Abstract：
AIM:To assess an association of uric acid level with preclinical target organ damage in patients with hypertensive disease (HD). SUBJECTS AND METHODS:The trial enrolled 100 patients (63 men and 37 women) with Stage I-II HD at moderate and high risk for cardiovascular events (CVEs). The mean age of the patients was 44.9 +/- 1.3 years. Their medical history showed that the duration of hypertension averaged 4.4 +/- 0.3 years. The average daily level of systolic blood pressure (BP) was 138.1 +/- 1.4 mm Hg and that of diastolic BP was 84.3 +/- 1.1 mm Hg. RESULTS:The entire patient group showed a positive correlation between C-reactive protein (CRP) and serum uric acid (SUA) (r = 0.27; p < 0.01), suggesting that the nonspecific inflammatory processes were associated with uric acid levels in patients with HD. An intragroup analysis also revealed a relationship between CRP and SUA levels in the hypertensive patients at high risk for CVEs (r = 0.43; p = 0.01); this relationship was not found in those at their low risk. The hypertensive patients were ascertained to have elevated CRP levels and microalbuminuria, hyperuricosuria, and glomerular hyperfiltration when they had a SUA level >319 micromol/l. CONCLUSION:It can be assumed that the SUA level >319 micromol/l triggers the activation of nonspecific inflammatory processes, which in turn affects renal microvessels.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Dmitriev VA,Oshchepkova EV,Titov BN,Rogoza AN,Saidova MA,Bolotova MN,Gushchina OV,Polevaia TYsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
52-7issue
9eissn
0040-3660issn
2309-5342journal_volume
85pub_type
临床试验,杂志文章abstract：:The hypotensive and diuretic properties of heparin were evaluated in 95 patients with different clinical and morphological varieties of chronic glomerulonephritis (CGN). The arterial blood pressure dropped in all the patients treated with heparin. The maximal effect was attained toward the end of heparin treatment (by...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The case report of botulinum toxin treatment of gastroparesis in a patient following allogenic bone marrow transplantation is described. The causes of gastroparesis and methods of prevention and treatment are discussed. It was noted that pyloric injection of botulinum toxin can improve symptoms and gastric emptying. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/terarkh201890160-64
更新日期：2018-02-14 00:00:00
abstract：:A total of 118 patients with erysipelatous inflammation were examined for functional-metabolic activity of leukocytes. The consistent changes in the content of glycogen, cationic protein, in phosphatase and myeloperoxidase activity and in the NBT test of neutrophils--the most important components of the microbicidal s...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:To evaluate incidence of C-reactive protein (CRP) rise and CRP associations with clinical manifestations in systemic sclerosis (SS). MATERIAL AND METHODS:CRP concentrations in blood serum were estimated with solid phase enzyme immunoassay in 21 SS patients (8 patients with diffuse SS--dSS and 13 patients with limi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:One of the mechanisms responsible for occupational dermatoses of constructors in contact with Cr-containing substances is supposed to be antibodies production as a result of Cr ion migration in the blood. The authors' measurements led them to the conclusions that no significant rise in blood Cr content occurs with an ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Comparative studies on changes of hemodynamics in manual and leg isometric loads were conducted in 30 healthy persons and 38 patients with coronary heart disease. A possibility of a leg isometric load with a maximum effort for 5 min. was shown. Intracardiac hemodynamics was estimated by echocardiography results. A pos...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：AIM:To characterize the spectrum, incidence rate and features of pulmonary pathology in HIV-infected inpatients with reference to a fall in the count of CD4-lymphocytes. MATERIAL AND METHODS:A total of 2370 patients with HIV infection admitted to Moscow infectious hospital N 2 were examined. The protocol of examinatio...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:To analyze prevalence and structure of thyroid pathology in women of reproductive age living in Shoria mountains. MATERIAL AND METHODS:The examination of 409 women aged 18 to 40 living in mountain Shoria included assessment of social status, heredity, actual nutrition, visit to endocrinologist, ultrasound investig...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：AIM:Assessment of NO-synthase (NOS) activity in bronchial asthma (BA) basing on cytochemical identification and quantitation of NADPN-diaphorase. MATERIALS AND METHODS:Operative samples from 12 BA patients and biopsies from 8 patients free of bronchial inflammation or obstruction. Experimental data on control and BA r...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：AIM:Investigation of functional-metabolic activity of leukocytes by assessment of basic components of the microbicidal system in the course of chronic brucellosis with reference to the stage, severity, complications and concomitant diseases. MATERIAL AND METHODS:Time course of changes in myeloperoxidase, acid and alka...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：AIM:To achieve a maximal complete remission rate in patients with recurrent and refractory Hodgkin's disease. To find out a group of patients in whom surgical removal of the residual mediastinal mass would be most effective. MATERIAL AND METHODS:46 patients with Hodgkin's disease received Dexa-BEAM chemotherapy follow...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:To investigate sex- and age-specific features of radiographic abnormalities in rheumatoid arthritis (RA) patients, radiographic signs in hands and feet were assessed using Steinbroker criteria. A score system from 0 to 3 was also introduced to evaluate every radiographic feature: osteoporosis, cysts, joint space narro...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The paper discusses treatment strategy and tactics for iron deficiency anemia. It gives data on the comparative efficacy of different iron sulfate drugs, their bioavailability, effects on peroxidation processes, and side effects. The paper also considers the clinical significance of a dosage form of iron-containing dr...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.17116/terarkh20178910108-112
更新日期：2017-01-01 00:00:00
abstract：:Lipid peroxidation was studied by the levels of malonic dialdehyde (MDA) in the platelets and red cells of patients with diabetes mellitus (DM) type 1 as to relationships to vascular complications and insulin therapy. MDA appeared elevated both in red cells and platelets of DM patients, but was high in red cells only ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:The aim of the study was to study the effectiveness of the complex use of bacterial therapeutic vaccine Immunovac-VP4 and allergen-specific immune therapy (ASIT) in pollinosis in children and adults. MATERIALS AND METHODS:Bacterial therapeutic vaccine Immunovac-VP4 was used annually, nasal and oral administration ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/terarkh201890316-20
更新日期：2018-04-19 00:00:00
abstract：:A study was made of exercise tolerance and indices of central hemodynamics in 151 patients with "isolated" angina and its combination with cardialgia, arterial hypertension and postinfarctional cardiosclerosis. Daily attacks of angina of effort (III functional class) were noted in all the patients. In patients with "i...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:541 workers with long-term history of occupational contact with antibiotics and chemicals were examined by a dermatologist, ENT specialist, neuropathologist, surgeon, ophthalmologist. Many workers complained of occasional skin eruption, rhinitis, skin itching, sneezing, cough, Quincke's edema. Allergic examination rev...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：AIM:To study mobilisation of peripheral blood stem cells (PBSC) via single and split subcutaneous injection of granulocytic colony-stimulating factor (G-CSF) and isolation of PBSC concentrates for their transplantation with leukapheresis (LA) and large volume leukapheresis (LVL) in patients with solid tumors and hemato...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The morphofunctional status of red blood cells was studied in patients with terminal renal failure associated with pyo-inflammatory complications treated by means of ultraviolet radiation of autologous blood. The authors have established that ultraviolet radiation of autologous blood results in the increase of the dis...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：AIM:To ascertain whether high arterial rigidity is obligatory in arterial hypertension (AH) and the presence of AH is obligatory in patients with rigid arteries. MATERIAL AND METHODS:Volume sphygmography (VS) was made in 153 patients aged 60-86 years: 96 patients with untreated AH of degree 1-3 (40 males aged 71.0 +/-...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Valsalva's sinus aneurysm is a congenital heart disease that may occur both as isolated abnormality or combined with other ailments. The present paper summarizes the results of the use in 20 patients of non-invasive research methods, namely ultrasound cardiography and Doppler's cardiography, in the diagnosis of Valsal...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：AIM:To study factors of anemia pathogenesis in patients with ulcerative colitis (UC) and Crohn's disease (CD). MATERIAL AND METHODS:A total of 80 patients (56% males and 44% females, mean age 39 +/- 15.8 years) with UC and CD were divided into two groups: group 1--40 patients with anemia, group 2--40 controls free of ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：AIM:Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. MATERIALS AND METHODS:A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men 265, women 251, ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2020.06.000277
更新日期：2020-07-09 00:00:00
abstract：AIM:To compare efficacy of avelox systemic antibiotic therapy with and without maxillary puncture in acute purulent rhinosinusitis (ARS). MATERIAL AND METHODS:A total of 40 ARS patients were divided into two groups: puncture was not made in 20 patients of the study group and was made in 20 patients of the control grou...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:To specify risk factors affecting development and frequency of complications early after the bypass operation in direct myocardial revascularization. MATERIAL AND METHODS:455 patients with ischemic heart disease (IHD) of whom 392 (86.2%) had stable angina pectoris class III-IV, 25 (5.5%) had unstable angina pector...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Clinical and instrumental manifestations of disorders of the regional blood circulation were studied in 47 patients with sclerodermia systematica. Hemodynamic changes of the lesser circulation were marked in patients under 44 with more active disease, longer disease duration, pulmonary pathology and cardiac decompensa...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:External respiration, circulation and gas exchange trends were investigated in acute pneumonia convalescents followed up on an outpatient basis. It was found that 72% of patients admitted to hospital for acute pneumonia, upon discharge demonstrated residual clinicoroentgenological effects. Cardiorespiratory distress, ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The authors analyze the results of investigations in accordance with the WHO program "MONICA" in one of the districts of Novosibirsk. The bases of the objective information system pertaining to the tendencies in mortality, morbidity and lethality due to cardiovascular diseases, the prevalence of risk factors in the po...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：AIM:To specify the risk of severe systemic manifestations and transformation into malignant lymphoma in Sjogren's disease (SD) patients with monoclonal mixed cryoglobulinemia (MMC). MATERIAL AND METHODS:A prospective study performed in 1985-1990 included 248 SD patients followed up after the initial detection of monoc...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:To elucidate efficacy of a combination almitrine+thiotropium bromide (TB)+pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) of stage II-III complicated with chronic respiratory failure (CRF). MATERIAL AND METHODS:Efficacy of therapy was compared in two groups of patients: group 1 (n = 2...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-01-01 00:00:00
