Abstract:
:Brain-Derived Neurotrophic Factor (BDNF) is a neuropeptide that plays an important role in Central Nervous System development, plasticity, learning, and memory. Its role has been explored in alcohol-dependent patients, though the results have been inconclusive. Thus, we aimed to compare serum BDNF levels in alcohol-dependent patients during withdrawal with age and gender matched controls, and assess changes in BDNF levels in the initial abstinence period. BDNF levels of alcohol-dependent patients (n = 25) were compared with controls (n = 25) at baseline. Additionally, BDNF levels were measured in cases on days 5 and 10 of inpatient detoxification. BDNF levels of controls did not differ with cases on day 1, 5, or 10. But BDNF levels increased significantly during alcohol abstinence from baseline to day 10 (Pillai's Trace F = 3.753, p = .039, partial η2 = 0.246), which may suggest its protective role. Thus, serum BDNF values may be potentially used as a biomarker to assess the abstinence state. However, longitudinal studies in different body samples is essential to better understand the role of BDNF in alcohol dependence.
journal_name
J Psychoactive Drugsjournal_title
Journal of psychoactive drugsauthors
Kethawath SM,Jain R,Dhawan A,Sarkar S,Kumar Mdoi
10.1080/02791072.2020.1795327subject
Has Abstractpub_date
2020-11-01 00:00:00pages
440-446issue
5eissn
0279-1072issn
2159-9777journal_volume
52pub_type
杂志文章abstract::Long-term use of opioid analgesics can lead to addiction and opioid-related death. We aimed to present the pattern of long-term opioid utilization and identify factors associated with it by using group-based trajectory modeling. We used the nationwide health insurance claims database from 2009 to 2013. Multinomial log...
journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1996.10471710
更新日期:1996-01-01 00:00:00
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
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更新日期:2000-01-01 00:00:00
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journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
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journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
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更新日期:2020-12-07 00:00:00
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journal_title:Journal of psychoactive drugs
pub_type: 历史文章,杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of psychoactive drugs
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journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
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