Abstract：
BACKGROUND:Delusional disorder is an uncommon psychotic disorder. The first-line treatments for this chronic and resistant condition are antipsychotic medications, usually associated with several side effects that can exacerbate poor adherence. Conversely, aripiprazole is a well-tolerated antipsychotic drug that is effective in the treatment of other psychotic disorders. Here, we aimed to systematically review and summarize the currently available literature to evaluate the effectiveness and tolerability of aripiprazole in delusional disorders. METHODS:A comprehensive literature search from inception until February 2020 was performed in PubMed, Cochrane Database of Systematic Reviews, and Scopus databases using The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RESULTS:We identified 21 single cases of delusional disorders, mostly somatic type, treated with aripiprazole. All studies reported patient clinical improvements after the beginning of the treatment with aripiprazole. The average dose of aripiprazole was 11.1 mg/day, and the average time to achieve a clinical response was 5.7 weeks. Few adverse effects were reported, including asthenia, extrapyramidal symptoms, hyperprolactinemia, and insomnia. CONCLUSIONS:Our findings suggest that aripiprazole may be an effective treatment for delusional disorders with good tolerability. Further studies comparing aripiprazole with other antipsychotics in the treatment of delusional disorders are needed.
journal_name
Gen Hosp Psychiatryjournal_title
General hospital psychiatryauthors
Miola A,Salvati B,Sambataro F,Toffanin Tdoi
10.1016/j.genhosppsych.2020.06.012subject
Has Abstractpub_date
2020-01-01 00:00:00pages
34-43eissn
0163-8343issn
1873-7714pii
S0163-8343(20)30096-7journal_volume
66pub_type
杂志文章,评审abstract：:Little is known about which factors may adversely affect response to psychotherapy in diabetic patients with major depression. We studied the relationship of various demographic, diabetes, and depression characteristics to change in depression in 42 patients with type 2 diabetes who completed a randomized clinical tri...
journal_title：General hospital psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0163-8343(98)00039-5
更新日期：1998-09-01 00:00:00
abstract：:This paper reports on the results of a pilot study comparing the efficacy of an experimental case review program between psychiatrists and primary care physicians (PCPs) with PCPs' usual care on the outcome of depressive disorders at 1-year. The secondary aim of the paper is to identify correlates of remission of depr...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(01)00182-7
更新日期：2002-03-01 00:00:00
abstract：:Psychotic symptoms and cognitive fluctuation are common manifestations of dementia with Lewy bodies (DLB). However, the differentiation of these symptoms is difficult because many psychiatric, neurologic, and medical conditions in addition to drug effects can mimic DLB in elderly people. We report on an 83-year-old wo...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.10.015
更新日期：2014-03-01 00:00:00
abstract：:The self-inflicted dermatoses, namely dermatitis artefacta, neurotic excoriations, and trichotillomania, have been reported to be associated with various degrees of psychopathology in the dermatologic literature, but have received surprisingly little emphasis in the psychiatric literature. This probably reflects, firs...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(87)90101-0
更新日期：1987-01-01 00:00:00
abstract：:A 63-year-old married man with idiopathic terminal cardiomyopathy was admitted to the medical service for treatment of advanced heart failure. A psychiatric consultation was requested to assist the medical treatment team in dealing with the patient's abusive behavior. The case is presented and discussed within the con...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(92)90099-v
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVE:Losing an infant or fetus late in pregnancy, during birth or in the first year of life is a potentially traumatic event for parents. However, little is known about the factors contributing to chronic posttraumatic stress reactions in this population. The present study examined chronic posttraumatic stress dis...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.06.006
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Optimism is prospectively and independently associated with superior cardiac outcomes, but there has been minimal study of optimism-specific interventions in persons with cardiovascular illness. We aimed to examine the feasibility and impact of an optimism-promoting program among patients with heart disease i...
journal_title：General hospital psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.genhosppsych.2017.12.004
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:There is widespread concern about access to good quality health care for ethnic minority groups. This study investigates differences between ethnic groups regarding prevalence of anxiety and depression, and adherence to treatment guidelines by family practitioners in urban areas in the Netherlands. METHOD:Da...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2010.04.010
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:Thyroid dysfunction is common during pregnancy and the postpartum period and is known to cause psychiatric disturbances. A woman with Graves' disease and psychosis in the postpartum period is described. METHODS:A 22-year-old woman with Graves' disease developed fluctuating orientation, catatonia, delusions o...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence of depression among otolaryngology patients with medically unexplained symptoms (MUS) and the outcome of treatment with selective serotonin reuptake inhibitors (SSRIs). METHOD:Ninety patients with MUS from a population of 983 consecutive otolaryngology outpatients were enrolled....
journal_title：General hospital psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.genhosppsych.2011.09.014
更新日期：2012-03-01 00:00:00
abstract：:Despite its relevance for quality care initiatives, the field of psychiatry has little scientific knowledge regarding the course of current major depression when primary care patients with the disorder remain undetected. Using statewide telephone screening, we identified and followed 98 adults with current major depre...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/s0163-8343(97)00095-9
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:Although breast cancer patients' depression changes over time, most longitudinal studies have assessed the influence of only baseline depression on quality of life (QoL). Therefore, this study investigated the influence of changes in depression status on QoL in the year after surgery. METHODS:Participants we...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2017.09.009
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Psychological morbidity in both patients and family members related to the intensive care unit (ICU) experience is an often overlooked, and potentially persistent, healthcare problem recognized by the Society of Critical Care Medicine as Post-intensive Care Syndrome (PICS). ICU diaries are an intervention in...
journal_title：General hospital psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.genhosppsych.2020.06.017
更新日期：2020-01-01 00:00:00
abstract：:A number of reports have suggested that some cases of multiple personality disorder might be due to temporal lobe epileptic discharges. We have administered a structured interview, the Dissociative Disorders Interview Schedule, to 20 subjects with multiple personality disorder, 20 with complex partial seizures, and 28...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(89)90026-1
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:In recent years, patients' preferences concerning treatment of emotional distress in general and of depression in particular have received more emphasis in the clinical setting as well as in research. METHODS:The treatment preferences of 607 primary care patients were assessed in a cross-sectional study usin...
journal_title：General hospital psychiatry
pub_type： 评论,杂志文章
doi：10.1016/j.genhosppsych.2005.10.001
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:Catatonia is classically associated with psychiatric conditions but may occur in medical and neurologic disorders. Status epilepticus (SE) is a seizure lasting more than five minutes or two or more seizures within a five-minute period without interictal recovery of consciousness. Non-convulsive status epil...
journal_title：General hospital psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.genhosppsych.2020.11.008
更新日期：2021-01-01 00:00:00
abstract：:The author reviews moral arguments supporting a right to medical care, as well as empirical data concerning the effects of mental illness on society, and explores their relevance to a rights-based claim to mental health care. He concludes that there is ample ethical justification for a right to mental health care, giv...
journal_title：General hospital psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0163-8343(99)00047-x
更新日期：2000-01-01 00:00:00
abstract：:Suicidal behavior is disproportionately frequent among inner-city Hispanic adolescent girls. In an attempt to generate a multifactorial set of hypotheses to explain this behavior, 33 such subjects consecutively admitted for suicidal behavior and 15 demographically identical nonsuicidal subjects were assessed by means ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(91)90009-l
更新日期：1991-01-01 00:00:00
abstract：:Posterior reversible encephalopathy syndrome (PRES) is known to be caused by a variety of clinical disorders. The authors encountered a case of PRES associated with acute pancreatitis and chronic alcoholism. A 49-year-old man presented with altered mental status. Magnetic resonance imaging (MRI) displayed vasogenic ed...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2014.12.004
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Hospital crowding is a public health problem that may impact on the quality of medical treatment and increase the risk of developing traumatic stress, e.g., after myocardial infarction (MI). This study examines whether subjective appraisal of crowding at hospital admission due to MI is associated with acute s...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2015.11.004
更新日期：2016-03-01 00:00:00
abstract：:Of growing concern has been the phenomenon of psychoactive chemicals legally marketed as a variety of products such as "bath salts" or "herbal incense." There is little in the formal literature about actual adverse effects of such chemicals. We have two cases of a paranoid psychosis in individuals consuming methylened...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2011.04.010
更新日期：2011-11-01 00:00:00
abstract：:This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patients. Patients were recruited from a variety of primary care prac...
journal_title：General hospital psychiatry
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/s0163-8343(99)00023-7
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:We investigated the influence of race/ethnicity in diagnostic and disposition decision-making for children and adolescents presenting to an urban psychiatric emergency service (PES). METHOD:Medical records were reviewed for 2991 child and adolescent African-American, Hispanic/Latino and white patients, treat...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2008.01.003
更新日期：2008-05-01 00:00:00
abstract：:There is still a striking lack of homogeneity in the terminology and classifications used in the registration of psychiatric consultation-liaison (C-L) data. Nowadays, the need for standardization of C-L data is greater than ever. Each registration consists of two components: the items and their categories. The presen...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(88)90064-3
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:Individuals with borderline personality disorder (BPD) consistently demonstrate high patterns of utilization in both mental health and non-psychiatric settings. However, utilization of primary care physicians by these individuals has not been examined. In this study, we examined physician use patterns and hyp...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2011.04.006
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:Previous epidemiologic studies have documented a link between anxiety disorders and ulcer among adults. Few studies have examined these associations over time and little is understood about the pathways underlying these relationships. METHOD:Data were drawn from n = 2101 adult participants in the Midlife Dev...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2014.07.005
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:This prospective study aimed to estimate the prevalence and course of depression during chemotherapy in women with Stage I-III breast cancer, identify potential risk factors for depression and determine which treatments for depression were being used and which were most preferred. METHOD:Thirty-two women wer...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2013.03.017
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:Patients with acute-on-chronic liver failure (ACLF) experience long-term chronic liver diseases plus an acute liver function decompensation. This study aimed to determine whether psychological symptoms in patients with hepatitis B virus (HBV)-related ACLF differ from those with other chronic liver diseases a...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2011.11.012
更新日期：2012-05-01 00:00:00
abstract：:Many general hospitals are confronting issues of financial strain precipitated to a large extent by Medicare payment reductions. The viability of psychiatry programs within general hospitals more than ever depends upon some demonstration of their financial as well as clinical contribution. The aim of this study is to ...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/0163-8343(91)90035-u
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:This study investigated pediatrician-reported practices in identifying, assessing, and treating traumatic exposure and posttraumatic stress disorder (PTSD) in children. METHOD:Focus groups guided the development of a survey that was mailed to primary care pediatricians in Massachusetts in 2005. Descriptive s...
journal_title：General hospital psychiatry
pub_type： 杂志文章
doi：10.1016/j.genhosppsych.2008.07.008
更新日期：2008-11-01 00:00:00
