Antiproliferative effect of guava fruit extracts in MDA-MB-435 and MCF-7 human breast cancer cell lines.

Abstract:

:Breast cancer is the most frequent and lethal neoplastic disease among women worldwide. Psidium Guajava is a promising functional food against cancer, owing to a variety of bioactive compounds. This study aimed to evaluate the anticarcinogenic potential of Pedro Sato (PS), Hitigio (HI) and Tsumori (TS) guava cultivars fruit pulp extracts in MDA-MB-435 and MCF-7 human breast cancer cells. The antioxidant capacity of the extracts and their effect on cell viability, cell cycle and apoptosis were assessed. Additionally, the concentration of carotenoids, total phenolics, ascorbic acid and other physicochemical parameters were evaluated. PS pulp extract showed the highest in vitro antioxidative activity by all tested methods, as well as the highest content of lycopene and total phenolics, while TS pulp extract presented the highest concentration of β-carotene. After 48 hours treatment, all guava cultivars' extracts caused reduction of MDA-MB-435 and MCF-7 cells viability, with PS and HI being the most effective extracts. All guava extracts caused MDA-MB-435 and MCF-7 cell count reduction in G0/G1 and G2/M phases and increased apoptosis. The present results strongly suggest that guava pulp exerts antiproliferative effect on breast adenocarcinoma cells.

journal_name

An Acad Bras Cienc

authors

Correa MG,Couto JS,Trindade BB,Abreu JP,Nakajima VM,Oliveira FL,Farah A,Teodoro AJ

doi

10.1590/0001-3765202020191500

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

e20191500

issue

2

eissn

0001-3765

issn

1678-2690

pii

S0001-37652020000300914

journal_volume

92

pub_type

杂志文章
  • Sawdust Derivative for Environmental Application: Chemistry, Functionalization and Removal of textile dye from aqueous solution.

    abstract::The adsorption of Violet Remazol 5R (VR 5) on wood sawdust modified with succinic anhydride (SSA) as a function of contact time, pH, and initial dye concentrations was investigated using a batch technique under ambient conditions. The SSA obtained was confirmed by IR spectroscopy, thermogravimetry and 13C NMR, and deg...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140656

    authors: Pinto TF,Bezerra CW,Silva DS,Silva EC Filho,Vieira AP,Airoldi C,Melo JC,Silva HA,Santana SA

    更新日期:2016-09-01 00:00:00

  • Flavonoids from leaves of Derris urucu: assessment of potential effects on seed germination and development of weeds.

    abstract::In some previous studies, we described the isolation of nine compounds from leaves of Derris urucu, a species found widely in the Amazon rainforest, identified as five stilbenes and four dihydroflavonols. In this work, three of these dihydroflavonols [urucuol A (1), urucuol B (2) and isotirumalin (3)] were evaluated t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300004

    authors: Silva EA,Lôbo LT,Silva GA,Souza Filho AP,Da Silva MN,Arruda AC,Guilhon GM,Santos LS,Arruda MS

    更新日期:2013-09-01 00:00:00

  • Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research.

    abstract::Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX)...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020200435

    authors: Coelho CA,Bordelo JP,Camassa JA,Barros VA,Babo PS,Gomes ME,Reis RL,Azevedo JT,Requicha JF,FaÍsca P,Carvalho PP,Viegas CA,Dias IR

    更新日期:2020-12-07 00:00:00

  • Pseudophacopteron longicaudatum (Hemiptera) induces intralaminar leaf galls on Aspidosperma tomentosum (Apocynaceae): a qualitative and quantitative structural overview.

    abstract::The structural complexity of galls depends on species-specific interaction driven by the galling taxa. However, the host plant and environment stressors can impose limits on gall developmental patterns and impact the establishment of gall morphology. Herein, we employed qualitative and quantitative approaches in order...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181002

    authors: Oliveira DC,Martini VC,Moreira ASFP,Fuzaro L,GonÇalves LA

    更新日期:2020-10-19 00:00:00

  • The theorical-methodological construction of theses and dissertations and their epistemological problems.

    abstract::This essay discusses the problem of the lack of dialogue between theory/empirical reality in the construction of the theoretical structure of dissertations and doctorates in Human Sciences in Brazil; taking Geography as an example, Santos (2000) observed this problem, which persists at the national level. The proposal...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920171020

    authors: Gomes RD

    更新日期:2019-01-01 00:00:00

  • Biochemical and hematological analysis in acute intermittent porphyria (AIP): a case report.

    abstract::Acute intermittent porphyria is the most common acute porphyria caused by a decrease in hepatic porphobilinogen deaminase activity, resulting in an accumulation of delta-aminolevulinic acid and porphobilinogen. This disease shows nonspecific signs and symptoms that can be confused with other diseases, thereby making t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300019

    authors: Dos Santos AR,De Albuquerque RR,Doriqui MJ,Costa GC,Dos Santos AP

    更新日期:2013-09-01 00:00:00

  • Uncertainties Associated with Arithmetic Map Operations in GIS.

    abstract::Arithmetic map operations are very common procedures used in GIS to combine raster maps resulting in a new and improved raster map. It is essential that this new map be accompanied by an assessment of uncertainty. This paper shows how we can calculate the uncertainty of the resulting map after performing some arithmet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170589

    authors: Yamamoto JK,Kikuda AT,Rampazzo GJ,Leite CBB

    更新日期:2018-08-01 00:00:00

  • Penguins and their noisy world.

    abstract::Penguins identify their mate or chick by an acoustic signal, the display call. This identification is realized in a particularly constraining environment: the noisy world of a colony of thousands of birds. To fully understand how birds solve this problem of communication, we have done observations, acoustic analysis, ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652004000200015

    authors: Aubin T

    更新日期:2004-06-01 00:00:00

  • Seismic Stratigraphy of Pleistocene Deltaic Deposits in Bahía Blanca Estuary, Argentina.

    abstract::The Bahía Blanca estuary (Argentina) has a morphological configuration resulting from hydrological and sedimentary processes related to Late Quaternary sea level changes. This estuarine system occupies a large coastal plain with a dense net of tidal channels, low-altitude islands and large intertidal flats. Little is ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Aliotta S,Ginsberg SS,Giagante D,Vecchi LG,Salvatierra MM

    更新日期:2014-06-01 00:00:00

  • Trade-off between reservoir yield and evaporation losses as a function of lake morphology in semi-arid Brazil.

    abstract::This study investigates the relationships between yield and evaporation as a function of lake morphology in semi-arid Brazil. First, a new methodology was proposed to classify the morphology of 40 reservoirs in the Ceará State, with storage capacities ranging from approximately 5 to 4500 hm3. Then, Monte Carlo simulat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150124

    authors: Campos JN,Lima IE Neto,Studart TM,Nascimento LS

    更新日期:2016-05-31 00:00:00

  • Production of crispy bread snacks containing chicken meat and chicken meat powder.

    abstract::Chicken meat in two different forms (chicken meat and chicken meat powder) were added into white flour and whole wheat blend baguette bread formulations for protein enrichment and finally developing new and healthy snacks. The chicken meat and powder levels were 10% for white flour baguette, and 15% for whole wheat bl...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150059

    authors: Cakmak H,Altinel B,Kumcuoglu S,Kisla D,Tavman S

    更新日期:2016-10-01 00:00:00

  • Last millennium environmental changes and climate inferences in the Southeastern Atlantic forest, Brazil.

    abstract::This study presents paleoenvironmental data based on pollen, elemental and isotopic compositions of organic matter (TOC, N, δ(13)C and δ(15)N) and (14)C dating of 170 cm lake sediment record. Samplings have been made in Lagoa Grande at Parque Estadual Turístico do Alto Ribeira - PETAR, Southern São Paulo State, Southe...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652010000300019

    authors: Pessenda LC,Saia SE,Gouveia SE,Ledru MP,Sifeddine A,Amaral PG,Bendassolli JA

    更新日期:2010-09-01 00:00:00

  • Administering ascorbic acid to rats undergoing ageing processes: effects on myosin-V immunoreactive myenteric neurons.

    abstract::During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse t...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013005000002

    authors: Mello SA,Marese AC,Brancalhão RM,Zanoni JN,Natali MR

    更新日期:2013-03-01 00:00:00

  • Production of transgenic goat (Capra hircus) with human Granulocyte Colony Stimulating Factor (hG-CSF) gene in Brazil.

    abstract::In order to produce transgenic goats with hG-CSF, a total of 24 adult Saanen and 48 adult undefined breed goats were used as donors and recipients, respectively. Donors were estrus-synchronized with vaginal sponges and superovulated by a treatment with 200 mg FSH given twice daily in decreasing doses over 3 days start...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000400003

    authors: Freitas VJ,Serova IA,Andreeva LE,Dvoryanchikov GA,Lopes ES Jr,Teixeira DI,Dias LP,Avelar SR,Moura RR,Melo LM,Pereira AF,Cajazeiras JB,Andrade ML,Almeida KC,Sousa FC,Carvalho AC,Serov OL

    更新日期:2007-12-01 00:00:00

  • L(+) lactate dehydrogenase activity from the electric organ of Electrophorus electricus (L.).

    abstract::Properties of L(+) lactate dehydrogenase (LDH) of Electrophorus electricus (L.) electric organ were studied, comparing the substrates pyruvate and lactate. Electric organ LDH is a soluble enzyme with a pH optimum of 7.4 for pyruvate and 9.0 for lactate. The apparent Km was lower for pyruvate (Km = 2.5 X 10(-4) M) than...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Torres-da Matta J,Nery da Matta A,Hassón-Voloch A

    更新日期:1976-01-01 00:00:00

  • Entropy Generation Minimization Analysis of Active Magnetic Regenerators.

    abstract::A performance assessment of active magnetocaloric regenerators using entropy generation minimization is presented. The model consists of the Brinkman-Forchheimer equation to describe the fluid flow and coupled energy equations for the fluid and solid phases. Entropy generation contributions due to axial heat conductio...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160427

    authors: Trevizoli PV,Barbosa JR

    更新日期:2017-05-01 00:00:00

  • Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities.

    abstract::Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproli...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160725

    authors: Santos TLAD,Queiroz RF,Sawaya ACHF,Lopez BG,Soares MBP,Bezerra DP,Rodrigues ACBC,Paula VF,Waldschmidt AM

    更新日期:2017-01-01 00:00:00

  • Molecular characterization of Moenkhausia (Pisces: Characiformes) populations with different lateral line developmental levels.

    abstract::The genera Hemigrammus and Moenkhausia have been traditionally diagnosed mainly by the former having lateral line completely pored whereas the latter having a lateral line with a few pored scales. Those features have been used to diagnose species of both genera in the upper Paraná River floodplain. Specimens with the ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170493

    authors: Mota TFM,Fabrin TMC,Deprá GC,Gasques LS,Oliveira AV,Pavanelli CS,Prioli SMAP,Prioli AJ

    更新日期:2018-07-01 00:00:00

  • Antioxidant and antimicrobial potential of selected varieties of Piper betle L. (Betel leaf).

    abstract::Piper betle L., is an evergreen perennial creeper belonging to family Piperaceae and is known to possess numerous medicinal properties. Current study focuses on evaluating antioxidant and antimicrobial potential of betel leaf. For the present study, distilled water, hexane, acetone and ethanolic extracts of two variet...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180285

    authors: Sarma C,Rasane P,Kaur S,Singh J,Singh J,Gat Y,Garba U,Kaur D,Dhawan K

    更新日期:2018-10-01 00:00:00

  • The holoplankton of the Santa Catarina coast, southern Brazil.

    abstract::This paper presents information from different sampling surveys carried out along the Santa Catarina coast in order to outline the biogeographical characteristics of the zooplankton in this region and identify species or groups of species with potential use as bioindicators. Based on a checklist of species of the zoop...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652011000200017

    authors: Resgalla C Jr

    更新日期:2011-06-01 00:00:00

  • Effects of grape juice consumption on muscle fatigue and oxidative stress in judo athletes: a randomized clinical trial.

    abstract::Physiological levels of reactive oxygen species (ROS) are important for intracellular and extracellular redox regulation in signaling and defense processes. Strenuous exercise can also contribute to this imbalance, and the muscle fatigue, evidenced by impaired strength or power generation, can be caused by various rea...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,随机对照试验

    doi:10.1590/0001-3765202020191551

    authors: Goulart MJVC,Pisamiglio DS,MÖller GB,Dani C,Alves FD,Bock PM,Schneider CD

    更新日期:2020-11-20 00:00:00

  • First Assessment of Carbon Stock in the Belowground Biomass of Brazilian Mangroves.

    abstract::Studies on belowground roots biomass have increasingly reported the importance of the contribution of this compartment in carbon stock maintenance in mangrove forests. To date, there are no estimates of this contribution in Brazilian mangrove forests, although the country has the second largest area of mangroves world...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160496

    authors: Santos DMC,Estrada GCD,Fernandez V,Estevam MRM,Souza BT,Soares MLG

    更新日期:2017-07-01 00:00:00

  • First record of Spirocamallanus krameri (Nematoda: Camallanidae) in Brazil: Morphological review.

    abstract::This study aimed to describe the occurrence, morphology and prevalence of Spirocamallanus krameri, a parasite of Hoplerythrinus unitaeniatus collected in state of Pará, Brazil. The morphological and morphometric characteristics are consistent with the species S. krameri, by having a hexagonal mouth opening, 16 cephali...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020180721

    authors: Pinheiro RHS,Cardoso PJC,Monks S,Santos JN,Giese EG

    更新日期:2020-10-28 00:00:00

  • Splendid oddness: revisiting the curious trophic relationships of South American Pleistocene mammals and their abundance.

    abstract::The South American Pleistocene mammal fauna includes great-sized animals that have intrigued scientists for over two centuries. Here we intend to update the knowledge on its palaeoecology and provide new evidence regarding two approaches: energetics and population density and relative abundance of fossils per taxa. To...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201420120010

    authors: Fariña RA,Czerwonogora A,di Giacomo M

    更新日期:2014-03-01 00:00:00

  • Ecological affinities of Brazil and the southeastern United States of America. A study in comparative physiological ecology.

    abstract::Brazil and the southeastern United States have faunistic similarities and differences which are of fundamental interest to the environmental scientist. These similarities and differences provide natural experimental organisms and habitats which can provide answers to basic and applied questions. What are the lethal li...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Vernberg FJ,Vernberg WB

    更新日期:1976-01-01 00:00:00

  • The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.

    abstract::Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protect...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181088

    authors: Haiyuan YU,Shen X,Liu D,Hong M,Lu Y

    更新日期:2019-12-02 00:00:00

  • Assessment of scientific programs: a necessary procedure for Brazilian scientific policy--the Young Investigator Program of the State of São Paulo Research Foundation.

    abstract::Programs of Science and Technology research have grown significantly in Brazil over the last decades. Until the 1980s the so-called undirected programs, without specific goals and requiring only scientific merit, prevailed. The few programs with defined goals in this period were never objectively assessed. The same si...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000300014

    authors: Pian CA,Meneghini R

    更新日期:2007-09-01 00:00:00

  • Unenlagiinae revisited: dromaeosaurid theropods from South America.

    abstract::Over the past two decades, the record of South American unenlagiine dromaeosaurids was substantially increased both in quantity as well as in quality of specimens. Here is presented a summary review of the South American record for these theropods.Unenlagia comahuensis, Unenlagia paynemili, and Neuquenraptor argentinu...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652011000100009

    authors: Gianechini FA,Apesteguia S

    更新日期:2011-03-01 00:00:00

  • Strawberry (Fragaria X ananassa Duch.) yield as affected by the soil pH.

    abstract::Two-year trials (20062007) suggested that the use of calcium oxide (CaO) on acid soils increased soil pH and yields in strawberry cultivars Marmolada, Selena and Senga Sengana, under the environmental conditions of Cacak (Western Serbia). The highest yield was obtained when CaO was applied at 750 kg ha-1 rate. Further...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000200012

    authors: Milosevic TM,Milosevic NT,Glisic IP

    更新日期:2009-06-01 00:00:00

  • The complete amino acid sequence of the Vigna unguiculata (L.) Walp. seed trypsin and chymotrypsin inhibitor.

    abstract::The amino acid sequence of the "double-headed" trypsin and chymotrypsin inhibitor (BTCI), purified from the cowpea Vigna unguiculata (L.) Walp. cv "Seridó" was determined in our laboratory. Tryptic and chymotryptic peptides were sequenced by the Edman-Gray and Edman-Chang N-terminal manual method as well as the carbox...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Morhy L,Ventura MM

    更新日期:1987-01-01 00:00:00