Clinical application of Cordyceps sinensis on immunosuppressive therapy in renal transplantation.

Abstract:

OBJECTIVE:We sought to explore the adjunctive effects of Cordyceps sinensis (CS) in clinical renal transplantation. MATERIALS AND METHODS:Patients (n = 202) were divided randomly by lottery into a treatment (n = 93) and a control group (n = 109). Patients in the treatment group were treated with CS 1.0 g 3 times a day in addition to the immunosuppressive regimen given to the control group. We compared patient and graft survivals, incidence, time and severity of acute rejection episodes, chronic allograft nephropathy (CAN), hepatotoxicity and nephrotoxicity, biochemistry parameters including indicators of liver and kidney functions, fats, proteinuria, dosages, and whole blood concentrations of cyclosporine (CsA). RESULTS:Patient and graft survival rates, serum creatinine (SCr), and blood urea nitrogen (BUN) were not significantly different between the 2 groups (P > .05). Serum uric acid (UA) and 24-hour urinary total protein (24-hour UTP) were significantly lower in the treatment group than in the control group (P < .05). The incidences (11.83% vs 15.60%) and times to acute renal allograft rejection (23.48 +/- 7.22 vs 22.27 +/- 8.03 days posttransplantation) were not significantly different between the treated and control groups (P > .05). Patients receiving thymoglobulin antirejection therapy (3 cases) were fewer in the heated versus control group (13 cases; P = .014). The incidences of hepatotoxicity and nephrotoxicity in the treated group were 12.90% and 19.35%, significantly lower than 24.77% and 33.94% in the control group, respectively (P < .05). At 2 to 6 months posttransplantation, the CsA dosages in the treated group were significantly lower than those in the control group (P < .05). The whole blood trough CsA concentrations in the treated group were significantly lower than those in the control group at 3 to 6 months posttransplantation (P < .05). The decreasing trends of the 2 aforementioned parameters in the treatment group were approximately linear among treated subjects compared with approximately quadratic in the control group (P < .05). The incidence of CAN in the treated group was 7.53%, which was significantly lower than 18.35% in the control group (P = .024). The 24-hour UTP level in CAN patients within the treated group was significantly lower than the control group after transplantation (P = .045). The differences in total bilirubin, SCr, serum UA, and total cholesterol levels among otherwise normal patients in the treated group were significantly lower than those among the control group (P < .05). CONCLUSIONS:The use of CS may allow decreased dosages and concentrations of CsA causing fewer side effects without an increased risk of acute rejection. In addition, CS with reduced dose CsA may decrease proteinuria and retard CAN progression.

journal_name

Transplant Proc

authors

Li Y,Xue WJ,Tian PX,Ding XM,Yan H,Pan XM,Feng XS

doi

10.1016/j.transproceed.2009.02.085

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1565-9

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00286-3

journal_volume

41

pub_type

杂志文章,随机对照试验
  • Vaccination Against Urinary Tract Infection After Renal Transplantation.

    abstract:BACKGROUND:Recurrent urinary tract infections (UTIs) increase mortality and reduce graft survival after renal transplantation. Because current prophylactic strategies such as methionine, cranberry juice, and antibiotics fail to sufficiently prevent recurrent infections in a substantial number of patients, there is a cl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.06.018

    authors: Zgoura P,Waldecker C,Bauer F,Seibert FS,Rohn B,Schenker P,Wunsch A,Hajt S,Viebahn R,Babel N,Westhoff TH

    更新日期:2020-12-01 00:00:00

  • Vascular access outcomes as a predictor of development of chronic allograft nephropathy.

    abstract:INTRODUCTION:The vascular condition influences the outcomes of arteriovenous fistula (AVF) surgery. However, it has not been established how it influences the outcomes of renal transplantation and the development of chronic allograft nephropathy (CAN). The aim of this study was to define the relationship between AVF fa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.08.189

    authors: Jushinskis J,Bicans J,Suhorukov V,Trushkov S,Rozental R

    更新日期:2006-10-01 00:00:00

  • Long-term Clinical Significance of Tacrolimus Trough Level at the Early Period After Kidney Transplantation.

    abstract:BACKGROUND:The stable immunosuppressant level at the early period after kidney transplantation (KT) is one of the most important factors for the prognosis of KT. However, the extent of immunosuppression varies according to the policies of each KT center. We investigated the relationship between the clinical outcome and...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.03.065

    authors: Park WY,Paek JH,Jin K,Park SB,Han S

    更新日期:2019-10-01 00:00:00

  • Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid.

    abstract::This study examined the combinatory effect on graft survival of neonatal pig pancreatic cell clusters (NPCC) with nordihydroguaiaretic acid (NDGA), a 5-lipoxygenase inhibitor, with systemic CTLA4Ig expression, with local CTLA4Ig and with interleukin-1 (IL-1) receptor antagonist (IL-1ra) expression using a pig to mouse...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.089

    authors: Fu SH,Chen YT,Chiang CH,Hsu BR

    更新日期:2006-12-01 00:00:00

  • Impact of Secondary Insults in Brain Death After Traumatic Brain Injury.

    abstract::In addition to primary injury in severe head trauma, secondary systemic insults that aggravate the brain injury may result in fatal neurologic outcome. We aim to evaluate the correlation between brain death and secondary systemic insults in 100 patients with severe traumatic brain injury (TBI) admitted to the intensiv...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.01.176

    authors: Heppekcan D,Ekin S,Çivi M,Aydın Tok D

    更新日期:2019-09-01 00:00:00

  • Graft-versus-host disease after liver transplantation: successful treatment of a case.

    abstract::Graft-versus-host disease (GVHD) is a rare, serious complication after liver transplantation. The incidence is about 1% abroad, but because of difficulties in diagnosis and treatment, the mortality rate is high (80%). Up to now, 78 patients have been reported to have this complication after liver transplantation world...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.03.164

    authors: Lu Y,Wu LQ,Zhang BY,Cao JY

    更新日期:2008-12-01 00:00:00

  • Dopamine and noradrenaline are unrelated to renalase, heart rate, and blood pressure in heart transplant recipients.

    abstract:INTRODUCTION:Renalase may degrade catecholamines and regulate sympathetic tone and blood pressure. The aim of this study was to assess dopamine, norepinephrine, and renalase in 80 heart transplant recipients and 22 healthy volunteers and their correlations with heart rate, blood pressure control, type of hypotensive th...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.09.033

    authors: Wasilewski G,Przybyłowski P,Janik L,Nowak E,Sadowski J,Małyszko J

    更新日期:2014-10-01 00:00:00

  • Long-term outcome in heart failure patients evaluated for heart transplantation but considered too well.

    abstract::Patients referred for heart transplantation evaluation may be accepted for transplantation, or denied due to existing contraindications or judged to be too well. There is little knowledge about long-term outcome in patients considered too well for transplantation. Ninety-five patients (mean age 47 +/- 12 years, 73% me...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.07.038

    authors: Westerlind A,Nilsson F,Andersson B,Bergh CH,Jeppsson A

    更新日期:2006-10-01 00:00:00

  • Surgical nuances in pancreas transplantation.

    abstract::The modern surgical era of vascularized pancreas transplantation (PTX) began with the systemic-bladder drainage technique. According to International Pancreas Transplant Registry (IPTR) data, most PTX procedures are performed with systemic venous delivery of insulin and either bladder (systemic bladder) or enteric (sy...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.transproceed.2004.12.210

    authors: Stratta RJ

    更新日期:2005-03-01 00:00:00

  • Mars and Prometheus: our clinical experience in acute chronic liver failure.

    abstract:INTRODUCTION:In our clinical context, there are two groups that practice blood purification treatments on acute or chronic liver failure (AoCLF) patients: one group used MARS (molecular adsorbent recirculating system) and the other Prometheus. MATERIALS AND METHODS:The MARS group used the lack of response to standard ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.03.069

    authors: Faenza S,Baraldi O,Bernardi M,Bolondi L,Coli L,Cucchetti A,Donati G,Gozzetti F,Lauro A,Mancini E,Pinna AD,Piscaglia F,Rasciti L,Ravaioli M,Ruggeri G,Santoro A,Stefoni S

    更新日期:2008-05-01 00:00:00

  • Atenolol attenuates autonomic dysfunction of rat jejunum submitted to cold ischemic preservation.

    abstract::In vitro studies have demonstrated that cold ischemic preservation (CIP) employed in small bowel transplantation produces loss of intestinal motility due to severe lesions of autonomic enteric nerves and that this autonomic dysfunction is attenuated by antioxidant agents. In this work, we investigated whether preserva...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.05.024

    authors: Taha MO,Fraga MM,Guimarães FA,Jurkiewicz A,Caricati-Neto A

    更新日期:2006-07-01 00:00:00

  • An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients.

    abstract::Mycophenolate mofetil (MMF) is an immunosuppressant used for the prophylaxis of rejection in renal, pancreas, and liver transplantation. It inhibits the inducible isoform of the enzyme inosine-monophosphate dehydrogenase (IMPDH II) via its active metabolite mycophenolic acid (MPA). IMPDH II is necessary for de novo pu...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.09.070

    authors: Vannozzi F,Filipponi F,Di Paolo A,Danesi R,Urbani L,Bocci G,Catalano G,De Simone P,Mosca F,Del Tacca M

    更新日期:2004-11-01 00:00:00

  • Anesthetic Fluid Management of Patients With Hyponatremia Undergoing Living Donor Liver Transplantation.

    abstract:OBJECTIVE:The objective of this study is to evaluate the changes in serum sodium levels in adult recipients with and without hyponatremia undergoing living donor liver transplantation (LDLT) without using hypertonic solution. METHODS:Patients were divided into 2 groups according to serum sodium level higher (GI) or lo...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.01.144

    authors: Wang CH,Tsai CE,Cheng KW,Chen CL,Huang CJ,Wu SC,Shih TH,Yang SC,Juang SE,Liu CK,Jawan B,Hou SY

    更新日期:2020-01-01 00:00:00

  • Intrathymic inoculation of donor HLA class I-derived peptide generates donor-specific CD4+CD25+ regulatory T cells.

    abstract::CD4(+)CD25(+) regulatory T cells are selected in the thymus to control autoreactive thymic escapees preventing autoimmunity that cannot be achieved by negative selection or deletion alone, thus playing an important role in the maintenance of immunological homeostasis. Not only significant in preventing autoimmunity, C...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.12.046

    authors: Tamura S,Beck Y,Ando Y,Tahara H

    更新日期:2005-01-01 00:00:00

  • Early coronary calcification in children and young adults with end-stage renal disease.

    abstract::Cardiovascular disease is a major cause of morbidity and mortality in children and young adults with end-stage renal disease. In our study, we retrospectively analyzed the records of 11 patients who had undergone electron beam computerized tomography in our dialysis unit. Our patients, aged 11 to 24 years (median, 19....

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.198

    authors: Lumpaopong A,Mathew AV,John E,Jelnin V,Benedetti E,Testa G,Oberholzer J,Sankary H,Ruiz C

    更新日期:2007-01-01 00:00:00

  • Surveillance Bronchoscopy in Lung Transplantation Recipients: A Single Center Experience Analysis.

    abstract::Bronchoscopy with bronchoalveolar lavage and transbronchial biopsy is the gold standard for the diagnosis of infection or acute cellular rejection in lung transplantation (LTx) recipients, but there is some controversy to perform it in asymptomatic patients. We conducted a retrospective analysis of medical reports of ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.02.029

    authors: Takizawa DB,de Castro CCB,Paiva MA,Campos SV,Carraro RM,Costa AN,do Nascimento ECT,Samano MN,de Oliveira Braga Teixeira RH

    更新日期:2020-06-01 00:00:00

  • Can liver transplantation achieve similar effects at high altitudes compared with plains: case report.

    abstract::In orthotopic liver transplantation, particular emphasis must be placed on the unique physiologic, pathologic, and clinical features in residents living in areas at high vs low altitude. Hypobaric hypoxia, hypothermia, heavy radiation, high wind speed, and superevaporation at high altitudes may lead to various disease...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.01.115

    authors: Jin S,Chen Z,Lunan Y,Zeng Y,Wen T,Li B,Zhao J,Wang W,Xu M,Yang J

    更新日期:2009-06-01 00:00:00

  • Liver transplant results for hepatocellular carcinoma applying strict preoperative selection criteria.

    abstract:INTRODUCTION:Liver transplantation is currently the best therapeutic option for small hepatocellular carcinoma (HC) in selected cirrhotic patients. The main aim of this study was to analyze the results of a recent series of liver transplant cirrhotic patients with small HC applying strict preoperative selection criteri...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.02.059

    authors: Santoyo J,Suarez MA,Fernández-Aguilar JL,Jiménez M,Perez Daga JA,Sánchez-Perez B,Gonzalez Poveda I,Gonzalez-Sanchez A,Ramírez C,de la Fuente A

    更新日期:2005-04-01 00:00:00

  • Short- and Long-Term Outcomes of Live Donor Renal Allografts From Older and Younger Donors.

    abstract:BACKGROUND:The rising demand for living renal donors has led to the recruitment of older donors. Findings vary, but these grafts appear to survive as long as grafts from standard criteria deceased and expanded criteria deceased donors. We investigated the effects of donor age ≥65 years and the presence or absence of do...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.08.046

    authors: Matsuyama T,Ushigome H,Osaka M,Masuda K,Harada S,Nakamura T,Nobori S,Iida T,Yoshimura N

    更新日期:2018-12-01 00:00:00

  • In the search of potential human islet stem cells: is tetranectin showing us the way?

    abstract::Pancreatic islet cell transplantation is a promising approach to restore the required mass of functional beta cells in diabetic patients as a means to achieve long-term normoglycemia. This therapy is, however, not yet widely used, in part because of the shortage of human islet cells. Gaining detailed knowledge of the ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.12.050

    authors: Hermann M,Pirkebner D,Draxl A,Margreiter R,Hengster P

    更新日期:2005-03-01 00:00:00

  • Current concepts of autoimmune disease.

    abstract::Our concepts of autoimmune disease have evolved with our changing understanding of the immune response. In recent years, clonal deletion theories have gradually given way to more dynamic views of the regulation of anti-self immune reactions. It is now clear that self-reactive B cells and some self-reactive T cells per...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Rose NR

    更新日期:1988-06-01 00:00:00

  • Dynamics of changes in heart conduction system in dialyzed young adults after kidney transplantation--pilot study.

    abstract:BACKGROUND:Cardiovascular complications are the main clinical problem in patients with end-stage renal failure (ESRF). After successful kidney transplantation, this situation improves, although cardiovascular complications remain a risk factor for increased mortality in these patients; therefore, their early identifica...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.09.038

    authors: Laszki-Szcząchor K,Zwolińska D,Sobieszczańska M,Makulska I,Polak-Jonkisz D

    更新日期:2014-10-01 00:00:00

  • Comparison of QuantiFERON-TB Gold with tuberculin skin test for detection of latent tuberculosis infection before kidney transplantation.

    abstract:INTRODUCTION:Screening for latent tuberculosis infection (LTBI) before kidney transplantation (KT) is an indispensable process, purposes of this study were to compare the QuantiFERON-TB Gold In-Tube test (QFT-GIT) with the tuberculin skin test (TST) for screening of LTBI in kidney transplant recipients (KTRs). METHODS...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.08.059

    authors: Kim JS,Cho JH,Park GY,Kang YJ,Kwon O,Choi JY,Park SH,Kim YL,Kim HK,Huh S,Kim CD

    更新日期:2013-10-01 00:00:00

  • Porcine endothelial cell activation in hDAF pig hearts transplanted in baboons with prolonged survival and lack of rejection.

    abstract::Depletion of anti-alphaGal antibodies before and after transplantation with GAS 914, a polylysine containing alphaGal epitopes, together with immunosuppression, has been shown to prevent acute humoral xenograft rejection (AHXR) in hDAF pig-to-baboon xenotransplantation. This therapy was associated with low levels of s...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/s0041-1345(03)00705-x

    authors: Doménech N,Diaz T,Moscoso I,Centeno A,Lopez-Pelaez E,Manez R

    更新日期:2003-08-01 00:00:00

  • Comparing Taguchi and anterior Lich-Gregoir ureterovesical reimplantation techniques for kidney transplantation.

    abstract::Urologic complications are common in renal transplant surgery. Numerous innovations have been developed to circumvent ureterovesical anastomotic failure. In addition to the popular modified Lich-Gregoir technique, we evaluated Taguchi's method which is both quick and easy to perform. One hundred forty four patients we...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.transproceed.2005.08.006

    authors: Zargar MA,Shahrokh H,Mohammadi Fallah MR,Zargar H

    更新日期:2005-09-01 00:00:00

  • Survival after disseminated invasive aspergillosis in a multivisceral transplant recipient.

    abstract::Disseminated invasive aspergillosis is a serious and potentially lethal infectious complication of immunosuppressed individuals, including transplant recipients. We report here a successfully treated case of disseminated Aspergillus fumigatus infection involving the lungs, brain, and endocardium in a multivisceral tra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.015

    authors: Vianna R,Misra V,Fridell JA,Goldman M,Mangus RS,Tector J

    更新日期:2007-01-01 00:00:00

  • UW solution improves duration and quality of clinical liver preservation.

    abstract::Prolonged liver preservation (up to 17 hours) with UW solution had no adverse effect on perioperative blood loss or results of postoperative serum biochemistry studies. After use of this solution, biliary and vascular complications as well as evidence of histologic damage were less. The advantages of the extended pres...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:

    authors: Cooper J,Rettke SR,Ludwig J,Ayalon A,Sterioff S,Wiesner RH,Krom RA

    更新日期:1990-04-01 00:00:00

  • Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST database.

    abstract:INTRODUCTION:Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results. METHODS:The MOST database of "de novo" patients treated with MMF at month 1 and functioning grafts at month 12 were di...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2005.06.053

    authors: Salvadori M,Bock A,Chapman J,Dussol B,Fritsche L,Kliem V,Lebranchu Y,Oppenheimer F,Pohanka E,Tufveson G,Rosati A,Puig X,Corbetta G,MOST International Study Group.

    更新日期:2005-07-01 00:00:00

  • Case report: HIV infection from a kidney transplant.

    abstract::The transmission of human immunodeficiency virus (HIV) through transplantation of human tissues and organs is rare but not impossible. A 27-year-old Bulgarian woman received a kidney transplant from a cadaveric donor owing to chronic renal failure due to glomerulonephritis of unknown etiology. Five days after the dona...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.05.026

    authors: Borchi B,Ambu S,Bresci S,Zanazzi M,Salvadori M,Leoncini F

    更新日期:2010-07-01 00:00:00

  • Mechanisms of prior blood transfusion-cyclosporine-induced tolerance: a potential role for immune-cellular chimerism.

    abstract::Skin allografts were not enhanced by prior conditioning of blood and CyA (5 or 10 mg/kg/d). However, when BM-CyA pretreatment was used, SA survival was significantly prolonged (CyA, 5 or 10 mg/kg/d). In examining differences between the BT-CyA and BM-CyA protocols, equivocal levels of donor microchimerism (1.5%) were ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:

    authors: Beko KR 2nd,Tran HO,Hewitt CW,Black KS,Patel MP,Ramsamooj R,Martin DC

    更新日期:1991-02-01 00:00:00