[Cilazapril replacing captopril in the therapy of medium-severe essential hypertension].

Abstract:

:Authors performed an open, crossover, multicenter study of oral cilazapril versus previous captopril treatment in mild to moderate hypertension. The treatment of the 100 outpatients on daily three or four times captopril was found ineffective, or in some cases side effects or non compliance necessitated a switch to a once daily dose of cilazapril. Reasons of ineffectivity were compliance problems in 76% of the patients during long term captopril therapy. Blood pressure decreased from 163.28 +/- 14.5/97.5 +/- 9.35 mmHg on captopril therapy to 136.67 +/- 12/83.49 +/- 7.77 mmHg at the end of a 12 week cilazapril treatment (p < 0.001). 80 patients received cilazapril monotherapy (with doses of 2.5 mg in 54 cases, 5 mg in 18 patients). 7.5 mg in 4 cases, 1 and 1.25 mg in 2 patients. In 20 patients an adjunctive diuretic was also added, while the cilazapril treatment was ineffective in 3 patients. In respect of the global evaluation and scoring of cilazapril versus captopril therapy, a clear and statistically significant improvement could be demonstrated in efficacy, tolerability and compliance after a 12 week cilazapril treatment. The 24 hour ambulatory blood pressure measurement performed in 13 patients also verified a decrease in blood pressure achieved by cilazapril therapy. Authors conclude that in case of ineffectivity of three or four times daily captopril treatment (caused most likely by non-compliance), a switch to a once daily dose drug like cilazapril is indicated.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Kovács P,Juhász A,Gábeli T,Karányi Z,Polgár P,Paragh G,Lörincz I,Arnold C

subject

Has Abstract

pub_date

1995-10-15 00:00:00

pages

2273-8

issue

42

eissn

0030-6002

issn

1788-6120

journal_volume

136

pub_type

临床试验,杂志文章,多中心研究
  • [Confirmation of a prenatal diagnosis of trisomy 13 with comparative genomic hybridization (CGH)].

    abstract::Trisomy 13 was diagnosed with genetic amniocentesis in a fetus of a 50 years old patient. Fetopathologic examination has shown cyclopy, proboscis and semilobar holoprosencephaly of the fetus, which is consistent with Patau syndrome. DNA was extracted from frozen liver tissue. Result of comparative genomic hybridizatio...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Marton T,Thein A,Bán Z,Soothill P,Oroszné NJ,Papp Z

    更新日期:2001-05-13 00:00:00

  • [Results of multicenter treatment of highly malignant non-Hodgkin's lymphomas].

    abstract::One hundred and eleven consecutive patients with highgrade non-Hodgkin's lymphoma treated in three centres between 1983 and 1988 were analysed to assess the efficacy of different types of chemotherapy. The median age at presentation was 56.9 +/- 16.6 years. According to the Kiel classification histological subtypes we...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,多中心研究,评审

    doi:

    authors: Varga G,Bérczi M,Borbényi Z,Zöllei M,István L,Szabó K,Berkessy S,Radványi G,Kelényi G

    更新日期:1991-05-26 00:00:00

  • [Prenatally diagnosed case of Pallister‒Killian syndrome].

    abstract::Pallister-Killian syndrome (PKS) is a rare, sporadic genetic disorder that is caused by the mosaic presence of a supernumerary marker chromosome, isochromosome 12p. The syndrome is a polydysmorphic condition characterized by mental retardation, craniofacial dysmorphism, hypotonia, seizures, epilepsy and certain organi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31015

    authors: Tidrenczel Z,P Tardy E,Sarkadi E,Simon J,Beke A,Demeter J

    更新日期:2018-05-01 00:00:00

  • [A case of numerous foreign bodies found in the esophagus and the right main bronchus].

    abstract::The authors report about the elimination of foreign bodies fixed in the oesophagus and aspirated into the right main bronchus. They discuss the diagnostic work and the ways of its elimination. They emphasize the importance of cooperation between the endoscopist and the surgeon. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Vass G,Réfi M,Juhász M

    更新日期:1992-07-12 00:00:00

  • [Isolation of free DNA from archived serum samples suitable for molecular genetic studies].

    abstract:INTRODUCTION:Collected and archived serum samples could be important sources for genetic studies, once DNA suitable for molecular genetic studies could be obtained from them. METHODS:DNA was isolated from 54 archived sera samples, collected previously from the participants of a Hungarian allergy study, with commercial...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Nagy B,Tarja L,Bán Z,Andrásofszky Z,Papp G,Lázár L,Nékám K,Papp Z,Réthy LA

    更新日期:2004-11-21 00:00:00

  • Long-term analysis of the results of aorto-bifemoral bypass surgery for diffuse aorto-biiliac occlusive disease

    abstract::Összefoglaló. Bevezetés: A diffúz aortobiiliacalis érszakasz occlusiv betegségének kezelésére alkalmazott aortobifemoralis bypass szerepe csökken az endovascularis műtétek térnyerése miatt. Célkitűzés: A vizsgálat célja volt a modern invazív kezelés korszakában a perioperatív és a hosszú távú eredmények elemzése aorto...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2021.31970

    authors: Pomozi E,Lengyel B,Osztrogonácz P,Nguyen DT,Szeberin Z

    更新日期:2021-01-17 00:00:00

  • [Drug therapy of gastroesophageal reflux (a prospective controlled clinical trial)].

    abstract::One year follow up(1.5, 3, 6, 12 months) study was established to examine the role of several classes of drugs in the treatment of reflux disease in 40 patients on the basis of objective control parameters (pH-metry, endoscopy, histology). The therapy was initiated, respectively, the different stage of severity (Savar...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:

    authors: Wittmann T,Rosztóczy A,Fehér A,Jármay K,Oláh T,Szendrényi V,Kiss I

    更新日期:1998-05-03 00:00:00

  • [Changes in the situation in out-of-hospital birth and the role of midwives in Hungary].

    abstract::The rate of homebirth decreased significantly by the 20th century, however, the practice has never disappeared. The Hungarian government issued a regulation of out-of-hospital birth in 2011, then allowed midwives to provide prenatal care for low-risk mothers in 2014. These were great steps toward the midwifery model o...

    journal_title:Orvosi hetilap

    pub_type: 历史文章,杂志文章,评审

    doi:10.1556/650.2016.30364

    authors: Vincze F,Lipienné Krémer I

    更新日期:2016-03-13 00:00:00

  • [Vena cava superior syndrome: surgical treatment of the thrombosis of the superior vena cava after implantation of a hemodialysis catheter--a case report and review of the literature].

    abstract::One of the rare reasons of the non malignant superior vena cava syndrome is the thrombosis of superior vena cava. Obstruction or occlusion of central veins is one of the many complications of the more and more frequently used central venous catheters and pacemaker electrodes. The authors report a case of superior vena...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2008.28207

    authors: Lénárd L,Szabados S,Imre J,Pintér O,Fazekas A,Tornai Z,Déczy K,Várady E,Papp L

    更新日期:2008-01-06 00:00:00

  • [Surgical treatment of laryngocele].

    abstract::Laryngocele is a unilateral or bilateral dilation of the saccule or appendix of the laryngeal ventricle. It is a benign lesion, often without any specific symptom, diagnosed unintentionally, but it can cause life-threatening airway obstruction, needing emergency tracheotomy. The authors present three cases of laryngoc...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2019.31447

    authors: Kiricsi Á,Fazekas P,Nagy A,Tóbiás Z,Bella Z,Rovó L,Csanády M

    更新日期:2019-08-01 00:00:00

  • [Risk of maternal and fetal disease among women older than 40 years].

    abstract::A rising trend in advanced maternal age has been observed over the last few decades. Several studies have assessed the association between advanced maternal age and adverse pregnancy outcome, including miscarriage, stillbirth, pre-eclampsia, gestational hypertension, gestational diabetes mellitus, preterm birth, deliv...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2015.30286

    authors: Vanya M,Szili K,Devosa I,Bártfai G

    更新日期:2015-12-06 00:00:00

  • [Normal values of sacroiliac index according to gender and age].

    abstract:UNLABELLED:Using quantitative sacroiliac joint scintigraphy for identifying patients with active sacroiliitis the diagnosis is relied on the abnormally high values of sacroiliac (SI) index. However, the normal range of SI index and the threshold for detecting the disease are still under discussion in the literature. A...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2009.28643

    authors: Bajner A

    更新日期:2009-08-16 00:00:00

  • [Fatal outcome of bilateral pulmonary embolism combined with ascending varicophlebitis of the lower limb: case report].

    abstract::The authors review the history and risk factors of thrombophlebitis of the lower limb, and describe the main points of surgical and conservative treatment of varicophlebitis. They present the case of a 71-year-old woman who had ascending varicophlebitis and bilateral pulmonary embolism. The authors draw attention to i...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2015.30130

    authors: Nagy I,Skribek L,Dienes AB,Rédei C,Tar M

    更新日期:2015-04-19 00:00:00

  • [Immune responses of IgG, IgA and anti-CagA IgG to Helicobacter pylori in dyspeptic and peptic ulcer patients].

    abstract::The anti-H. pylori IgG, IgA, and anti CagA responses in dyspeptic patients have been evaluated. Of 481 patients 76% tested positive for IgG anti-H. pylori, 57% for anti-CagA, and 52% IgA for anti H. pylori. There was a significant age-related increase in IgG anti-H. pylori and IgA anti-H. Pylori prevalence, whereas an...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Tamássy K,Auli P,Fekete B,Antonello C

    更新日期:1997-04-20 00:00:00

  • [Introduction of a quality index in a Hungarian endoscopy unit].

    abstract:UNLABELLED:The quality of endoscopic examinations substantially determines their value. In developed countries, Continuous Quality Management is used to improve it permanently. In Hungary there is no example for measuring quality in the field of gastrointestinal endoscopy. AIM:The measurement and improvement of qualit...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2012.29408

    authors: Gyökeres T,Rusznyák K,Visnyei Z,Schäfer E,Szamosi T,Banai J

    更新日期:2012-07-22 00:00:00

  • [Elevated pentachlorphenol in urine following Fungifen therapy].

    abstract::Urinary pentachlorophenol (PCP) was monitored in male volunteers exposed to Fungifen solution which is a readily accessible pharmaceutical product containing 1% of PCP as active ingredient, and is recommended for the local treatment of interdigital mycoses. PCP absorbed readily through the skin and its elimination was...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gönczi C,Holló A,Komáromi S,Molnár J

    更新日期:1991-02-17 00:00:00

  • [Familial hyperinsulinism].

    abstract::The authors present the case history of a 2 year old child suffering from nesidioblastosis. Severe non-ketotic symptomatic hypoglycaemia developed within the first hour of birth. Diagnosis of nesidioblastosis was confirmed by high insulin concentration accompanying hypoglycaemia, the increase in blood glucose level af...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Lásztity N,Balogh L

    更新日期:1995-07-23 00:00:00

  • [Budapest physicians practicing alternative medicine (based on a September 1991 survey)].

    abstract::Our essay is the first attempt to raise the problems related to the Hungarian alternative medicine and to outline the tendencies in this field. In our research we tried to find answers to the following questions: 1. whether the physicians in disadvantageous position show a greater tendency to start dealing with altern...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gyukits G,Koltay E

    更新日期:1993-05-30 00:00:00

  • [Experience with gestodene-containing hormonal contraceptive].

    abstract::An oral contraceptive containing gestodene (Minulet) was examined in collaborating with the Richter-Wyeth Pharmaceutical Factory. The authors present their experiences of monitoring of 591 cycles of a hundred women between 18 and 35 years of age. There were no pregnancy and severe side effects during that period. Irre...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Szabó L,Nagy K,Godó G

    更新日期:1998-03-01 00:00:00

  • [Oncologic diagnosis of serous effusions in body cavities (cytologic study and evaluation of cholesterol and carcinoembryonic antigen levels)].

    abstract::Conventional cytological evaluation of serous effusions often yields border line result: apart from positive (malignant) or negative (benign) diagnoses, a relatively large part of the findings are "suspicious for malignancy" (P3). In the present paper the authors have analysed to what extent contributes the determinat...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gulyás M,Elek G,Molnár M,Szollár L

    更新日期:1995-11-05 00:00:00

  • [Complex analysis of prognostic factors in chronic lymphocytic leukemia].

    abstract:INTRODUCTION:Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. AIMS:The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. METHODS:The mutation status o...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2007.27943

    authors: Kajtár B,Jáksó P,Kereskai L,Lacza A,Méhes G,Bodnár MA,Dombi JP,Gasztonyi Z,Egyed M,Iványi JL,Kovács G,Marton E,Palaczki A,Petz S,Tóth P,Sziládi E,Losonczy H,Pajor L

    更新日期:2007-04-22 00:00:00

  • [Transient left ventricular dysfunction: special form of stress cardiomyopathy].

    abstract:INTRODUCTION:The phenomenon of stress induced left ventricular dysfunction has been long recognised. A special reversible form of it, characterized by left ventricular apical dilatation, is the so-called "tako-tsubo" or ampoule cardiomyopathy, based on its first description by Sato et al. in 1990. The tako-tsubo cardio...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2008.28181

    authors: Tomcsányi J,Somlói M,Frész T,Arabadzisz H,Toldy-Schedel E,Sármán B,Zsoldos A,Nagy E,Farbaky Z

    更新日期:2008-02-24 00:00:00

  • [Passive euthanasia and living will].

    abstract::This article deals with the intentional distinction between murder of first degree and passive euthanasia. In Hungary, active euthanasia is considered to be a murder of first degree, whilst the Netherlands, Belgium, Luxemburg and Switzerland have legalized the active form of mercy killing in Europe. The palliative ter...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.29950

    authors: Julesz M

    更新日期:2014-07-06 00:00:00

  • [Neurovascular compression of the medulla oblongata: a rare cause of secondary hypertension].

    abstract::Compression of the rostral ventrolateral medulla oblongata is one of the rarely identified causes of refractory hypertension. In patients with severe, intractable hypertension caused by neurovascular compression, neurosurgical decompression should be considered. The authors present the history of a 20-year-old man wit...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2014.29908

    authors: Nádas J,Czirják S,Igaz P,Vörös E,Jermendy G,Rácz K,Tóth M

    更新日期:2014-05-25 00:00:00

  • [Unstable angina pectoris associated with surgically treated coronary artery atresia].

    abstract::A case report of a rare, presumably congenital form of "single coronary artery", is presented. The authors review the classification and clinical significance of the entity with special emphasis with regard to anginal symptoms and the so called sudden unexpected death syndrome. Details and result of surgical intervent...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Vaszily M,Zöllei E,Rudas L,Boda L,Ungi I,Gaál T,Török Z

    更新日期:1995-10-22 00:00:00

  • [Relationship between intestinal permeability and antibodies against food antigens in IgA nephropathy].

    abstract::Elevated antibody titers to food antigens and increased intestinal permeability in IgA nephropathy (IgA NP) suggest that these factors may be interdependent and play a role in the pathogenesis of the disease. In 1989 IgA and IgG antibodies against eight common food antigens were examined in the sera of 35 IgA NP patie...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Kovács T,Mette H,Per B,Kun L,Schmelczer M,Barta J,Jean-Claude D,Nagy J

    更新日期:1996-01-14 00:00:00

  • [Physical measurement of the dorsal kyphosis in 14-17-year old patients with Scheuermann's disease and in matched healthy controls].

    abstract::The modified use of the Debrunner-kyphometer (a special protractor to measure the dorsal kyphosis by an objective physical method) is presented. After proving the validity and reproducibility of the measuring method, the dorsal kyphosis of patients with Scheuermann's disease and of matched healthy controls was measure...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Somhegyi A,Tóth Z,Ratkó I

    更新日期:1992-03-22 00:00:00

  • [Gastric and duodenal intramural hematoma: report of two cases].

    abstract::Two cases of intramural hematoma arising in the duodenum and the stomach are reported. Both patients were male, aged 40 and 58 years, and suffered from chronic pancreatitis. Hematoma of the duodenal wall may have resulted from the acute exacerbation of the chronic pancreatitis in the first patient. As to the second ca...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Dibuz M,Szabó T,Monoki E,Nagymélykuti L,Illyés M,Varga E,Csípö L

    更新日期:1998-12-06 00:00:00

  • [Value of the Medicor CT 0100 equipment in a county hospital in the diagnosis of cerebrovascular diseases].

    abstract::Data of patients with CVD in the ward of the authors in the last quarters of 1986 and 1987 has been compared, in the second period they used a MEDICOR CT 0100 computer tomograph. The subsequent results are stressed: The rate of the patients with CVD in the Department of Neurology was approximately 40% in the studied p...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Horváth G,Szirmai I,Guseo A,Than Z

    更新日期:1990-01-14 00:00:00

  • [Implementation status of cervical screening in Europe].

    abstract::Following the recommendation of the Council of the European Union, almost all governments made a policy statement on the introduction of cytology-based cervical screening for the health care system. However, the status of implementation is uneven. In the majority of the developed countries an organised model of screen...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.30053

    authors: Döbrőssy L,Cornides A,Kovács A,Budai A

    更新日期:2014-12-14 00:00:00