Acceleration of tensile strength of incisions treated with EGF and TGF-beta.

Abstract:

:The ability of surgeons to accelerate wound healing through pharmacologic intervention is limited. The effects of locally applied, biosynthetic human epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) on tensile strength of experimental incisions were investigated. A single dose of EGF in saline failed to increase tensile strength over controls. Thus, EGF was incorporated into multilamellar liposomes, which prolonged the exposure of incisions to EGF (p less than 0.001). A single dose of EGF in multilamellar liposomes produced a 200% increase in wound tensile strength over controls between 7 and 14 days (p less than 0.05). Light and electron microscopy of the wounds revealed increased collagen formation and fibroblast proliferation. A single dose of TGB-beta in a collagen vehicle stimulated a 51% increase in wound tensile strength at 9 days (p less than 0.01). We conclude that addition of EGF and TGF-beta in appropriate vehicles stimulates early transient increases in wound tensile strength in normal rats.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Brown GL,Curtsinger LJ,White M,Mitchell RO,Pietsch J,Nordquist R,von Fraunhofer A,Schultz GS

doi

10.1097/00000658-198812000-00019

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

788-94

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

208

pub_type

杂志文章
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    authors: Mehtsun WT,Papanicolas I,Zheng J,Orav EJ,Lillemoe KD,Jha AK

    更新日期:2018-04-01 00:00:00

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    abstract:OBJECTIVE:The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease. SUMMARY BACKGROUND DATA:In the absence of esophageal mucosal injury, the diagnosis of ga...

    journal_title:Annals of surgery

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    doi:10.1097/00000658-199710000-00013

    authors: Oberg S,Peters JH,DeMeester TR,Chandrasoma P,Hagen JA,Ireland AP,Ritter MP,Mason RJ,Crookes P,Bremner CG

    更新日期:1997-10-01 00:00:00

  • Surgical management of carcinoma of the junction of the main hepatic ducts.

    abstract::Twenty-six patients are reviewed who had primary carcinomas involving the junction of the hepatic ducts. The majority had had an initial procedure of palliative biliary diversion elsewhere and were referred for further treatment. In three cases, en bloc resection of the tumor with total hepatectomy and orthotopic live...

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    doi:10.1097/00000658-197607000-00012

    authors: Fortner JG,Kallum BO,Kim DK

    更新日期:1976-07-01 00:00:00

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    authors: Ku Y,Iwasaki T,Fukumoto T,Tominaga M,Muramatsu S,Kusunoki N,Sugimoto T,Suzuki Y,Kuroda Y,Saitoh Y,Sako M,Matsumoto S,Hirota S,Obara H

    更新日期:1998-04-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00004

    authors: Knaus WA,Draper EA,Wagner DP,Zimmerman JE

    更新日期:1985-12-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Bauer T,Vennits B,Holm B,Hahn-Pedersen J,Lysen D,Galatius H,Kristensen ES,Graversen P,Wilhelmsen F,Skjoldborg H

    更新日期:1989-03-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Pedrazzoli S,DiCarlo V,Dionigi R,Mosca F,Pederzoli P,Pasquali C,Klöppel G,Dhaene K,Michelassi F

    更新日期:1998-10-01 00:00:00

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    journal_title:Annals of surgery

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    更新日期:2011-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001298

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    更新日期:2016-02-01 00:00:00

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    更新日期:2015-02-01 00:00:00

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  • Biostatistical basis of elective node dissection for malignant melanoma.

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    doi:10.1097/00000658-197707000-00014

    authors: Fortner JG,Woodruff J,Schottenfeld D,Maclean B

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    doi:10.1097/00000658-198407000-00013

    authors: Thomas M,Otis SM,Rush M,Zyroff J,Dilley RB,Bernstein EF

    更新日期:1984-07-01 00:00:00

  • Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group.

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    pub_type: 杂志文章,多中心研究

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    authors: Gronchi A,Strauss DC,Miceli R,Bonvalot S,Swallow CJ,Hohenberger P,Van Coevorden F,Rutkowski P,Callegaro D,Hayes AJ,Honoré C,Fairweather M,Cannell A,Jakob J,Haas RL,Szacht M,Fiore M,Casali PG,Pollock RE,Raut CP

    更新日期:2016-05-01 00:00:00

  • Tumor-infiltrating Neutrophils is Prognostic and Predictive for Postoperative Adjuvant Chemotherapy Benefit in Patients With Gastric Cancer.

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    更新日期:2018-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1989-04-01 00:00:00

  • Hepatic abscess in patients with chronic granulomatous disease.

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  • Smartphone-Based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study.

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    pub_type: 杂志文章

    doi:10.1097/00000658-197511000-00004

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    更新日期:1975-11-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1996-04-01 00:00:00

  • Fresh frozen plasma supplement to massive red blood cell transfusion.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198510000-00010

    authors: Martin DJ,Lucas CE,Ledgerwood AM,Hoschner J,McGonigal MD,Grabow D

    更新日期:1985-10-01 00:00:00

  • Cytology of peritoneal lavage performed during staging laparoscopy for gastrointestinal malignancies: is it useful?

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00005

    authors: Dudrick SJ,Daly JM,Castro G,Akhtar M

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    doi:10.1097/00000658-198907000-00009

    authors: Nubiola P,Badia JM,Martinez-Rodenas F,Gil MJ,Segura M,Sancho J,Sitges-Serra A

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