Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

Abstract:

:The prevalence of obesity and diabetes is epidemic. Severe insulin resistance (defined as the need for > or = 200 units of insulin per day to achieve glycemic control) is commonly seen with obesity and can complicate diabetes management. The management of patients with diabetes who have severe insulin resistance is difficult, and at times frustrating, and requires a multifaceted approach. Weight loss is the best treatment option, which can be a challenging task for patients to achieve and maintain. Medications that decrease insulin needs like metformin, thiazolidinediones, or pramlintide may help, but some patients also need high doses of insulin. This article reviews these different treatment options and provides practical advice on weight loss, use of insulin sensitizers, and use of U-500 insulin.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Brown A,Desai M,Taneja D,Tannock LR

doi

10.3810/pgm.2010.01.2110

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

163-71

issue

1

eissn

0032-5481

issn

1941-9260

journal_volume

122

pub_type

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