Abstract：
:There are a number of new genetic tests and a variety of recommendations for obstetrician-gynecologists. In recent years, screening of low-risk pregnant women with noninvasive prenatal testing has been proposed as well as universal BRCA1 and BRCA2 screening of all women regardless of risk status. Both proposed genetic screening tests raise complicated issues relating to predictive value, cost, and consequences after screening to both the health care system as a whole as well as serious potential adverse consequences for the patient. In addition, there are significant barriers relating to clinician education in proper use of these genetic tests as well as logistic issues of performing adequate genetic counseling in a busy general practice. We recommend that pregnant women offered noninvasive prenatal testing be informed of its advantages and disadvantages compared with standard screening with the caveat that positive noninvasive prenatal tests must be confirmed with further, invasive testing. We recommend against population genetic screening of all women for BRCA1 and BRCA2 mutations until there are comprehensive data regarding harms and benefits as well as cost-effectiveness. Finally, we recommend that new educational models for genetics be developed for obstetrics and gynecology residency training so that future health care providers will be prepared for the opportunities and challenges that genetic testing creates.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Adams MC,Berg JS,Pearlman MD,Vora NLdoi
10.1097/AOG.0000000000000871subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1299-1305issue
6eissn
0029-7844issn
1873-233Xpii
00006250-201506000-00006journal_volume
125pub_type
杂志文章abstract：OBJECTIVE:To estimate the prevalence of group B streptococci (GBS) colonization in a subsequent pregnancy in women with and without GBS colonization in an index pregnancy. METHODS:A retrospective cohort study of women who had two consecutive deliveries with the availability of GBS culture result at 35 to 37 weeks of g...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31817f5cb9
更新日期：2008-08-01 00:00:00
abstract：:A retrospective review of placental material derived primarily from preterm deliveries was conducted and inflammatory changes graded on a scale of 0-3. Reviewers were blind as to the clinical outcomes. Other reviewers, unaware of the pathologic results, surveyed the clinical data, and results were combined for analysi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:Case-control studies begin at the end. Two groups of patients, those with disease (cases) and those without (controls), are compared to determine the degree of exposure to a presumed risk factor. This research method is commonly used to study rare diseases or diseases that take years to develop. If a higher proportion...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:To assess total time for evaluation of women with first-trimester pregnancy concerns in an early pregnancy unit compared with an emergency department (ED) within a single safety net hospital system. METHODS:We performed a retrospective cohort study at Denver Health Medical Center from May 1, 2017, to April 3...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000004080
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Postpartum uterine scar dehiscence is a rare but potentially lethal complication of cesarean deliveries. CASE:Concurrent abdominal and uterine dehiscences after cesarean delivery for arrest of descent with chorioamnionitis occurred in a 16-year-old patient after her first delivery. The uterine and fascia in...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31821619e9
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Heterotopic pregnancy is a rare event in natural conception cycles. Diagnosis of heterotopic pregnancy requires a high index of suspicion. Described herein is a reported case of a heterotopic pregnancy presenting as hematometra. CASE:A young, multiparous woman, with her last menstrual period 6 weeks before ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000142698.17433.cd
更新日期：2004-11-01 00:00:00
abstract：:Preterm birth is the leading cause of neonatal mortality and a substantial portion of all birth-related short- and long-term morbidity. Spontaneous preterm labor is responsible for more than half of preterm births. Its management is the topic of this review. Although there are many maternal characteristics associated ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0029-7844(02)02212-3
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To characterize long-term national trends in surgical approach for hysterectomy after the U.S. Food and Drug Administration (FDA) warning against power morcellation for laparoscopic specimen removal. METHODS:This was a descriptive study using data from the American College of Surgeons National Surgical Quali...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000003181
更新日期：2019-04-01 00:00:00
abstract：:Fetal oxytocin contribution to the mother during spontaneous labor was investigated using a specific and sensitive radioimmunoassay to measure oxytocin in blood, amniotic fluid, and urine. In 26 subjects with spontaneous labor and vaginal delivery (Group I) and 18 subjects with cesarean section after labor (Group II),...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Burkitt lymphoma during pregnancy is a rare event, and outcomes have been poor. However, few patients were treated by current standards, with nearly half receiving single-agent cyclophosphamide or no chemotherapy. CASE:A patient with Burkitt lymphoma presenting at 11 6/7 weeks' gestation was treated with su...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0029-7844(98)00282-8
更新日期：1998-10-01 00:00:00
abstract：:As the surgical approach for ectopic pregnancies evolves from radical to conservative procedures, the potential hazard of persistent ectopic pregnancy has become increasingly pertinent. From September 1, 1986 to August 31, 1989, 11 women with persistent ectopic pregnancy after laparoscopic salpingostomy were diagnosed...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:To facilitate extraction and avoid intra-abdominal spillage during laparoscopic removal of adnexal masses, various designs and sizes of endopouches (bags) have been used. We describe a simple technique using a special laparoscopic bag that requires no additional instruments to hold, open, or close the bag. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Postoperative bleeding may be complicated by failure to identify the site of bleeding, multiple bleeding points, and persistent hemorrhage despite surgical intervention. CASE:Activated recombinant factor VII was used successfully in a patient with life-threatening postsurgical bleeding after resection of tw...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:To determine whether planned anterior vaginotomy is a logical and safe means of avoiding a uterine scar with term abdominal delivery. I recorded the complications of the technique and whether vaginal birth after anterior vaginotomy occurred. Thirteen anterior vaginotomies were done when the vagina had advanced during ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(96)00209-8
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To compare amniotic fluid index (AFI) with the single deepest pocket in the identification of actual abnormal amniotic fluid (AF) volumes. METHODS:One hundred seventy-nine women with singleton pregnancies at the University of Mississippi between March 1994 and June 1999 had ultrasound estimations of AF volum...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)01020-6
更新日期：2000-11-01 00:00:00
abstract：:Short-term oral steroid therapy was used to treat a capillary hemangioma of the vagina and urethra in a young child. After 8 weeks of prednisolone therapy (40 mg every other day decreasing to 2.5 mg every other day), vaginal bleeding has not recurred. At 2 years and 8 months, the patient presented with severe hematuri...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：:A double-blind placebo-controlled experiment was performed in 100 patients in labor with membrane rupture to determine the bacteriologic effects of antibiotic prophylaxis. Each subject received either 2.0 g cefamandole or placebo after cord clamping and 4 and 8 hours later. The cefamandole group had significantly less...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：:There is growing recognition of the importance and potential benefit of information technology and electronic medical records in providing quality care for women. Incorporation of obstetrician-gynecologist-specific requirements by electronic medical record vendors is essential to achieve appropriate electronic medical...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181e1328c
更新日期：2010-07-01 00:00:00
abstract：:Three cases of mucinous carcinoma of the endometrium are presented. These can be distinguished anatomically from endocervical carcinomas and histochemically from endometrial clear cell carcinomas. Clinically these patients do not differ significantly from others with endometrial carcinoma, but the tumors produce large...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-02-01 00:00:00
abstract：BACKGROUND:Transurethral bladder eversion is rare. A case of transurethral bladder eversion with concurrent uterovaginal prolapse is presented. CASE:The patient was postmenopausal, had a long history of uterovaginal prolapse, and developed bladder eversion. Examination under anesthesia revealed full-thickness transure...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(01)01669-6
更新日期：2002-05-01 00:00:00
abstract：:Two hundred seven high-risk patients were studied prospectively by standardized nonstressed fetal heart rate monitoring followed immediately by contraction stress testing (CST). Of the 604 combined procedures examined, 90.2% of nonstress tests (NST) were interpreted as reactive; none was associated with a positive CST...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:This Committee Opinion is being revised to provide updated guidance on the management of pregnant women during pregnancy and delivery to prevent mother-to-child transmission of the human immunodeficiency virus (HIV). Prevention of transmission of HIV from the woman to her fetus or newborn is a major goal in the care o...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,实务指引
doi：10.1097/AOG.0000000000002821
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To identify the effect of human immunodeficiency virus (HIV) infection on the clinical course of pelvic inflammatory disease (PID). METHODS:Women hospitalized with PID at an urban hospital serving a population at high risk for HIV were studied cross-sectionally. Data abstracted from medical records of 349 wo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(96)00387-0
更新日期：1997-01-01 00:00:00
abstract：:The rising cesarean birth rate is a matter of national concern, and the goal of clinical obstetricians is to contain this trend while maintaining good maternal and perinatal outcome. Despite published reports suggesting that excellent perinatal outcome can be achieved with modest cesarean birth rates, the general incr...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Granulosa and theca cell tumors are rather common gonadal stromal tumors. A postmenopausal patient with a granulosa cell tumor, who complained chiefly of breast tenderness and enlarging, abdomen, is presented. Preoperative and postoperative studies including serum estrone, estradiol, prolactin, FSH, and LH,as well as ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:The author recounts her recent "high-risk" pregnancy. She relates the feelings experienced by many women in this situation, with the added insights of a certified nurse midwive. The author observes how these insights can be applied by health professionals who deliver care to expectant families. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the cumulative probability of regret after tubal sterilization, and to identify risk factors for regret that are identifiable before sterilization. METHODS:We used a prospective, multicenter cohort study to evaluate the cumulative probability of regret within 14 years after tubal sterilization. P...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0029-7844(98)00539-0
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To estimate the safety of fertility-conserving surgery for stage IA1 cervical cancer and to analyze predictors of access to conization. METHODS:We analyzed women with stage IA1 cervical cancer aged 40 years or younger who were diagnosed between 1988 and 2005 and recorded in the Surveillance, Epidemiology, an...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181d06b68
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To examine current levels, current correlates of, and changes in long-acting reversible contraceptive (LARC) use, including intrauterine devices and implants, among females aged 15-44 years using contraception between 2008-2010 and 2011-2013 with specific attention to associations between race, income, and ag...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001094
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the relationship among gestational age at elective cesarean delivery, neonatal intensive care unit (NICU) admission, and whether the presence of pre-cesarean delivery labor or ruptured membranes affected the incidence of neonatal respiratory distress. METHODS:A chart review was performed of all e...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31816736e7
更新日期：2008-04-01 00:00:00
