Genetic Biomarkers: Implications of Increased Understanding and Identification in Lung Cancer Management.

Abstract:

BACKGROUND:In the management of lung cancer, molecular profiling of the tumor is pivotal to defining a personalized treatment plan and is recommended for each patient. OBJECTIVES:The purpose of this article is to provide an update on genomic testing in lung cancer and the associated targeted treatment options. In addition, emerging biomarkers and mechanisms of resistance are discussed. METHODS:A comprehensive review of the CINAHL®, MEDLINE®, and PubMed® databases was performed. FINDINGS:Molecular tumor profiling has advanced treatment options for patients diagnosed with lung cancer. Knowledge about pathologic variants and inhibitory pathways have led to the development of targeted treatments for lung cancer. Based on a solid understanding of molecular biomarkers, testing protocols, testing results, and how biomarkers affect treatment decisions, nurses can best educate and support patients and family members as clinical care incorporates molecular profiling. :

journal_name

Clin J Oncol Nurs

authors

Martin JC

doi

10.1188/20.CJON.648-656

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

648-656

issue

6

eissn

1092-1095

issn

1538-067X

journal_volume

24

pub_type

杂志文章
  • Putting Evidence into Practice: nursing assessment and interventions to reduce family caregiver strain and burden.

    abstract::Family caregiving often is associated with multiple rewards, yet the diversity and intensity of caregiving roles also can result in caregiver strain and burden. Using interventions to reduce the strain and burden on caregivers of patients with cancer is an important role nurses play. This article is a critical review ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/08.CJON.507-516

    authors: Honea NJ,Brintnall R,Given B,Sherwood P,Colao DB,Somers SC,Northouse LL

    更新日期:2008-06-01 00:00:00

  • How Do You Provide Humanistic Care During a Pandemic?

    abstract::Because of the COVID-19 pandemic, we are at an unprecedented time in history. We practice at Monter Cancer Center in Lake Success, New York, which is part of Northwell Health, the largest health system in New York state, located in the initial epicenter of COVID-19 in the United States. ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.711

    authors: Lee MY,Jose J,Lakhani S

    更新日期:2020-12-01 00:00:00

  • Dyspnea and Delirium at the End of Life.

    abstract::This article focuses on the symptoms of dyspnea and delirium, which can be extremely distressing to patients with cancer at the end of life. Oncology nurses are well suited to detect and treat these symptoms.

. ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.244-246

    authors: Bobb B

    更新日期:2016-06-01 00:00:00

  • Integrating a Question Prompt List on an Inpatient Oncology Unit to Increase Prognostic Awareness.

    abstract:BACKGROUND:Many patients with incurable cancer do not accurately understand their prognosis, which can lead to aggressive and, often, futile treatment. Improved prognostic awareness can help patients to appropriately de-escalate aggressive treatment sooner in an illness trajectory. OBJECTIVES:The purpose of this artic...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.385-390

    authors: McLawhorn VC,Vess J,Dumas BP

    更新日期:2016-08-01 00:00:00

  • Caregiver Burden in End-Stage Ovarian Cancer.

    abstract:BACKGROUND:Caregiver burden associated with caring for women with ovarian cancer has received limited focus. However, these patients often have complex needs, requiring a high level of care at home and imposing substantial burdens on caregivers. OBJECTIVES:This pilot study assessed the level of caregiver burden experi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/16.CJON.169-173

    authors: Hartnett J,Thom B,Kline N

    更新日期:2016-04-01 00:00:00

  • Atypical fatigue.

    abstract:CASE STUDY:Mrs. S is a 63-year-old retired teacher who returns to the office for breast cancer follow-up. She was diagnosed with intraductal carcinoma, and her treatment included a modified radial mastectomy followed by four cycles of doxorubicin and cyclophosphamide. Her tumor was estrogen receptor-positive, progester...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/07.628-630

    authors: Sharp K

    更新日期:2007-10-01 00:00:00

  • Building a Program: Implications for Infrastructure, Nursing Education, and Training for CAR T-Cell Therapy.

    abstract:BACKGROUND:Chimeric antigen receptor (CAR) T-cell therapy program development has regulatory demands and unique operational processes that vary across settings. The infrastructure in which CAR T-cell therapy is implemented has implications for nursing education and competencies. OBJECTIVES:This article presents an ove...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/19.CJON.S1.20-26

    authors: Taylor L,Rodriguez ES,Reese A,Anderson K

    更新日期:2019-04-01 00:00:00

  • The role of urinary assessment scores in the nursing management of patients receiving prostate brachytherapy.

    abstract::Nearly all patients experience some degree of urinary irritative or obstructive symptoms following brachytherapy for definitive treatment of early-stage prostate cancer. The American Urological Association (AUA) Symptom Index is a tool developed to measure urinary function and can be incorporated into postoperative nu...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Abel LJ,Blatt HJ,Stipetich RL,Fuscardo JA,Dafoe-Lambie JC,Dorsey AT,Butler WM,Merrick GS

    更新日期:2000-05-01 00:00:00

  • The rationale for fractionation in radiotherapy.

    abstract::The use of radiotherapy as a cancer treatment is common, so an appreciation of the biologic effects of radiation at a cellular level is essential to help nurses prepare their patients for the challenging journey ahead using appropriate lay language. The four Rs of radiotherapy (repair, redistribution, reoxygenation, a...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.412-417

    authors: Mitchell G

    更新日期:2013-08-01 00:00:00

  • Inflammatory breast cancer.

    abstract::IBC is a rare clinical occurrence. Signs and symptoms include erythema and edema of the skin. Diagnosis is made by skin biopsy. Treatment for this aggressive form of breast cancer is multimodal, including chemotherapy, surgery, radiation therapy, and hormonal therapy. Advances in treatment continue to improve prognosi...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Gordon L

    更新日期:2001-07-01 00:00:00

  • Sleep interrupted: nocturnal care disturbances following hematopoietic stem cell transplantation.

    abstract::Sleep is an essential biologic and physiologic process that is vital for maintaining or achieving optimal health outcomes. Care requirements in hospitalized patients frequently result in nocturnal disruptions that impact sleep quality. This exploratory, retrospective study aimed to identify and quantify nocturnal care...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.517-523

    authors: Hacker ED,Patel P,Stainthorpe M

    更新日期:2013-10-01 00:00:00

  • Oncology nurses' grief: a literature review.

    abstract::The oncology practice setting can be a highly emotional workplace because nurses provide care to many of the same patients and their families over time. Comparing and contrasting nurses from different clinical settings would provide insight into the more common themes of nursing grief and might give guidance on how to...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/09.CJON.625-627

    authors: Brown C,Wood A

    更新日期:2009-12-01 00:00:00

  • Acute myeloid leukemia: a classification and treatment update.

    abstract::Approximately 11,000 Americans will be diagnosed with acute myeloid leukemia (AML) in 2003, and about 75% ultimately will die from the disease. Despite significant advances in understanding biologic, molecular, and cytogenetic aspects of this malignancy, several other areas remain poorly understood. During the 1990s, ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/03.CJON.535-540

    authors: Iovino CS,Camacho LH

    更新日期:2003-09-01 00:00:00

  • Extravasation of infusate via implanted ports: two case studies.

    abstract::Over the past two decades, implanted ports have become widely used infusion therapy devices. Although these devices have revolutionized the care of patients with cancer and are used routinely to administer various treatments, complications still can occur. Nurses must be vigilant in identifying potential and actual po...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:

    authors: Viale PH,Yamamoto DS,Geyton JE

    更新日期:1999-10-01 00:00:00

  • A feasibility study of low-cost, self-administered skin care interventions in patients with head and neck cancer receiving chemoradiation.

    abstract::Current evidence for the management of radiation skin toxicities demonstrates equivocal outcomes using a variety of interventions, leaving substantial gaps in knowledge. Skin toxicities can lead to treatment delays, infection, pain, and increased costs for the patient. Patients with head and neck cancers receiving che...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.278-285

    authors: Mannix CM,Bartholomay MM,Doherty CS,Lewis M,Bilodeau ML

    更新日期:2012-06-01 00:00:00

  • Colorectal Cancer Screening: An Educational Intervention for Nurse Practitioners to Increase Screening Awareness and Participation
.

    abstract::Colorectal cancer screening aims to detect colorectal cancer at an early stage, when treatment is more likely to be curative. Lack of participation in such screening is a major issue in primary care practices, where nurse practitioners (NPs) often provide care. This study aimed to determine whether an educational inte...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.543-546

    authors: Slyne TC,Gautam R,King V

    更新日期:2017-10-01 00:00:00

  • Risk Prediction Tools in Oncology.

    abstract::Cancer prediction tools are widely available to clinicians, and the data retrieved from these tools can assist with patient counseling sessions on risk, prognosis, treatment, and recurrence. Current tools are able to synthesize data in a concise, unbiased, and evidence-based method, allowing patients to make better-in...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.665-666

    authors: Doyle-Lindrud S

    更新日期:2015-12-01 00:00:00

  • Optimal Topical Agent for Radiation Dermatitis During Breast Radiotherapy: A Pilot Study.

    abstract:BACKGROUND:Women receiving radiation to the breast will likely be recommended to use a topical cream to minimize and delay the development of radiation dermatitis. Although many topical products are commercially available and have been tested for safety and efficacy, few studies have compared various products to one an...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/15.CJON.451-455

    authors: Fenton-Kerimian M,Cartwright F,Peat E,Florentino R,Maisonet O,Budin W,Rolnitzky L,Formenti S

    更新日期:2015-08-01 00:00:00

  • Hazardous Drugs: Legislative and Regulatory Efforts to Improve Safe Handling

    abstract::Several organizations have safety guidelines regarding handling of hazardous drugs. That said, only Washington and California have enforceable laws that regulate these practices. This article shares the experiences of three states-Washington, Michigan, and North Carolina-in advancing legislative and regulatory efforts...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/17.CJON.254-256

    authors: Walton AL,Eisenberg S,Friese CR

    更新日期:2017-04-01 00:00:00

  • Can a Recent Nurse Graduate Thrive in the Oncology Setting?

    abstract::My personal experience with nursing school can be best described as floating in the middle of the ocean with a life vest while kicking and paddling to keep my head above the water. I spent countless hours studying for examinations, rewriting care plans, and practicing skills. In addition to my own efforts to survive, ...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.455

    authors: Waldo A

    更新日期:2020-08-01 00:00:00

  • Quality of life and mood state in Iranian women post mastectomy.

    abstract::This study was conducted to examine mood state and quality of life (QOL) in patients who had undergone a mastectomy. The study used a descriptive design and was conducted in outpatient oncology clinics in northeastern Iran. Using the Profile of Mood States and the Ferrans and Powers Quality of Life Index, the mood sta...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/12.CJON.E118-E122

    authors: Tirgari B,Iranmanesh S,Fazel A,Kalantari B

    更新日期:2012-06-01 00:00:00

  • Taste alterations among patients with cancer.

    abstract::Patients with cancer frequently develop taste alterations, which are manifested by food aversions and decreased caloric intake. Many etiologies are recognized, including the effect of tumors, cancer cell mitosis, vitamin deficiencies, and cytokine involvement. Preventing or improving taste alterations in patients with...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/02.CJON.73-77

    authors: Sherry VW

    更新日期:2002-03-01 00:00:00

  • Translating research on the distress thermometer into practice.

    abstract::Distress is commonly experienced by people with cancer. The National Comprehensive Cancer Network (NCCN) developed a guideline for screening and managing distress in 1999 and has updated the guideline on an annual basis ever since. Using the five-phase framework for translational research, this article summarizes rese...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/14.CJON.S1.26-30

    authors: Tavernier SS

    更新日期:2014-01-01 00:00:00

  • Malnutrition Screening: An Interprofessional Approach in Outpatient Oncology.

    abstract:BACKGROUND:Malnutrition is highly prevalent in the oncology population and is associated with poor treatment outcomes. OBJECTIVES:This study aimed to implement a malnutrition screening process using a validated tool in three outpatient cancer centers. METHODS:Nursing and nutrition department leaders collaborated to e...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/20.CJON.E28-E33

    authors: Schneider CK,Bressler T

    更新日期:2020-06-01 00:00:00

  • Genomics Education: Knowledge of Nurses Across the Profession and Integration Into Practice.

    abstract:BACKGROUND:Since the completion of the Human Genome Project in 2003, the implications of genetics and genomics for health and illness have become clearer. All nurses, at all levels and across all specialties, must have a basic understanding of genetics and genomics to provide appropriate care. 
. OBJECTIVES:This artic...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/17.CJON.747-753

    authors: Aiello LB

    更新日期:2017-12-01 00:00:00

  • Computer-Based Cognitive Training for Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors.

    abstract:BACKGROUND:Advancements in chemotherapy have greatly increased breast cancer survival, leading to an increased focus on the management of long-term effects of treatment. Chemotherapy-related cognitive impairment, one such long-term effect, is experienced by as many as 90% of breast cancer survivors (BCS) and negatively...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/16.CJON.504-509

    authors: Bail J,Meneses K

    更新日期:2016-10-01 00:00:00

  • Current methods for the assessment and management of taxane-related neuropathy.

    abstract::Taxane-induced peripheral neuropathy (TIPN) affects a number of patients with breast cancer. To properly manage these patients, nurses must be able to identify and assess TIPN, as well as educate patients on TIPN as a side effect of taxane therapy. This article provides practical suggestions regarding how nurses can i...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.S1.22-34

    authors: Smith EM

    更新日期:2013-02-01 00:00:00

  • Nursing perspectives on trastuzumab emtansine for the treatment of metastatic breast cancer.

    abstract::Increased understanding of the molecular composition of breast cancer tumors has led to the development of targeted anticancer agents. Novel therapies directed against human epidermal growth factor receptor 2 (HER2) in breast cancer have been developed. One such agent, trastuzumab emtansine (T-DM1), is an antibody dru...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:10.1188/13.CJON.E58-E62

    authors: Bourdeanu L,Luu T

    更新日期:2013-10-01 00:00:00

  • Myelosuppression, Bone Disease, and Acute Renal Failure: Evidence-Based Recommendations for Oncologic Emergencies

    abstract:BACKGROUND:Oncologic emergencies associated with multiple myeloma include myelosuppression (anemia, neutropenia, and thrombocytopenia), bone-related emergencies, and acute renal failure. 
. OBJECTIVES:This article reviews the pathophysiology of these multiple myeloma-associated oncology emergencies and provides a fram...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章,评审

    doi:10.1188/17.CJON.S5.60-76

    authors: Brigle K,Pierre A,Finley-Oliver E,Faiman B,Tariman JD,Miceli T

    更新日期:2017-10-01 00:00:00

  • Development of a protocol to prevent opioid-induced constipation in patients with cancer: a research utilization project.

    abstract::Opioids are the major class of analgesics used in the management of moderate to severe cancer pain, and constipation is a common side effect of opioid administration. While monitoring for quality-assurance, nurses found that 95% of patients interviewed on a 28-bed oncology unit of a Midwestern hospital reported consti...

    journal_title:Clinical journal of oncology nursing

    pub_type: 杂志文章

    doi:

    authors: Robinson CB,Fritch M,Hullett L,Petersen MA,Sikkema S,Theuninck L,Timmer K

    更新日期:2000-03-01 00:00:00