Effect of long-term triphasic oral contraceptive use on glucose tolerance and insulin secretion.

Abstract:

:This study was designed to compare the effects of two low-dose triphasic oral contraceptives (OCs) on glucose tolerance and insulin secretion. Fifty-seven women were randomized to receive OCs containing ethinyl estradiol and either levonorgestrel or norethindrone. Ten subjects using nonhormonal contraception served as controls. Glucose tolerance and insulin secretion were measured at baseline and at 6 and 12 months after an oral glucose stimulus. Both preparations produced a relative hyperglycemia at 6 and 12 months compared with baseline, but within the norms for glucose tolerance. The insulin response, measured in 48 treated and eight control subjects, also increased over 12 months in both treated groups, but the total insulin area was within the range of the reference laboratory. Such minor changes have not been associated with cardiovascular diseases and support the safety of low-dose triphasic preparations.

journal_name

Obstet Gynecol

authors

Gillespy M,Notelovitz M,Ellingson AB,Khan FY

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

108-14

issue

1

eissn

0029-7844

issn

1873-233X

journal_volume

78

pub_type

临床试验,杂志文章,随机对照试验
  • Active and passive cigarette smoking and the risk of cervical neoplasia.

    abstract:OBJECTIVE:Evidence links active cigarette smoking to cervical neoplasia, but much less is known about the role of passive smoking. Using a prospective cohort design, we examined personal cigarette smoking and household passive smoke exposure in relation to the risk of cervical neoplasia. METHODS:Cohorts were establish...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000148268.43584.03

    authors: Trimble CL,Genkinger JM,Burke AE,Hoffman SC,Helzlsouer KJ,Diener-West M,Comstock GW,Alberg AJ

    更新日期:2005-01-01 00:00:00

  • Preeclampsia and Long-term Risk of Maternal Retinal Disorders.

    abstract:OBJECTIVE:To evaluate whether preeclampsia is associated with risk of maternal retinal disease in the decades after pregnancy. METHODS:We carried out a longitudinal cohort study of 1,108,541 women who delivered neonates in any hospital in Quebec, Canada, between 1989 and 2013. We tracked women for later hospitalizatio...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001758

    authors: Auger N,Fraser WD,Paradis G,Healy-Profitós J,Hsieh A,Rhéaume MA

    更新日期:2017-01-01 00:00:00

  • Pulmonary edema following ritodrine-saline infusion in premature labor.

    abstract::Twenty-three patients with premature uterine contractions occurring between the 27th and 35th weeks of pregnancy were treated in a prospective and randomized study with intravenous ritodrine in a 0.1 wt/vol% solution of isotonic saline (N = 12) or isotonic glucose (N = 11). The aim of the study was to record the effec...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Philipsen T,Eriksen PS,Lynggård F

    更新日期:1981-09-01 00:00:00

  • Early-onset preeclampsia and the prevalence of postpartum metabolic syndrome.

    abstract:OBJECTIVE:To determine the prevalence of the metabolic syndrome postpartum in women with a history of pregnancy complicated by early-onset vascular disorders compared with women with late-onset disorders. METHODS:In this retrospective cohort study 849 women with a history of pregnancy complicated by vascular disorders...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181b7b242

    authors: Stekkinger E,Zandstra M,Peeters LLH,Spaanderman MEA

    更新日期:2009-11-01 00:00:00

  • Treatment of common gynecologic-endocrinologic symptoms by allergy management procedures.

    abstract::The technique of managing allergies by optimum-dose (provocative neutralization) testing and treatment using aqueous progesterone has been studied in 132 women having progesterone-related symptoms due to the menstrual cycle, pregnancy, or exogenous hormone administration. When extremely small doses of progesterone (0....

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Mabray CR,Burditt ML,Martin TL,Jaynes CR,Hayes JR

    更新日期:1982-05-01 00:00:00

  • Changes in thyroid function tests during danazol therapy.

    abstract::Danazol is a synthetic steroid with antigonadotropic properties useful in treating endometriosis, especially in young infertile women. Prior to its availability for clinical use in September 1976, thyroid function studies other than thyroid-stimulating hormone (TSH), which was normal, had not been reported. Soon after...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198003000-00028

    authors: Graham RL,Gambrell RD Jr

    更新日期:1980-03-01 00:00:00

  • Fostering harmony in labor and delivery: a nursing preceptorship for clinical clerks.

    abstract:OBJECTIVE:The relationship between the specialized nurses of the Labor and Delivery Suite and the medical students who are rotating through the unit as clinical clerks has traditionally been a poor one. The objective of this project was to develop a program which pairs medical students with nurse preceptors to improve ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000223202.04393.2a

    authors: Skoll MA,Dueckman R,Liston R

    更新日期:2006-07-01 00:00:00

  • Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy.

    abstract:OBJECTIVE:To investigate whether pregnancy-induced regulatory T cells are generated specifically for paternal antigens or expanded by hormonal changes and to study regulatory T cell-related mechanisms during pregnancy. METHODS:We used murine models of normal, abortion-prone, and pseudopregnancy to characterize regulat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000284625.10175.31

    authors: Schumacher A,Wafula PO,Bertoja AZ,Sollwedel A,Thuere C,Wollenberg I,Yagita H,Volk HD,Zenclussen AC

    更新日期:2007-11-01 00:00:00

  • Factors predisposing to and outcome of gestational diabetes.

    abstract::Two hundred thirteen women with abnormal glucose tolerance tests (GTTs) were diagnosed over 9 years by a screening program involving the total antenatal population. Each subject was matched for age, parity, and ethnic group with a control. The gestational diabetics were subdivided into classes A1 or A2 based on the fa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Maresh M,Beard RW,Bray CS,Elkeles RS,Wadsworth J

    更新日期:1989-09-01 00:00:00

  • Risk factors for adult paternity in births to adolescents.

    abstract:OBJECTIVE:To examine the risk factors for adult (aged 20 years and older) paternity in births to teenagers (14-17 years of age). METHODS:This was a population-based, retrospective cohort analysis of 27,215 adolescent mothers residing in California who had a live singleton birth during 1993. Adjusted risks for adult pa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/S0029-7844(96)00481-4

    authors: Taylor D,Chavez G,Chabra A,Boggess J

    更新日期:1997-02-01 00:00:00

  • Verrucous carcinoma of the vulva associated with an unusual type 6 human papillomavirus.

    abstract::An unusually rapid growing vulvar verrucous carcinoma found associated with human papillomavirus type 6 is described. Both human papillomavirus structural antigens and deoxyribonucleic acid (DNA) sequences were detected in the tumor biopsy. The human papillomavirus genome was isolated and compared with the genome of h...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198603001-00021

    authors: Rando RF,Sedlacek TV,Hunt J,Jenson AB,Kurman RJ,Lancaster WD

    更新日期:1986-03-01 00:00:00

  • Urethral closure pressure and leak-point pressure in incontinent women.

    abstract:OBJECTIVE:To examine the association between maximum urethral closure pressure and Valsalva leak-point pressure in women with genuine stress incontinence (GSI). METHODS:Fifty-six women with GSI were evaluated in a urodynamics laboratory. Maximum urethral closure pressure and vesical leak-point pressure were measured w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(95)00263-Q

    authors: Sultana CJ

    更新日期:1995-11-01 00:00:00

  • Prevalence of anal incontinence in women with symptoms of urinary incontinence and genital prolapse.

    abstract:OBJECTIVE:To investigate risk factors and prevalence of anal incontinence among women with pelvic floor dysfunctions. METHODS:We evaluated 881 women with symptoms of urinary incontinence and/or genital prolapse. Each completed a bowel questionnaire and underwent a detailed medical, surgical, obstetric, and gynecologic...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(02)02215-9

    authors: Meschia M,Buonaguidi A,Pifarotti P,Somigliana E,Spennacchio M,Amicarelli F

    更新日期:2002-10-01 00:00:00

  • Pregnancy outcome after intra-abdominal bleeding due to placenta percreta at 14 weeks of gestation.

    abstract:BACKGROUND:With the rising rate of cesarean deliveries, the rate of placenta previa and placenta percreta will rise concomitantly resulting in a greater incidence of severe complications. CASE:This case report describes a pregnancy with a massive intra-abdominal bleeding due to placenta percreta at 14 weeks of gestati...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000254168.73160.21

    authors: Roeters AE,Oudijk MA,Heydanus R,Bruinse HW

    更新日期:2007-02-01 00:00:00

  • Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial.

    abstract:OBJECTIVE:To assess the effect of low-dose mifepristone on quality of life, pain, bleeding, and uterine size among women with symptomatic leiomyomata. METHODS:Forty-two women with symptomatic uterine leiomyomata and uterine volume of 160 mL or more were randomized to mifepristone, 5 mg daily, or placebo for 26 weeks. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000243776.23391.7b

    authors: Fiscella K,Eisinger SH,Meldrum S,Feng C,Fisher SG,Guzick DS

    更新日期:2006-12-01 00:00:00

  • Endogenous creatinine clearance during pregnancy. Part I. Methodologic considerations.

    abstract::The effect of noncreatinine chromogens on the endogenous creatinine clearance (ECC) during pregnancy was investigated. It was found that these chromogens measured as plasma "creatinine" cause a significant reduction in the ECC value. This fact should be considered when the ECC value is used to evaluate renal function ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Abdul-Karim RW,Harris JE,Beydoun SN,Cuenca VG

    更新日期:1976-08-01 00:00:00

  • Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up.

    abstract::A 21-year-old white woman presented with virilization, hirsutism, and acne of 1.5 years' duration. Endocrine testing demonstrated complete suppression of serum testosterone, from 5.3 to 0.6 ng/mL, and serum androstenedione, from 4.7 to 1.7 ng/mL, after oral administration of 50 micrograms of mestranol and 1 mg of nore...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Haning RV Jr,Loughlin J,Shapiro SS

    更新日期:1989-05-01 00:00:00

  • Academic manpower for obstetrics and gynecology in the United States.

    abstract::All 119 medical schools in the United States provided information for a study of academic manpower conducted by the Association of Professors of Gynecology and Obstetrics (APGO). The average number of full-time faculty members per medical school is 13.2, with 2 positions vacant per school. Subspecialists are concentra...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Messer RH,Pearse WH,Fielden JG

    更新日期:1979-05-01 00:00:00

  • Oncogene expression: long-term compared with short-term survival in patients with advanced epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine if oncogene overexpression in patients with advanced epithelial ovarian cancer correlates with survival. METHODS:Twenty-two women with stage III ovarian cancer, observed for a median of 66 (range 48-204) months were compared with 30 with a median survival of 18 (range 2-28) months. Using immunoc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(98)00121-5

    authors: Goff BA,Muntz HG,Greer BE,Tamimi HK,Gown AM

    更新日期:1998-07-01 00:00:00

  • Landry Guillain-Barré Strohl syndrome in pregnancy: report of three cases treated with plasmapheresis.

    abstract::Landry Guillain-Barré Strohl syndrome complicating pregnancy is a rare occurrence, with only 31 cases previously reported in the obstetric literature. Cytomegalovirus as a potential etiologic agent has been documented in only two of these cases. In the past, symptomatic treatment of pregnant patients with severe and p...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hurley TJ,Brunson AD,Archer RL,Lefler SF,Quirk JG Jr

    更新日期:1991-09-01 00:00:00

  • Look before you leap: genomic screening in obstetrics and gynecology.

    abstract::There are a number of new genetic tests and a variety of recommendations for obstetrician-gynecologists. In recent years, screening of low-risk pregnant women with noninvasive prenatal testing has been proposed as well as universal BRCA1 and BRCA2 screening of all women regardless of risk status. Both proposed genetic...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000871

    authors: Adams MC,Berg JS,Pearlman MD,Vora NL

    更新日期:2015-06-01 00:00:00

  • Social factors affecting treatment of cervical cancer: ethical issues and policy implications.

    abstract::Health care in the United States has become a privilege rather than a right. Patients who have the greatest need are the ones most likely to be denied this privilege. Despite recent advances in disease detection and treatment, many patients do not receive even the bare minimum of care. The high complexity of the healt...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e318165f1a9

    authors: Westin SN,Bustillos D,Gano JB,Fields MM,Coker AL,Sun CC,Ramondetta LM

    更新日期:2008-03-01 00:00:00

  • Ulipristal Acetate for Treatment of Uterine Leiomyomas: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To assess the efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas. METHODS:This phase 3, double-blind, double-dummy, placebo-controlled trial randomized premenopausal women (18-50 years) with uterine leiomyomas and abno...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/AOG.0000000000002942

    authors: Liu JH,Soper D,Lukes A,Gee P,Kimble T,Kroll R,Mallick M,Chan A,Gillard P,Harrington A,Sniukiene V,Shulman LP

    更新日期:2018-11-01 00:00:00

  • Counterregulatory hormonal responses to hypoglycemia during pregnancy.

    abstract:OBJECTIVE:To evaluate the counterregulatory responses to insulin-induced hypoglycemia in healthy women and in women with insulin-dependent diabetes during pregnancy and in the nonpregnant state. METHODS:Hypoglycemia was induced using the hypoglycemic clamp technique in 17 women with insulin-dependent diabetes and in t...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(95)00495-5

    authors: Rosenn BM,Miodovnik M,Khoury JC,Siddiqi TA

    更新日期:1996-04-01 00:00:00

  • The management of severe toxemia in patients at less than 36 weeks' gestation.

    abstract::Fifty-five patients at less than 36 weeks' gestation with severe toxemia were treated conservatively. The pregnancies were continued for a mean duration of 19.2 days and the mean gestation at delivery was 35.2 weeks. Fifty-three percent of the deliveries were by cesarean section. Of the neonates, 56.5% showed severe i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Martin TR,Tupper WR

    更新日期:1979-11-01 00:00:00

  • Discordant middle cerebral artery peak systolic velocity Doppler studies in a fetus with RhD alloimmunization.

    abstract:BACKGROUND:Doppler measurement of the fetal middle cerebral artery peak systolic velocity is a valuable tool in detecting the presence of fetal anemia in Rh-sensitized pregnancies. We present a case in which discordant left and right middle cerebral artery Dopplers complicated clinical management. CASE:An RhD-alloimmu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000263463.09931.40

    authors: Berkley EM,Rappaport VJ,Hurley TJ

    更新日期:2007-08-01 00:00:00

  • A prospective study investigating the mechanism of thrombocytopenia in preeclampsia.

    abstract::Hemostatic and platelet function studies were performed prospectively on 61 preeclamptic patients and 24 healthy pregnant control patients to delineate possible causes of thrombocytopenia in preeclampsia. Thrombocytopenia occurred in 50% of the preeclamptic patients, and was accompanied by qualitative platelet defects...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Burrows RF,Hunter DJ,Andrew M,Kelton JG

    更新日期:1987-09-01 00:00:00

  • Immunologic thrombocytopenic purpura and pregnancy: six new cases.

    abstract::Six new cases of idiopathic thrombocytopenic purpura (ITP) associated with pregnancy are reported; one of these patients delivered triplets. In addition, 78 patients with 122 pregnancies and 124 fetuses have been reported previously. The maternal mortality rate was 4% and the fetal mortality rate was 18%. Prior recomm...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-197805000-00018

    authors: O'Reilly RA,Taber BZ

    更新日期:1978-05-01 00:00:00

  • Is the Papanicolaou smear useful for diagnosing sexually transmitted diseases?

    abstract::To examine the validity of cervical cytologic diagnosis of sexually transmitted diseases, we reviewed the literature and calculated the efficacy of the Papanicolaou smear as a diagnostic technique. The predictive value of a positive test varied widely, but was generally higher for Trichomonas vaginalis (0.81-1.00) tha...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Roongpisuthipong A,Grimes DA,Hadgu A

    更新日期:1987-05-01 00:00:00

  • Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation.

    abstract:OBJECTIVE:To estimate the incidence of occult uterine sarcoma and leiomyosarcoma in hysterectomies for leiomyomas and the risk associated with their morcellation. METHODS:We conducted a population-based cohort study. All uterine sarcomas from 2006-2013 in an integrated health care system were identified. Age- and race...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000001187

    authors: Raine-Bennett T,Tucker LY,Zaritsky E,Littell RD,Palen T,Neugebauer R,Axtell A,Schultze PM,Kronbach DW,Embry-Schubert J,Sundang A,Bischoff K,Compton-Phillips AL,Lentz SE

    更新日期:2016-01-01 00:00:00