Functional differences in insulin receptors in rat adipocyte and human placenta membranes.

abstract：:Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiol...

journal_title：Endocrinology

authors： Rettori V,Milenkovic L,Aguila MC,McCann SM

更新日期：1990-05-01 00:00:00

abstract：:PTH-related protein (PTHrP) is expressed in a stretch-responsive manner in several types of smooth muscle. We previously demonstrated the production of PTHrP in adult rat heart muscle. In this study, we demonstrate the production of PTHrP in the cardiovascular systems of several mammalian species, including human. We ...

journal_title：Endocrinology

authors： Burton DW,Brandt DW,Deftos LJ

更新日期：1994-07-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) improves glucose metabolism and growth in patients with leprechaunism. We investigated signal transduction through IGF-I receptor in comparison with epidermal growth factor (EGF) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprec...

journal_title：Endocrinology

authors： Takahashi Y,Tobe K,Kadowaki H,Katsumata D,Fukushima Y,Yazaki Y,Akanuma Y,Kadowaki T

更新日期：1997-02-01 00:00:00

abstract：:Myocardial fibrosis is a key pathological change in a variety of heart diseases contributing to the development of heart failure, arrhythmias, and sudden death. Recent studies have shown that relaxin prevents and reverses cardiac fibrosis. Endogenous expression of relaxin was elevated in the setting of heart disease; ...

journal_title：Endocrinology

authors： Gu HP,Lin S,Xu M,Yu HY,Du XJ,Zhang YY,Yuan G,Gao W

更新日期：2012-08-01 00:00:00

abstract：:Studies on hormone-receptor interactions generally assume that the formation of a hormone-receptor complex is a reversible process. This assumption has been examined directly in three experiments using liver membrane receptor preparations from pregnant rats and ovine PRL (oPRL). In Exp 1, Receptors were preincubated w...

journal_title：Endocrinology

authors： van der Gugten AA,Waters MJ,Murthy GS,Friesen HG

更新日期：1980-01-01 00:00:00

abstract：:Recent studies from our laboratory (Endocrinology 136:4762-4768, 1995) demonstrating that the expression of cAMP-dependent nuclear transcription factor CREB (cAMP response element binding protein) is lost following ovulation in macaques has revealed a novel mechanism by which the cytoplasmic and nuclear actions the cA...

journal_title：Endocrinology

authors： Benyo DF,Zeleznik AJ

更新日期：1997-08-01 00:00:00

abstract：:Hypophyseotropic dopamine exerts a tonic inhibitory tone on pituitary lactotrophs by the activation of dopamine D2 receptors (D2R). Ablation of D2R through gene knock-out approaches results in hyperprolactinemia and prolactinomas. This phenotype is more severe and develops more rapidly in female mice. We tested whethe...

journal_title：Endocrinology

authors： Hentges ST,Low MJ

更新日期：2002-12-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indic...

journal_title：Endocrinology

authors： Williams DL

更新日期：2009-07-01 00:00:00

abstract：:Prolactin (PRL) receptors are expressed in a broad range of human cell types and in a majority of human breast and prostate cancers. Experimentally, normal and malignant human cells are typically cultured in vitro in media containing bovine PRL (bPRL) from fetal bovine serum or as xenotransplants in vivo in the presen...

journal_title：Endocrinology

authors： Utama FE,Tran TH,Ryder A,LeBaron MJ,Parlow AF,Rui H

更新日期：2009-04-01 00:00:00

abstract：:The adrenal medulla contains fenestrated capillaries that allow catecholamines and neuropeptides secreted by adrenal chromaffin cells (ACCs) to readily access the circulation. These capillaries may also allow bacterial products to enter the adrenal medulla and interact with ACCs during infection. One potential mediato...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2013-01-01 00:00:00

abstract：:This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...

journal_title：Endocrinology

authors： Foster DL,Ebling FJ,Claypool LE,Woodfill CJ

更新日期：1988-09-01 00:00:00

abstract：:Modulation of activin and other TGF beta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). However, most studies of these ligands use activin A due to its wide availability. We have now tested the ability of FS288 and FSTL-3 to bind and neutralize activin B rela...

journal_title：Endocrinology

authors： Schneyer A,Schoen A,Quigg A,Sidis Y

更新日期：2003-05-01 00:00:00

abstract：:In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be en...

journal_title：Endocrinology

authors： Zdanowicz MM,Moyse J,Wingertzahn MA,O'Connor M,Teichberg S,Slonim AE

更新日期：1995-11-01 00:00:00

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal blood. Using alert, normally behaving, ovariectomized ewes, we sampled hypophyseal portal blood at 10-min intervals beginni...

journal_title：Endocrinology

authors： Battaglia DF,Bowen JM,Krasa HB,Thrun LA,Viguié C,Karsch FJ

更新日期：1997-10-01 00:00:00

abstract：:We hypothesized the existence of vagal arginine sensors in the liver which modulate arginine-induced pancreatic hormone secretion. The present study was carried out to examine the efferent pathways and receptor mechanisms from arginine sensors using selective vagotomies and autonomic drugs on the secretion of insulin ...

journal_title：Endocrinology

authors： Tanaka K,Inoue S,Nagase H,Takamura Y

更新日期：1990-10-01 00:00:00

abstract：:Aggression enables individuals to obtain and retain limited resources. Studies of the neuroendocrine regulation of aggression have focused on territorial and reproductive contexts. By contrast, little is understood concerning the neuroendocrine regulation of aggression over other resources, such as food. Here, we deve...

journal_title：Endocrinology

authors： Fokidis HB,Prior NH,Soma KK

更新日期：2013-11-01 00:00:00

abstract：:To elucidate the metabolic fate and possible role of androgens and their derivatives during primate fetal development, aromatase (AROM), 5 alpha-reductase (5 alpha R), and androgen receptor (AR; cytosolic) levels were assessed in the brain, heart (HRT), lung (LNG), and skeletal muscle (MUS) of fetal rhesus monkeys. An...

journal_title：Endocrinology

authors： Sholl SA,Goy RW,Kim KL

更新日期：1989-02-01 00:00:00

abstract：:Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...

journal_title：Endocrinology

authors： Tsuchida K,Vaughan JM,Wiater E,Gaddy-Kurten D,Vale WW

更新日期：1995-12-01 00:00:00

abstract：:Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4 measurements, but qWestern is technically complex and labor intensiv...

journal_title：Endocrinology

authors： Yang Q,Eskurza I,Kiernan UA,Phillips DA,Blüher M,Graham TE,Kahn BB

更新日期：2012-03-01 00:00:00

abstract：:Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...

journal_title：Endocrinology

authors： Coste SC,Heldwein KA,Stevens SL,Tobar-Dupres E,Stenzel-Poore MP

更新日期：2001-08-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is specifically and reversibly bound by particulate fractions from adrenals from fetal calves and lambs. These binding sites appear to be located primarily in the adrenal medulla and have properties very similar to those which we have detected in adult human, bovine, and ovine adrenal medulla. ...

journal_title：Endocrinology

authors： Karaplis AC,Powell WS

更新日期：1981-12-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:In seasonal species, various physiological processes including reproduction are organized by photoperiod via melatonin, but the mechanisms of melatonin action are still unknown. In birds, the peptide gonadotropin-inhibiting hormone (GnIH) has been shown to have inhibitory effects on reproductive activity and displays ...

journal_title：Endocrinology

authors： Revel FG,Saboureau M,Pévet P,Simonneaux V,Mikkelsen JD

更新日期：2008-03-01 00:00:00

abstract：:The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal ca...

journal_title：Endocrinology

authors： Prosser CG,Sankaran L,Hennighausen L,Topper YJ

更新日期：1987-04-01 00:00:00

abstract：:A1/A2 noradrenergic neurons in the medulla oblongata are well known to mediate stress signals in the central nervous system. Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH. On the other hand, PRL-releasing peptide (PrRP) was recently isolate...

journal_title：Endocrinology

authors： Maruyama M,Matsumoto H,Fujiwara K,Noguchi J,Kitada C,Fujino M,Inoue K

更新日期：2001-05-01 00:00:00

abstract：:Insulin-like growth factor (IGF) action in the brain is modulated by IGF-binding proteins (IGFBPs) whose abundance can be altered by other locally expressed growth factors. However, the mechanisms involved are unclear. We here employed the neuroblastoma cell line SK-N-MC as a model to define the mechanisms involved in...

journal_title：Endocrinology

authors： Russo VC,Rekaris G,Baker NL,Bach LA,Werther GA

更新日期：1999-07-01 00:00:00

abstract：:We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB(1)) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA) axis with respect to both gender and time of day. Blood samples were collected from conscious male and female rats every 5 min using an automated blood sampli...

journal_title：Endocrinology

authors： Atkinson HC,Leggett JD,Wood SA,Castrique ES,Kershaw YM,Lightman SL

更新日期：2010-08-01 00:00:00

abstract：:Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are present in brain regions regulating LH secretion. Similarities in the molecular structure of these peptides suggest similar physiological function within the brain. This study examined the effects of centrally administered BNP and ANP on LH secre...

journal_title：Endocrinology

authors： Zhang J,Yuen BH,Currie WD,Leung PC

更新日期：1991-08-01 00:00:00