Abstract:
BACKGROUND:Accurate assessment of therapeutic response in patients with brain abscess (BA) is essential to direct appropriate therapy. This study was performed with an aim to see the treatment-induced changes in diffusion tensor imaging (DTI) indices (i.e., fractional anisotropy [FA] and mean diffusivity [MD]) in follow-up patients with BA after treatment. METHODS:Twenty patients with BA were prospectively studied in this study. Diffusion tensor imaging in first follow-up was done in all after 1 week and in 6 at 4 weeks of the initial study. RESULTS:The mean FA and MD values in first, second, and third studies were 0.28 +/- 0.03 and (0.81 +/- 0.07) x 10(-3) mm(2)/s, 0.18 +/- 0.09 and (1.08 +/- 0.09) x 10(-3) mm(2)/s, and 0.13 +/- 0.04 and (0.99 +/- 0.13) x 10(-3) mm(2)/s, respectively. The FA value was significantly (P < .01) decreased along with no significant change in MD value (P = .08) for 3 study periods. The mean volume (in milliliter) of the abscesses was 2.14 +/- 1.04, 1.34 +/- 0.45, and 0.77 +/- 0.14 in first, second, and third studies, respectively. CONCLUSIONS:We conclude that the reduction in FA value reflects the down-regulation of the neuroinflammatory molecules in response to treatment in patient with BA and may be used to assess therapeutic response in these patients in future.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Nath K,Ramola M,Husain M,Kumar M,Prasad K,Gupta Rdoi
10.1016/j.surneu.2009.04.003subject
Has Abstractpub_date
2010-01-01 00:00:00pages
63-8; discussion e6issue
1eissn
1878-8750issn
1878-8769pii
S0090-3019(09)00351-6journal_volume
73pub_type
临床试验,杂志文章abstract:BACKGROUND:Head computed tomography (CT) with perfusion imaging has become crucial in the selection of patients for mechanical thrombectomy. In recent years, machine learning has rapidly evolved and found applications in a wide variety of health care tasks. We report our initial experiences with training a neural netwo...
journal_title:World neurosurgery
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.wneu.2015.03.059
更新日期:2015-09-01 00:00:00
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更新日期:2010-04-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.wneu.2017.06.023
更新日期:2017-09-01 00:00:00
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更新日期:2020-02-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:World neurosurgery
pub_type: 传,历史文章,杂志文章
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更新日期:2013-07-01 00:00:00
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更新日期:2015-12-01 00:00:00