Abstract：
:Aquaporins (AQPs) were discovered as channels facilitatingwater movement across cellular membranes. Whereas much of the research has focused on characterizing AQPs with respect to cell water homeostasis, recent discoveries in terms of the transport selectivity of AQP homologs has shed new light on their physiological roles. In fact, whereas some AQPs behave as "strict" water channels, others can conduct a wide range ofnonpolar solutes, such as urea or glycerol and even more unconventional permeants, such as the nonpolar gases carbon dioxide and nitric oxide, the polar gas ammonia, the reactive oxygen species hydrogen peroxide and the metalloids antimonite, arsenite, boron and silicon. This suggests that AQPs are also key players in various physiological processes not related to water homeostasis. The function, regulation and biological importance of AQPs in the different kingdoms is reviewed in this chapter, with special emphasis on animal and plant AQPs.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Hachez C,Chaumont Fdoi
10.1007/978-1-4419-6315-4_1subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1-17eissn
0065-2598issn
2214-8019journal_volume
679pub_type
杂志文章,评审abstract：:Methylglyoxal (MG), a highly reactive alpha-oxoaldehyde generated by oxidation of carbohydrate and glycolysis, binds to proteins and forms advanced glycation end products (AGE). MG and MG adducts have been implicated in oxidative stress-related diseases, therefore, MG detoxifying system such as the glyoxalase system (...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1241-1_6
更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-5959-7_17
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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journal_title：Advances in experimental medicine and biology
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pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-1-4615-2548-6_18
更新日期：1994-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4899-2626-5_7
更新日期：1991-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-9510-6_31
更新日期：1988-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-94-024-1079-2_72
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:In the second half of the 20th century it became obvious that a relentless increase in Type 2 diabetes mellitus (T2DM), affecting the economically affluent countries, is gradually afflicting also the developing world. This chapter shows the threat that the T2DM epidemic represents to mankind, with the astonishing rece...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4614-5441-0_6
更新日期：2012-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-024-1079-2_2
更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 临床试验,杂志文章
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更新日期：1999-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
abstract：:NCDs including diabetes, heart disease and stroke are global epidemics of the 21st century. The greatest burden on health will be in developing countries and sub-Saharan Africa is an area of major challenge: We are concerned with planning for the adult victims of the new epidemic and this includes the development of a...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4615-1321-6_4
更新日期：2001-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) negatively regulate gene expression level of mRNA post-transcriptionally. Deep sequencing and large-scale screening methods have yielded about 1,500 miRNA sequences in human. Each miRNA contains a seed sequence that is required, but not sufficient, for the correct matching with its targets. Recent t...
journal_title：Advances in experimental medicine and biology
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更新日期：2013-01-01 00:00:00
abstract：:Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections in the world and is a leading cause of morbidity and mortality in hospitalized patients.Although several antibiotics effectively treat CDI, some individuals do not respond to these drugs and may be cured by transplanting s...
journal_title：Advances in experimental medicine and biology
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更新日期：2018-01-01 00:00:00
abstract：:Tropomyosins constitute a family of highly related actin-binding proteins found in the animal kingdom from yeast to human. In vertebrates, they are encoded by a multigene family where each member can produce several isoforms through alternative splicing and for some of them with alternate promoters. Tropomyosin isofor...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-0-387-85766-4_2
更新日期：2008-01-01 00:00:00
abstract：:Fertility preservation includes all the necessary steps that have to be taken in order to implement a woman's aim for preserving and enhancing her future chances of having her own biological offspring.There are two available choices for patients to maintain their fertility.The first category includes all the preventiv...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-41596-9_25
更新日期：2020-01-01 00:00:00
