Abstract：
AIM:To investigate the effects of coronary stenting with rapamycin-eluting stents on parameters of cell immunity. METHODS:26 patients (group 1) with stable coronary heart disease and angiographically proved coronary stenosis underwent stenting with rapamycin-eluting stents. The control group (group 2) consisted of 6 patients: 4 patients underwent diagnostic coronaroangiography, I patient got a bare metal stent and in 1 patient angioplasty was unsuccessful. Blood samples were obtained before and 1 month after the intervention. The quantity of activated (CD4+CD25low+) and regulatory (CD4+CD25high+) T cells was measured by direct immunofluorescence and flow cytometry. Plasma concentration of IL-10 was determined by ELISA. RESULTS:In group 1 the percentages of CD4+CD25high+ regulatory T-cells increased significantly one month after stenting, while in group 2 no difference in regulatory T-cell levels before and after the intervention was observed. No changes in total number of leukocytes, relative levels of lymphocytes, CD4+ T-cells, activated CD4+CD25+low T-cells and IL-10 plasma concentration before and after the procedure were detected in both groups. CONCLUSION:Rapamycin-eluting stent implantation is associated with a significant increase of circulating CD4+CD25high+ regulatory T-cell level.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Aref'eva TI,Provatorov SI,Potekhina AV,Sokolov VO,Kukhtina NB,Samko AN,Krasnikova TLsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
33-7issue
9eissn
0040-3660issn
2309-5342journal_volume
81pub_type
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journal_title：Terapevticheskii arkhiv
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