Abstract:
:The pathomechanism of diabetic neuropathy remains still poorly understood, however, a broad spectrum of novel findings associated with therapeutic consequences emerged during the last decades. Both disturbed function of primary hemostasis and increased activity of coagulation system contribute to the reduced endoneurial blood flow. Increased superoxide anion production induced by hyperglycemia leads to decreased activity of glycerinaldehid-3-phosphate dehydrogenase and to consequential increased activity of alternative pathways, including the polyol-, hexosamine-, diacilglycerol protein kinase-C- and advanced glycation pathways. Advanced glycation endproducts increase the activity of the nuclear-factor kappa-B, as well as the production of vasoactive factors and cytokines (interleukin-1, -6, tumor necrosis factor alpha). The aim of pathogenetic oriented treatment is to slow down, stop or reverse the progression of neuropathy. Components of pathogenetic oriented treatment are glycaemic control, management of risk factors, benfotiamine and alpha-lipoic acid. On one hand, transketolase-activator benfotiamine inhibits alternative pathways induced by hyperglycemia (the polyol-, hexosamine-, diacilglycerol protein kinase-C-, and advanced glycation pathways), while, on the other hand, it increases the activity of the pentose-phosphate-shunt. The clinical effectiveness of benfotiamine has been shown in many international and Hungarian trials. Alpha-lipoic acid as a powerful antioxidant decreases oxidative stress and this way increases the activity of glycerinaldehid-3-phosphate dehydrogenase. Alpha-lipoic acid administered in infusion or oral treatment decreases both symptoms of neuropathy and neuropathic deficit. In conclusion, the case of diabetic neuropathy illustrates well, how widening of our knowledge on pathogenesis might contribute to successful therapy.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Winkler G,Kempler Pdoi
10.1556/OH.2010.28898subject
Has Abstractpub_date
2010-06-13 00:00:00pages
971-81issue
24eissn
0030-6002issn
1788-6120pii
1H633K5177555307journal_volume
151pub_type
杂志文章,评审相关文献
ORVOSI HETILAP文献大全abstract::In some patients with functioning thyroid autonomous nodules preclinical hyperthyroidism is detected. It is important to know, whether in this intermediate clinical state beside the suppression of pituitary TSH secretion other target organs are also affected by serum free-thyroxine and free-triiodothyronine levels sti...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1991-09-08 00:00:00
abstract::Left ventricular aneurysm had detected at the 55-year-old woman after extensive anterior myocardial infarction in association with progressive ventricular dilatation and symptoms of heart failure. Coronary angiogram revealed a serious lesion in the proximal segment of the left anterior descending coronary branch with ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-08-08 00:00:00
abstract::The case of a bilateral total knee arthroplasty in a hemophiliac patient is presented below. Postoperative blood loss, required factor substitution, complications after surgery were observed. Functional results were evaluated using the Hospital for Special Surgery Score. The pathophysiology of hemophilic arthropathy i...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-05-21 00:00:00
abstract::During the first 3 months of the full-time lactation the level of the lipid and lipoprotein fractions does not change in the mother's blood. The levonorgestrel contraceptive pills taken during the lactation do not influence considerably the lipid-metabolism either. There is only one minute deviation in the levonorgest...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-02-09 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, is originated from the interstitial cells of Cajal. As a sign of malignancy, intestinal tumors particularly tend to metastasize, primarily in the abdominal cavity and in the liver. The authors present a gastrointe...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2005-01-30 00:00:00
abstract::Authors give a brief description of a case of adult polycystic disease of the lung which was diagnosed by chest X-ray, real-time abdominal ultrasound and fluoroscopy. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:INTRODUCTION:The accreditation system for health care providers was developed in Hungary aiming to increase safety, efficiency, and efficacy of care and optimise its organisational operation. AIM:The aim of this study was to assess changes of organisational culture in pilot institutes of the accreditation program. ME...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2016.30556
更新日期:2016-10-01 00:00:00
abstract::The article summarises the statistical data of bone marrow transplantation (BMT) carried out in Hungary between 1990-1995 in yearly distribution. Since the first BMT up to the end of 1995, 168 BMT were performed. The number of transplantations since 1990 to our days was gradually increasing. As a result of this activi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-10-06 00:00:00
abstract::In 10th district of Budapest a longitudinal, epidemiological examination was started in 1975 with the aim of analysis of the objective factors influencing the population screening and determination of possibilities of screening effectiveness. It was found that effectiveness of lung cancer detection with screening depe...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1989-07-30 00:00:00
abstract::A computer-based data processing was made at 6762 motor handicapped children. The data were obtained by questionnaires about the health status, educational, social level and rehabilitation of these children. The authors could state the use of therapeutical equipment, the further need for rehabilitation--specialists an...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-05-02 00:00:00
abstract::Összefoglaló. Gyógyszereink egy részének jelentős, az eredeti alkalmazástól eltérő hatása is van. Ezek felismerése fontos, hogy elkerüljük a nem várt mellékhatásokat, vagy kihasználjuk ezeket a kedvező adottságokat. A helyi érzéstelenítők antibakteriális hatása 1909 óta ismert, de ennek több évtizeden keresztül nem tu...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2021.32002
更新日期:2021-01-31 00:00:00
abstract::Introduction: Subtotal petrosectomy (STP) has been known for decades and it is considered being on the borderline between ear and skull-base surgery. Due to its excessive radicalism and adverse effects on hearing, it has been a forgotten surgical technique until recently. Over the last decade, due to its many benefits...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2020.31691
更新日期:2020-04-01 00:00:00
abstract::Aim of the present work was the development of a mechanic cell separation protocol for gastrointestinal biopsy analysis. Evaluation of the technique was performed on selected group of patients who underwent routine endoscopy. Routine gastrointestinal biopsies were obtained after informed consent. 23 gastric (6 healthy...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-04-09 00:00:00
abstract::Seven children with albinism were examined for haemorrhagic diathesis. In 6 patients coagulation screening tests (prothrombin time, activated partial thromboplastin time, thrombin time) were normal, in 1 patient prolongation of activated partial thromboplastin time due to mild factor XI deficiency was found. Platelet ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1997-02-23 00:00:00
abstract::Cervical regional lymphadenectomy, also known as neck dissection, is a fundamental procedure in head and neck surgery. Its evolution over 110 years resulted in a great deal of confusion in the literature and in clinical practice, due to the heterogenicity in training, classification and surgical techniques, which make...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2016.30570
更新日期:2016-11-01 00:00:00
abstract::The author summarizes the most effective types of glaucoma surgery in advanced glaucoma. In high pressure advanced glaucoma a low target intraocular pressure is to be set. The most effective method of reaching this target pressure level is mitomycin C trabeculectomy combined with effective pre- and postoperative antii...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2013.29801
更新日期:2013-12-29 00:00:00
abstract::Introduction: Cytokeratin-18 (CK-18) is releasing into the blood during systemic cell death due to ischemia-reperfusion injury after cardiac arrest. Its caspase-cleaved form is specific to apoptosis. Previous investigations proved their prognostic value in different conditions. We firstly investigated the prognostic v...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2020.31564
更新日期:2020-01-01 00:00:00
abstract::(A multicentre clinical trial) The authors treated 120 patients showing the symptoms of chronic bronchitis with BV or placebo for 6 months during the winter period of 1992-93 in a multicentre double-blind clinical trial. The status of the patients was evaluated monthly and the data were analyzed at an independent comp...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1994-06-05 00:00:00
abstract::Compression of the rostral ventrolateral medulla oblongata is one of the rarely identified causes of refractory hypertension. In patients with severe, intractable hypertension caused by neurovascular compression, neurosurgical decompression should be considered. The authors present the history of a 20-year-old man wit...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2014.29908
更新日期:2014-05-25 00:00:00
abstract:UNLABELLED:Sapporo-like viruses (SLVs) are members of the family Caliciviridae. The etiologic role of these viruses is evident but little is known about the incidence of acute gastroenteritis caused by them. Sapporo-like viruses have not been detected in Hungary before. METHODS:Between October and December 2000, 72 sp...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-02-17 00:00:00
abstract::Systemic sclerosis is a generalized systemic autoimmune disorder frequently involving the oesophagus causing reflux oesophagitis in the majority of patients. Barrett's oesophagus is one of the most serious complication of the reflux oesophagitis, in which the normal oesophageal squamous epithelium is partially replace...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Polymyositis-dermatomyositis is a rare systemic autoimmune disease which belongs to the class of idiopathic inflammatory myopathies. The disease exhibits high inter-individual variability, but chronic myositis is a common feature. As different manifestations often appear in atypical forms, establishing the precise dia...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2012.29300
更新日期:2012-03-25 00:00:00
abstract::The history of the robotic surgery is only 22 years old. The article gives a short overview regarding the history of robotics, the surgical robots, the da Vinci telemanipulator system and some further commercial and experimental surgical robotic surgical simulation is also emphasized. Robotic surgery has its own place...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2007.28225
更新日期:2007-12-09 00:00:00
abstract:INTRODUCTION:Metal elements and their excess intake have significant influence on general health. AIM:There is only little information how Far Eastern herbs resemble European's regarding their purity and essential metal element content. The aim of the authors was to determine metal elements in different Chinese and Eu...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2015.30193
更新日期:2015-08-02 00:00:00
abstract::In the past years great importance has been attributed to antioxidant therapy in the prevention and treatment of disorders developed in connection with oxidative stress. After initial success, undesirable effects, toxicities, and prooxidant effects of antioxidants were reported [CARET, ATBC study]. In addition, metaan...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2015.30302
更新日期:2015-11-22 00:00:00
abstract::The authors investigated the difficulties of differential diagnosis in diabetes, beginning in young age. They analysed the case records of fifteen young diabetics. The authors pointed out, that clinical diagnosis, carried out early, has utmost importance both of theoretical and practical significance, for correct clas...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1993-07-25 00:00:00
abstract::The authors present a case of a papillary type renal cell carcinoma. The tumor is mostly discovered accidentally; a histopathological evaluation is indispensable for an exact diagnosis. Because of a better prognosis, differentiation of this tumor type from the classic variant of renal cell carcinoma is necessary, howe...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2001-08-12 00:00:00
abstract::Authors performed an open, crossover, multicenter study of oral cilazapril versus previous captopril treatment in mild to moderate hypertension. The treatment of the 100 outpatients on daily three or four times captopril was found ineffective, or in some cases side effects or non compliance necessitated a switch to a ...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1995-10-15 00:00:00
abstract::Nowadays, keratitis, corneal infection due to wearing contact lens means an increasingly serious problem. Neglected cases may lead to corneal damage that can cause blindness in cases of otherwise healthy eyes. Early diagnosis based on the clinical picture and the typical patient history is an important way of preventi...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2013.29717
更新日期:2013-11-10 00:00:00
abstract::Diagnosis and treatment of hepatitis B virus (HBV) and hepatitis D virus infection mean for the patient to be able to maintain working capacity, to increase quality of life, to prevent cancer, and to prolong life expectancy, while the society benefits from eliminating the chances of further transmission of the viruses...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2018.31004
更新日期:2018-02-01 00:00:00