Abstract:
BACKGROUND:Adherence to highly active antiretroviral treatment (HAART) is critical to long-term treatment success in patients infected with human immunodeficiency virus (HIV). However, the relationship between psychological variables and medication adherence is still poorly understood. The aim of this study was to investigate how anger dimensions in subjects with HIV affect adherence to antiretroviral drugs. METHODS:One hundred and thirty outpatients with HIV who were nondepressed and receiving HAART were administered the State-Trait Anger Inventory and a compliance self-report questionnaire. They also underwent clinical laboratory tests aimed at investigating immune function and disease stage. RESULTS:Forty-three patients (33%) reported suboptimal adherence. Full compliance with HAART was related to higher age, lower HIV RNA level, lower trait anger, lower outside-directed anger and greater anger control. In a multiple regression analysis, low trait anger (p = 0.02) and high anger control (p = 0.03) were significantly associated with full adherence to HAART. CONCLUSIONS:Anger dimensions are linked with, and may affect, adherence to HAART. A better understanding of the psychological determinants of compliance might allow for the identification of patients who are at higher risk of nonadherence. To sustain adherence to HAART, these patients may benefit from increased clinical attention or intervention.
journal_name
Psychother Psychosomjournal_title
Psychotherapy and psychosomaticsauthors
Leombruni P,Fassino S,Lavagnino L,Orofino G,Morosini P,Picardi Adoi
10.1159/000219525subject
Has Abstractpub_date
2009-01-01 00:00:00pages
254-7issue
4eissn
0033-3190issn
1423-0348pii
000219525journal_volume
78pub_type
杂志文章abstract::Adolescents are frequently entangled in a web of transitions during their developmental journey from child to adult. These modulations include physiological and psychological changes: individual, familial and social readjustments, and alterations in the evolving family group. Psychosomatic manifestations are often tar...
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journal_title:Psychotherapy and psychosomatics
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