[PET-CT for evaluation of the solitary pulmonary nodule: an update].

Abstract:

INTRODUCTION:Positron emission tomography (PET) with 18F-FDG has become an important tool for the characterization of solitary pulmonary nodules (SPN). BACKGROUND:The results of the main meta-analyses show that the sensitivity and specificity of 18F-FDG PET for determining malignancy of SPN are close to 95% and 80% respectively. The limits of the technology are now well known. False negative results are mainly due to certain histological types with low metabolic activity (such as bronchiolo-alveolar carcinoma and typical carcinoid), or small size (nodules less than 8 mm). False positives are mainly represented by granulomatous and infectious processes. VIEWPOINTS:A gain in accuracy occurred with the advent of hybrid PET/CT machines that combine the functional data from 18FDG-PET and the morphological data of computed tomography. Improved imaging protocols (eg. injection of iodinated contrast media) could further enhance the performance of PET-CT. Further improvements will rely on respiratory synchronization protocols and on the advent of new PET tracers. CONCLUSION:18F-FDG PET-CT should be performed for any nodule over 8 mm in size when the pre-test probability of malignancy is not deemed negligible.

journal_name

Rev Mal Respir

authors

Groheux D,Hindié E,Trédaniel J,Giraudet AL,Vaylet F,Berenger N,Moretti JL

doi

10.1016/s0761-8425(09)73531-4

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1041-55

issue

10

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(09)73531-4

journal_volume

26

pub_type

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