199712000-00009
更新日期:1997-12-01 00:00:00
abstract::Postbariatric patients undergoing abdominoplasties were retrospectively analyzed to correlate postoperative local complications with the 2 most commonly used techniques of raising the abdominal flap: diathermocoagulation versus scalpel. All patients undergoing body-contouring abdominoplasties were included. Excluded w...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181856d85
更新日期:2009-06-01 00:00:00
abstract::The previously reported surgical methods for eyelid entropion are basically manipulations of the skin or the conjunctival surface. When entropion is marked, manipulations also involve the tarsus. In the most widely used method, the eyelashes are directed outward by horizontal wedge resection of an appropriate amount o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000106426.86478.dc
更新日期:2004-07-01 00:00:00
abstract::A severe case is reported of a rare skin disorder characterized by multiple intracutaneous cystic lesions; the condition is difficult to manage and impossible to cure. The complicating cystic infections that accompany the condition are treated acutely using sound surgical principles, yet long-term management remains a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198409000-00010
更新日期:1984-09-01 00:00:00