Abstract:
BACKGROUND:Our current understanding of the role of dequalinium chloride (DECA) in the progression of glioma remains very limited. This study was aimed to investigate the effect of DECA on human glioma cell lines in vitro and vivo. METHODS:The underlying molecular mechanism was analyzed for developing potential targeted agents. MTT assay, genomic DNA electrophoresis, DAPI staining, TUNEL staining, and wound scratch assay were performed to evaluate the effect of DECA on human glioma cell lines. Bioinformatics methods were used to screen the possible signaling pathway proteins, and the expression of these proteins and the corresponding mRNA was measured. RESULTS:DECA significantly inhibited the growth and proliferation of human glioma cells. Screening of apoptosis-related proteins showed the mRNA expression level of 6 genes was significantly changed after DECA administration. CONCLUSION:This study shows that DECA effectively inhibits the growth of glioma cells in vitro and vivo. DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Yu Y,Yang B,Yu J,Zhao G,Chen Fdoi
10.1007/s00701-020-04401-xsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
1683-1690issue
7eissn
0001-6268issn
0942-0940pii
10.1007/s00701-020-04401-xjournal_volume
162pub_type
杂志文章abstract:BACKGROUND:Brain arteriovenous malformations (AVMs) of the elderly have not received sufficient attention, given the increase in age of individuals in recent years. We therefore designed a retrospective study to clarify features of brain AVMs in this age group in comparison with their counterparts in the general popula...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0346-9
更新日期:2004-10-01 00:00:00
abstract::Early onset "juvenile type" Parkinson's disease is commonly associated with disabling bilateral levodopa-induced dyskinesias. We report here a successful contemporaneous bilateral postero-ventral pallidotomy performed on a 46-year-old male with juvenile type Parkinson's and associated levodopa incited symmetric dyskin...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808622
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare the effects of single and dual nerve transfer for the repair of shoulder abduction in patients with upper or upper and middle trunk root avulsion. METHODS:We carried out a retrospective analysis of 20 patients with C5-C6 or C5-C7 root avulsion treated by nerve transfe...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03847-y
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate gross and microscopic anatomical features of the vestibulocochlear nerve or eighth cranial nerve (CNVIII) from fresh cadavers, especially the nerve's central myelin portion (CMP) and transitional zone (TZ), and to consider any pathological implications. METHODS:Six fres...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1479-x
更新日期:2012-12-01 00:00:00
abstract::The clinical features of 6 children who are probable sufferers of "unilateral" Moyamoya disease are here reported. They showed angiographic findings which were compatible with those of Moyamoya disease, albeit only on one side. They did not, however, show any basic aetiologic factors. The age of onset, the clinical sy...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808612
更新日期:1994-01-01 00:00:00
abstract::Thirteen of 145 patients with post-traumatic subdural hygroma (SDHy) developed chronic subdural haematoma (CSDH) at the involved site over a period of 6 years. CSDHs were found at the site of SDHys with no history of further head injury at a mean interval of 56 days. It appeared that these 13 patients did not have any...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808545
更新日期:1994-01-01 00:00:00
abstract::Patients with multiple intracranial aneurysms present a great challenge to neurosurgical practice. The presence of one or more additional aneurysms, whether recognized or unrecognized, along with the source of the haemorrhage profoundly changes the outcome. It also alters the timing and strategy of surgery. In this st...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456314
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Most complications of radiosurgery occur after 6-12 months and some long term complications up to after 5-10 years. Although severe, immediate side effects are rare, we report a patient who shows that this possibility should be taken into account when large volumes are treated especially in the posterior fos...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0053-y
更新日期:2003-08-01 00:00:00
abstract::We investigated the role of plasminogen activators (PAs) and their inhibitor (plasminogen activator inhibitor-1, PAI-1) in human brain tumours. The amounts of urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1), and the activity of u-PA a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050112
更新日期:1998-01-01 00:00:00
abstract::In patients with brain metastasis from lung cancer, we have been able to control local recurrence in approximately 80% of cases. But many of them tend to show brain atrophy with mental deterioration developing a few months after whole brain radiation. To prevent brain atrophy, we have attempted treating patients, whos...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401458
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Some intracranial aneurysms treated by stent-assisted coiling (SAC) with incomplete occlusion undergo progressive occlusion (PO) during follow-up period. We analyzed the predictors for the occurrence of PO. METHODS:Among 74 cerebral aneurysms treated by SAC using the Enterprise or Neuroform stents from 2010...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3199-8
更新日期:2017-07-01 00:00:00
abstract::In this study, which comprises 144 consecutive head injuries, the initial clinical assessment and the findings of the initial CT scan are related to the outcome. The mortality is related to the patient's level of consciousness and pupillary light reflex on admission. The disability rate (= number of disabled/number of...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405444
更新日期:1982-01-01 00:00:00
abstract::Our study was carried out in 34 rabbits which were divided into three groups (A, B, C). In group A (10 animals), a mid-laminectomy of the first lumbar (L1) vertebra was performed and the circulation in the exposed spinal cord segment was examined using both procedures, the videomicroscopy as well as the r.S.C.B.F. mea...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01404150
更新日期:1987-01-01 00:00:00
abstract::In the arteriovenous malformations of the posterior fossa the arterial feeders and the dural venous sinuses can be identified in anatomical terminology. The arterialised veins which do not conform to adult anatomical descriptions represent the persistent embryonic veins of the metencephalic and myelencephalic segments...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406021
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Management of asymptomatic meningiomas represents a challenge due to the absence of a solid consensus on which is the best management strategy. There are various known factors predicting meningiomas growth risk. However, the Asian Intracranial Meningioma Scoring System (AIMSS) is the only described score to ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04056-3
更新日期:2019-11-01 00:00:00
abstract::In 15 patients without acute brain injury the concentrations of Neuron-specific Enolase (NSE), S-100 Protein (S-100), Creatine Kinase (CK), and Creatine Kinase BB isoenzyme (CK-BB) in ventricular cerebrospinal fluid (CSF) were measured immediately after lateral ventricle cannulation for diagnostic or treatment purpose...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400675
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Awake craniotomy is a valuable procedure since it allows brain mapping and live monitoring of eloquent brain functions. The advantage of minimizing resource utilization is also emphasized by some physicians in North America. Data on how well an awake craniotomy is tolerated by patients and how much stress it...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-014-2038-4
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Z-L response (ZLR) has been suggested to a new electromyographic (EMG) potential recorded from the facial muscle of patient with hemifacial spasm (HFS) during microvascular decompression (MVD). Although ZLR has been suggested to be useful, experience of ZLR monitoring is limited and its significance during M...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3462-z
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Autogenous cranioplasty infection requiring bone flap removal is under-recognised as a major complication causing significant morbidity. Microbial contamination of stored bone flaps may be a significant contributing factor. Current infection control practices and storage procedures vary. It is not known whet...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1517-8
更新日期:2013-02-01 00:00:00
abstract::At the National Institute of Neurosurgery a team of ophthalmologists and neurosurgeons has for 20 years been collaborating in the research and treatment of optic nerve gliomas. Among 34 patients, 30 were under the age of 20 years, and 20 under the age of 10 years. Of the 20 patients younger than 10 years, 16 were girl...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01809149
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Microscopic transsphenoidal surgery (mTSS) is a well-established method to address adenomas of the pituitary gland. Endoscopic transsphenoidal surgery (eTSS) has become a viable alternative, however. Advocates suggest that the greater illumination, panoramic visualization, and angled endoscopic views afforde...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00701-017-3438-z
更新日期:2018-05-01 00:00:00
abstract::The hypothesis is developed that plateau waves (PW) are caused by an abrupt elevation of postcapillary flow resistance induced by compression of the outlets of the leptomeningeal veins. It is shown by means of a physical model that the main prerequisite for venous outlet compression consists in an elevation of the out...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01407125
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:Cardiopulmonary bypass with profound hypothermia and circulatory arrest has seen a resurgence as an adjunct technique in neurological surgery. We report our experience with this technique in treating seven complex vertebro-basilar aneurysms. METHODS:Skull base approaches were used in all cases, providing exc...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章
doi:10.1007/s007010050259
更新日期:1999-01-01 00:00:00
abstract::The cavum septi pellucidi (CSP) and cavum Vergae (CV) are persistent, primitive, or acquired, midline structures of adult human brain. It is customary to distinguish between the non-communicating and the communicating cava, depending on whether the cavum communicates with the cerebral ventricular system or not. Only a...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808836
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:For gliomas, the goal of surgery is to maximise the extent of resection (EOR) while minimising the postoperative morbidity. The purpose of this study was to evaluate the benefits of a protocol developed for the surgical management of gliomas located in language areas, where tractography-integrated navigation...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1580-1
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Catheter-assisted Guglielmi detachable coiling (CAGDC) is a technical option that was developed to allow the endovascular treatment of wide-necked aneurysms. We report upon our experiences of the CAGDC in treating aneurysms with an assessment of its efficacy and safety. METHODS:The effect of CAGDC of wide-n...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0881-7
更新日期:2006-10-01 00:00:00
abstract::The authors report their experience with CT scanning ina series of 4 cases of subdural empyema, over a period of 10 months; all the patients were male, aged 16 to 25 years. A review of the literature shows that this disease, in spite of the large variety and efficacy of the available antibiotics, is marked by a signif...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01740084
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The effectiveness of pallidal deep brain stimulation (GPi DBS) for cervical dystonia has been extensively described, but controversies exist about which prognostic factor is clinically useful. We previously reported that classification of tonic- or phasic-type cervical dystonia is useful for predicting clini...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-04076-z
更新日期:2019-12-01 00:00:00
abstract::The authors report seven cases of cerebellar infarcts in the distribution of the PICA, of whom six were treated surgically. Only one patient died and he was not operated on. Although of the remaining six patients four were comatose, and two presented obvious signs of midbrain decerebration, all of them subsequently sh...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401324
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Adjuvant systemic chemotherapy increases survival of primary malignant glioma patients beyond 12-18 months. The only interstitial chemotherapy treatment approved for malignant glioma is Gliadel wafer containing carmustine (BCNU) placed in the resection cavity at surgery. Analysis of a large trial by Westphal ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00701-005-0707-z
更新日期:2006-03-01 00:00:00