Abstract:
BACKGROUND:Breast capsular contracture (BCC) is a commonly adverse event postmammoplastly characterized by an immune response mediated by cytokines and transforming growth factor (TGF)-β1 resulting in excessive synthesis and deposit of extracellular matrix around the breast implant. Presence of TGF-β1 polymorphisms has been associated as a risk factor to develop fibroproliferative diseases. METHODS:This open, controlled, prospective, and pilot clinical trial with 6 months duration was carried out to evaluate the efficacy of 1800 mg a day, of oral Pirfenidone (PFD) in the treatment of BCC (Baker Score III/IV) postmammoplasty. Twenty BCC cases received PFD and 14 BCC control cases underwent capsulectomy after 6 months of enrollment. Both groups were followed up for 6 more months up to 12 months to determine the relapse in the absence of PFD. Determination of TGF-β1 polymorphisms was performed to establish a correlation with capsular contracture. RESULTS:PFD group experienced BCC-reduction in all breasts 6 months after enrollment. Only 1 of 20 cases relapsed after follow-up. In capsulectomy group, 2 of 14 cases presented progression to grade IV during presurgical period. All capsulectomy cases relapsed at end of follow-up. Nearly hundred percent of all patients studied in this protocol had a profibrogenic homozygous TGF-β1 polymorphism (codon 25; genotype Arg25Arg). CONCLUSIONS:PFD is useful to improve BCC (Baker Score III/IV) postmammoplasty with no relapse after drug administration. There is also an association between capsular contracture and the presence of homozygous G/G TGF-β1 genotype.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Veras-Castillo ER,Cardenas-Camarena L,Lyra-Gonzalez I,Muñoz-Valle JF,Lucano-Landeros S,Guerrerosantos J,Gonzalez-Ulloa B,Mercado-Barajas JL,Sanchez-Parada MG,Azabache-Wennceslao R,Armendariz-Borunda Jdoi
10.1097/SAP.0b013e31822284f4subject
Has Abstractpub_date
2013-01-01 00:00:00pages
16-22issue
1eissn
0148-7043issn
1536-3708journal_volume
70pub_type
杂志文章abstract::Island skin flaps based on the latissimus dorsi muscle were raised in domestic pigs. Flap circulation, maintained only by the vascular pedicle, was monitored by laser Doppler flowmetry, laser photometry, and transcutaneously measured carbon dioxide tension. Both arterial and venous occlusion were accompanied by very l...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198501000-00005
更新日期:1985-01-01 00:00:00
abstract::There are only a few reports that investigate the measurement of functional penile length and compare the methods used for this purpose. The aim of this study was to determine the correlation between the measurement techniques and to determine an appropriate method that correlates the erect state most closely. Measure...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200204000-00008
更新日期:2002-04-01 00:00:00
abstract::The gastrocnemius muscle flap has gained wide acceptance as a reconstructive technique for management of wounds of the knee and proximal tibia. The use of the muscle as a pedicle flap to the distal and middle femur has not been well quantified, and the proximal rotation arc has been underestimated. We report the use o...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199504000-00014
更新日期:1995-04-01 00:00:00
abstract::We have previously demonstrated in a rat surgical incision model that charged dextran beads enhance wound repair in a charge-specific manner: positively charged beads increased wound breaking strength (WBS), whereas neutral or negatively charged beads were ineffective. The present work extends these observations into ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199606000-00008
更新日期:1996-06-01 00:00:00
abstract::Free flaps are increasingly being chosen to solve complex reconstruction problems. We describe a fascial sleeve approach to elevation of the donor flap which increases its safety and reliability. We report examples in which resultant revascularization of the recipient site causes the free flap to be irreplaceable for ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198212000-00006
更新日期:1982-12-01 00:00:00
abstract::A common unsatisfactory long-term outcome of otoplasty is undercorrection and residual deformity. Aggressive scoring with a scalpel blade can cause unattractive and painful ridging, especially in older patients with stiffer cartilage. We developed an ex vivo pig ear model to compare the effectiveness of bipolar diathe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000237684.42771.10
更新日期:2007-03-01 00:00:00
abstract::Internal and external diameters of sections of radial and ulnar arteries obtained from fresh cadavers were measured. Statistical analysis of the results obtained shows significant correlation (p less than 0.05). The wide range of values obtained suggests that, despite this degree of correlation, the internal diameter ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198709000-00006
更新日期:1987-09-01 00:00:00
abstract::We report 2 patients with paraspinous sarcoma treated with omental transposition tunneled through a defect in the lumbar fascia that resurfaced in the soft tissues of the lower back. Traditional reconstruction with skin flaps was unsatisfactory because of prior irradiation to the area. In 1 patient the omentum obliter...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199312000-00015
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:Rhabdomyolysis often occurs after traumatic compartment syndrome, and high morbidity and mortality have been reported with the acute kidney injury that develops subsequently. We focused on the risk factors for rhabdomyolysis and acute kidney injury in patients with traumatic compartment syndrome. We also analyz...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000460
更新日期:2015-05-01 00:00:00
abstract::In this case, after augmentation mammaplasty without infection or gross inflammatory reaction, Etheron implants decreased to a small volume of densely hyalinized tissue, leaving essentially no breast augmentation. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198803000-00016
更新日期:1988-03-01 00:00:00
abstract::This study documents that reduction mammoplasty is a procedure with excellent long-term patient satisfaction. This has not been previously well documented. One hundred nine patients after reduction mammoplasty were surveyed by questionnaire. Results of the questionnaire indicated that the majority of patients were ple...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199204000-00011
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:A bilayered artificial dermis is widely applied for skin defects. Its collagen sponge is biodegraded and replaced with dermis-like tissue after application. There is no reliable method for quantitatively evaluating the blood flow of artificial dermis. In this study, we used laser Doppler imaging to evaluate ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182590948
更新日期:2014-01-01 00:00:00
abstract::A muscle bow traction method was developed for dynamic facial reanimation utilizing the masseter muscle and a fascial sling. The principle of this method is that the sling around the muscle pulls the oral commissure laterally and backward by the restoring force of the muscle from its relaxed position to its contracted...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199910000-00002
更新日期:1999-10-01 00:00:00
abstract::A short operative time and a high successful rate of microvascular anastomosis are the goals of many plastic surgeons. The authors present their experimental and clinical experience in microvascular anastomoses with the use of a combination of continuous suture and interrupted tie. Twenty rats were divided into two gr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200045030-00010
更新日期:2000-09-01 00:00:00
abstract::The vascularized whole femur transplantation model is one of the commonly used vascularized bone marrow transplant models. It involves technical complexity and morbidities. To optimize this model, we took 2/3 femur as the carrier of bone marrow cells, and developed a vascularized partial femur model. Four experimental...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000114
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Hematomas after tissue expander immediate breast reconstruction (TE-IBR) pose a significant challenge during the recovery period. In this study, we aim to evaluate whether hematoma formation leads to subsequent complications and how management can impact final reconstructive goals. METHODS:A single-institut...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002343
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:The surgical management of craniofacial fibrous dysplasia is controversial. The purpose of this study was to report the surgical outcomes of individualized management of craniofacial fibrous dysplasia of a single institution. METHODS:Data from patients (n = 20) with craniofacial fibrous dysplasia, who were ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000640
更新日期:2016-08-01 00:00:00
abstract::Infected wounds after total hip arthroplasty can be limb threatening. Management strategies are designed to eradicate infection, to obtain stable wound coverage, and to preserve the prosthesis. However, there is no general consensus for optimal management. The authors reviewed their 7-year combined orthopaedic and pla...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200212000-00006
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Scalp melanoma is aggressive and has a proclivity for regional metastasis. We hypothesize that subperiosteal scalp melanoma resection reduces in-transit/satellite recurrence, when compared with subgaleal resection. METHODS:We identified patients with intermediate to deep, primary scalp melanoma referred to ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822592e7
更新日期:2012-08-01 00:00:00
abstract::A patient with malignant fibrous histiocytoma of the dorsum of the hand, managed with irradiation and wide local excision, is presented. Biopsy technique, the rationale for preoperative irradiation, and the details of extensor tendon reconstruction are discussed. Tendon grafts, rather than transfers, were used to reco...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199811000-00016
更新日期:1998-11-01 00:00:00
abstract::Intraosseous ganglia are occasionally found affecting the carpal bones of the hand and should be considered in the differential diagnosis of chronic wrist pain. They have characteristic radiographic findings of a cyst with a thin sclerotic rim. This case report illustrates an unusual presentation of a cyst in the luna...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200204000-00018
更新日期:2002-04-01 00:00:00
abstract::Despite intense research, etiologies underlying syndromic craniosynostosis remain poorly understood. While syndrome-related genetic factors have garnered much attention, external forces likely play a large role as well. In contrast to well-defined genetic abnormalities that may be precisely identified and statisticall...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31815d5c14
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:Hand photography is effective and advantageous for assessing functional deficits and improvements related to surgery. In this study, it is aimed to investigate whether the correct active range of motion (ROM) is masked by the passive ROM in a wrist joint. METHOD:Eleven patients who were treated for unilat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001845
更新日期:2019-06-01 00:00:00
abstract::The gold standard for mandibular defect reconstruction is the fibular free flap. Nevertheless, the pedicled osteomuscular dorsal scapular flap as a reconstructive tool offers promise for mandibular defect reconstruction and could be the first choice in certain circumstances. Its use in resource-limited settings offers...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318230992e
更新日期:2013-01-01 00:00:00
abstract::We present a new concept of vascular anatomy, proposing that a complex subcutaneous vascular network, located between the dense and loose adipose tissue, connects the larger subcutaneous vessels, the vertical perforators, and the subdermal plexus. Knowledge of the location of these vessels helps determine optimal flap...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198308000-00002
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:Data regarding donor-site morbidity, postoperative clinical course, and functional outcome after hemisoleus muscle flap reconstruction are rare. The aim of this study was to determine the clinical and functional outcome of distally based medial hemisoleus flaps used for the reconstruction of defects in the l...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001539
更新日期:2018-10-01 00:00:00
abstract::Cytokines are peptide mediators of inflammation that are being extensively studied in several aspects of disease. I provide an introduction to the general features of cytokine biology. Cytokines may be considered as either proinflammatory or anti-inflammatory compounds, and they also have potent hematopoietic effects....
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-199511000-00021
更新日期:1995-11-01 00:00:00
abstract::Estrogenic steroids have been used as hemostatic agents in various surgical procedures in humans. Their use to reduce bleeding has been based mainly on clinical observation. The present study was carried out to test experimentally whether intravenously administered Premarin reduces capillary bleeding. Skin-graft donor...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198205000-00005
更新日期:1982-05-01 00:00:00
abstract::Tattooing is increasingly common in Western society. The aim of the study was to create an overview of the surgical options when a tattoo is present in the operative site and to present an algorithm for the surgical plan.A literature-based study was conducted, using the Pubmed database. The following search terms have...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0b013e3181b1429f
更新日期:2010-01-01 00:00:00
abstract::Crushing injuries, including electrical burns on the dorsum of the foot, result in extensive tissue loss and exposure of bone and tendon. Debridement and covering of the wound with richly vascularized tissue are necessary at an early date. Flaps for the dorsum of the foot should be thin and the donor tissue to be sacr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198509000-00011
更新日期:1985-09-01 00:00:00