Anxiety disorders and risk of self-reported ulcer: a 10-year longitudinal study among US adults.

Abstract:

OBJECTIVE:Previous epidemiologic studies have documented a link between anxiety disorders and ulcer among adults. Few studies have examined these associations over time and little is understood about the pathways underlying these relationships. METHOD:Data were drawn from n = 2101 adult participants in the Midlife Development in the United States I and II. Data on ulcer diagnoses were collected through self-report: among participants in the current sample, 38 reported ulcer at Waves 1 and 2 (prevalent ulcer), and 18 reported ulcer at Wave 2 but not at Wave 1 (incident ulcer). Panic attacks and generalized anxiety disorder at Wave 1 (1994) were examined in relation to prevalent (past 12 months) and incident ulcer approximately 10 years later at Wave 2 (2005). RESULTS:Anxiety disorders at Wave 1 were associated with increased prevalence of ulcer [odds ratio (OR) = 4.1, 95% confidence interval (CI) = 2.0-8.4], increased risk of incident ulcer at Wave 2 (OR = 4.1, 95% CI = 1.4-11.7) and increased risk of treated ulcer at Wave 2 (OR = 4.7, 95% CI = 2.3-9.9) compared with those without anxiety. CONCLUSIONS:In this large population sample of adults, anxiety disorders were associated with an increased risk of ulcer over a 10-year period. These relationships do not appear to be explained by confounding or mediation by a wide range of factors. Future studies should address potential mechanisms underlying the relationship between anxiety and ulcer.

journal_name

Gen Hosp Psychiatry

authors

Taha F,Lipsitz JD,Galea S,Demmer RT,Talley NJ,Goodwin RD

doi

10.1016/j.genhosppsych.2014.07.005

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

674-9

issue

6

eissn

0163-8343

issn

1873-7714

pii

S0163-8343(14)00174-1

journal_volume

36

pub_type

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