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Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.

Abstract：

:Diisopropyl-1,3-dithiol-2-ylidenemalonate (malotilate) was studied for and compared with cyanidanol, hydrocortisone and colchicin on its impact on fibroblast cultures. Under in vitro conditions, malotilate specifically reduces collagen synthesis of fibroblasts. In addition, malotilate is an efficient inhibitor of fibroblast migration as tested by a chemotaxis assay in a modified Boyden chamber. Our data may support the notion that malotilate is of potential interest for interfering with fibrotic processes.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Poeschl A,Rehn D,Dumont JM,Mueller PK,Hennings G

doi

10.1016/0006-2952(87)90464-3

subject

Has Abstract

pub_date

1987-11-15 00:00:00

pages

3957-63

issue

22

eissn

0006-2952

issn

1873-2968

pii

0006-2952(87)90464-3

journal_volume

36

pub_type

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