Abstract:
OBJECTIVES:Exposure to high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) may cause cancer in chimney sweeps and creosote-exposed workers, however, knowledge about exposure to low-molecular-weight PAHs in relation to cancer risk is limited. In this study, we aimed to investigate occupational exposure to the low-molecular-weight PAHs phenanthrene and fluorene in relation to different cancer biomarkers. METHODS:We recruited 151 chimney sweeps, 19 creosote-exposed workers and 152 unexposed workers (controls), all men. We measured monohydroxylated metabolites of phenanthrene and fluorene in urine using liquid chromatography coupled to tandem mass spectrometry. We measured, in peripheral blood, the cancer biomarkers telomere length and mitochondrial DNA copy number using quantitative PCR; and DNA methylation of F2RL3 and AHRR using pyrosequencing. RESULTS:Median PAH metabolite concentrations were higher among chimney sweeps (up to 3 times) and creosote-exposed workers (up to 353 times), compared with controls (p<0.001; adjusted for age and smoking). ∑OH-fluorene (sum of 2-hydroxyfluorene and 3-hydroxyfluorene) showed inverse associations with percentage DNA methylation of F2RL3 and AHRR in chimney sweeps (B (95% CI)=-2.7 (-3.9 to -1.5) for F2RL3_cg03636183, and -7.1 (-9.6 to -4.7) for AHRR_cg05575921: adjusted for age and smoking), but not in creosote-exposed workers. In addition, ∑OH-fluorene showed a 42% mediation effect on the inverse association between being a chimney sweep and DNA methylation of AHRR CpG2. CONCLUSIONS:Chimney sweeps and creosote-exposed workers were occupationally exposed to low-molecular-weight PAHs. Increasing fluorene exposure, among chimney sweeps, was associated with lower DNA methylation of F2RL3 and AHRR, markers for increased lung cancer risk. These findings warrant further investigation of fluorene exposure and toxicity.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Alhamdow A,Essig YJ,Krais AM,Gustavsson P,Tinnerberg H,Lindh CH,Hagberg J,Graff P,Albin M,Broberg Kdoi
10.1136/oemed-2020-106413subject
Has Abstractpub_date
2020-07-01 00:00:00pages
488-495issue
7eissn
1351-0711issn
1470-7926pii
oemed-2020-106413journal_volume
77pub_type
杂志文章abstract:OBJECTIVES:To determine the prevalence and risk factors for symptoms related to gloves, and the relation between symptoms and immunological evidence of type 1 hypersensitivity to latex in a United Kingdom health care setting. METHODS:A cross sectional survey was carried out among 773 employees at a British hospital. A...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.12.833
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence inform...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102728
更新日期:2015-07-01 00:00:00
abstract:AIMS:To investigate the acute systemic inflammatory response to welding fume exposure. METHODS:Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM2.5) was assessed using cyclone samplers. Markers of systemic inflammatio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014795
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The effect of indoor temperature control on summer and winter ambulatory blood pressure levels at work was studied. METHOD:Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored once in summer and once in winter in 101 healthy normotensive subjects aged 28-63 years, engage...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.11.715
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Office computer workers are at increased risk for neck/upper extremity (UE) musculoskeletal pain. METHODS:A seven-month office ergonomic intervention study evaluated the effect of two engineering controls plus training on neck/UE pain and mechanical exposures in 113 computer workers, including a 3-month fol...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2014-102160
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To describe the methods used in the nuclear industry family study for which a comprehensive database has been assembled that links employment in the nuclear industry and dosimetry records to information on employees' reproductive health and the health of their children. To discuss the response rates and chara...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.12.793
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:Vibration white finger (VWF), also known as "occupational Raynaud's phenomenon", is marked by arterial hyperresponsiveness and vasoconstriction during cold stimulation. The impact of tobacco use, and by extension stopping smoking, on the long term course of the disease has been inconclusively characterised. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.5.341
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. METHODS:The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105606
更新日期:2019-10-01 00:00:00
abstract:AIMS:To describe the age standardised prevalence of symptomatic osteoarthritis (OA) in a nationwide cross sectional survey of 10 412 patients in France, and their functional and work limitations. METHODS:Cases in the survey were compared with their expected counterpart by age, gender, and occupational groupings using ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.882
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:There have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11 years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure. METHODS:Using Cox proportional hazards models, we estimated mortality risks accordin...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101859
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Because of the rarity of small bowel adenocarcinoma (SBA), little is known about the aetiology of this disease. This study aimed to identify occupational clustering of cases SBA as a systematic approach to new hypotheses on the aetiology of this disease. METHODS:A European multicentre case-control study was...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.57.11.760
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:Few studies have assessed the effects of policies aimed to reduce traffic-related air pollution. The aims of this study were to evaluate the impact, in terms of air quality and health effects, of two low-emission zones established in Rome in the period 2001-2005 and to assess the impact by socioeconomic posi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.063750
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:Limited evidence suggests the association between severity of acute occupational pesticide poisoning and depressive symptoms in farmers. The aim of this study was to investigate the association between occupational pesticide exposure and depressive symptoms among male farmers in South Korea. METHODS:A natio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101005
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). METHODS:A cross sectional medical survey. The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufactur...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.11.742
更新日期:1998-11-01 00:00:00
abstract:AIMS:To determine the cancer incidence in Swedish cabin crew. METHODS:Cancer incidence of cabin crew at the Swedish Scandinavian Airline System (SAS) (2324 women and 632 men) employed from 1957 to 1994 was determined during 1961-96 from the Swedish National Cancer Register. The cancer incidence in cabin crew was compa...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.11.810
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:To determine whether employees in the automobile industry in Michigan are at elevated risk of urinary bladder cancer. METHODS:The authors conducted a population-based case-control study including 418 cases and 571 controls. History of employment within the automobile industry was coded according to the US C...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.041616
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To obtain knowledge on male reproductive toxicity of inorganic lead at current European exposure levels and to establish lowest adverse effect levels, if any. METHODS:A cross sectional survey of the semen of 503 men employed by 10 companies was conducted in the United Kingdom, Italy, and Belgium. The mean b...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.59.4.234
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:Occupational workload has been associated with an increased risk of osteoarthritis. The objective was to further examine the association between workload and occurrence of osteoarthritis and in particular to study whether heavy workload has similar importance as a causative factor for osteoarthritis of the hi...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2007.033365
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Rates of surgically treated carpal tunnel syndrome (CTS) among blue- and white-collar workers and housewives in the general population were compared. METHODS:Surgically treated cases of idiopathic CTS were investigated among 25-59-year-old residents of Tuscany, Italy, during 1997-2000, based on obligatory d...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.040212
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although past studies of workplace exposures have contributed greatly to our understanding of carcinogens, significant knowledge gaps still exist with regard to the actual extent of exposure among current workers, with no routinely collected population-based data being available in most countr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101651
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence and incidence of upper extremity musculoskeletal pain (UEMP) and related disability among office workers in Costa Rica, Nicaragua and Spain. METHODS:Data from the multinational Cultural and Psychosocial Influences on Disability (CUPID) study on 947 (93%) participants at baseline w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103327
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS:107 participants (mean age 41.4 year...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-102808
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:To investigate the association between preeclampsia and maternal exposure to ambient particulate matter (PM) with aerodynamic diameter less than 10 μm (PM10) and 2.5 μm (PM2.5) mass and sources. METHODS:Our analysis was based on a hospital cohort of pregnant women (N=3182) residing in Barcelona, Spain, duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101693
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Psychosocial work characteristics have been prospectively associated with depressive symptoms. However, methodological limitations have raised questions regarding causality. It is also unclear to what extent depressive symptoms affect the experience of the psychosocial work environment. We examined contempor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105450
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult. This study explores the role and significance of the physical and psychosocial work env...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.022889
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. METHODS:The Italian SETIL study (Study on the aetio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101604
更新日期:2013-12-01 00:00:00
abstract:AIMS:To investigate the hypothesis that long term exposure to excessive noise can increase the risk of ischaemic heart disease. METHODS:A case-control design, nested within a cohort of nuclear power workers employed at two sites in England over the period 1950-98, was used. Cases were men who died from ischaemic heart...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.026245
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To carry out a comprehensive field investigation to evaluate various conventional and recently developed biomarkers for exposure to low concentrations of benzene. METHODS:Analyses were carried out on environmental air, unmetabolised benzene in blood and urine, urinary trans, transmuconic acid, and three majo...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.5.328
更新日期:1996-05-01 00:00:00
abstract::Mortality data have been updated for a further 12 years for a cohort of workers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The cohort consisted of 15,826 male and female employees who were exposed to styrene for at least six months between 1948 and 1977 at...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.6.386
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVES:We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS:Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial ca...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2009.052571
更新日期:2011-04-01 00:00:00