Abstract：
:Topography at the nanoscale can lead to dramatic changes in the adhesion of cells to surfaces and their subsequent viability. For biological applications, including tissue engineering and cell-based sensing, the large internal surface area of ordered mesoporous carbons provides an opportunity for enhanced sensitivity and performance, but the mesostructure also affects the topography of the material. In this work, we probe the viability and adhesion of osteoblasts on ordered mesoporous materials with different morphologies and matrix chemistries. FDU-15 (hexagonal) and FDU-16 (cubic) films were processed at either 350 degrees C (polymeric) or 800 degrees C (carbon) to provide these different materials. For the films processed at 350 degrees C, the cell adhesion was markedly improved on the mesoporous films in comparison to a dense film analog, consistent with many reports in the literature that nanostructuring of surfaces improves the viability and adhesion of osteoblasts. Conversely, osteoblast adhesion was reduced on the carbonized surfaces processed at 800 degrees C when ordered mesopores were introduced, particularly for the cubic mesostructure (FDU-16). We attribute the decrease in cell adhesion to the propensity of the ordered mesoporous carbon films to sorb organics from aqueous solution, which could lead to removal of adhesion-promoting compounds at the film surface. These results suggest that cell viability on mesoporous polymer and carbon films can be controlled through simple changes in the pyrolysis temperature.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Chavez VL,Song L,Barua S,Li X,Wu Q,Zhao D,Rege K,Vogt BDdoi
10.1016/j.actbio.2010.02.005subject
Has Abstractpub_date
2010-08-01 00:00:00pages
3035-43issue
8eissn
1742-7061issn
1878-7568pii
S1742-7061(10)00066-8journal_volume
6pub_type
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pub_type： 杂志文章,评审
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journal_title：Acta biomaterialia
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更新日期：2013-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2018.07.041
更新日期：2018-09-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.05.009
更新日期：2007-11-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2008.03.005
更新日期：2008-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：Acta biomaterialia
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abstract：:The physical and mechanical properties of structural proteins such as silk fibroin can be modified by controlled conformational change, which is regularly monitored by Fourier transform infrared spectroscopy by peak fitting of the amide I band envelope. Although many variables affecting peak shape are well established...
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更新日期：2018-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
abstract：:Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironm...
journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
