Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction.

abstract：:Contact sensitization is caused by low molecular weight compounds which penetrate the skin and bind to protein. In many cases, these compounds are activated to reactive species, either by autoxidation on exposure to air or by metabolic activation in the skin. Geraniol, a widely used fragrance chemical, is considered t...

journal_title：Toxicology and applied pharmacology

authors： Hagvall L,Baron JM,Börje A,Weidolf L,Merk H,Karlberg AT

更新日期：2008-12-01 00:00:00

abstract：:An in vitro model, the aggregating brain cell culture of fetal rat telencephalon, has been used to study the maturation-dependent sensitivity of brain cells to two organophosphorus pesticides (OPs), chlorpyrifos and parathion, and to their oxon derivatives. Immature (DIV 5-15) or differentiated (DIV 25-35) brain cells...

journal_title：Toxicology and applied pharmacology

authors： Monnet-Tschudi F,Zurich MG,Schilter B,Costa LG,Honegger P

更新日期：2000-06-15 00:00:00

abstract：:The correlation among hyperammonemia, brain neutral amino acid, and encephalopathy induced by cyanide was investigated in mice. Subcutaneous injection of 10 mg/kg of potassium cyanide increased the levels of blood ammonia by 2.5-fold as compared to those of the corresponding controls and caused loss of consciousness i...

journal_title：Toxicology and applied pharmacology

authors： Yamamoto H

更新日期：1989-07-01 00:00:00

abstract：:Pulmonary responses after continuous exposure of rats to concentrations of ozone (O3) ranging from 0.12 to 0.64 ppm were quantified by measuring tissue collagen synthesis rate, tissue protein and DNA content, and various constituents of bronchoalveolar lavage fluid. After 7 days of exposure to 0.64 ppm of O3, lung col...

journal_title：Toxicology and applied pharmacology

authors： Warren DL,Guth DJ,Last JA

更新日期：1986-07-01 00:00:00

abstract：:Follicle growth culminates in ovulation, which allows for the expulsion of fertilizable oocytes and the formation of corpora lutea. Bisphenol A (BPA) is present in many consumer products, and it has been suggested that BPA impairs ovulation; however, the underlying mechanisms are unknown. Therefore, this study first e...

journal_title：Toxicology and applied pharmacology

authors： Moore-Ambriz TR,Acuña-Hernández DG,Ramos-Robles B,Sánchez-Gutiérrez M,Santacruz-Márquez R,Sierra-Santoyo A,Piña-Guzmán B,Shibayama M,Hernández-Ochoa I

更新日期：2015-12-15 00:00:00

abstract：:Methylmercury (MeHg) is an environmental neurotoxicant which induces neuropathological changes in both the central nervous and peripheral sensory nervous systems. Our recent study demonstrated that down-regulation of Ras-related C3 botulinum toxin substrate 1 (Rac1), which is known to promote neuritic extension, prece...

journal_title：Toxicology and applied pharmacology

authors： Fujimura M,Usuki F,Kawamura M,Izumo S

更新日期：2011-01-01 00:00:00

abstract：:In this study, the effects of pentavalent dimethylarsinic acid ((CH(3))(2)AsO(OH); DMA(V)) and trivalent dimethylarsinous acid ((CH(3))(2)As(OH); DMA(III)) on synaptic transmission generated by the excitatory Schaffer collateral-CA1 synapse were tested in hippocampal slices of young (14-21 day-old) and adult (2-4 mont...

journal_title：Toxicology and applied pharmacology

authors： Krüger K,Repges H,Hippler J,Hartmann LM,Hirner AV,Straub H,Binding N,Musshoff U

更新日期：2007-11-15 00:00:00

abstract：:Some widely used psychoactive drugs, such as tricyclic antidepressants and antipsychotic phenothiazines exhibit iatrogenic effects on the thyroid. These side effects may arise from interactions at different steps of thyroid hormone biosynthesis. These drugs can induce a change in iodine capture by thyroid cells or can...

journal_title：Toxicology and applied pharmacology

authors： Sauvage MF,Marquet P,Rousseau A,Raby C,Buxeraud J,Lachâtre G

更新日期：1998-04-01 00:00:00

abstract：:Trimethyltin (TMT), is a hippocampal neurotoxicant characterized by neuronal degeneration, astrogliosis, and microglia reactivity with an associated elevation in proinflammatory cytokine mRNA levels. To examine the role of proinflammatory cytokines in the TMT-induced glia response, mixed cortical glia cultures were ex...

journal_title：Toxicology and applied pharmacology

authors： Harry GJ,Tyler K,d'Hellencourt CL,Tilson HA,Maier WE

更新日期：2002-05-01 00:00:00

abstract：:High- and low- Se diets received by dams during gestation and lactation are related to insulin resistance in their pups. High-Se diet leads to an increase in serum insulin levels, which does not function properly, and an anabolic process. Low-Se diet is related to very low insulin values and an extreme catabolic energ...

journal_title：Toxicology and applied pharmacology

authors： Ojeda ML,Carreras O,Díaz-Castro J,Murillo ML,Nogales F

更新日期：2019-11-01 00:00:00

abstract：:Tissue factor (TF) is involved not only in the progression of atherosclerosis and other cardiovascular diseases, but is also associated with tumor growth, metastasis, and angiogenesis and hence may be an attractive target for directed cancer therapeutics. Gynostemma pentaphyllum (GP) is widely used in the treatment of...

journal_title：Toxicology and applied pharmacology

authors： Huang TH,Tran VH,Roufogalis BD,Li Y

更新日期：2007-01-01 00:00:00

abstract：:The Constitutive Androstane Receptor (CAR, NR1I3) has been newly described as a regulator of energy metabolism. A relevant number of studies using animal models of obesity suggest that CAR activation could be beneficial on the metabolic balance. However, this remains controversial and the underlying mechanisms are sti...

journal_title：Toxicology and applied pharmacology

authors： Marmugi A,Lukowicz C,Lasserre F,Montagner A,Polizzi A,Ducheix S,Goron A,Gamet-Payrastre L,Gerbal-Chaloin S,Pascussi JM,Moldes M,Pineau T,Guillou H,Mselli-Lakhal L

更新日期：2016-07-15 00:00:00

abstract：:3-Methylindole (3MI), a fermentation product of tryptophan produced by intestinal and ruminal microflora, has been shown to cause pneumotoxicity in several species subsequent to cytochrome P450-mediated biotransformation. Among several species studied, rabbits are comparatively resistant to 3MI-induced pneumotoxicity,...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Nichols WK,Manning BW,Skiles GL,Yost GS

更新日期：1993-10-01 00:00:00

abstract：:The toxic milk mutation is an autosomal recessive mutation found in an inbred C57BL/6J strain of mice which results in an excessive hepatic accumulation of copper (Cu), mostly associated with metallothionein (MT). The possible toxicological significance of elevated levels of hepatic copper-metallothionein (Cu-MT) was ...

journal_title：Toxicology and applied pharmacology

authors： Stephenson GF,Chan HM,Cherian MG

更新日期：1994-03-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates toxicity of xenobiotics, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Genetic deletion of the AhR leads to cardiac hypertrophy, suggesting a role for the AhR in cardiovascular physiology and disease; however, the pathways invo...

journal_title：Toxicology and applied pharmacology

authors： Lund AK,Goens MB,Kanagy NL,Walker MK

更新日期：2003-12-01 00:00:00

abstract：:The Bcl-2 family contains a panel of proteins which are conserved regulators of apoptosis in mammalian cells, like the anti-apoptotic protein Bcl-2. According to its significant role in altering susceptibility to apoptosis, the deciphering of the mechanism of Bcl-2 expression modulation may be crucial for identifying ...

journal_title：Toxicology and applied pharmacology

authors： Liang X,Xu K,Xu Y,Liu J,Qian X

更新日期：2011-10-01 00:00:00

abstract：:It was investigated whether protective influence of zinc (Zn) against cadmium (Cd)-induced disorders in bone metabolism may be related to its antioxidative properties and impact on the receptor activator of nuclear factor (NF)-κΒ (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. Numerous indices of oxidative/an...

journal_title：Toxicology and applied pharmacology

authors： Brzóska MM,Rogalska J

更新日期：2013-10-01 00:00:00

abstract：:Inhalation of nitrogen dioxide (NO2) produces injury to the epithelium of terminal airways and the alveoli proximal to the airways. Techniques were devised to isolate alveolar tissue from this region for morphometric studies to define the extent of alveolar septal injury caused by NO2. One-day-old and six-week-old rat...

journal_title：Toxicology and applied pharmacology

authors： Chang LY,Graham JA,Miller FJ,Ospital JJ,Crapo JD

更新日期：1986-03-30 00:00:00

abstract：:The pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) were measured in the beagle dog and rhesus monkey and compared with the kinetics observed in rats and humans. In addition, studies were conducted in anesthetized dogs to better understand the mechanism by which [14C]triclopyr is eliminated i...

journal_title：Toxicology and applied pharmacology

authors： Timchalk C,Nolan RJ

更新日期：1997-06-01 00:00:00

abstract：:Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of a...

journal_title：Toxicology and applied pharmacology

authors： El-Awady RA,Saleh EM,Ezz M,Elsayed AM

更新日期：2011-09-15 00:00:00

abstract：:The results of a series of screening tests to determine the potential teratogenicity and neurotoxicity of developmental exposure to TBTO in rats are presented in this paper. For prenatal exposure, pregnant Long Evans rats were intubated with 0-16 mg/kg/day bis(tri-n-butyltin)oxide TBTO from Days 6 to 20 of gestation (...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Boncek VM,Rosen MB,Sheets LP,Chernoff N,Reiter LW

更新日期：1989-01-01 00:00:00

abstract：:F(ab')2 fragments are sometimes preferred to whole IgG for therapeutic or diagnostic uses. Preclinical pharmaceutical development studies are necessary before their use in humans. Here we propose an allometric approach among three mammalian species to predict F(ab')2 pharmacokinetic parameters in humans. Plasma dispos...

journal_title：Toxicology and applied pharmacology

authors： Bazin-Redureau M,Pepin S,Hong G,Debray M,Scherrmann JM

更新日期：1998-06-01 00:00:00

abstract：:The physicochemical complexity of airborne particulate matter (PM) has hampered identifying a specific mechanism(s) for its toxicity. In this study, selected physicochemical characteristics (i.e., size, particle number, acidity, and surface charge) were measured on various field PM, derived from urban ambient (St. Lou...

journal_title：Toxicology and applied pharmacology

authors： Veronesi B,de Haar C,Lee L,Oortgiesen M

更新日期：2002-02-01 00:00:00

abstract：:The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus Gliocephalotrichum simplex was examined in BALB/C mice, and the probable mechanism of action was established. At an effective dose of 50mg/kg body weight, melanin exhibited both prophylactic and mitigative acti...

journal_title：Toxicology and applied pharmacology

authors： Kunwar A,Adhikary B,Jayakumar S,Barik A,Chattopadhyay S,Raghukumar S,Priyadarsini KI

更新日期：2012-10-15 00:00:00

abstract：:Intravesical gemcitabine has recently been introduced for the treatment of superficial bladder cancer and has a favourable efficacy and toxicity profile in comparison to mitomycin c (MMC), the most commonly used chemotherapeutic agent. The aim of this study was to assess the cytotoxic potency of gemcitabine in compari...

journal_title：Toxicology and applied pharmacology

authors： Farr SE,Chess-Williams R,McDermott CM

更新日期：2017-02-01 00:00:00

abstract：:Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (IVIVE) of lindane neurotoxicity. Lindane cell and media concentrations...

journal_title：Toxicology and applied pharmacology

authors： Croom EL,Shafer TJ,Evans MV,Mundy WR,Eklund CR,Johnstone AF,Mack CM,Pegram RA

更新日期：2015-02-15 00:00:00

abstract：:Di-Calciphor is a synthetic derivative of prostaglandin B1 that protects against cerebral and cardiac ischemia apparently by preserving mitochondrial function. To determine whether di-Calciphor specifically protects against mitochondrial failure, we studied its effects on mitochondrial functions in hepatocytes treated...

journal_title：Toxicology and applied pharmacology

authors： Park Y,Devlin TM,Jones DP

更新日期：1994-05-01 00:00:00

abstract：:It has been proposed [J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, and W. Briner (1985). Environ. Health Perspect. 61, 41-53] that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces toxic responses through persistent occupancy of nuclear thyroxine (T4) receptors, and that maintenance of re...

journal_title：Toxicology and applied pharmacology

authors： Osborne R,Dold KM,Greenlee WF

更新日期：1987-09-30 00:00:00

abstract：:Subchronic and chronic studies in rats of the gasoline oxygenates ethyl tert-butyl ether (ETBE) and tert-butanol (TBA) report similar noncancer kidney and liver effects but differing results with respect to kidney and liver tumors. Because TBA is a major metabolite of ETBE, it is possible that TBA is the active toxic ...

journal_title：Toxicology and applied pharmacology

authors： Salazar KD,Brinkerhoff CJ,Lee JS,Chiu WA

更新日期：2015-11-01 00:00:00

abstract：:Triaryl phosphates including tricresyl phosphate (TCP) and butylated triphenyl phosphate (BTP) are organophosphates used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. Rat steroidogenic tissues such as adrenocortical (AC), ovarian interstitial (OI), and Leydig cells use an intracellular p...

journal_title：Toxicology and applied pharmacology

authors： Latendresse JR,Azhar S,Brooks CL,Capen CC

更新日期：1993-10-01 00:00:00