Abstract:
:Modern cancer therapy has improved the prognosis for several tumour types. This, however, does not apply to the largest group of brain tumours, the malignant astrocytomas grades III-IV. Hence, there is need for new ideas to improve treatment. Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be involved in the processes conferring stability to DNA in proliferating neoplastic cells. We have combined the calmodulin-inhibiting neuroleptic drug chlorpromazine (CPZ), with the anti-neoplastic drug 1,3-bis(2-chloroethyl-1)-nitrosourea (BCNU) in a treatment regime for rats with glioma cells implanted in the brain. A highly significant inhibiting effect upon the tumour growth was noticed, not by CPZ or BCNU as single drugs, but with their combination.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Aas AT,Brun A,Pero RW,Salford LGdoi
10.3109/02688699409027965subject
Has Abstractpub_date
1994-01-01 00:00:00pages
187-92issue
2eissn
0268-8697issn
1360-046Xjournal_volume
8pub_type
杂志文章abstract::Cytogenetic studies over many years have established absence or deletion of chromosome 22 as a common finding in meningiomas. Enormous karyotypic variation is recognised: an abnormal hyperdiploid clone can occur in a histologically benign meningioma. The cytogenetic, histopathological and macroscopic findings in 13 me...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698909002850
更新日期:1989-01-01 00:00:00
abstract::OBJECTIVES. To analyze the indications of surgical treatment, surgical management strategies and post-surgical outcome in patients with brainstem glioma (BSG). METHODS. In this retrospective study conducted from 1998 to 2012, 58 patients of surgically treated intrinsic BSG, meeting the inclusion criterion were enrolle...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.829562
更新日期:2014-04-01 00:00:00
abstract::Background: Vertebral body compression fractures are one of the most common causes of disability and morbidity, especially among the elderly population. The present study was performed in order to evaluate the effect of percutaneous balloon kyphoplasty (BKP) on patients' pain and quality of life (QOL) in Iran.Methods:...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1777254
更新日期:2020-06-09 00:00:00
abstract::Twenty-four patients with intractable partial epilepsy underwent surgery between 1969 and 1988. Localization was by non-invasive means using scalp EEG and CT. In 12 cases the focus was temporal and in eight frontal. Craniotomy was undertaken with intraoperative electrocorticography (ECoG). Ten cases had a standard tem...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Introduction Stereotactic mesencephalotomy is an ablative procedure which lesions the pain pathways (spinothalamic and trigeminothalamic tracts) at the midbrain level to treat medically refractory, nociceptive, contralateral pain. Sparsely reported in contemporary English language literature, this operation is at risk...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2015.1133805
更新日期:2016-08-01 00:00:00
abstract::The objective was to measure metabolic changes monitored by bedside microdialysis during impending and manifest hypoxia in traumatic brain injury. In 41 patients, a PtiO2-catheter (Licox; 1/min) was placed into non-lesioned frontal white matter together with a microdialysis catheter (CMA, hourly). Data were analysed f...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690310001601234
更新日期:2003-08-01 00:00:00
abstract::Rupture of cerebral aneurysm during CT angiogram is a rare occurrence. Here we present such a case where an aneurysmal re-rupture during CT angiogram was demonstrated. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.584984
更新日期:2011-12-01 00:00:00
abstract::Background: Bow hunter's syndrome (BHS), also known as rotational vertebral artery occlusion syndrome, is rare. Occasionally, it combines with dissection/pseudoaneurysm of the ipsilateral VA.Methods: We report a case of BHS combined with ipsilateral VA dissection/pseudoaneurysm and review eight similar cases reported ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1718604
更新日期:2020-02-03 00:00:00
abstract::Ultrasonic aspirators are commonly used to resect brain tumours because they allow safe, rapid and accurate removal of diseased tissue. Since ultrasonic aspirators generate a spray of aerosolized irrigating fluid around the instrument tip, we questioned whether this spray might contain viable tumours cells that could ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Confusion frequently occurs in patients with gliomas for a number of reasons. One cause is a superimposed intracerebral infection. The case of a 73-year-old man who deteriorated after debulking of a high-grade glioma is described. However, he was successfully treated for Listeria monocytogenes (L. monocytogenes) diagn...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.535927
更新日期:2011-06-01 00:00:00
abstract::A retrospective study was performed to evaluate the rate of infection in free and osteoplastic bone flaps after craniotomy. Two hundred and two craniotomies were performed in 98 cases of tumour, 35 cases of trauma and 69 cases of vascular disease. The overall incidence of infection was 6.4% (13 cases). The infectious ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699008993798
更新日期:1990-01-01 00:00:00
abstract::Several studies have demonstrated an association between arterial hypertension (AH) and an increased morbidity and mortality from both cardiovascular diseases and stroke (including subarachnoid haemorrhage, SAH). Among the functional disturbances implicated in hypertension much interest has been focused on the calcium...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699108998477
更新日期:1991-01-01 00:00:00
abstract::We report a case of an aneurysm-like finding of MCA with severe atherosclerosis on standard radiological evaluation, which led us to plan surgical clipping. In particular, patients, whose modalities usually performed for preoperative assessment of cerebral aneurysms, such as DSA, 3D CTA and MRA, are insufficient. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.633639
更新日期:2012-06-01 00:00:00
abstract::Lymphocytic and granulocytic hypophysitis are rare pituitary masses. A series of five dealt with at a single centre is presented and discussed. Retrospective analysis of pathology records revealed the cases. Of pituitary mass lesions dealt with in this centre, 0.8% have the diagnosis. Five females presented, one pregn...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120057664
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:There is a dearth of comparative outcome data on vertebroplasty for the treatment of vertebral compression fractures (VCF) according to vertebral level, the number of levels and aetiology. The aim of this study was to investigate the improvement of pain and function following vertebroplasty for a heterogeneo...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1096901
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Gross congenital lesions of the nervous system are obvious at birth and usually present early for management and corrective surgery. However in tropical and developing nations, late presentations are common. AIMS:To determine the factors responsible for very late presentations of gross congenital lesions. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802485113
更新日期:2008-12-01 00:00:00
abstract::A patient with a chronic encapsulated intracerebral haematoma presenting with medically intractable epilepsy is described. A tough capsule containing an old haematoma was confirmed surgically, and consisted of dense collagenous tissue with rich neovascularization. The radiological features, aetiology and treatment of ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699845537
更新日期:1998-02-01 00:00:00
abstract::A 39-year-old lady presented with low back pain and neurogenic claudication. Magnetic resonance imagining revealed an intradural neoplasm in the cauda equina region. The patient underwent lumbar laminectomy and total excision of the neoplasm. Biopsy showed it to be a ganglioneuroblastoma, which is rare in the spinal c...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/026886900408513
更新日期:2000-06-01 00:00:00
abstract::We present two cases of symptomatic, post-lumbar surgery cauda equina compression due to formation of a dissecting subdural extra-arachnoid cerebrospinal fluid (CSF) collection (hygroma) under tension. In both cases, a small inadvertent durotomy was sustained during the initial surgery. Surgical re-exploration confirm...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.625063
更新日期:2012-06-01 00:00:00
abstract::An obese woman with benign intracranial hypertension had been managed for several years with lumbo-peritoneal shunting. Following a bilopancreatic procedure performed for management of her obesity dense peritoneal adhesions caused repeated shunt failure. The shunt system was successfully converted to a lumbo-atrial sy...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690601127460
更新日期:2006-12-01 00:00:00
abstract::Cerebellar haemangioblastomas commonly arise in patients with von Hippel - Lindau disease. We present the case of a 47-year-old male who has successfully undergone 10 separate procedures for symptomatic cerebellar haemangioblastomas. To our knowledge, this case is unique with respect to the frequency of symptomatic re...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701552864
更新日期:2008-02-01 00:00:00
abstract::Survivors of head injury are often left with varying degrees of disability and complex and varied needs, necessitating prolonged periods of rehabilitation and continuing care. Advances have been made in the acute management of these patients, but continuing management in terms of rehabilitation remains deficient with ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690903078874
更新日期:2009-01-01 00:00:00
abstract::Attempts at radical excision of craniopharyngioma have been made increasingly possible by progress in neuroradiological imaging and the use of microscopic technique. Between 1977 and 1990, 50 patients of The National Hospital for Neurology and Neurosurgery, London, have undergone radical surgical excision of craniopha...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699109002877
更新日期:1991-01-01 00:00:00
abstract::A subdural empyema with a Salmonella species as the likely causative organism is presented. We believe that this is the first reported case of such an infection in an HIV positive patient. The difficulties in treatment and diagnosis are discussed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699550041818
更新日期:1995-01-01 00:00:00
abstract::The aim of this report is to introduce a simple modification to the free-hand frameless stereotactic placement of ventriculoperitoneal shunts in undersized ventricles. In this technical note, we describe our experience with ventricular catheter placement in two children suffering from shunt dependent idiopathic intrac...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690500495166
更新日期:2005-12-01 00:00:00
abstract::Incapacitating and drug-resistant posttraumatic movement disorders have successfully been treated by stereotactic thalamotomy. We describe the case of a young man with a posttraumatic hemiballismoid type movement disorder of the left arm, persistent for 2 years, who was selected for treatment with a thalamic deep brai...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120082468
更新日期:2001-10-01 00:00:00
abstract::The aim of this randomized prospective study was to compare the efficacy of endoscopic versus standard microsurgical excision of pituitary adenomas, and to evaluate the merits and demerits of each approach. Twenty patients with a pituitary adenoma were randomly divided into two groups comprising of 10 cases each. Ten ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,随机对照试验
doi:10.1080/02688690701395447
更新日期:2007-08-01 00:00:00
abstract::A 72-year-old woman previously operated for a sphenoid-ridge meningioma, now presented with double vision. Histology showed a secretory meningioma with an epithelial-appearing, malignant component. Malignant transformation in a secretory meningioma is not known. This is the first report of such an occurrence. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690600875432
更新日期:2006-08-01 00:00:00
abstract::Objective: To evaluate the clinical efficacy, practicability, and safety of an ultrasonic osteotome for percutaneous transforaminal endoscopic discectomy (PTED) in patients with calcified lumbar disc herniation (CLDH).Methods: A total of 25 CLDH patients who underwent PTED at our department between December 2017 and A...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1687850
更新日期:2020-02-01 00:00:00
abstract::Twenty patients bearing malignant brain tumours (18 glioblastoma multiforme, one malignant meningioma, one melanoma metastasis) were treated 25 times with photodynamic therapy (PDT)--the combination of Hematoporophyrin derivative and light at 630 nm (40-120 J/cm2). Sixteen times the PDT was followed immediately by a s...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698808992675
更新日期:1988-01-01 00:00:00