Abstract:
PURPOSE:Akt/mTOR/p70S6K signaling pathway promotes motor function recovery after spinal cord injury (SCI) in both neurons and astrocytes. But the role and mechanism of this pathway in oligodendrocytes during nerve repair following SCI has not been researched. This study aimed to investigate the effect and mechanism of this signaling pathway in oligodendrocytes on nerve myelin regeneration and motor function recovery in rats with SCI. METHODS:After inhibiting or activating this signaling pathway, Western blotting and double immunofluorescence labeling were used to determine the levels of the signaling molecules in this pathway and myelin formation-related proteins in the plane of the thoracic segment of the injured spinal cord. The level of motor function recovery was evaluated and the oligodendrocytes involved in nerve myelin regeneration were studied. Primary oligodendrocytes were isolated and cultured in vitro, then MBP, PLP, and MOG were measured with reverse transcription-quantitative polymerase chain reaction (RT-qPCR). RESULTS:Akt/mTOR/p70S6K signaling pathway was activated after SCI compared with the sham-operated rats, prominently elevated levels of the pathway components were observed in the SC79-treated group. The activation of the signaling pathway significantly increased the expression levels of myelin formation-related proteins, including MBP, PLP, and MOG, and improved the Basso, Beattie, and Bresnahan (BBB) scores in the injured spinal cord. Conversely, rapamycin suppressed the expression of these signaling molecules and reduced the levels of myelin formation-related proteins. CONCLUSION:Akt/mTOR/p70S6K signaling pathway activation can contribute to nerve myelin regeneration and has the potential to improve the regenerative environment and motor function, as well as the potential to promote repair of SCI.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Ge C,Liu D,Sun Ydoi
10.1080/02688697.2020.1862056subject
Has Abstractpub_date
2020-12-21 00:00:00pages
1-9eissn
0268-8697issn
1360-046Xpub_type
杂志文章abstract::Venous oxygen saturation at the clinically dominant jugular bulb (SjO2) and that at the confluence of the cerebral sinuses (SccsO2) were compared by direct simultaneous blood sampling of 13 severely head injured patients. The side of dominant jugular bulb (JB) was determined by neck compression test. The right side wa...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699647276
更新日期:1996-08-01 00:00:00
abstract::Background: Few data are available on the risk factors involved in nosocomial meningitis from multi-drug-resistant Gram-negative bacteria (MDR-GNB). Our aim was to identify the risk factors of prognosis for MDR-GNB nosocomial meningitis.Methods: Retrospective study of patients undergoing neurosurgery and with positive...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1710819
更新日期:2020-06-01 00:00:00
abstract::Epidermoid cyst may rarely arise within the lateral wall of the cavernous sinus (CS) and produce clinical symptoms mimicking the Tolosa-Hunt syndrome. Pathogenically, it is suggested that some of the subpopulation of cells arising from the neural crest which give rise to skin, may remain entrapped in the meninges arou...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688690050206747
更新日期:2000-12-01 00:00:00
abstract::The endoscopic technique is increasingly being used for the resection of pituitary adenomas. Its efficacy and safety have been generally accepted, but its impact on the quality of life of the patients treated has not been previously addressed. Most of the studies assessing the quality of life after long-term cure of p...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802220379
更新日期:2008-10-01 00:00:00
abstract::Ultrasonic aspirators are commonly used to resect brain tumours because they allow safe, rapid and accurate removal of diseased tissue. Since ultrasonic aspirators generate a spray of aerosolized irrigating fluid around the instrument tip, we questioned whether this spray might contain viable tumours cells that could ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Cavernous sinus meningiomas (CSM) are complex skull base lesions that, due to their particular anatomical location, render surgical management difficult. Their symptomatology is versatile, and the clinical outcome is difficult to predict. We present the case of a 57-year old female patient who experienced phantosmia -...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1834510
更新日期:2020-10-14 00:00:00
abstract::A retrospective review of all patients who had surgery for cauda equina syndrome (CES) due to a herniated lumbar disc between January 1996 and November 1999 was undertaken. All underwent laminectomy and discectomy, and had been admitted as emergencies with cauda equina syndrome. Ten women and 10 men with a mean age of...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/0268869031000109098
更新日期:2003-04-01 00:00:00
abstract::We report a series of 14 patients who underwent partial or complete trigeminal nerve root section for chronic unremitting migrainous neuralgia. They had all suffered attacks with severe pain for over 18 months without remission (mean duration 5.5 years). Symptoms were refractory to extended medical intervention and ha...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699308995070
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify independent anatomic, morphologic and hemodynamic features of the ACoA (anterior communicating artery) complex that serve as risk factors for the occurrence of ACoA aneurysms. METHODS:Fifteen consecutive patients with 15 ACoA aneurysms were included. Computational fluid ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1821867
更新日期:2020-09-29 00:00:00
abstract::Subarachnoid haemorrhage (SAH) of the posterior fossa in cases of acoustic neurinoma is very rare. The authors present the clinical, neuroradiological and histological findings of an acoustic neurinoma presenting with SAH. The literature regarding this subject is reviewed and the pathogenesis of haemorrhage from neuri...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688690903506085
更新日期:2010-02-01 00:00:00
abstract::Some degree of hydrocephalus is present in almost all cases of medium to large posterior fossa tumours. The initial symptoms in such cases are usually due to the hydrocephalus and the consequent increased supratentorial pressure, and more often precede the symptoms primarily due to the local invasion and compression o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699309103494
更新日期:1993-01-01 00:00:00
abstract::Fifty-six patients with low back pain and sciatica following radiological investigation were found to have abnormalities at multiple levels, more than one of which could be responsible for the clinical picture or at a single level, which correlated poorly with the clinical findings. Thirty-four patients had a diagnost...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699943709
更新日期:1999-06-01 00:00:00
abstract::Primary melanocytic tumors of the central nervous system (CNS) are rare lesions, but primary sellar tumors are rarer. Only 10 cases have been reported, and they are often misdiagnosed as pituitary macroadenoma. We report the case of a 54-year-old Chinese man who developed progressive bitemporal hemianopsia and visual ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2014.967752
更新日期:2015-04-01 00:00:00
abstract::A subgaleal collection of blood or cerebrospinal fluid (CSF) is commonly encountered after craniotomy. In spite of the placement of subgaleal drains by many neurosurgeons, a collection at this site is frequent and occasionally can result in complications. 'Tenting' scalp stitches are described. Three to four (or more)...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699209023795
更新日期:1992-01-01 00:00:00
abstract::The objective of this study was to investigate if there are possible gender differences in relation to outcome following closed severe traumatic brain injury (TBI) in a predominantly Asian population. A study was conducted using our prospectively maintained TBI database of 672 patients with severe TBI admitted into ou...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690600682259
更新日期:2006-04-01 00:00:00
abstract::We report a previously undescribed complication of long-term epidural catheter placement for the administration of analgesia in terminal malignancy. Spinal cord compression resulted from a drug-related precipitate forming around the epidural catheter tip, which was successfully treated by surgical decompression. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699844673
更新日期:1998-10-01 00:00:00
abstract::A series of 510 patients with proven aneurysmal subarachnoid haemorrhage (SAH) is reported. The incidence of recurrent haemorrhage during the period awaiting surgery was 13.7%. There was no significant difference in incidence between good and poor grade patients. Following rebleeding there was an immediate mortality o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698808999657
更新日期:1988-01-01 00:00:00
abstract::Brainstem cavernomas can present very challenging operative problems. Endoscopic endonasal approaches to these lesions in the mesencephalon and pons have been described. In this article the authors present the first case of a medullary cavernoma resected by an endoscopic transclival approach. A 26 year-old woman with ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1408777
更新日期:2019-12-01 00:00:00
abstract::Intraparenchymal meningiomas are rare. To date, no such lesion has been reported within the basal ganglia of a paediatric patient. Here, we describe the case of a 15-year-old-boy who presented with symptoms referable to a cystic, calcified, left basal ganglia intraparenchymal meningioma and discuss the surgical manage...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1096910
更新日期:2016-06-01 00:00:00
abstract::The long-term outcome of 78 patients with spinal meningiomas operated on over 20 years at a single neurosurgical unit was analysed. Age, sex and tumour location were similar to those reported by others. Overall, 95% of our patents were independently mobile postoperatively, despite 25% of the group being unable to walk...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699844367
更新日期:1998-12-01 00:00:00
abstract::A case of primary Ewing's sarcoma involving a large portion of the petrous temporal bone in an eighteen month old child is reported. The lesion was treated by radical surgery and adjuvant chemotherapy and radiotherapy. An extremely rare age of presentation, an unusual location and an excellent response to treatment ar...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688690050004606
更新日期:2000-04-01 00:00:00
abstract::We present a series of eight patients undergoing circumferential neural decompression and stabilization of the thoracolumbar spine via a single midline posterior approach, with complete vertebrectomy for a variety of indications. Four had primary tumours, two secondary tumours, one patient had tuberculosis and one had...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701837273
更新日期:2008-04-01 00:00:00
abstract::Modern cancer therapy has improved the prognosis for several tumour types. This, however, does not apply to the largest group of brain tumours, the malignant astrocytomas grades III-IV. Hence, there is need for new ideas to improve treatment. Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be involve...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699409027965
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Meningiomas are one of the most common tumours to affect the central nervous system. Genetic mutations are important in meningeal tumourigenesis, progression and prognosis. In this study, we aimed to examine the effect of 1p/19q deletion on the diagnosis and prognosis of meningioma subtypes using the fluores...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1181155
更新日期:2016-10-01 00:00:00
abstract::Fibrous dysplasia (FD) is an uncommon benign fibro-osseous abnormality of bone, of unknown aetiology and equal sex incidence, which is most commonly restricted to one bone (monostotic FD: MFD, 70%). Less commonly multiple bones are affected (polyostotic FD: PFD, 27%). Vertebral involvement is uncommon (4%), but more c...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688690400012525
更新日期:2004-10-01 00:00:00
abstract::Subfalcine brain herniation is well documented in the presence of raised intracranial pressure. However, we report a case of herniation occurring after decompression of bilateral chronic subdural haematomas, which did not appear to be related to high pressure. We suggest that after rapid decompression of a collection,...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690410001732724
更新日期:2004-06-01 00:00:00
abstract::This paper presents a male, immunocompetent case aged 62-year-old with cryptococcal granuloma in the basal ganglia. No cryptococcal infection occurred in other areas. The diagnosis was made by biopsy. Cryptococcal granuloma was tough and unsuitable for sterotactic biopsy. The patient died of postoperative bleeding and...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1550190
更新日期:2019-01-17 00:00:00
abstract::The azygous anterior cerebral artery (AACA) is a rare anatomical variant, which is frequently associated with saccular aneurysms. These aneurysms are often located in the distal segment of the AACA. Proximal AACA aneurysms are rare and pose considerable challenges, both in radiological characterization and in manageme...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1071333
更新日期:2016-01-01 00:00:00
abstract:OBJECT:With an increasingly ageing population, the number of elderly people diagnosed with pituitary tumours continues to rise. There is a concern that with increasing age and comorbidities, there is higher anaesthetic risk, as well as peri-operative morbidity and mortality from pituitary surgery. This study aimed to a...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.872225
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The optic nerve is an unusual site of schwannoma as it lacks Schwannoma cells on it. We report a primary optic sheath schwannoma and to review the literature. CASE REPORT:A 29-year old female presented with progressive painless non-pulsatile proptosis. Ocular examination revealed only axial proptosis. Imagi...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1869181
更新日期:2021-01-08 00:00:00