Abstract：
OBJECTIVE:Primary outcomes from the COMBINE Study indicated support for naltrexone (Revia) on measures of abstinence and time to heavy drinking; however, effect sizes were modest. The delineation of individual difference variables that qualify these results could aid efforts to target treatment approaches appropriately. Laboratory and clinical studies have found greater effectiveness of naltrexone among men and those with familial alcoholism. The present study used multilevel modeling to investigate family history of alcoholism (FHA) based on first-degree relatives and gender as moderators of naltrexone's effects on three drinking outcomes: percentage of days abstinent, drinks per drinking day, and percentage of heavy drinking days. METHOD:Data were drawn from the COMBINE public data set and included the subsample of participants (n = 603) randomized to receive active medication or placebo plus medical management. RESULTS:We observed a main effect of FHA on drinks per drinking day (B = 2.01, SE = .91, p = .03) such that greater FHA was associated with greater alcohol use per drinking occasion. No other main effects of FHA were observed on drinking outcomes. A significant Naltrexone × Time interaction was observed for percentage of heavy drinking days (B = -1.61, SE = .69, p = .02), consistent with the previously published COMBINE results. No significant Naltrexone × FHA interactions were observed for any of the three outcomes. Gender did not modify these results. CONCLUSIONS:Taken together, these results indicate an effect of FHA on drinking behavior but do not support FHA among first-degree relatives as a moderator of naltrexone's efficacy in this sample.
journal_name
J Stud Alcohol Drugsjournal_title
Journal of studies on alcohol and drugsauthors
Capone C,Kahler CW,Swift RM,O'Malley SSdoi
10.15288/jsad.2011.72.135subject
Has Abstractpub_date
2011-01-01 00:00:00pages
135-40issue
1eissn
1937-1888issn
1938-4114journal_volume
72pub_type
杂志文章,多中心研究,随机对照试验abstract：OBJECTIVE:Alcohol brief interventions (BIs) for youth are efficacious, but effect sizes found have been modest. This article presents secondary data analyses from a randomized controlled trial of motivational interviewing-based (MI) alcohol BIs among youth in an emergency department, examining within-session predictors...
journal_title：Journal of studies on alcohol and drugs
pub_type： 杂志文章,随机对照试验
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更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has developed a two-question tool for the detection of unhealthy drinking (NIAAA-2Q) that investigates excessive alcohol consumption per single occasion. NIAAA-2Q can be commuted into a four-question tool (NIAAA-4Q) by the addition of two question...
journal_title：Journal of studies on alcohol and drugs
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abstract：OBJECTIVE:Relatively little research has evaluated motives for using marijuana based on users' self-reported reasons. This article details the construction and psychometric validation of a new marijuana motives questionnaire. METHOD:Participants included 346 marijuana-using college students who completed online assess...
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更新日期：2009-03-01 00:00:00
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journal_title：Journal of studies on alcohol and drugs
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The current study examined the relationship between severity of alcohol use disorders (AUDs) and the neural circuits that underlie response inhibition and error monitoring. In addition, we explored pre- and post-inhibition trial processes to determine the potential causal mechanisms responsible for disinhibit...
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doi：10.15288/jsad.2013.74.141
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journal_title：Journal of studies on alcohol and drugs
pub_type： 杂志文章,多中心研究
doi：10.15288/jsad.2012.73.613
更新日期：2012-07-01 00:00:00
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journal_title：Journal of studies on alcohol and drugs
pub_type： 杂志文章
doi：10.15288/jsad.2007.68.548
更新日期：2007-07-01 00:00:00
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doi：10.15288/jsad.2015.76.552
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pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Journal of studies on alcohol and drugs
pub_type： 杂志文章
doi：10.15288/jsad.2007.68.824
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doi：10.15288/jsad.2008.69.915
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of studies on alcohol and drugs
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