Hemorrhage and intracranial hypertension in combination increase cerebral production of thromboxane A2.

abstract：OBJECTIVES:To determine whether contemporary β-lactam anti-infective dosing recommendations in critically ill children achieve concentrations associated with maximal anti-infective activity. The secondary objective was to describe the microbiological and clinical outcomes associated with β-lactam therapeutic drug manag...

journal_title：Critical care medicine

authors： Cies JJ,Moore WS 2nd,Enache A,Chopra A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Spread of multidrug-resistant organisms within the intensive care unit (ICU) results in substantial morbidity and mortality. Novel strategies are needed to reduce transmission. This study sought to determine if the use of daily chlorhexidine bathing would decrease the incidence of colonization and bloodstream...

journal_title：Critical care medicine

authors： Climo MW,Sepkowitz KA,Zuccotti G,Fraser VJ,Warren DK,Perl TM,Speck K,Jernigan JA,Robles JR,Wong ES

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To review current knowledge about cell-free hemoglobin solutions. DATA SOURCES:All studies involving cell-free hemoglobin were retrieved from a computerized MEDLINE search from 1980 to 1998. We also reviewed the reference lists of all available review articles and primary studies to identify references not f...

journal_title：Critical care medicine

authors： Creteur J,Sibbald W,Vincent JL

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To determine the specific effect of peak volume history pressure on the inflation limb of the pressure-volume curve and peak pressure-volume curve pressure on the deflation limb of the pressure-volume curve. DESIGN:Prospective assessment of pressure-volume curves in saline, lung lavage injured sheep. SETTIN...

journal_title：Critical care medicine

authors： Nishida T,Suchodolski K,Schettino GP,Sedeek K,Takeuch M,Kacmarek RM

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to identify which patient demographic, patient health, and hospital characteristics were associated with in-hospital mortality. A secondary objective was to determine the relative influence of these characteristics on mortality. DESIGN AND SETTING:Public-use data for ...

journal_title：Critical care medicine

authors： Banta JE,Joshi KP,Beeson L,Nguyen HB

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The demand for intensive care beds far exceeds their availability in many European countries. Consequently, many critically ill patients occupy hospital beds outside intensive care units, throughout the hospital. The outcome of patients who fit intensive care unit admission criteria but are hospitalized in re...

journal_title：Critical care medicine

authors： Simchen E,Sprung CL,Galai N,Zitser-Gurevich Y,Bar-Lavi Y,Gurman G,Klein M,Lev A,Levi L,Zveibil F,Mandel M,Mnatzaganian G

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To determine the long-term outcome of noninvasive ventilation in chronic obstructive pulmonary disease patients who refused intubation for acute hypercapnic respiratory failure. DESIGN:Prospective, observational study. SETTING:Noninvasive ventilation unit in an acute regional hospital in Hong Kong. METHODS...

journal_title：Critical care medicine

authors： Chu CM,Chan VL,Wong IW,Leung WS,Lin AW,Cheung KF

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation. DESIGN:Prospective, observational cohort study with patient recruitment over 26 months and follow-up for 1 yr. SETTING:Intensive care units at a tertiary care university hospital....

journal_title：Critical care medicine

authors： Chelluri L,Im KA,Belle SH,Schulz R,Rotondi AJ,Donahoe MP,Sirio CA,Mendelsohn AB,Pinsky MR

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To assess whether, in patients under mechanical ventilation, fluid responsiveness is predicted by the effects of short respiratory holds on cardiac index estimated by esophageal Doppler. DESIGN:Prospective, monocentric study. SETTING:Medical ICU. PATIENTS:Twenty-eight adult patients with acute circulatory...

journal_title：Critical care medicine

authors： Dépret F,Jozwiak M,Teboul JL,Alphonsine JE,Richard C,Monnet X

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Cocaine, which first made its appearance >1,000 yrs ago, is now widely used throughout the world. The physiologic responses to cocaine may cause severe pathologic effects. This review highlights the many critical care challenges resulting from these effects. DESIGN:Historical vignettes, epidemiologic factors...

journal_title：Critical care medicine

authors： Shanti CM,Lucas CE

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:Our primary goal was to evaluate the impact on in-hospital mortality rate of adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort of patients admitted to the intensive care unit (ICU) with sepsis. The impact of adequate empirical antibiotic therapy on early (<3 days...

journal_title：Critical care medicine

authors： Garnacho-Montero J,Garcia-Garmendia JL,Barrero-Almodovar A,Jimenez-Jimenez FJ,Perez-Paredes C,Ortiz-Leyba C

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Sepsis is a frequent cause of admission, but incidence rates based on administrative data have previously produced large differences in estimates. The aim of the study was to estimate the incidence of community-acquired sepsis based on patients' symptoms and clinical findings at arrival to the hospital. DESI...

journal_title：Critical care medicine

authors： Henriksen DP,Laursen CB,Jensen TG,Hallas J,Pedersen C,Lassen AT

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Procalcitonin may be associated with reduced antibiotic usage compared to usual care. However, individual randomized controlled trials testing this hypothesis were too small to rule out harm, and the full cost-benefit of this strategy has not been evaluated. The purpose of this analysis was to evaluate the ef...

journal_title：Critical care medicine

authors： Heyland DK,Johnson AP,Reynolds SC,Muscedere J

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To determine the incidence and characteristics of children with brain death in the pediatric intensive care unit (ICU), and to assess the incidence of the clinical triad (Turner's triad) of central diabetes insipidus, low glucose demand, and low CO2 production. DESIGN:Retrospective review of medical records...

journal_title：Critical care medicine

authors： Staworn D,Lewison L,Marks J,Turner G,Levin D

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:Although the development of ventilator-associated pneumonia (VAP) is assumed to increase costs of intensive care unit stay, it is unknown whether prevention of VAP by means of oropharyngeal decontamination is cost-effective. Because of wide ranges of individual patient costs, crude cost comparisons did not sh...

journal_title：Critical care medicine

authors： van Nieuwenhoven CA,Buskens E,Bergmans DC,van Tiel FH,Ramsay G,Bonten MJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:With decreasing mortality in PICUs, a growing number of survivors experience long-lasting physical impairments. Early physical rehabilitation and mobilization during critical illness are safe and feasible, but little is known about the prevalence in PICUs. We aimed to evaluate the prevalence of rehabilitatio...

journal_title：Critical care medicine

authors： Kudchadkar SR,Nelliot A,Awojoodu R,Vaidya D,Traube C,Walker T,Needham DM,Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. DESIGN:Pilot prospective, multicenter, randomized, controlled trial. SETTING:Six ICUs. PATIENTS:Critically ill adults mechanically ventilated for greater than 24 hours. INTERVENTIONS:Patients r...

journal_title：Critical care medicine

authors： Shehabi Y,Bellomo R,Reade MC,Bailey M,Bass F,Howe B,McArthur C,Murray L,Seppelt IM,Webb S,Weisbrodt L,Sedation Practice in Intensive Care Evaluation Study Investigators.,Australian and New Zealand Intensive Care Society Clinical

更新日期：2013-08-01 00:00:00

abstract：:Colloid osmotic pressure (COP) was measured simultaneously with cardiorespiratory measurements in 103 surgical patients suspected of having circulatory problems. In a small subset of 28 patients, measurements were taken before, during, and after surgical operations. Similarly, data sets were taken before, during, and ...

journal_title：Critical care medicine

authors： Shippy CR,Shoemaker WC

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVES:The impact of recruitment maneuvers on gas exchange, hemodynamics, alveolar recruitment, and hyperinflation is highly variable among patients with acute respiratory distress syndrome. The objective was to determine whether differences in lung morphology, defined as differences in the pulmonary distribution o...

journal_title：Critical care medicine

authors： Constantin JM,Grasso S,Chanques G,Aufort S,Futier E,Sebbane M,Jung B,Gallix B,Bazin JE,Rouby JJ,Jaber S

更新日期：2010-04-01 00:00:00

abstract：:Thromboembolic disease ranks among the most dangerous and common complication in the postoperative or post-traumatic patient. As previously mentioned, the incidence is increasing and fatalities from this complication have also risen substantially. The pathogenesis of thromboembolic disease and the predictability of it...

journal_title：Critical care medicine

authors： Evarts CM

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVES:To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time. DESIGN:Re...

journal_title：Critical care medicine

authors： Dennis JM,McGovern AP,Vollmer SJ,Mateen BA

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:Hepatic ischemia-reperfusion is a major clinical problem with limited treatment options. The pathophysiology of hepatic ischemia-reperfusion is characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 is an energy-sensing enzyme known to modulate mitochondrial biogenesis. We hypothe...

journal_title：Critical care medicine

authors： Khader A,Yang WL,Godwin A,Prince JM,Nicastro JM,Coppa GF,Wang P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The flow rate of a liquid drainage from the lungs is limited because of the elastic nature of the airways. This study was designed to clarify the relationship between intrapulmonary liquid volume and the development of the flow limitation or choked flow phenomenon as a function of expiratory flow rate during ...

journal_title：Critical care medicine

authors： Baba Y,Brant D,Brah SS,Grotberg J,Bartlett RH,Hirschl RB

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Therapeutic hypothermia has been used to attenuate the effects of traumatic brain injuries. However, the required degree of hypothermia, length of its use, and its timing are uncertain. We undertook a comprehensive meta-analysis to quantify benefits of hypothermia therapy for traumatic brain injuries in adult...

journal_title：Critical care medicine

authors： Crompton EM,Lubomirova I,Cotlarciuc I,Han TS,Sharma SD,Sharma P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND METHODS:Calcium-channel blockers may attenuate vasospasm after transient ischemia and improve organ blood flow after resuscitation. Our aim was to assess the effect of diltiazem on systemic oxygen delivery and consumption, hemodynamics, electroencephalogram (EEG), and organ blood flow after restoration o...

journal_title：Critical care medicine

authors： Lindner KH,Prengel AW,Ahnefeld FW,Ensinger H,Schürmann W

更新日期：1992-05-01 00:00:00

abstract：:A high rate of death from septic shock persists despite general improvements in care. The relative failure of mechanistically based therapies in various clinical trials should also trigger a reconsideration of such mechanistic approaches. Despite reversion of shock by hydrocortisone, the similar death rate compared wi...

journal_title：Critical care medicine

authors： Lukaszewicz AC,Payen D

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:To address the association between the 2003 heat wave in Paris (France) and the occurrence of out-of-hospital cardiac arrest. DESIGN:: An analysis of the interventions of the medical mobile intensive care units of the City of Paris for out-of-hospital cardiac arrest and prehospital myocardial infarctions, w...

journal_title：Critical care medicine

authors： Empana JP,Sauval P,Ducimetiere P,Tafflet M,Carli P,Jouven X

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The physicochemical approach, described by Stewart to investigate the acid-base balance, includes the strong ion gap (SIG), a quantitative measure of "unmeasured" anions, which strongly correlates to the corrected anion gap. The chemical nature of these anions is for the most part unknown. We hypothesized tha...

journal_title：Critical care medicine

authors： Moviat M,Terpstra AM,Ruitenbeek W,Kluijtmans LA,Pickkers P,van der Hoeven JG

更新日期：2008-03-01 00:00:00

abstract：:A difference between potassium concentrations in arterial plasma and venous serum was evaluated. The difference was 0.5 mM/litre, with a range of 0.1 to 1.1 mM/liter. Multiple factors operating primarily upon the venous sample are responsible for this difference. The value for arterial plasma potassium is stable and p...

journal_title：Critical care medicine

authors： Ward CF,Arkin DB,Benumof JL,Saidman LJ

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:To determine whether continuous gas flow in the breathing circuit or an airleak around the tracheal tube cuff will introduce errors into the measurement of oxygen consumption (VO2) with indirect calorimetry. DESIGN:Nonrandomized, controlled trial. SETTING:Experimental laboratory. SUBJECTS:Ten healthy, anes...

journal_title：Critical care medicine

authors： Räsänen J

更新日期：1992-09-01 00:00:00