Stimulus-specific expression of inducible transcription factors in identified oxytocin neurones.

Abstract:

:The activation of the magnocellular oxytocin system by different physiological stimuli will require specific genomic responses that may or may not reflect the electrical and short-term secretory activity of the neurones. One of the main determinants of synthetic activity is the rate of transcription and this can be altered acutely by the action of inducible transcription factors (iTFs). Having shown that the expression of two iTFs, the protein products of the c-fos and c-jun genes, does not correlate directly to the electrical activity of magnocellular neurones (Luckman et al., 1994) the expression of leucine zipper iTF mRNAs was measured following different stimuli using combined radioactive and non-radioactive in situ hybridization. Stimuli that are dependent on brainstem afferents such as parturition and systemic injection of cholecystokinin caused co-induction of c-fos and c-jun in oxytocin neurones. Mild osmotic stimulation, a stimulus dependent on forebrain afferents, induced c-fos, fos B and jun B, but inhibited c-jun. Similar patterns of leucine zipper iTF expression have been noted in cultured cells following activation of protein kinases C and A, respectively. Input from the brainstem appears to be mediated, at least in part, by noradrenaline acting on alpha(1)-adrenoceptors. While the forebrain inputs are not well characterised they do appear to include a glutaminergic component that may activate a variety of receptors. Interestingly, another member of the leucine zipper family known to be induced by protein kinase A, inducible cAMP early repressor (ICER), that was previously thought to be restricted to the pineal gland, was expressed in magnocellular neurones following osmotic stimulation but not parturition. Furthermore, the differential expression of iTFs is not limited to this family. Osmotic stimulation influences c-fos, but it also causes the expression of NGFI-A and NGFI-B, members of the zinc finger family of iTFs. By contrast, an acute suckling stimulus is able to induce c-fos and NGFI-A, but not nGFI-B.

journal_name

Adv Exp Med Biol

authors

Luckman SM

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

37-48

eissn

0065-2598

issn

2214-8019

journal_volume

395

pub_type

杂志文章
  • Intracellular signaling in vascular smooth muscle.

    abstract::The two major modalities of pharmacomechanical coupling, inositol 1,4,5, trisphosphate induced Ca2+ release and modulation of Ca(2+)-sensitivity, are reviewed. Recent studies show that although changes in cytoplasmic Ca2+ play the major role in regulating smooth muscle contraction, agonists can also significantly affe...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-2946-0_4

    authors: Somlyo AV,Somlyo AP

    更新日期:1993-01-01 00:00:00

  • Role of Oligodendrocyte Dysfunction in Demyelination, Remyelination and Neurodegeneration in Multiple Sclerosis.

    abstract::Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during development and throughout adulthood. They result from a complex and well controlled process of activation, proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs) from the germinative niches of ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-47861-6_7

    authors: Dulamea AO

    更新日期:2017-01-01 00:00:00

  • Combining Membrane Potential Imaging with Other Optical Techniques.

    abstract::Membrane potential imaging using voltage-sensitive dyes can be combined with other optical techniques for a variety of applications. Combining voltage imaging with Ca2+ imaging allows correlating membrane potential changes with intracellular Ca2+ signals or with Ca2+ currents. Combining voltage imaging with uncaging t...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-17641-3_4

    authors: Jaafari N,Vogt KE,Saggau P,Leslie LM,Zecevic D,Canepari M

    更新日期:2015-01-01 00:00:00

  • Pharmacological targets for pulmonary vascular disease: vasodilation versus anti-remodelling.

    abstract::Two gross mechanisms of pathology are central to pulmonary arterial hypertension - increased pulmonary vascular tone and remodelling of the pulmonary arteries. These pathologies can be caused by a variety of aberrant processes, and combine to cause an increase in pulmonary vascular resistance and consequent right vent...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-60761-500-2_31

    authors: Thomas M

    更新日期:2010-01-01 00:00:00

  • Storyboarding in Medical Animation.

    abstract::Storyboards are a series of thumbnail images that act as a planning document for your overall animation project. Each thumbnail image is part of what is known as a shot, and shots are strung together to create scenes, which in turn create a whole animation. Medical animations, compared to film or animated movies, have...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-37639-0_8

    authors: Okemow SJ

    更新日期:2020-01-01 00:00:00

  • Electron microscopy of an oligomeric protein stabilized by polyfunctional cross-linking.

    abstract::Oligomeric proteins can be intramolecularly cross-linked with polylysine in a reaction in which a water soluble carbodiimide mediates an amide linkage between the protein carboxyl groups and the epsilon-amino groups of polylysine. Studies carried out with a cytochrome p-450 indicate that a small number of molecules in...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-3282-4_39

    authors: Gordon CN

    更新日期:1977-01-01 00:00:00

  • Hydrolysis of gangliosides in micellar and liposomal dispersion by bacterial neuraminidases.

    abstract::Aqueous dispersions of pure gangliosides contain micelles of these compounds. In this dispersion state, the rates of hydrolysis of the neuraminyl residues by bacterial neuraminidases are slowest. Incorporation of gangliosides into mixed dispersion with other lipids or into mixed micelles with bile salts considerably i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-7844-0_13

    authors: Gatt S,Gazit B,Cestaro B,Barenholz Y

    更新日期:1980-01-01 00:00:00

  • Sequence Variant and Posttranslational Modification Analysis During Cell Line Selection via High-Throughput Peptide Mapping.

    abstract::Selection of high-producing lead and backup cell lines with high-fidelity primary structure is a major goal of cell line development of protein therapeutics. Conventional techniques for sequence variant analysis, such as mass spectrometry (MS) and next-generation sequencing (NGS) have limitations on the sample number ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-15950-4_12

    authors: Xu CF,Wang Y,Bryngelson P,Sosic Z,Zang L

    更新日期:2019-01-01 00:00:00

  • Regulatory Oversight of Cell- and Tissue-Based Therapeutic Products and Gene Therapy Products in Singapore.

    abstract::The regulatory environment for cell- and tissue-based therapeutic products and gene therapy products is rapidly evolving and drug regulatory agencies are working towards establishing a risk-based system in the regulatory framework. Similarly in Singapore, a risk-based tiered approach has been applied whereby clinical ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-18618-4_11

    authors: Goh CW,Kellathur SN,Ong LL,Wu X

    更新日期:2015-01-01 00:00:00

  • Increased reduction in bone density and skin thickness in postmenopausal women on long-term corticosteroid therapy. A suggested role for estrogen add back therapy.

    abstract:BACKGROUND:Long term steroid therapy is complicated by osteoporosis and generalised thinning of the skin. These two complications of long term corticosteroid therapy were routinely assessed at the Menopause Clinic of St. Luke's Hospital, Medical School, University of Malta. METHODS:A cross sectional study was performe...

    journal_title:Advances in experimental medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1007/978-1-4615-4857-7_65

    authors: Baron YM,Brincat M,Galea R

    更新日期:1999-01-01 00:00:00

  • Effect of high hydrostatic pressure on Pacific whiting surimi.

    abstract::The effects of high hydrostatic pressure (HHP) on gel strength, microbial numbers, proteolytic activity, color and pH of Pacific whiting surimi gels were investigated. Strong gels without the use of protease inhibitors were formed with HHP treatments from 1-4 kBars. Gel strength was not affected by holding time. Total...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4899-1925-0_6

    authors: Morrissey MT,Karaibrahimoglu Y,Sandhu J

    更新日期:1998-01-01 00:00:00

  • Antiendothelial cells antibodies in patients with systemic sclerosis in relation to pulmonary hypertension and lung fibrosis.

    abstract::Although scleroderma is generally considered a fibrosing disease, it is now recognized that the underlying vascular pathology is playing a fundamental role in its pathogenesis. The present study was aimed at testing the prevalence of anti-endothelial cell antibodies (AECA) in systemic scleroderma (SSc) patients with a...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-94-007-4549-0_19

    authors: Lewandowska K,Ciurzynski M,Gorska E,Bienias P,Irzyk K,Siwicka M,Zycinska K,Pruszczyk P,Demkow U

    更新日期:2013-01-01 00:00:00

  • Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells.

    abstract::Recently advances in cancer genomics revealed the unexpected high frequencies of epigenetic abnormalities in human acute myeloid leukemia (AML). Accumulating data suggest that these leukemia-associated epigenetic factors play critical roles in both normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs)....

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-981-13-7342-8_8

    authors: Xu J,Hang X,Wu B,Chen C,Liu Y

    更新日期:2019-01-01 00:00:00

  • Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective.

    abstract::All who have contributed in writing this chapter have been patients and parents that have experienced an horrific life event. The horrific disease named necrotising fasciitis has affected our lives for ever. All four stories have explained how easily an everyday infection can develop incredibly quickly into a life-thr...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-030-57616-5_2

    authors: Cartledge D,Dove L,Richardson E,Wilkie R

    更新日期:2020-01-01 00:00:00

  • Transcriptional regulation in embryonic stem cells.

    abstract::Transcriptional regulation is a pivotal process that confers cellular identity and modulates the biological activities within a cell. In embryonic stem cells (ESCs), the intricate interplay between transcription factors and their targets on the genomic template serves as building blocks for the transcriptional network...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-7037-4_6

    authors: Heng JC,Ng HH

    更新日期:2010-01-01 00:00:00

  • Implantation associated changes in uterine secreted proteins.

    abstract::Cross sectional segments were removed from the uteri of pregnant and pseudopregnant mice and incubated in vitro with labeled amino acids. Proteins that were synthesized and secreted by these explants were separated by two-dimensional polyacrylamide gel electrophoresis and localized by fluorography. As expected, the ov...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-1297-0_12

    authors: Weitlauf HM

    更新日期:1987-01-01 00:00:00

  • In vitro interaction of coronaviruses with primate and human brain microvascular endothelial cells.

    abstract::Primary human and primate brain microvascular endothelial cells were tested for permissiveness to coronaviruses JHM and 229E. While sub-genomic viral RNAs could be detected up to 72 hours post-infection, primate cells were abortively infected and neither virus caused cytopathology. Human cells were non-permissive for ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-1899-0_11

    authors: Cabirac GF,Murray RS,McLaughlin LB,Skolnick DM,Hogue B,Dorovini-Zis K,Didier PJ

    更新日期:1995-01-01 00:00:00

  • Role of Tumor Specific niche in Colon Cancer Progression and Emerging Therapies by Targeting Tumor Microenvironment.

    abstract::Colorectal cancer is the third most common form of cancer worldwide leading to escalating mortality rates and mainly includes hereditary, sporadic and colitis-associated cancer development. The escalated mortality rates is due to the limited treatment options as this form of cancer is usually not easy to diagnose in i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2019_355

    authors: Banerjee A,Chabria Y,Kanna N R R,Gopi J,Rowlo P,Sun XF,Pathak S

    更新日期:2019-04-11 00:00:00

  • EM reconstruction of adhesins: future prospects.

    abstract::Both Gram-negative and Gram-positive pathogenic bacteria present a remarkable number of surface-exposed organelles and secreted toxins that allow them to control the primary stages of infection, bacterial attachment to host cell receptors and colonization. The mediators of these processes, called adhesins, form a hete...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-94-007-0940-9_17

    authors: Ferlenghi I,Giusti F

    更新日期:2011-01-01 00:00:00

  • Septic-Induced microRNA Expression Modulations Are Linked to Angiogenesis, Vasomotion, and Hypoxia-Induced Processes.

    abstract::Sepsis is an exaggerated immune reaction to an infection, which leads to organ dysfunction especially circulatory failure. This is based on cellular processes, which are regulated by post-transcriptional gene expression modulations including microRNAs (miRNAs). In order to elucidate the role miRNAs play in septic proc...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-91287-5_36

    authors: Schmidt B,Roessler C,Schumann J

    更新日期:2018-01-01 00:00:00

  • Regulation of taurine release in the hippocampus of developing and adult mice.

    abstract::Taurine release in mouse hippocampal slices is regulated by several neurotransmitter receptor systems. The ionotropic glutamate receptors and the adenosine receptor A(1) are the most effective. The effect of N-methyl-D-aspartate receptors is mediated via activation of the pathway involving nitric oxide and 3',5'-cycli...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4614-6130-2_11

    authors: Oja SS,Saransaari P

    更新日期:2013-01-01 00:00:00

  • Effect of continuous melatonin infusions on steady-state plasma melatonin levels, metabolic fate and tissue retention in rats under near physiological conditions.

    abstract::The fate and disposition of melatonin released into the circulation is still poorly understood, and almost all current knowledge is derived from measurements made after one single, often very large dose of labeled melatonin. In continuous infusion experiments in freely moving rats, 500 ng melatonin/mL hr had to be inf...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4709-9_39

    authors: Messner M,Hardeland R,Rodenbeck A,Huether G

    更新日期:1999-01-01 00:00:00

  • Lipid rafts, caveolae and GPI-linked proteins.

    abstract::Lipid rafts and caveolae are specialized membrane microdomains enriched in sphingolipids and cholesterol. They function in a variety of cellular processes including but not limited to endocytosis, transcytosis, signal transduction and receptor recycling. Here, we outline the similarities and differences between lipid ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-1222-9_1

    authors: Reeves VL,Thomas CM,Smart EJ

    更新日期:2012-01-01 00:00:00

  • Animal Models to Study Cancer and Its Microenvironment.

    abstract::Cancers are complex tissues composed by genetically altered cancer cells and stromal elements such as inflammatory/immune cells, fibroblasts, endothelial cells and pericytes, neuronal cells, and a non-cellular component, the extracellular matrix. The complex network of interactions and crosstalk established between ca...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34025-4_20

    authors: Mendes N,Dias Carvalho P,Martins F,Mendonça S,Malheiro AR,Ribeiro A,Carvalho J,Velho S

    更新日期:2020-01-01 00:00:00

  • Proglucagon-derived peptides in the neuroendocrine system.

    abstract::Using several novel in vitro culture systems, we have examined the tissue-specific regulation of the proglucagon-derived peptides, at the levels of proglucagon gene expression and pGdp synthesis and secretion. Our studies indicate that proglucagon gene expression in intenstine, hypothalamus and pancreas is under the r...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4684-5931-9_12

    authors: Brubaker PL,Stobie KM,Roberge JN,Lui EY,Drucker DJ

    更新日期:1991-01-01 00:00:00

  • Effect of Transcranial Direct Current Stimulation over the Primary Motor Cortex on Cerebral Blood Flow: A Time Course Study Using Near-infrared Spectroscopy.

    abstract::Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that is applied during stroke rehabilitation. The purpose of this study was to examine diachronic intracranial hemodynamic changes using near-infrared spectroscopy (NIRS) during tDCS applied to the primary motor cortex (M1). Se...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4939-3023-4_42

    authors: Takai H,Tsubaki A,Sugawara K,Miyaguchi S,Oyanagi K,Matsumoto T,Onishi H,Yamamoto N

    更新日期:2016-01-01 00:00:00

  • Mycotoxins and fermentation--beer production.

    abstract::Along with food safety issues due to mycotoxins, the effects of Fusarium infections on malt and beer quality can be disastrous. While some of the Fusarium head blight mycotoxins, such as DON, present in infected barley may be lost during steeping, the Fusarium mold is still capable of growth and mycotoxin production d...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-0629-4_22

    authors: Wolf-Hall CE,Schwarz PB

    更新日期:2002-01-01 00:00:00

  • Induction of indoleamine 2,3-dioxygenase in human cells in vitro.

    abstract::IFN-gamma is the most effective principle responsible for IDO induction in human cells in vitro. Lymphocyte factors support the effect of other IFN species. Induction of IDO and influence of various factors on IDO is correlated to pteridine synthesis. Cooperative effects of several mediators may account for in vivo ob...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-5952-4_55

    authors: Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

    更新日期:1991-01-01 00:00:00

  • Effect of processing on Fusarium mycotoxins.

    abstract::Mycotoxins are secondary metabolites produced by a wide variety of fungal species that contaminate food or feed. Fumonisins (FUM), deoxynivalenol (DON) and zearalenone (ZEN) are examples of common mycotoxins in grains that have been shown to affect human and/or animal health. Physical, chemical and biological methods ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-4853-9_16

    authors: Jackson LS,Bullerman LB

    更新日期:1999-01-01 00:00:00

  • Virological Situation in Poland in the 2016/2017 Epidemic Season Based on Sentinel Data.

    abstract::The influenza Sentinel surveillance system is a source of valuable data about the dynamics of epidemic seasons in Poland. During the epidemic season 2016/2017, more than 1,000 samples were examined, of which 48% were positive for influenza diagnosis. The predominance of influenza A/H3N2/ was confirmed. Influenza B vir...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2018_237

    authors: Cieślak K,Szymański K,Kowalczyk D,Hallmann-Szelińska E,Brydak LB

    更新日期:2018-01-01 00:00:00