Abstract:
:The aim of the study was to investigate whether lifestyle factors modify the association between fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed using FTO SNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated with FTO SNP rs9939609 (p = 0.001 and p = 0.002, respectively) and GRS (p = 0.002 and p = 0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (Pinteraction = 0.027 and Pinteraction = 0.044, respectively). Our study has demonstrated that the association between FTO SNPs and central obesity might be modified by lifestyle factors in this Turkish population.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Isgin-Atici K,Alsulami S,Turan-Demirci B,Surendran S,Sendur SN,Lay I,Karabulut E,Ellahi B,Lovegrove JA,Alikasifoglu M,Erbas T,Vimaleswaran KS,Buyuktuncer Zdoi
10.1080/09637486.2020.1802580subject
Has Abstractpub_date
2020-08-04 00:00:00pages
1-11eissn
0963-7486issn
1465-3478pub_type
杂志文章abstract::The objective of the present investigation was to study the relationship between breakfast consumption and subjective reports of mental health and health-related behaviours in a general population sample (126 subjects aged between 20 and 79 years). Individuals who consumed a cereal breakfast each day were less depress...
journal_title:International journal of food sciences and nutrition
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