Spatial regression and spillover effects in cluster randomized trials with count outcomes.

Abstract:

:This paper describes methodology for analyzing data from cluster randomized trials with count outcomes, taking indirect effects as well spatial effects into account. Indirect effects are modeled using a novel application of a measure of depth within the intervention arm. Both direct and indirect effects can be estimated accurately even when the proposed model is misspecified. We use spatial regression models with Gaussian random effects, where the individual outcomes have distributions overdispersed with respect to the Poisson, and the corresponding direct and indirect effects have a marginal interpretation. To avoid spatial confounding, we use orthogonal regression, in which random effects represent spatial dependence using a homoscedastic and dimensionally reduced modification of the intrinsic conditional autoregression model. We illustrate the methodology using spatial data from a pair-matched cluster randomized trial against the dengue mosquito vector Aedes aegypti, done in Trujillo, Venezuela.

journal_name

Biometrics

journal_title

Biometrics

authors

Anaya-Izquierdo K,Alexander N

doi

10.1111/biom.13316

subject

Has Abstract

pub_date

2020-06-18 00:00:00

eissn

0006-341X

issn

1541-0420

pub_type

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